Radiesse (calcium hydroxylapatite) / Merz Pharma - LARVOL DELTA

Successful treatment of stretch marks using calcium hydroxylapatite biostimulation and fractionated microneedle radiofrequency (EADV 2025) - No abstract available

Aesthetic Medicine • Dermatology

A Study to Determine if RADIESSE® Dilute Treatment in Décolleté of Adult Women Affects Radiographic Imaging Assessments (clinicaltrials.gov) - P=N/A | N=30 | Recruiting | Sponsor: Merz North America, Inc. | Not yet recruiting ➔ Recruiting

Enrollment open

A Study to Determine if RADIESSE® Dilute Treatment in Décolleté of Adult Women Affects Radiographic Imaging Assessments (clinicaltrials.gov) - P=N/A | N=30 | Not yet recruiting | Sponsor: Merz North America, Inc.

New trial

Commentary On: Three Calcium Hydroxylapatite-Based Dermal Fillers Marketed in Mexico: Comparison of Particle Size and Shape Using Electron Microscopy. (PubMed, J Cosmet Dermatol) - No abstract available

Journal • Aesthetic Medicine

Morphometric effectiveness of calcium hydroxylapatite application in zygomatic and malar area on correction of nasolabial folds. (PubMed, Medicine (Baltimore)) - "Furthermore, our study provides standardized quantitative methods that can be used to assess the effectiveness of treatments in the nasolabial area. These analyses offer reliable tools for evaluating aesthetic procedures and provide valuable contributions to clinical practice."

Journal • Observational data • Retrospective data • Aesthetic Medicine

Hyaluronic Acid Combined with Diluted and Hyperdiluted Calcium Hydroxylapatite to Treat the Periocular Area. (PubMed, Clin Cosmet Investig Dermatol) - "For most patients, results varied according to the dilution of the blend; lower dilutions (1:1) lasted longer than higher dilution (1:4), even though results were still noticeable for patients treated with the latter (1:4) at the 1-year evaluation. This study validates the use of a HA and CaHA blend (CaHA-CPM) for periocular rejuvenation, addressing various aging symptoms in this complex facial region."

Journal • Aesthetic Medicine

Proposing a New Classification for Managing Prostaglandin-Induced Enophthalmos in Glaucoma Patients. (PubMed, Clin Ophthalmol) - "It included a two-phase approach: (1) classification of enophthalmos using clinical and radiological measures to create a composite PAPS score; and (2) evaluation of treatment options, including Calcium Hydroxylapatite (CAHY) injections and autologous fat grafting...We propose a novel composite scoring system integrating six clinical parameters to stratify patients and tailor a minimally invasive therapeutic approach using calcium hydroxyapatite fillers and autologous fat grafting to restore orbital volume, improve eyelid aesthetics, and reduce complications. This classification system may serve as a clinical tool in patients with persistent or advanced PAPS who seek cosmetic correction or relief from functional symptoms."

Journal • Aesthetic Medicine • Glaucoma • Metabolic Disorders • Ophthalmology

Post-Operative Stridor in an Asymptomatic Myasthenia Gravis Patient After Sugamaddex Reversal Treated with Neostigmine (ASA 2025) - "He had general anesthesia with rocuronium for paralysis and sugammadex for reversal. Elderly male with history of myasthenia gravis (diagnosed 2011 - recently weaned off of Azathioprine) who underwent thyroidectomy (2014) and found to have vocal cord paralysis with bowing. He was scheduled for microlaryngoscopy with injection of calcium hydroxylapatite due to worsening dysphonia. PACU course was complicated by stridor that partially responded to racemic epinephrine and lidocaine nebulizers. There was concern for myasthenic crisis, so he was challenged with neostigmine/glycopyrrolate, which significantly improved his voice strength and oxygen requirement. Consider acetylcholinesterase inhibitors for inadequate reversal of myasthenia gravis patients."

Clinical • Anesthesia • CNS Disorders • Dysphonia • Myasthenia Gravis

Reduction of Early-Onset Calcium Hydroxylapatite-Carboxymethylcellulose Accumulations Using Focused Mechanical Vibration: An Experimental Model and Case Report. (PubMed, J Cosmet Dermatol) - No abstract available

Journal • Aesthetic Medicine

The Price of Beauty: Analyzing Medical Malpractice Cases Related to Dermal Fillers (PSTM 2025) - "Silicone was the most frequently cited filler (n=4), followed by Juvederm, Radiesse, Restylane, and Sculptra (all n=3). Medical malpractice cases involving dermal fillers mainly favored defendants. Most defendants were aesthetic specialized physicians, though some lacked medical licenses or board certification in aesthetic specialties. Cases involving unqualified injectors or allegations of battery or fraud had higher odds of plaintiff verdicts or settlements."

