UbiQGel (co-enzyme Q10) / Tishcon - LARVOL DELTA

Comparative study on Perfluoro(2-methyl-3-oxahexanoic) acid removal by quaternary ammonium functionalized silica gel and granular activated carbon from batch and column experiments and molecular simulation-based interpretation. (PubMed, Sci Total Environ) - "However, in the presence of carbamazepine, neither of the adsorbents significantly changed the breakthrough time for HFPO-DA. Consequently, our study positions Qgel as a promising alternative for effective HFPO-DA removal, contributing uniquely to the field. Additionally, our exploration of molecular simulations in predicting micropollutant removal adds novelty to our study."

Journal

Reciprocal crosslink among MeCP2/BDNF /CREB signaling pinpointed in autism spectrum disorder. (PubMed, Toxicol Rep) - "NQ and LNQ displayed improvement in DNA damage in almost all brain regions after EFA alterations; even better results were noticed post-LNQ therapy. Therefore, it may be concluded that neuquinon and liposomal-loaded neuquinon have a therapeutic index versus EFA-induced autism in a rat model."

Journal • Autism Spectrum Disorder • CNS Disorders • Genetic Disorders • Pain

Comparative Single-dose Bioavailability Study of Different CoQ10 Formulations (clinicaltrials.gov) - P=N/A | N=30 | Completed | Sponsor: Nutrition Institute, Slovenia | Recruiting ➔ Completed | Trial completion date: Dec 2021 ➔ Dec 2022

Trial completion • Trial completion date

"PSC Software Releases Four New Free Features to ACE Quality Management Software Customers https://t.co/qGElZspv1G" (@NewsFromBW)

".@BoehringerES, amb seu a #SantCugat del Vallès, registra un augment de les seves vendes netes d’un 6,3% https://t.co/QgeLX2Hc3I" (@DiarideTerrassa)

Synthesis of Oxidant Functionalised Cationic Polymer Hydrogel for Enhanced Removal of Arsenic (III). (PubMed, Gels) - "A cationic polymer gel (N-[3-(dimethylamino)propyl]acrylamide, methyl chloride quaternary)(DMAPAA-Q gel)-supported oxidising agent (KMnO or KCrO) was proposed to remove As from water...The removal of As is influenced by the co-existing high-valence anions. Based on these results, the gels were found to be efficient for the As(III) adsorption and could be employed for the As(III) removal from the industrial wastewater."

Journal

Comparative Single-dose Bioavailability Study of Different CoQ10 Formulations (clinicaltrials.gov) - P=N/A; N=30; Recruiting; Sponsor: Nutrition Institute, Slovenia

Clinical • New trial

Designer microenvironments to control oncogenic phenotype (AACR 2018) - "This suggests that ECM-cell interaction solely reversibly influences the cell morphology and no selective pressure of specific clones occurs. Encouraged by these findings, we are now characterizing the gene expression profiles of the different phenotypes and exploiting this QGel platform to study drug responses."

Non Small Cell Lung Cancer

"Links to the basic research papers covered by Richard Bucala at #ACR20 1. https://t.co/qgeLdBE8bl 2. https://t.co/a1YF3EDVRq 3. https://t.co/DQDF7nRCSN 4. https://t.co/Gdv8xEQ48E 5. https://t.co/qbNsxTOQm4 6. https://t.co/yIh3sOAVGJ Happy reading!" (@NatRevRheumatol)

A fully defined 3D matrix for ex vivo expansion of human colonic organoids from biopsy tissue. (PubMed, Biomaterials) - "In order to overcome these limitations, and to enable clinical translation, we tested the use of a fully defined hydrogel matrix, QGel CN99, to establish and expand intestinal organoids directly from human colonic biopsies...All data proved comparable to organoids cultured in the BME-benchmark Matrigel. The application of a fully defined hydrogel, completely bypassing the use of BMEs, will drastically improve the reproducibility and scalability of organoid studies, but also advance translational applications in personalized medicine and stem cell-based regenerative therapies."

Journal • Preclinical • Oncology

Immediate or Delayed Naturopathic Medicine in Combination With Neo-Adjuvant Chemotherapy for Breast Cancer (clinicaltrials.gov) - P1/2; N=20; Not yet recruiting; Sponsor: Christina Shannon; Initiation date: Aug 2015 ➔ Dec 2015; Trial primary completion date: Aug 2017 ➔ Jan 2018

Trial initiation date • Trial primary completion date • Biosimilar • Breast Cancer • Immunology • Inflammation • Oncology • Triple Negative Breast Cancer

A Safety Study of Orally Administered BPM31510 in Healthy Subjects (clinicaltrials.gov) - P1; N=20; Completed; Sponsor: Berg, LLC; Not yet recruiting ➔ Completed; Initiation date: Aug 2015 ➔ Nov 2015

Trial completion • Trial initiation date • Biosimilar

ESTABLISHING HUMAN COLONIC ORGANOIDS FROM TISSUE BIOPSIES IN A FULLY-DEFINED HYDROGEL (DDW 2020) - "of Gastroenterology at Herlev Hospital collaborated with QGel SA to successfully identify an easy-to-use and fully-defined extracellular matrix for the culture of human intestinal organoids established directly from fresh colonic biopsies... We have identified a fully-defined matrix that efficiently supports primary human colonic organoids long-term, completely by-passing the use of BME. We expect this novel fully-defined matrix to drastically improve the reproducibility of organoid studies and to advance the translational use of stem cell-based therapies in clinical settings."

Gastroenterology

How can multi-bond network hydrogels dissipate energy more effectively: an investigation on the relationship between network structure and properties. (PubMed, Soft Matter) - "The obtained quaternary-crosslinked hydrogels (Q-gel 10%-Fe5) (50 wt% water content) exhibit significantly improved mechanical properties: tensile strength as high as 6.83 MPa with a fracture energy of 29.9 MJ m-3. This work provides clear insight into the relationship between network structure and mechanical properties in super tough MBN hydrogels."

Journal • Musculoskeletal Diseases • Orthopedics