interferon-alpha sustained release (LBSI5536) / LG Chem - LARVOL DELTA

Interferon regulatory factor 4-releasing 3D-printed scaffolds enhance spinal cord repair by modulating macrophage polarization. (PubMed, Neural Regen Res) - "The sustained-release interferon regulatory factor 4 competitively bound to myeloid differentiation factor 88 to inhibit the pro-inflammatory effects of interferon regulatory factor 5, and activated the signal transducer and activator of transcription 6 pathway to promote M2 macrophage polarization, thereby facilitating neural regeneration and recovery of spinal cord function. This indicates that the constructed interferon regulatory factor 4-loaded 3D-printed methyl acrylate-modified gelatin scaffold can regulate macrophage polarization through the interferon regulatory factor 4/5 axis, improve the inflammatory microenvironment after spinal cord injury, and thus provide a new target for promoting neural regeneration."

Journal • CNS Disorders • Orthopedics • IRF4 • IRF5 • STAT6

Use of DosR and Rpf antigens from Mycobacterium tuberculosis to screen for latent and relapse tuberculosis infection in a tuberculosis endemic community of Huainan City. (PubMed, Eur J Clin Microbiol Infect Dis) - "Besides, the selected DosR antigens and Rpfs showed ideal specificity and inadequate sensitivity, which could have been enhanced by the fusion antigens prepared by the DosR antigens or Rpfs, respectively. The results of this study can provide more accurate detection methods for LTBIs and RTBs and could be used for screening the dormant M. tuberculosis throughout reactivation."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis • IFNG