Clinical • Aesthetic Medicine • Dermatology • Otorhinolaryngology

Who's Injecting You? Assessing Provider Credentials Among Manhattan's Aesthetic Injectors (PSTM 2025) - "First, providers were located through the "Find a Provider" feature on the official websites of dermal filler brands, including Bellafill, Juvederm, Radiesse, Restylane, RHA, Belotero, and Sculptra, with search parameters set to Manhattan, New York, and within a 5-mile radius. Our review of the top online results for aesthetic injectors in Manhattan reveals a wide variation in provider qualifications. Although most clinics are physician-owned, a notable number were founded by non-physicians that often lacked on-site doctor or employed non-aesthetic board certified specialists with limited credential transparency. These findings potentiate the need for greater regulatory oversight and consumer education in cosmetic injections."

Aesthetic Medicine • Dermatology • Otorhinolaryngology

Evaluating the Efficacy of Dermal Fillers for Hand Rejuvenation: A Systematic Review (PSTM 2025) - "The following keywords were used: filler, hyaluronic acid, dermal filler, calcium hydroxyapatite, L-lactic acid, Restylane Lyft, Radiesse, hand rejuvenation, volume, aging, and veins... Using fillers for hand rejuvenation is an effective approach, with high patient satisfaction as per GAIS and low complication rates. Improvements in the MGHS suggest fillers successfully restore hand volume and provide aesthetic outcomes at long-term follow-up."

Clinical • Review • Aesthetic Medicine

The Studded Neck: Complication of Improper CaHa Filler Placement (PSTM 2025) - "Filler-related complications are likely underreported, particularly vascular compromise and delayed inflammation (5). This case highlights the need for cautious application of calcium hydroxylapatite fillers, thorough patient counseling, and adherence to established guidelines to minimize adverse outcomes."

Anesthesia • Metabolic Disorders • Oncology

Filler Up! Key Quality and Safety Considerations in Non-Cosmetic Applications of Soft-Tissue Fillers in Otolaryngology (AAO-HNSF 2025) - "Starting in 2003 with Restylane, hyaluronic acid (HA) fillers led the way, sparking a wave of innovation that now includes over 20 FDA-approved formulations for aesthetic use. Beyond hyaluronic acid, the filler market also includes calcium hydroxylapatite, poly-L-lactic acid, and polymethylmethacrylate microspheres, each with distinct properties tailored for specific applications.While fillers are well-established in cosmetic practices, their non-cosmetic applications are recently gaining more prominence in otolaryngology...Additionally, autologous fat grafting, as a potentially more permanent alternative, will be addressed. Panelists will also examine the potential risks associated with these products and discuss best practices for complication management.OUTCOME OBJECTIVE 1: Review the development, properties, and regulatory approval of various soft-tissue fillers and their implications for clinical use.OUTCOME OBJECTIVE 2: Examine the non-aesthetic applications of..."

Clinical • Aesthetic Medicine • Otorhinolaryngology

The L-Lift: A Novel Technique for Jawline Contouring Using Calcium Hydroxylapatite in Southeast Asians. (PubMed, Plast Aesthet Nurs (Phila)) - "Notably, patients with severe facial sagging may require alternative interventions. Tailoring treatments to patient needs is crucial for obtaining optimal results."

Journal • Aesthetic Medicine • CNS Disorders • Depression • Psychiatry

A Novel Six-Point Supraperiosteum Injection with Calcium Hydroxyapatite for Jawline Refining and Facial Anti-aging in Asian Patients. (PubMed, Aesthetic Plast Surg) - "The 6-point calcium hydroxyapatite filler injection achieved facial rejuvenation. After a single session, the injection recontoured the jawline and lifted the eyebrow tail."

Journal

The Foaming Technique: Innovation in Mixing Calcium Hydroxylapatite Applied in Hybrid Filler. (PubMed, Aesthetic Plast Surg) - "The foaming technique demonstrates improved homogeneity and distribution of the premixed hybrid filler, along with the absence of adverse events and smoother particle surfaces observed in electron microscopy samples. Sonography further corroborated these findings, revealing a more uniform pattern with the foam, thereby influencing imaging characteristics. This technique signifies a significant advancement in optimizing hybrid filler applications."

