Vecuron (vecuronium) / Sun Pharma - LARVOL DELTA

In silico assessment of neuromuscular blocking agents and fluoroquinolones as ligands of the Mas-related G protein-coupled receptor X2. (PubMed, Pharmacol Rep) - "In contrast to fluoroquinolones, NMBAs displayed different affinity for MRGPRX2. Cellular responses in bench experiments closely reflected the MD predictions. Alanine scanning revealed that the MRGPRX2 binding pocket exhibits low susceptibility to single-site mutations that enhance receptor responsiveness."

Journal • Immunology

Optimization and Validation of a Green Shelf Life HPLC Technique for Testing Sugammadex Sodium in Raw Material and Parenteral Medications. (PubMed, Biomed Chromatogr) - "An intravenous drug called sugammadex is used to counteract the adverse reactions of the relaxation medications rocuronium and vecuronium, which are given during operations to provide full anesthesia. It includes the eluting phase that comprises of 7 mL/L aqueous solution of triethylamine adjusted at pH 3.0 with phosphoric acid: ethanol (750:250) (V:V). The positive environmental impacts of the LC technique are demonstrated by the combined AES grade of 87, CACI rating of 78, AGSA rating of 75, MoGAPI rating of 80, BAGI rating of 82.5, and final whiteness rating of 96.7."

Journal • Anesthesia • Cerebral Hemorrhage

Risk of postoperative urinary retention after sugammadex use in laparoscopic hernia repair: A matched cohort study of 23,444 cases. (PubMed, PLoS One) - "Sugammadex use is associated with a 77% reduction in POUR and 24% fewer ED visits than neostigmine following hernia repair, suggesting that it may be the preferred reversal agent, particularly for older adults who gain the most benefit."

Journal • Retrospective data • Benign Prostatic Hyperplasia • Gastroenterology • Infectious Disease • Pneumonia • Respiratory Diseases

Peri-operative hypersensitivity reactions to neuromuscular blocking drugs in New Zealand 2013-2019: a retrospective observational study. (PubMed, Anaesthesia) - "We found a significant difference between the rates of peri-operative hypersensitivity reactions with rocuronium and suxamethonium vs. atracurium. The increased risk of a peri-operative hypersensitivity reaction is a factor that should be weighed against the benefits of using suxamethonium or rocuronium. Females may be higher risk than males of reacting to neuromuscular blocking drugs."

Journal • Observational data • Retrospective data • Allergy • Anesthesia • Immunology

Not the Drugs: When Antiseptics Cause the Shock. (ACAAI 2025) - "The first episode followed induction with propofol, fentanyl and rocuronium, causing tachycardia, hypotension (SBP of 53 mmHg), and elevated PEEP (6 cm H2O)...Nine months later, a second attempt using vecuronium and etomidate instead of rocuronium and propofol led to a similar reaction (SBP of 40 mmHg)...Latex serum specific IgE was negative (<0.10 kU/L ref;<0.70), and tolerated graded challenges to lidocaine, trimethoprim-sulfamethoxazole, and latex...In this case, neuromuscular blockers were initially suspected, but anaphylaxis recurred despite using alternatives. Standard testing identified chlorhexidine as the trigger."

Cardiovascular • Chronic Kidney Disease • Glomerulonephritis • Hypotension • IgA Nephropathy • Immunology • Nephrology • Renal Disease

Comparing sugammadex to neostigmine and their effects on delirium and postoperative cognitive function: A systematic review. (PubMed, J Perioper Pract) - "This systematic review suggests the possibility of a very limited neurological protective role of sugammadex compared to neostigmine, but no clinical significance was reported. Only a limited number of studies were available, suggesting the need for further research."

Journal • Review • Anesthesia • CNS Disorders • Cognitive Disorders

Hydatid Cyst in the Right Ventricle leading to Tricuspid stenosis and Heart Failure– A Case Report (AHA 2025) - "After 2 weeks of albendazole therapy (400 mg), emergency cardiac surgery was performed...Premedication with midazolam (0.05 mg/kg IV) was administered. General anesthesia was induced with fentanyl (50 µg/kg), thiopental (5 mg/kg), and vecuronium (0.1 mg/kg) for intubation. Anesthesia was maintained with fentanyl (5 µg/kg) and isoflurane...Cardiac hydatid cysts in the right ventricle are exceptionally rare but can be life-threatening. Cardiac involvement is rare as larvae are usually filtered by the liver and lungs; however, some may bypass these organs. The left ventricle is most commonly involved (50%), followed by the right ventricle (20%), interventricular septum (13%), left atrium (9%), right atrium (6%), and interatrial septum (2%)."

