BMS-962476 / BMS - LARVOL DELTA

LDL cholesterol reduction with BMS-962476, an adnectin inhibitor of PCSK9: Results of a single ascending dose study (ACC 2014) - Presentation time: Mar 30, 9:45 - 10:30 AM; Abstract #1183-127; P1, N=64; NCT01587365; Sponsor:Bristol-Myers Squibb; "BMS-962476 was well tolerated and AEs were similar to PBO. Maximal dose related reductions of LDL-C up to 48% occurred between day 4 and 14...Doses >0.3 mg/kg reduced free PCSK9 >90%."

P1 data • Atherosclerosis • Dyslipidemia