Radiesse (calcium hydroxylapatite) / Merz Pharma - LARVOL DELTA

Multimodal Treatment Combinations and Layering to Restructure the Aging Face: Recommendations From an Expert Panel. (PubMed, Plast Reconstr Surg Glob Open) - "Correction of the signs of facial aging can be achieved with various aesthetic treatments, including Cohesive Polydensified Matrix hyaluronic acid (CPM-HA), calcium hydroxylapatite in carboxymethylcellulose (CaHA-CMC), microfocused ultrasound with visualization (MFU-V), and incobotulinumtoxinA (incoBoNT-A). Step-by-step procedures for targeting each layer-including product, injection or application technique, and/or rationale-are provided. CPM-HA, CaHA-CMC, MFU-V, and incoBoNT-A are considered by the expert panel of aesthetic physicians to be ideal treatment options to obtain a synergistic effect in layered whole-face rejuvenation."

Journal • Aesthetic Medicine

Shoulder Aesthetics: A Novel Synergy of Calcium Hydroxylapatite Fillers and Neuromodulators. (PubMed, Aesthetic Plast Surg) - "Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 ."

Journal • Aesthetic Medicine

Combined and Hybrid Treatments of Hyaluronic Acid (HA) and Calcium Hydroxylapatite (CaHA): A Systematic Review of Mechanisms of Action, Aesthetic Effectiveness, Satisfaction, and Safety Profile. (PubMed, Aesthetic Plast Surg) - "The combinations and hybrid treatments of HA and CaHA appear to be a promising, safe, and efficacious treatment for facial rejuvenation, offering both immediate volumizing effects and longer-term benefits through collagen synthesis. Future research should employ rigorous study designs aimed at refining treatment protocols and generating strong, long-term evidence for the safety and effectiveness of this combination or hybrid therapy in aesthetic medicine."

Journal • Review • Aesthetic Medicine • Dermatology

Chronic facial abscess mimicking cervicofacial actinomyces from dermal filler migration (SID 2025) - "Composed of materials such as hyaluronic acid, calcium hydroxylapatite, and polymethylmethacrylate (PMMA), these fillers provide long-lasting results with minimal recovery time...Treatment for PMMA-based filler reactions relies on adequate excision as noted in this case, but may respond to intralesional steroids. Although PMMA-fillers are not widely used, the need to consider reactions to these could provide valuable insight into the recognition and management of chronic, non-healing wounds of the head and neck."

Aesthetic Medicine • Infectious Disease

Direct comparison of molecular effects of PLLA-SCA and CaHA-R in a standardized human 3D skin model containing macrophages (SID 2025) - "Modern bio-stimulatory fillers like poly-L-lactic acid (PLLA-SCA; Sculptra) and calcium hydroxylapatite (CaHA-R; Radiesse) induce the synthesis of major structural components of the extracellular matrix such as collagen...Our data provide novel molecular insights into the bio-stimulatory effects of PLLA-SCA and CaHA-R on collagen production using 3D skin models comprising macrophages. Due to their special properties, these new in vitro models could also be used in future for research into fibrosing skin disorders."

Dermatology • Fibrosis

Safety and Effectiveness of ELLANSÉ®-S Dermal Filler in the Treatment of Nasolabial Folds (clinicaltrials.gov) - P=N/A | N=126 | Recruiting | Sponsor: AQTIS Medical B.V.

New trial • Aesthetic Medicine

Nonsurgical Chin and Prejowl Modification. (PubMed, Facial Plast Surg) - "Aging induces volume loss, tissue laxity, and bony absorption, leading to the formation of the prejowl sulcus and reduced jawline definition.Injectable fillers and biostimulators such as hyaluronic acid, calcium hydroxylapatite, and poly-L-lactic acid address volume loss, enhance contours, correct chin underprojection, and fill both deep and superficial rhytids...Energy-based modalities, including radiofrequency, ultrasound, and laser, offer options for skin tightening, fat reduction, and improving skin texture.The paper highlights the benefits and limitations of nonsurgical techniques available to treat the chin and prejowl, emphasizing the need for anatomical precision to optimize safety and efficacy. Although nonsurgical treatments cannot replace surgical interventions, they often provide effective, temporary solutions for patients seeking low-downtime alternatives."

