Radiesse (calcium hydroxylapatite) / Merz Pharma - LARVOL DELTA

Sculpting the Midface and Lower Face: A Novel Biostimulatory Technique Using Hyperdilute Calcium Hydroxylapatite. (PubMed, Aesthet Surg J Open Forum) - "The results of this study support the safety and efficacy of the author's novel technique with hyperdilute CaHA for lower and midface rejuvenation, further enhancing the utility of biostimulators in aesthetic medicine. 4 (Therapeutic)."

Journal • Aesthetic Medicine

Hand Rejuvenation with Dermal Fillers: Key Aspects and a Comparison of Commonly Used Fillers. (PubMed, Clin Dermatol) - "Dermal fillers, including hyaluronic acid (HA), calcium hydroxylapatite (CaHA) and poly-L-lactic acid (PLLA), can address volume loss, contour irregularities, and texture changes associated with aging...HA fillers provide instant volume restoration and hydration, while CaHA and PLLA are advantageous for improving texture and skin quality. Patient counseling on available options and selecting the most suitable filler that aligns with patient expectations are crucial to achieving successful outcomes."

Journal • Aesthetic Medicine

Optimizing Collagen Biostimulator Choice in LATAM: Expert Consensus on Patient Selection, Ethnic Skin Phenotypes, and Accessibility. (PubMed, J Cosmet Dermatol) - "This consensus provides the first LATAM-specific framework for CaHA and PLLA use, integrating ethnic diversity, anatomical considerations, and accessibility to optimize safety and efficacy in regenerative aesthetics."

Journal • Review

Regenerative Strategies for Vocal Fold Repair Using Injectable Materials. (PubMed, Biomimetics (Basel)) - "Recent hydrogels based on hyaluronic acid (HA) derivatives, calcium hydroxylapatite and decellularized matrix scaffolds are designed to approximate the viscoelastic behavior of native tissue, allow controlled degradation, and modulate local immune responses...In clinical series, benefits from basic fibroblast growth factor can persist for up to 12 months. Further progress will depend on correlating material properties with objective vibratory performance to achieve lasting restoration of phonation and advance true tissue-regenerative therapy."

Journal • Review • Fibrosis • Immunology • FGF

Electron Microscopy-Based Study of Cannulas for Suspension-Based Dermal Filler and Biostimulator Application. (PubMed, J Cosmet Dermatol) - No abstract available

Journal • Aesthetic Medicine

Visual Loss in Biostimulator Injectables: A Review of Incidence, Risk Factors, Etiology and Management Proposal. (PubMed, Aesthetic Plast Surg) - "Our review and proposed management protocol is timely in guiding physicians of the recognition and management of vascular occlusion causing visual loss by biostimulator injectables, especially in a time of rising popularity of these injectables in medical aesthetics."

Journal • Review • Aesthetic Medicine • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain

Aesthetic Medicine in Oncology: A Systematic Review of Botulinum Toxin, Dermal Fillers, Chemical Peels, and Laser Therapies in Cancer Patient. (PubMed, Aesthetic Plast Surg) - "Aesthetic treatments can be safely and effectively integrated into the care of cancer patients, with careful consideration of individual treatment regimens and potential contraindications. Further research is warranted to establish standardized guidelines."

Journal • Review • Actinic Keratosis • Aesthetic Medicine • Breast Cancer • Dermatitis • Dermatology • Immunology • Oncology • Solid Tumor

Expert Panel Guidelines for Hybrid CaHA-CMC/CPM-HA Fillers in the Mexican Population. (PubMed, J Cosmet Dermatol) - "This paper provided recommendations regarding the preparation and injection of CaHA-CMC and CPM-HA combinations across different anatomical regions. These contributions aim to support clinical decision-making, optimize outcomes, and improve patient safety in aesthetic treatments."

Journal • Aesthetic Medicine • Anesthesia

Forehead Volumization and Rejuvenation with Hybrid Fillers. (PubMed, Aesthetic Plast Surg) - "The combination of CaHA and HA fillers administered via a retrograde fanning injection technique in the deep forehead fat plane proved to be both safe and effective in improving frontal depressions, with no adverse events reported during the 12 month observation period."

