Vecuron (vecuronium) / Sun Pharma - LARVOL DELTA

Clinical application of sugammadex in renal impairment: pharmacokinetics and pharmacodynamics. (PubMed, Front Pharmacol) - "Sugammadex, a modified γ-cyclodextrin, rapidly and predictably reverses aminosteroid neuromuscular blockade by directly encapsulating rocuronium and vecuronium, thereby avoiding the cholinergic adverse effects associated with acetylcholinesterase inhibitors. Overall, sugammadex may serve as an effective and generally well-tolerated reversal agent in carefully selected patients with severe renal impairment. Additional prospective studies are required to establish its long-term safety and guide clinical recommendations."

Journal • PK/PD data • Review • Chronic Kidney Disease • Nephrology • Renal Disease

Impact of Sugammadex on Clinical and Patient-Centered Outcomes: Beyond Neuromuscular Recovery. (PubMed, J Clin Med) - "Sugammadex provides rapid and predictable reversal of rocuronium- and vecuronium-induced blockade and reduces residual neuromuscular blockade more effectively than conventional anticholinesterase-based reversal. Sugammadex may be associated with favorable selected postoperative outcomes, but it should not be regarded as an independent determinant of recovery. Its clinical effects must be interpreted as part of optimized neuromuscular management incorporating quantitative monitoring, blockade-depth-appropriate dosing, confirmation of recovery, and comprehensive perioperative care."

Journal • Review • Anesthesia • Cardiovascular • CNS Disorders • Immunology • Pain • Renal Disease

Total intravenous anesthesia for open fetal myelomeningocele repair: a case series from a single-center in Peru (2017-2025). (PubMed, Int J Obstet Anesth) - "Total intravenous anesthesia combined with intravenous uterine relaxants was feasible for open fetal myelomeningocele repair in this case series."

Journal • Anesthesia • Cardiovascular • Respiratory Diseases

Anesthetic Considerations for a Bedside Tracheostomy in a Critically Ill Infant (ASA 2026) - "Intraoperatively, baseline sedation/paralysis, milrinone, and iNO were continued, with fentanyl and vecuronium boluses administered as needed. Postoperatively, he required full ventilatory support with pulmonary vasodilators. About 3 weeks later, his mother elected to withdraw care and proceed with organ donation."

Bronchopulmonary Dysplasia • Cardiovascular • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Severe Anaphylaxis After Sugammadex Administration: A Case Report (ASA 2026) - "2023 ASA guidelines recommend sugammadex for reversal of rocuronium or vecuronium-induced neuromuscular blockade...She required multiple doses of epinephrine and albuterol and ICU stabilization followed by full recovery. Serum tryptase was elevated at 124 µg/L. This case highlights the importance of continued vigilance with sugammadex administration."

Case report • Clinical • Cardiovascular • Chronic Obstructive Pulmonary Disease • Immunology • Respiratory Diseases

Anesthetic Management of Tryptase-Negative Rocuronium Anaphylaxis (ASA 2026) - "Resuscitation with epinephrine, sugammadex, antihistamines, and corticosteroids was successful. Negative tryptase did not exclude anaphylaxis; clinical recognition proved decisive. This case advocates for diagnosis-driven management, meticulous allergen documentation, and proactive alternative agent selection — principles that enabled the patient's safe return to the operating room two months later with vecuronium."

Cardiovascular

Perioperative management of emergency non-cardiac surgery in a pediatric patient with Eisenmenger syndrome: a case report. (PubMed, Transl Pediatr) - "Anesthesia was inducted with etomidate, midazolam, vecuronium, and sufentanil, and maintained with propofol, remifentanil and sevoflurane...Prompt treatment with amiodarone, treprostinil, sodium bicarbonate, and supplemental oxygen successfully restored sinus rhythm and hemodynamic stability...It is critical to avoid factors that elevate pulmonary vascular resistance, ensure meticulous monitoring, and recognize and treat PHC early. This case underscores the importance of personalized anesthetic planning and multidisciplinary perioperative management for this vulnerable population."

Journal • Anesthesia • Cardiovascular • Heart Failure • Hypertension • Hypotension • Pediatrics • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Ventricular Tachycardia

From metabolic dysregulation to clinical alert: a novel panel of biomarkers for staging alcohol-associated liver disease. (PubMed, J Transl Med) - "We delineate stage-specific metabolic fingerprints of ALD and present robust, non-invasive models for early identification of cirrhosis. Incorporating metabolomic biomarkers with routine clinical variables markedly improves diagnostic precision and offers a practical tool for risk stratification and personalized management of alcohol-related liver disease."

