Radiesse (calcium hydroxylapatite) / Merz Pharma - LARVOL DELTA

Morphological and Rheological Analysis of an Injectable Calcium Hydroxylapatite Dermal Filler with Lattice-Pore Surface Architecture. (PubMed, J Funct Biomater) - " Facetem demonstrated a consistent microsphere population, an organized lattice-pore surface, hydroxylapatite stoichiometry, and diluent-dependent rheology. The integrated analysis defines its physicochemical profile; the PBS findings should be interpreted as morphological stability under non-biological buffer conditions rather than in vivo degradation."

Journal • Aesthetic Medicine

Enhancing Regenerative Outcomes: Histopathological Comparison of Calcium Hydroxylapatite Alone and Combined With Platelet-rich Fibrin: A 6-week Study. (PubMed, Plast Reconstr Surg Glob Open) - "The addition of PRF to CaHA-CMC may enhance subdermal tissue remodeling at 6 weeks. However, given the small sample size and semiquantitative methodology, these results should be interpreted as exploratory and require further validation."

Journal • Aesthetic Medicine • PTPRC

Longitudinal multimodal split-face evaluation of calcium hydroxylapatite and poly-D, L-lactic acid biostimulation using ultrasound imaging and extracellular matrix genetic profiling: a pilot observational study (EADV 2026) - No abstract available

Clinical • Observational data • Aesthetic Medicine • Dermatology

Poly-L-lactic acid & calcium hydroxylapatite- fillers or biostimulators? (EADV 2026) - "The safety profiles also differ. Vascular occlusion is a recognized complication of CaHA when used as a filler, whereas delayed inflammatory nodules and granulomatous reactions have been reported more commonly with PLLA."

Aesthetic Medicine

Calcium hydroxylapatite and polylactic acid: synergy or conflict in facial biostimulation? (EADV 2026) - No abstract available

Filler Up! Key Quality and Safety Considerations in Non-cosmetic Applications of Soft-tissue Fillers in Otolaryngology (AAO-HNSF 2026) - "Attendees will learn how to select the most appropriate product, including hyaluronic acid formulations, calcium hydroxylapatite, poly-L-lactic acid, and polymethylmethacrylate, based on material properties, durability, and clinical indication...• Examine the non-aesthetic applications of soft-tissue fillers in otolaryngology and offer guidelines for selecting the most suitable filler based on specific clinical needs. • Identify common adverse effects associated with soft-tissue fillers and outline evidence-based strategies for minimizing and managing complications."

Clinical • Aesthetic Medicine • Cognitive Disorders • Otorhinolaryngology

Efficacy of hyaluronidase in treating calcium hydroxylapatite-induced arterial occlusion: an experimental study using the leporine auricular artery as a model. (PubMed, Facial Plast Surg) - "Hyaluronidase improves tissue viability after arterial occlusion by CaHA. This finding has important implications for patient care."

Journal

Re: "Three Calcium Hydroxylapatite-Based Dermal Fillers Marketed in Mexico: Comparison of Particle Size and Shape Using Electron Microscopy" by Sanchez Rico and Andrade Canto, Journal of Cosmetic Dermatology 2025; 24(3): e70100. (PubMed, J Cosmet Dermatol) - No abstract available

Journal • Aesthetic Medicine • Dermatology

Severe Iatrogenic Facial Lipoatrophy Following Intralesional Corticosteroid Injections: Management with a Personalised Multimodal Protocol-A Case Report. (PubMed, Reports (MDPI)) - "The patient underwent a stepwise multimodal protocol delivered over approximately 18 months (November 2023 to April 2025), combining non-ablative fractional laser remodelling (LightScan-Eufoton), Autologous Regenerative Therapy (ART, Seffiller technique, Seffiline srl), hyperdiluted calcium hydroxylapatite (CaHA-Radiesse, Merz Aesthetics) biostimulation, and additional non-ablative fractional photothermolysis sessions, supported by a topical cosmeceutical protocol...While the observed improvement is encouraging, the single-case design does not permit conclusions regarding the efficacy, reproducibility, or generalisability of this approach. Future controlled studies are needed to determine the therapeutic value of this multimodal strategy for this rare condition."