Case report • Clinical • Anesthesia • Cardiovascular • Congestive Heart Failure • Heart Failure • Infectious Disease • Pulmonary Disease

Obstetric and Fetal Anesthesia for EXIT Procedure: A Challenge for Anesthesiologists (ASA 2025) - "Fetal anesthesia with vecuronium, fentanyl and atropine was administered under ultrasound vision. A high level of experience is required for anesthesiologists to provide targeted anesthesia guaranteeing safety for both the mother and the newborn."

Anesthesia • Obstetrics

The Effect of Continuous Neuromuscular Blockade in a Cohort of Patients with Evolving or Grade 3 Bronchopulmonary Dysplasia. (PubMed, Am J Perinatol) - "This study aimed to describe the use of continuous neuromuscular blockade (NMBA) in patients with life-threatening hypoxia and/or hypercarbia secondary to evolving or grade 3 bronchopulmonary dysplasia (BPD) and its association with short-term death, as well as clinical measures of respiratory severity.We identified a cohort of patients with evolving or grade 3 BPD at Riley Children's Health who received continuous infusion vecuronium for greater than 48 hours...· Unstable gas exchange on high BPD ventilator settings may necessitate NMBA use.. · NMBA use may decrease respiratory support needed and improve clinical stability in unstable BPD patients.."

Journal • Bronchopulmonary Dysplasia • Pulmonary Disease • Respiratory Diseases

Comparative Outcomes of Corticosteroids, Neuromuscular blocking agents (NMBAs) and Inhaled nitric oxide (iNO) in adult patients with acute respiratory distress syndrome (ARDS):A systematic review and network meta‑analysis (EUSEM 2025) - "Vecuronium bromide was the best strategy to reduce 28-day mortality compared with the conventional treatment, iNO, methylprednisolone and placebo. This NMA suggested that corticosteroids are possibly beneficial in the patients with ARDS while application of NMBAs may reduce 28-day mortality, iNO as a therapeutic measure which did not show a prominent beneficial effect."

Retrospective data • Review • Acute Respiratory Distress Syndrome • Infectious Disease • Respiratory Diseases

The prevalence of genetic variants of the Mas-related G-protein-coupled receptor X2 in patients does not explain perioperative hypersensitivity reactions to neuromuscular blocking agents. (PubMed, Front Pharmacol) - "The most common causative drugs were rocuronium (n = 17) and atracurium (n = 7), the others were cisatracurium, vecuronium, suxamethonium (n = 2 each) and pipecuronium (n = 1). Analysis of root mean square deviation and fluctuation plots showed no significant differences between wild-type and N62S variants. SNPs detected within the protein coding sequence of the MRGPRX2 gene were not risk factor in NMBA-induced POH, regardless of the clinical characteristics of the patients and the causative drug in question."

Journal • Immunology

Use of Muscle Relaxants in Emergency Medicine: A Review. (PubMed, Med Sci Monit) - "Non-depolarizing agents are further classified by chemical structure into aminosteroids (eg, rocuronium, vecuronium), benzylisoquinolinium compounds (eg, atracurium, cisatracurium), and asymmetric mixed-onium chlorofumarates (gantacurium). However, such monitoring methods are rarely used in ED. This review article explores the pharmacological characteristics, clinical indications, and emergency applications of NMBAs, emphasizing the need for increased awareness of their risks and proper use."

Journal • Review • Anesthesia • Critical care

Analgesia, Sedation, and Neuromuscular Blockade in Pediatric Severe Traumatic Brain Injury: Secondary Analysis of the "Approaches and Decisions in Acute Pediatric TBI Trial" (ADAPT). (PubMed, Neurocrit Care) - P | "Fentanyl and midazolam were the most common analgesic and sedative continuous infusions during acute pediatric sTBI management. Propofol and dexmedetomidine were used less frequently. Opioid (specifically morphine) and dexmedetomidine infusions were associated with survival. Larger studies are needed to determine the safest and most effective analgesia, sedation, and NMB medication strategy for children with sTBI."

Journal • Anesthesia • CNS Disorders • Critical care • Pain • Pediatrics • Vascular Neurology

A Comparative Study of Sugammadex and Neostigmine: A Bibliometric Analysis of the Past 15 Years. (PubMed, Drug Des Devel Ther) - "Sugammadex surpasses neostigmine in rapidly, effectively, and safely reversing NMB induced by rocuronium/vecuronium across all depths. Its use expands to reversing residual NMB from NMBAs in various patient groups (hepatic/renal impairment, obese, neuromuscular disease, elderly, pediatric) and scenarios like difficult airways. Future research will focus on adverse reactions, effects in special populations, establishing quantitative NMB monitoring standards, and understanding NMBA antagonism failure mechanisms."