Journal

Clinical Evaluation of an Innovative CaHA Bio-Stimulator in Facial Rejuvenation: 1 Year Follow-Up. (PubMed, J Cosmet Dermatol) - "This novel CaHA-based bio-stimulator demonstrates a safe and effective profile for facial rejuvenation, providing significant aesthetic and structural improvements with long-lasting results. It offers a promising option for addressing the challenges of skin aging."

Journal • Aesthetic Medicine

Single Session of Calcium Hydroxylapatite, Incobotulinumtoxin A, and Hyaluronic Acid for Gluteal Aesthetic Improvement. (PubMed, J Cosmet Dermatol) - "A single-session combined application of CaHA-CMC, IncoBoNT-A, and CPM-HA effectively improved flaccidity and cellulite, resulting in high patient satisfaction."

Journal • Observational data • Retrospective data

Exploratory Analysis of Age-Related Trends in Biostimulatory Response to Combined Calcium Hydroxylapatite-Carboxymethylcellulose and Microfocused Ultrasound With Visualization Treatments. (PubMed, Aesthet Surg J Open Forum) - "This exploratory analysis suggests that within the studied age range, patient age may not significantly influence the histological response to combined CaHA-CMC and MFU-V treatments. Larger, statistically powered studies are needed to validate these findings and further investigate age-related effects."

Journal

Nonsurgical Temple Volumization with Soft-Tissue Fillers: A Systematic Review of the Literature. (PubMed, Aesthetic Plast Surg) - "Temporal volume loss is a natural consequence of aging that can be safely and effectively improved with soft-tissue fillers."

Journal • Review • Pain

Feasibility of calcium hydroxyapatite (Radiesse®) for improving the biomechanical properties of facial burn scars: A pilot study. (PubMed, JPRAS Open) - "This feasibility study indicated that subdermal CaHA injections have potential as a noninvasive approach for improving the biomechanical properties of facial burn scars. However, further studies with larger sample sizes and long-term follow-up are needed to confirm these findings."

Journal • Dermatology • Fibrosis • Immunology • Thermal Injury

Sonographic Analysis of CureJet Injection Depth Consistency After Abdominal Stretch Mark Treatment Using Hyperdiluted Calcium Hydroxylapatite. (PubMed, Plast Reconstr Surg Glob Open) - "This study highlights the need for further refinement in injector technology and technique to improve uniformity in treatment depth, particularly for applications like scar treatment and stretch mark reduction. Enhancing precision in such devices could lead to better patient outcomes and increased safety in aesthetic treatments."

Journal • Aesthetic Medicine

Evaluation of the Effectiveness and Safety of Diluted RADIESSE® in the Treatment of Décolleté Wrinkles (clinicaltrials.gov) - P=N/A | N=152 | Active, not recruiting | Sponsor: Merz North America, Inc. | Completed ➔ Active, not recruiting | Trial completion date: Nov 2023 ➔ May 2025

Enrollment closed • Trial completion date

In Vitro Comparative Study of Calcium Hydroxyapatite (Stiim): Conventional Saline Dilution Versus Poly-Micronutrient Dilution. (PubMed, Cureus) - "Calcium hydroxylapatite (CaHA) is widely used in aesthetics for its dual role as a dermal filler and biostimulator, promoting collagen and elastin synthesis...CaHA/PMN outperformed conventional CaHA, with greater increases in cell viability, collagen synthesis, elastin synthesis, and the expression of SIRT-1, SIRT-3, and FOXO3. These findings suggest that poly-micronutrient-enriched solutions can enhance CaHA's regenerative potential, providing a promising approach for skin rejuvenation and elasticity improvement."

Journal • Preclinical • Aesthetic Medicine • FOXO3 • SIRT3

Hybrid Fillers Personal Experience of Premixing Calcium Hydroxylapatite and Hyaluronic Acid for Natural Face Reshaping. (PubMed, J Craniofac Surg) - "Premixing CaHA and HA offers a safe, effective, and reproducible technique for natural facial reshaping and rejuvenation. The combination enhances skin quality while providing immediate volumization and long-term collagen stimulation, meeting the aesthetic expectations of patients seeking minimally invasive anti-aging solutions."