Journal • CNS Disorders • Depression • Psychiatry

A Comparative Study of the Efficacy of Different Tissue Fillers for Nasolabial Fold Correction. (PubMed, Aesthetic Plast Surg) - "In terms of the effectiveness of tissue fillers for the amelioration of NLFs, CaHA achieved better efficacy compared to HA and collagen at 6-9 months post-treatment. No significant difference was observed between monophasic HA and biphasic HA. However, additional reviews of rigorous RCTs are required for further verification."

Clinical • Journal

Facial Injectable Fillers in Aesthetic Medicine: Clinical Applications and Safety Strategies. (PubMed, Med Sci Monit) - "Commonly used materials include hyaluronic acid, polycaprolactone, calcium hydroxylapatite, and poly-L-lactic acid, each offering unique benefits in terms of safety, durability, and biocompatibility...In this review, we comprehensively analyze the properties, clinical applications, and mechanisms of action of major filler materials, while emphasizing reported complications and their management strategies. By integrating current evidence, we aim to guide clinicians in selecting appropriate fillers, optimizing injection techniques, and minimizing risks, thereby improving patient outcomes in aesthetic medicine."

Journal • Review • Aesthetic Medicine • Infectious Disease • Ophthalmology • Pain

Hyperdilute Radiesse Preserves Facial Volume in Glucagon-Like Peptide-1 Receptor Agonist Users Undergoing Rapid Weight Loss. (PubMed, Aesthet Surg J Open Forum) - "Further studies are warranted to elucidate the mechanisms and optimize treatment protocols for this population. Level of Evidence: 4 (Therapeutic)."

Journal • MAGEA3

Clarification of the Concept of "Regeneration" in the Context of Calcium Hydroxylapatite and Its Promotion in Regenerative Aesthetics. (PubMed, Aesthet Surg J) - No abstract available

Journal

Post-Operative Stridor in an Asymptomatic Myasthenia Gravis Patient After Sugamaddex Reversal Treated with Neostigmine (ASA 2025) - "He had general anesthesia with rocuronium for paralysis and sugammadex for reversal. Elderly male with history of myasthenia gravis (diagnosed 2011 - recently weaned off of Azathioprine) who underwent thyroidectomy (2014) and found to have vocal cord paralysis with bowing. He was scheduled for microlaryngoscopy with injection of calcium hydroxylapatite due to worsening dysphonia. PACU course was complicated by stridor that partially responded to racemic epinephrine and lidocaine nebulizers. There was concern for myasthenic crisis, so he was challenged with neostigmine/glycopyrrolate, which significantly improved his voice strength and oxygen requirement. Consider acetylcholinesterase inhibitors for inadequate reversal of myasthenia gravis patients."

Clinical • Anesthesia • CNS Disorders • Dysphonia • Myasthenia Gravis

Complications of Various Materials for Injection Laryngoplasty: Systematic Review and Meta-Analysis. (PubMed, J Voice) - "IL is generally safe with the commonly used materials (AF, CaHA, HA, and CMC), with a low overall complication rate across materials. CaHA demonstrates a higher rate of procedural complications, while HA carries a mildly higher risk for airway compromise. Clinicians should select injection material based on patient factors with an awareness for the likelihood of risks based on material."

Journal • Retrospective data • Review • Inflammation • Pulmonary Disease

Enhanced Facial Rejuvenation: Biostimulatory Effects of Hylan Gel Dermal Filler DX on Collagen Synthesis and Tissue Regeneration. (PubMed, Aesthetic Plast Surg) - "HA + DX exhibited considerable benefits in collagen stimulation, wound healing, and cytokine modulation. Its favorable rheological characteristics and regenerative potential make it a promising option for facial rejuvenation and tissue regeneration."

Journal • Aesthetic Medicine • IL10 • IL1B • IL6 • TGFB1 • TNFA

Exploring the Rheology and Clinical Potential of Calcium Hydroxylapatite-Hyaluronic Acid Hybrids. (PubMed, J Cosmet Dermatol) - "The properties of CaHA-CMC and CPM-HA hybrids influence their injection behavior and clinical outcomes. Understanding these factors can guide filler selection and application techniques to maximize safety, efficacy, and patient satisfaction in aesthetic treatments."

