brozopentyl sodium / Zhejiang Ausun Pharmaceutical - LARVOL DELTA

Research progress of 3-n-butylphthalide and its derivatives in combating cerebral ischemia. (PubMed, Chin J Nat Med) - "Specifically, potassium 2-(1-hydroxypentyl)-benzoate (PHPB), brozopentyl sodium (BZP), and XY-03-EA (ZONK1103) have reached phase II clinical trials, while (S)-2-(1-acetoxypentyl)benzoic acid L-arginine salt (AAPB) has received clinical trial approval for 2024. This review examines the structural modification and optimization of NBP over the past two decades from a medicinal chemistry perspective, aiming to facilitate the development of superior derivatives and advance cerebral ischemia treatment."

Journal • Review • Cardiovascular • CNS Disorders • Ischemic stroke