Journal • Acne Vulgaris • Aesthetic Medicine • Lipodystrophy

The Biochemistry and Histopathological Tissue Response to Injectable Fillers: A Scoping Review (AAD 2026) - "Some representative examples include hyaluronic acid, calcium hydroxylapatite (CaHA), poly-L-lactic acid (PLLA), and polymethylmethacryalte (PMMA) fillers...The complexities behind the histologic and biochemical reactions to injectable fillers are vast. This review provides background for future dermatopathological studies visualizing and understanding long-term effects of fillers."

Review • Aesthetic Medicine • Dermatopathology • Inflammation

Defining and measuring 'Lift' in soft tissue filler-based facial rejuvenation: a critical review and proposed framework. (PubMed, JPRAS Open) - "We undertook a structured narrative critique of how "lift" is operationalised in the peer-reviewed filler literature for hyaluronic acid, calcium hydroxylapatite, poly-l-lactic acid, polycaprolactone, and hybrid products, and compared reported effect sizes against the documented accuracy of the measurement modalities used...These observations do not establish that fillers do not produce lift; they establish that the construct of filler-mediated lift has not yet been operationalised with the precision its claims now require. We propose a five-standard framework toward an operational definition."

Journal • Aesthetic Medicine

When Labiaplasty is Not Enough: Rejuvenation of the Labia Majora Using Hybrid Calcium Hydroxylapatite With Hyaluronic Acid Filler for Increased Satisfaction and Uniform Results. (PubMed, Aesthet Surg J Open Forum) - "The treatment presented here offers a promising solution for postlabiaplasty patients seeking further labia majora rejuvenation, offering preliminary evidence of the safety and efficacy of hybrid fillers for addressing laxity. Level of Evidence: 4 (Therapeutic)."

Journal • Aesthetic Medicine

From ECM Aging to Mechanobiological Restoration: Injectable Fillers and Dermal Fibroblast Mechanotransduction-A Narrative Review. (PubMed, Gels) - "A composite of PEGDE-cross-linked hyaluronic acid and calcium hydroxylapatite microspheres is considered as an explicitly preliminary example. This review defines the current evidence, its key limitations, and the mechanistically informed studies needed to determine whether, and which, fillers can meaningfully modify dermal mechanobiology."

Journal • Review • JUN • STING • TGFB1

Calcium Hydroxylapatite-Carboxymethylcellulose Gel Embolization in a Simulated Microvascular Environment: Occlusion, Retrograde Flow Dynamics, and Enzymatic Recanalization. (PubMed, Aesthet Surg J) - "CaHA-CMC gels demonstrate significant distal microvascular occlusion potential highly influenced by dilution and bolus volume, with larger volumes increasing occlusive burden and retrograde dissemination. Cellulase-mediated degradation of CMC enables recanalization, suggesting a potential strategy for reversal of CaHA-CMC embolic occlusions."

Journal

Safety and Effectiveness of ELLANSɮ-S Dermal Filler in the Treatment of Nasolabial Folds (clinicaltrials.gov) - P=N/A | N=126 | Active, not recruiting | Sponsor: AQTIS Medical B.V. | Recruiting ➔ Active, not recruiting

Enrollment closed • Aesthetic Medicine

Improving Striae Distensae With Combined Hyperdiluted Calcium Hydroxylapatite Injection and Fractional Microneedling Radiofrequency: A Pilot Study. (PubMed, Aesthet Surg J Open Forum) - "Larger controlled studies are warranted. Level of Evidence: 4 (Therapeutic) For image description, please refer to the figure legend and surrounding text."

Journal • Aesthetic Medicine • Dermatology

Diluted Calcium Hydroxylapatite Carboxymethylcellulose (Radiesse) for Décolleté Wrinkles: Safety and Effectiveness in Adult Females. (PubMed, Aesthet Surg J) - "Diluted Radiesse provided clinically meaningful improvement in décolleté wrinkles with a favorable safety profile and no observed impact on breast imaging, supporting its use as a nonpermanent injectable option for décolleté rejuvenation."