Biomarker • Journal • Fibrosis • Gastroenterology • Hepatology • Immunology • Inflammation • Liver Cirrhosis • Metabolic Disorders

Sugammadex versus neostigmine for reversal of neuromuscular blockade and postoperative pulmonary complications (SNaPP): an international, randomised, controlled, phase 4 trial. (PubMed, Lancet Respir Med) - P4 | "Sugammadex reduced the incidence of postoperative pulmonary complications or death compared with neostigmine. The risk reduction was small with atelectasis of uncertain clinical significance being the most common complication. Sugammadex can be considered as a first-line drug for reversal of aminosteroid-induced neuromuscular blockade at the end of surgery."

Journal • P4 data • Acute Respiratory Distress Syndrome • Anesthesia • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Effect of Intraoperative Low-Dose Lidocaine Administration on the Consumption of Mivacurium During Gynecological Laparoscopic Surgery: A Prospective Clinical Study. (PubMed, Drug Des Devel Ther) - "Recent literatures have shown that lidocaine obviously shortened the onset time and reduced the maintenance dose of vecuronium...Intravenously administered lidocaine significantly decreased the requirement of mivacurium, shortened the onset time, accelerated the extubation time, and alleviated pain intensity at 6 h and 12 h after surgery, without increasing adverse events in patients with a low risk of airway difficulty undergoing gynecological laparoscopic surgery. Given the small sample size from a single centre, our result requires further verification."

Clinical • Journal • Pain

Allergic reactions to anaesthetics in surgery: current challenges and perspectives. (PubMed, Drug Metab Pers Ther) - "Preventive measures to reduce the risk of AR include: a detailed patient history and diagnostic testing using skin tests, provocation tests, and/or blood tests for Immunoglobulin E (IgE); replacement of the allergenic drug with a safer alternative if an allergy is confirmed; close monitoring for allergic manifestations during surgery, with professional preparedness for resuscitation in cases of anaphylaxis; postoperative patient monitoring to detect potential delayed AR; documentation of all AR for future reference. The findings of this study may be applied in clinical practice to mitigate the risks of AR associated with anaesthetic use during surgical interventions."

Journal • Review • Allergy • Anesthesia • Immunology

Half-dose neostigmine and low dose sugammadex as a reversal agent for vecuronium: a pilot randomized trial. (PubMed, Anaesth Crit Care Pain Med) - "A low-dose sugammadex (1.0 and 0.5 mg/kg) after half-dose reversal of neostigmine provides shorter recovery times compared to full-dose neostigmine reversal agent, and it has no statistically significant differences in recovery times compared with the standard dose of sugammadex (2.0 mg/kg) using our administration method."

Journal • Anesthesia

A Dose-Finding Study of Amogammadex Sodium for Reversing Vecuronium and Rocuronium-Induced Neuromuscular Blockade (clinicaltrials.gov) - P2 | N=64 | Not yet recruiting | Sponsor: Amckaus PTY LTD.

New P2 trial • Anesthesia

Neuromuscular blockade and reversal practices at a single center: Impact of sugammadex and quantitative twitch monitoring (IARS-SOCCA 2026) - "The introduction of sugammadex, a steroidal NMB (rocuronium, vecuronium) selective binding agent approved in the USA for clinical use in December 2015, represented a novel means of reversal of steroidal NMBs. The introduction of sugammadex and subsequent introduction of QNM has revolutionized the delivery of care at our institution. Availability of a rapid reversal agent with a favorable side effect profile further solidified rocuronium's place as the primary NMB agent. When clinicians have the option to reverse rocuronium rapidly with sugammadex, neostigmine and cisatracurium are practically obsolete."

Clinical

Effect of Opioid-Free vs Opioid-Based Anesthesia on Postoperative Pain and Emergence Agitation in Children Undergoing Cleft Surgery (clinicaltrials.gov) - P=N/A | N=90 | Recruiting | Sponsor: Iva Smiljanić

New trial • Anesthesia • Pain • Pediatrics

Safety and Efficacy of Intranasal Fentanyl Use in Early Infancy: A Single-Center Experience (PAS 2026) - "Concomitant sedatives included midazolam (34%), morphine (9.4%), IV fentanyl (3.8%), vecuronium (3.8%), and lorazepam (1.9%). Out of 9,965 infants, 40 (0.4%) received 53 INF doses (mean = 1.4 ± 0.45 µg/kg), with increasing use over time (Figure 1B); recipient characteristics are shown in Figure 1A. Most infants (82.5%) lacked IV access at administration. The primary indications were peripherally inserted central catheter (PICC) placement (47.2%) and intubation (32.1%) (Figure 2)."

Clinical

Short-term respiratory response to furosemide among infants with grade 3 bronchopulmonary dysplasia (BPD) (PAS 2026) - "We identified 247 infants contributing 427 qualifying furosemide exposures (Table 1). Most exposures were intravenous (62.3%) and equivalent to a 1 mg/kg IV dose (85.2%). Figure 1 displays unadjusted mean outcome values 24h pre- and post-furosemide exposure."