Journal

Panfacial Approach to Rejuvenation Using Calcium Hydroxylapatite: A Case Series Illustrating Calcium Hydroxylapatite Versatility Through Dilution and a Multilayered Treatment Approach. (PubMed, Aesthet Surg J Open Forum) - "Although undiluted product can be used to provide deeper volume and structural support in areas like the chin, jawline, and temples, more dilute product (1:1 and 1:2) can be used to provide some volume and/or smooth transitions in the face, whereas hyperdilute CaHA can be used over an even wider surface area in the face, neck, or décolletage to tighten skin and improve skin quality (1:3 and 1:4 dilutions). In the cases presented, patients achieved improvement in appearance through treatment with multiple dilutions of CaHA, providing several examples of how CaHA may be used as part of a multilayered approach to facial rejuvenation."

Journal • Aesthetic Medicine

Conditions to Consider When Choosing Fillers. (PubMed, J Cosmet Dermatol) - "Understanding the rheological and safety profiles of fillers is essential for achieving optimal aesthetic outcomes. HA fillers are recommended for novice practitioners due to their reversibility, while experienced clinicians may explore non-HA options. Tailored filler selection based on rheological properties and clinical context ensures safer and more effective treatments."

Journal • Review • Aesthetic Medicine • Inflammation

Comparative Bulk RNA-seq Analysis of Poly-L-Lactic Acid vs Calcium hydroxylapatite Reveals PLLA has an Adipocyte Mediated Regenerative Mechanism of Action (AAD 2025) - "Further, the adipokines that appear to be upregulated are regenerative with a positive impact on skin health. Summary: PLLA-SCA has a novel signature which may support a potential regenerative mechanism of action via the role in the modulation of adipocyte function."

Three Calcium Hydroxylapatite-Based Dermal Fillers Marketed in Mexico: Comparison of Particle Size and Shape Using Electron Microscopy. (PubMed, J Cosmet Dermatol) - "Gaining a deeper understanding of these differences enables the improved development of dermal fillers to meet the growing demand for safe and effective aesthetic treatments. This study contributes to building knowledge about the use of microparticles in soft tissue fillers for aesthetic treatments and medical applications."

Clinical • Journal • Aesthetic Medicine • Dermatology

Labia Majora Rejuvenation With Hybrid Filler: A Narrative Review of the Literature and Report of Two Cases. (PubMed, J Cosmet Dermatol) - "These two case reports and a narrative literature review suggest that a combined HA/CaHA filler may be a safe and effective treatment for labia majora rejuvenation."

Journal • Review • Aesthetic Medicine • Gynecology

Multilayer Technique Using Calcium Hydroxylapatite Biostimulation With Different Dilutions in the Lateral Face. (PubMed, Aesthet Surg J Open Forum) - "The technique described in this pilot study provides a full-face approach with CaHA based on the current concepts of the line of ligaments and facial biomechanics. Further studies are needed to validate the results."

Journal

Characterization of Particles From Collagen Bio-Stimulating Materials Used in Facial Filling Procedures. (PubMed, Microsc Res Tech) - "Five collagen bio-stimulating materials were evaluated: Radiesse, Rennova Diamond, HarmonyCa, Victalab Bio-stimulator, and Optimus Bio-stimulator...FTIR analyzes showed that all materials presented CaHA with similar composition. It can be concluded that the collagen bio-stimulator materials presented different inorganic contents in terms of size and morphology."

Journal

Arterioembolic Characteristics of Differentially Diluted CaHA-CMC Gels Within an Artificial Macrovascular Perfusion Model. (PubMed, Aesthet Surg J) - "Embolized CaHA-CMC gels produce polydisperse particle mixtures with a preponderance of microparticles. Hyperdilution profoundly reduced the proximally occlusive potential of the product."

Journal

Comparative Rheology of Hyaluronic Acid Fillers, Poly-l-lactic Acid, and Varying Dilutions of Calcium Hydroxylapatite. (PubMed, Plast Reconstr Surg Glob Open) - No abstract available

Journal