Journal

Comparative Effects of Injectable Biostimulatory Agents (Calcium Hydroxyapatite, New Cellular Treatment Factor, VAMP, and Human Exosomes) and Their Combination on Skin Regeneration. (PubMed, Aesthet Surg J Open Forum) - "Polydeoxyribonucleotide (PDRN), polyrevitalizing multicomponent solutions, calcium hydroxylapatite microspheres, and human-derived exosomes have been proposed to stimulate fibroblast activity, collagen remodeling, and angiogenesis...Injectable bioactive and biostimulatory agents enhance dermal remodeling and neovascularization in intact skin, with combination therapy targeting complementary regenerative pathways yielding the most pronounced histological effects. These findings support multimodal injectable strategies for skin rejuvenation and regenerative dermatology."

Journal • Dermatology • CD34

Computational Trial of Prophylactic Biostimulator Interventions to Mitigate Facial Sagging Associated With GLP-1 Receptor Agonist Induced Weight Loss. (PubMed, Aesthetic Plast Surg) - "Prophylactic lateral-vector injectables reduced facial sagging in this virtual trial. Within the modelled parameter space, CaHA-based strategies predicted the greatest one-year protection. PLLA's delayed action may be underrepresented in single-session designs. These findings provide proof-of-concept support for preventive aesthetic approaches in GLP-1 RA patients and generate testable hypotheses requiring prospective clinical validation. The comparative rankings observed should be interpreted as model-derived predictions contingent on underlying parameter assumptions rather than definitive clinical evidence."

Journal

Calcium Hydroxylapatite Combined with CO2 Ablative Fractional Laser for Atrophic Acne Scars: A Randomized Controlled Study. (PubMed, Aesthetic Plast Surg) - "The combination of CaHA with AFL demonstrates both efficacy and safety for atrophic acne scars, particularly boxcar and rolling subtypes."

Journal • Acne Vulgaris • Aesthetic Medicine • Dermatology • Pain

A Multilayered Gradient Approach to Calcium Hydroxylapatite for Enhanced Full-Face Contouring and Biostimulation. (PubMed, Plast Aesthet Nurs (Phila)) - "Highly concentrated formulations are deposited on the periosteum to mimic-skeletal projection, while hyperdiluted solutions are placed in the subdermal plane to improve skin texture and quality through neocollagenesis. By integrating novel rheological data with practical injection strategies, the protocol offers a layered, adaptable approach to facial rejuvenation that addresses both volume and skin laxity."

Journal • Aesthetic Medicine

Clinical Outcomes of HArmonyCa® in South American Patients: A Case Series Using Vectra 3D Technology. (PubMed, Aesthetic Plast Surg) - "This case series highlights the potential of HArmonyCa® as an effective, safe, and versatile approach for facial rejuvenation, adaptable to a wide range of patient profiles. The integration of objective tools such as 3D imaging further enhances treatment planning and outcome evaluation."

Clinical data • Journal

A Comprehensive Review of Dermal Fillers and Biostimulators for Neck Rejuvenation. (PubMed, Dermatol Surg) - "This review synthesizes current approaches using HA, CaHA, and PLLA for neck rejuvenation with favorable safety profiles."

Journal • Aesthetic Medicine

Polycaprolactone versus calcium hydroxylapatite injectable treatments in the T-zone for facial rejuvenation: a clinical comparative study. (PubMed, Am J Transl Res) - "CaHA is clinically advantageous over PCL in injectable T-zone rejuvenation."

Journal

Micropuncture Decompression With High-Dose Hyaluronidase for Early Reversal of Nasal Ischaemia from HA-Biostimulator Mixed Fillers: An Illustrative Case and Technical Algorithm. (PubMed, Aesthetic Plast Surg) - "In this illustrative case, a dual-approach rescue strategy combining high-dose hyaluronidase with superficial micropuncture was associated with favorable early recovery. This case-derived technical framework may be considered in selected early cases of mixed-filler nasal ischemia, but its independent benefit and generalizability remain uncertain and require further evaluation in larger series."

Journal • Cardiovascular • Pain