cefixime/ofloxacin / Generic mfg. - LARVOL DELTA

Ofloxacin, paracetamol and cefixime induced Stevens-Johnson syndrome - toxic epidermal necrolysis in an adult female patient: a case report. (PubMed, J Pharm Health Care Sci) - "This case highlights the necessity for clinicians to maintain high suspicion for SCARs in patients presenting with mucocutaneous symptoms and recent drug exposure-even with commonly used medications not frequently associated with SJS-TEN. The unique presentation involving synchronous ocular, nasal, oral, and genital erosions alongside use of a rare drug combination strengthens the need for early recognition, comprehensive clinical assessment, and cautious prescription practices. Individualized treatment and close monitoring are crucial in preventing mortality and minimizing complications. This case underscores the importance of pharmacovigilance and personalized care in managing drug-induced hypersensitivity reactions, especially in resource-limited or polypharmacy scenarios."

Journal • Hematological Disorders • Immunology • Ophthalmology • Pain • Steven-Johnson Syndrome

Prevalence and integrated risk assessment of antibiotics from River Chenab Pakistan; human and ecotoxicological prospectives. (PubMed, Sci Total Environ) - "Ofloxacin, cefixime and ciprofloxacin were also detected in considerable concentration (6.70 ± 4.89, 1.67 ± 3.57 and 1.66 ± 2.93 μg/L, respectively). Health quotient (HQHH), health index (HI) and drinking water equivalent levels (DWEL) reflected that ofloxacin (chronic daily oral intake 1.8 × 10-4 and dermal 2.2 × 10-3) and ciprofloxacin exhibited potential risk to human health while azithromycin (chronic daily dermal exposure: 6.2 × 10-3) also posed considerable health risk to life. These results are the indication of possible risks associated with the prevalence of antibiotics in the Chenab River and needs to be considered a threat to be treated on priority basis by the concerned governmental authorities of the country."

Journal

Quantifying antibiotic use in typhoid fever in India: a cross-sectional analysis of private sector medical audit data, 2013-2015. (PubMed, BMJ Open) - "Nationally representative private sector antibiotic prescription data during 2013-2015 indicate a higher disease burden of typhoid in India than previously estimated. The total prescription rate shows a declining trend. Young adult patients account for close to one-third of the cases and children less than 10 years account for more than a million cases annually."

Journal • Infectious Disease

Evaluation of efflux pump activity and biofilm formation in multidrug resistant clinical isolates of Pseudomonas aeruginosa isolated from a Federal Medical Center in Nigeria. (PubMed, Ann Clin Microbiol Antimicrob) - "Multidrug resistance, biofilm and efflux pump capabilities in Pseudomonas aeruginosa have serious public health implications in the management of infections caused by this organism."

Clinical • Journal • Infectious Disease

High global consumption of potentially inappropriate fixed dose combination antibiotics: Analysis of data from 75 countries. (PubMed, PLoS One) - "Of these, the most sold were ampicillin/cloxacillin, cefixime/ofloxacin and metronidazole/spiramycin. The majority of FDC antibiotic were not approved by either US FDA or WHO EML. International initiatives such as clear guidance from the WHO EML on which FDCs are not appropriate may help to regulate the manufacturing and sales of these antibiotics."

Clinical • Journal • Complement-mediated Rare Disorders

Microbiota and P. aeruginosa adhesions to worn cosmetic contact lenses (cosCL) (RCOP 2017) - "...Hilafilcon lenses had significantly higher chance of isolating CNS and pseudomonal spp compared to etafilcon and nelficon (p<0.001 and p<0.05)...With emmetropic individual wearing cosCL, clinicians should be aware that different cosCls adhere a variety of microbes. Pseudomonal spp surprisingly is commonly found attached to cosCLs in asymptomatic individuals."

Clinical • Biosimilar • Immunology • Ocular Inflammation • Ophthalmology