Etrafon (perphenazine/amitriptyline) / Viatris - LARVOL DELTA

[VIRTUAL] A DANGEROUS DRUG AND HERBAL MIXTURE (CHEST 2020) - "In addition, he takes perphenazine 2 mg-amitriptyline 10 mg per day prescribed by his psychiatrist for anxiety. Bupropion and sertraline were recently discontinued due to lack of symptomatic improvement... Early recognition of SS is essential to initiate supportive treatment and stop all potential substances responsible for serotonin mediated toxicity. It is important to recognize herbal medications as a potential cause of SS."

Anorexia • Cardiovascular • CNS Disorders • Critical care • Depression • Insomnia • Metabolic Disorders • Mood Disorders • Movement Disorders • Ophthalmology • Psychiatry • Sleep Disorder • Substance Abuse • Myoglobin

Sensitive detection of piperazinyl phenothiazine drugs by field-amplified sample stacking in capillary electrophoresis with dispersive liquid-liquid microextraction. (PubMed) - "The recoveries of all phenothiazines in urine and plasma ranged from 85.7 % to 107.6 % and 95.6 % to 105.4, respectively. The proposed method was demonstrated to be a rapid and convenient method for the determination of four piperazinyl phenothiazine drugs in human urine and plasma."

Journal • Biosimilar

AMITRIPTYLINE AND PERPHENAZINE IN CRONIC PAIN: A LITERATURE REVIEW (EPA 2019) - "More research is needed, in order to determine the exact mechanism of action of these combined agents in chronic pain. The knowledge that a low dosage of perphenazine can be used in gastrointestinal disorders, such us nausea and vomiting,might be contributive to amitriptyline's adverse effects."

SAFETY OF AMITRIPTYLINE-PERPHENAZINE DURING BREASTFEEDING (EPA 2019) - "The combination of amitriptyline/perphenazine seems to be safe during breastfeeding,although more research is needed."

Clinical