Journal • Aesthetic Medicine

Calcium Hydroxylapatite-Based Fillers in Facial Rejuvenation: A Prospective, Single-Center, Unblinded Comparative Outcome Study of Radiesse® vs. Rennova® Diamond Intense. (PubMed, J Clin Med) - " Rennova® Diamond Intense effectively increases dermal thickness, improves skin elasticity, and reduces transepidermal water loss, achieving high patient and physician satisfaction. These findings underscore its safety, versatility, and efficacy for esthetic facial rejuvenation, warranting further long-term evaluation."

Journal • Aesthetic Medicine • Pain

Subcision Followed by Diluted Calcium Hydroxylapatite Injection Versus Subcision Followed by Painting CROSS TCA Technique for the Treatment of Atrophic Acne Scars (clinicaltrials.gov) - P=N/A | N=13 | Completed | Sponsor: Tanta University

New trial • Acne Vulgaris

Multimodal Treatment Combinations and Layering to Restructure the Aging Face: Recommendations From an Expert Panel. (PubMed, Plast Reconstr Surg Glob Open) - "Correction of the signs of facial aging can be achieved with various aesthetic treatments, including Cohesive Polydensified Matrix hyaluronic acid (CPM-HA), calcium hydroxylapatite in carboxymethylcellulose (CaHA-CMC), microfocused ultrasound with visualization (MFU-V), and incobotulinumtoxinA (incoBoNT-A). Step-by-step procedures for targeting each layer-including product, injection or application technique, and/or rationale-are provided. CPM-HA, CaHA-CMC, MFU-V, and incoBoNT-A are considered by the expert panel of aesthetic physicians to be ideal treatment options to obtain a synergistic effect in layered whole-face rejuvenation."

Journal • Aesthetic Medicine

Shoulder Aesthetics: A Novel Synergy of Calcium Hydroxylapatite Fillers and Neuromodulators. (PubMed, Aesthetic Plast Surg) - "Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 ."

Journal • Aesthetic Medicine

Combined and Hybrid Treatments of Hyaluronic Acid (HA) and Calcium Hydroxylapatite (CaHA): A Systematic Review of Mechanisms of Action, Aesthetic Effectiveness, Satisfaction, and Safety Profile. (PubMed, Aesthetic Plast Surg) - "The combinations and hybrid treatments of HA and CaHA appear to be a promising, safe, and efficacious treatment for facial rejuvenation, offering both immediate volumizing effects and longer-term benefits through collagen synthesis. Future research should employ rigorous study designs aimed at refining treatment protocols and generating strong, long-term evidence for the safety and effectiveness of this combination or hybrid therapy in aesthetic medicine."

Journal • Review • Aesthetic Medicine • Dermatology

Chronic facial abscess mimicking cervicofacial actinomyces from dermal filler migration (SID 2025) - "Composed of materials such as hyaluronic acid, calcium hydroxylapatite, and polymethylmethacrylate (PMMA), these fillers provide long-lasting results with minimal recovery time...Treatment for PMMA-based filler reactions relies on adequate excision as noted in this case, but may respond to intralesional steroids. Although PMMA-fillers are not widely used, the need to consider reactions to these could provide valuable insight into the recognition and management of chronic, non-healing wounds of the head and neck."

Aesthetic Medicine • Infectious Disease

Direct comparison of molecular effects of PLLA-SCA and CaHA-R in a standardized human 3D skin model containing macrophages (SID 2025) - "Modern bio-stimulatory fillers like poly-L-lactic acid (PLLA-SCA; Sculptra) and calcium hydroxylapatite (CaHA-R; Radiesse) induce the synthesis of major structural components of the extracellular matrix such as collagen...Our data provide novel molecular insights into the bio-stimulatory effects of PLLA-SCA and CaHA-R on collagen production using 3D skin models comprising macrophages. Due to their special properties, these new in vitro models could also be used in future for research into fibrosing skin disorders."

Dermatology • Fibrosis

Safety and Effectiveness of ELLANSÉ®-S Dermal Filler in the Treatment of Nasolabial Folds (clinicaltrials.gov) - P=N/A | N=126 | Recruiting | Sponsor: AQTIS Medical B.V.

New trial • Aesthetic Medicine