BG136 / Sino Biopharm - LARVOL DELTA

In Vitro Digestion and Gut Microbiota Fermentation of the Anticancer Marine Drug BG136: Stability and Biotransformation Investigation. (PubMed, Mar Drugs) - "Meanwhile, the process was accompanied by significant microbial regulation, including an increase in beneficial genera (Lactobacillus, Enterococcus) and a reduction in Lachnoclostridium populations. Overall, these findings systematically map the oral bioavailability challenges and prebiotic potential of BG136, highlighting its microbiota-modulating capacity through species-specific ecological regulation, providing insights into oral drug development for BG136."

Journal • Preclinical • Gastrointestinal Disorder • Oncology

Exploring the In Vivo Fate of β-1, 3/1, 6-Glucan Using Quantitative Tandem Mass Spectrometry Based on a Structure-Specific Fragment. (PubMed, Mar Drugs) - "These achievements provide insight into the "black box" of BG136 from administration to elimination in vivo. This work marks the first practical application of this strategy in complex biological matrices, offering methodological support for the successful execution of the BG136 Phase I clinical trial."

Journal • Preclinical • Oncology

A β-1,3/1,6-glucan enhances anti-tumor effects of PD1 antibody by reprogramming tumor microenvironment. (PubMed, Int J Biol Macromol) - "In addition, an increase in innate and adaptive immune cell infiltration and activation, enhanced lipid metabolism, and a decreased in ascorbate and aldarate metabolism were also found. These findings provide mechanistic insights that support the potent antitumor efficacy of BG136 when combined with immune checkpoint inhibitor antibodies."

Biomarker • Journal • Tumor microenvironment • Metabolic Disorders • Oncology

A Clinical Study of BG136 Injection in Healthy Chinese Volunteers (clinicaltrials.gov) - P1 | N=74 | Recruiting | Sponsor: The Affiliated Hospital of Qingdao University | Not yet recruiting ➔ Recruiting

Enrollment open

A Clinical Study of BG136 Injection in Healthy Chinese Volunteers (clinicaltrials.gov) - P1 | N=74 | Not yet recruiting | Sponsor: The Affiliated Hospital of Qingdao University

New P1 trial