Bronchopulmonary Dysplasia • Pulmonary Disease • Respiratory Diseases

Attention of LEadeRs during Tracheal intubation (ALERT); An eye-tracking study (PAS 2026) - "These findings highlight the impact of technology on provider VA during neonatal TI and the potential impact on situational awareness.Table 1: Patient characteristics and indication for intubation by device typeTL= traditional laryngoscope; VL= video laryngoscope; SD= standard deviation1 Can select more than one diagnosis2 Can select more than one indication for intubationTable 2: Intubation attempt characteristics and outcomes by device typeTL= traditional laryngoscope; VL= video laryngoscope; NICU= neonatal intensive care unit; NP= nurse practitioner; PA= physician assistant; IQR= interquartile range1 Premedication defined as atropine, fentanyl, and vecuronium 2 Duration of attempt defined as time from mask off face until re-establishment of ventilation through correctly placed endotracheal tube or mask ventilation if tube was not placed3 Severe desaturation defined as ≥20% drop in oxygen saturation from highest prior to attempt to lowest during attempt4 Bradycardia..."

Intubation • Cardiovascular

Pharmacokinetics of Sugammadex in Reversal of Vecuronium-induced Neuromuscular Blockade in Patients During Laparoscopic Surgery (clinicaltrials.gov) - P4 | N=48 | Completed | Sponsor: Guangzhou General Hospital of Guangzhou Military Command | Recruiting ➔ Completed | Trial completion date: Nov 2022 ➔ Apr 2026

Trial completion • Trial completion date • Obesity

Role of Dexmedetomidine on Hemodynamics and Anesthetic Requirement in Patients Undergoing Elective Infratentorial Tumor Surgery: A Prospective, Randomized, Double-blind, Placebo-controlled Study. (PubMed, Ann Afr Med) - "The use of dexmedetomidine infusion in patients scheduled for infratentorial brain tumor surgery ensures stable perioperative hemodynamics, reduces isoflurane requirements, and reduces intraoperative fentanyl needs."

Clinical • Journal • Anesthesia • Brain Cancer • Oncology • Pain • Solid Tumor

Efficacy and safety of ciprofol for general anesthesia in pediatric strabismus correction surgery: a prospective, randomized, double-blind, non-inferiority study. (PubMed, Front Med (Lausanne)) - P1 | "For anesthesia induction, Group C received an intravenous injection of ciprofol 0.5 mg/kg, alfentanil 20 μg/kg, and vecuronium bromide 0.05 mg/kg; Group P received an intravenous injection of propofol 2 mg/kg, alfentanil 20 μg/kg, and vecuronium bromide 0.05 mg/kg. Ciprofol can be safely used for general anesthesia in pediatric strabismus correction surgery, with non-inferior anesthesia success rate compared with propofol and a lower incidence of adverse reactions. https://www.chictr.org.cn, identifier ChiCTR2300078654."

Clinical • Head-to-Head • Journal • Anesthesia • Ophthalmology • Pediatrics • Strabismus

Early Neurodegeneration in an Experimental Model of Pediatric Cardiac Arrest Is Sex Dependent (SCCM 2026) - "Vecuronium was administered i.v. and ventilation was discontinued to induce ACA. After 14 minutes, return of spontaneous circulation was achieved with chest compressions, epinephrine, and resuming ventilation... Contrary to our initial hypothesis, juvenile female rats had increased neurodegeneration and neuroinflammation vs. male rats 7d post-insult. These findings warrant additional studies with larger sample sizes to verify sex-dependent differences in vulnerability to global hypoxia-ischemia produced by ACA, and long term histologic and behavioral outcome assessments to determine if this vulnerability is enduring."

Clinical • Cardiovascular • CNS Disorders • Inflammation • Pediatrics • Vascular Neurology

Breaking the block: Sugammadex as the last resort for refractory vecuronium-induced neuromuscular blockade in a patient receiving hydroxychloroquine. (PubMed, Indian J Anaesth) - No abstract available

Journal

Perioperative Anaphylaxis in Children at a Large, Academic Pediatric Hospital (AAAAI 2026) - "3 on skin prick testing (morphine, rocuronium, sugammadex) and 2 on ID testing (vecuronium, midazolam). The 3 patients with elevated tryptase levels all had severe anaphylaxis or arrest (grades 3 or 4 on Ring and Messmer scale) and positive skin testing to medication during subsequent evaluation. Conclusions In this cohort of pediatric patients with perioperative anaphylaxis, confirmatory allergy testing identified drug culprits in less than half of cases."

Clinical • Immunology • Pediatrics

Comparison of the Effects of Remimazolam and Propofol on Emergence Delirium in Children Undergoing General Anesthesia (ChiCTR) - P=N/A | N=130 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Xiamen University; The First Affiliated Hospital of Xiamen University

New trial • Anesthesia • CNS Disorders