Journal • Aesthetic Medicine

Filler Up! Key Quality and Safety Considerations in Non-Cosmetic Applications of Soft-Tissue Fillers in Otolaryngology (AAO-HNSF 2025) - "Starting in 2003 with Restylane, hyaluronic acid (HA) fillers led the way, sparking a wave of innovation that now includes over 20 FDA-approved formulations for aesthetic use. Beyond hyaluronic acid, the filler market also includes calcium hydroxylapatite, poly-L-lactic acid, and polymethylmethacrylate microspheres, each with distinct properties tailored for specific applications.While fillers are well-established in cosmetic practices, their non-cosmetic applications are recently gaining more prominence in otolaryngology...Additionally, autologous fat grafting, as a potentially more permanent alternative, will be addressed. Panelists will also examine the potential risks associated with these products and discuss best practices for complication management.Learning Objectives: Review the development, properties, and regulatory approval of various soft-tissue fillers and their implications for clinical use.Examine the non-aesthetic applications of soft-tissue fillers in..."

Clinical • Aesthetic Medicine • Otorhinolaryngology

Response to: Combined and Hybrid Treatments of Hyaluronic Acid (HA) and Calcium Hydroxylapatite (CaHA): A Systematic Review of Mechanisms of Action, Aesthetic Effectiveness, Satisfaction, and Safety Profile. (PubMed, Aesthetic Plast Surg) - No abstract available

Journal

PLLA and CaHA-R for Aesthetic Rejuvenation (clinicaltrials.gov) - P4 | N=45 | Recruiting | Sponsor: Erevna Innovations Inc.

New P4 trial

In Vivo Biostimulatory Efficacy of Ascorbic Acid-Loaded Poly(lactic-co-glycolic Acid) Nanoparticles Hydrogel for Dermal Remodeling. (PubMed, ACS Omega) - "Prospectively, after one month, the AANps hydrogel developed in this study could promote a more pronounced collagen increase compared to commercial products such as calcium hydroxylapatite (CaHA) microparticles and PLLA microparticles. These findings suggest that the AA-loaded PLGA nanoparticle hydrogel is a promising strategy for dermal remodeling."

Journal • Preclinical • Inflammation

A Study to Determine if RADIESSE® Dilute Treatment in Décolleté of Adult Women Affects Radiographic Imaging Assessments (clinicaltrials.gov) - P=N/A | N=30 | Active, not recruiting | Sponsor: Merz North America, Inc. | Recruiting ➔ Active, not recruiting

Enrollment closed

Successful treatment of stretch marks using calcium hydroxylapatite biostimulation and fractionated microneedle radiofrequency (EADV 2025) - "During the initial session, CaHA was diluted at a ratio of 1:4 with an equivalent volume of lidocaine 2% and saline solution. To the best of our knowledge, this study is the first to reveal the safety and efficacy of hyperdiluted CaHA and microneedling radiofrequency for the aesthetic enhancement of stretch marks. The suggested combination is a promising treatment for a common disfiguring disease with few treatment options. Future research should investigate how fractionated microneedling radiofrequency and hyperdiluted CaHA work best for treating stretch marks."

CNS Disorders • Dermatology

Who's Injecting You? Assessing Provider Credentials Among Manhattan's Aesthetic Injectors (PSTM 2025) - "First, providers were located through the "Find a Provider" feature on the official websites of dermal filler brands, including Bellafill, Juvederm, Radiesse, Restylane, RHA, Belotero, and Sculptra, with search parameters set to Manhattan, New York, and within a 5-mile radius. Our review of the top online results for aesthetic injectors in Manhattan reveals a wide variation in provider qualifications. Although most clinics are physician-owned, a notable number were founded by non-physicians that often lacked on-site doctor or employed non-aesthetic board certified specialists with limited credential transparency. These findings potentiate the need for greater regulatory oversight and consumer education in cosmetic injections."

Aesthetic Medicine • Dermatology • Otorhinolaryngology

The Price of Beauty: Analyzing Medical Malpractice Cases Related to Dermal Fillers (PSTM 2025) - "Silicone was the most frequently cited filler (n=4), followed by Juvederm, Radiesse, Restylane, and Sculptra (all n=3). Medical malpractice cases involving dermal fillers mainly favored defendants. Most defendants were aesthetic specialized physicians, though some lacked medical licenses or board certification in aesthetic specialties. Cases involving unqualified injectors or allegations of battery or fraud had higher odds of plaintiff verdicts or settlements."

Clinical • Aesthetic Medicine • Dermatology • Otorhinolaryngology