Clinical • Journal • CNS Disorders • Geriatric Disorders • Obesity • Pediatrics • Renal Disease

Comparison of Phonomyography Prototype With Train-of-Four Watch SX for Neuromuscular Monitoring: A Prospective Observational Study. (PubMed, Anesth Analg) - "When non-depolarizing NMBs were administered, the PMG prototype measured a significantly longer onset and a shorter recovery time compared with TOF-Watch SX. The same trend was also found when depolarizing NMBs were administered. The PMG prototype is clinical feasible and stable but not interchangeable with TOF-Watch SX."

Journal • Observational data

The Use of Cisatracurium in Cardiac Surgery. (PubMed, Turk J Anaesthesiol Reanim) - "Innumerable clinical experiments and trials suggest cisatracurium as safe, cost-effective, and better molecule with predictable recovery and no postoperative residual paralysis in comparison to other NMBs such as rocuronium, vecuronium, and pancuronium. In this review, we aimed to provide critical insights on the properties of NMBs first and then focused on the use of cisatracurium in cardiac surgeries."

Journal • Anesthesia • Cardiovascular

Comparison of intravenous versus nebulized magnesium sulfate on attenuation of hemodynamic response to laryngoscopy in adult patients undergoing elective surgery: A randomized, double-blind study. (PubMed, J Anaesthesiol Clin Pharmacol) - "Secondary outcomes included propofol consumption for anesthesia induction, time to achieve a train-of-four (TOF) ratio of 0 after vecuronium administration, and any adverse effects...However, the time (seconds) to achieve a TOF ratio of 0 was significantly shorter in Group IV compared to Group IN (228.33 vs. 247.09, P = 0.035). Nebulized magnesium sulfate was as effective as intravenous magnesium sulfate in reducing hemodynamic changes during intubation, offering a noninvasive alternative for managing this response."

Clinical • Journal • Anesthesia

Magnesium sulfate and sugammadex: implications for routine practice. (PubMed, Curr Opin Anaesthesiol) - "In both clinical scenarios, sugammadex-induced reversal is rapid and reliable."

Journal • Review

Sugammadex reduces urinary retention after laparoscopic inguinal hernia repair: a retrospective analysis and brief literature review. (PubMed, Surg Endosc) - "Patients who received sugammadex compared to neostigmine/glycopyrrolate had lower rates of POUR and shorter recovery times, suggesting that sugammadex should be the routine reversal agent in laparoscopic IHR, especially in older men with prostate disease at increased risk of retention."

Journal • Retrospective data • Anesthesia • Gastroenterology • Urology

Sugammadex for Neuromuscular Blockade Reversal: A Narrative Review. (PubMed, J Clin Med) - "Sugammadex represents a significant advancement in neuromuscular blockade management, enabling rapid, predictable, and highly effective reversal of steroidal neuromuscular blockers such as rocuronium and vecuronium. Economic considerations are explored, highlighting sugammadex's cost-effectiveness through reduced postoperative complications and enhanced operational efficiency, despite higher initial costs. Finally, the review outlines ongoing research directions, including emerging reversal agents, advanced neuromuscular monitoring technologies, and potential future clinical applications, underscoring sugammadex's evolving role in improving patient safety and anesthetic practice."

Journal • Review • Anesthesia • Critical care • Obesity • Obstetrics • Pediatrics • Renal Disease

2-Hydroxypropyl-β-cyclodextrin, solubiliser in a novel dantrolene formulation: Its binding affinities to clinical compounds that may be used during anaesthesia or management of malignant hyperthermia. (PubMed, Eur J Pharm Biopharm) - "In vitro isothermal titration calorimetry (37 °C, pH 7) was also used to determine the enthalpy of interaction of HP-β-CD with 18 of the most clinically relevant compounds, including rocuronium, vecuronium and remifentanyl (the strongest predicted binder from the in silico work). All had low injection heats with assay parameters of 1500 µM test compound and 50 µM HP-β-CD, i.e. there was no discernible binding to HP-β-CD. Thus, the HP-β-CD component of NPJ5008 is unlikely to interfere with other drugs clinically relevant in MH."

Journal • Anesthesia

The Application of TPVB Combined with Dezocine in Peritoneal Dialysis Catheter Placement (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Chen Jumei Public Welfare Foundation; Qingdao University Affiliated Hospital

New trial • Nephrology • Renal Disease • CXCL8

When reversal fails: investigating recurarization after sugammadex administration (Euroanaesthesia 2025) - "Background: Sugammadex, a modified γ-cyclodextrin, has transformed clinical practice by providing rapid and reliable reversal of neuromuscular blockade (NMB) induced by rocuronium and vecuronium, even at profound levels...Induction was achieved with fentanyl (2 mcg/kg), lidocaine (1 mg/kg), propofol (2 mg/kg), and rocuronium (0.6 mg/kg). Intraoperative medications included dexamethasone, ondansetron, ketorolac, paracetamol, and metamizole...Other causes were systematically ruled out. To minimize recurarization risks, clinicians should ensure rigorous monitoring, individualized dosing, drug quality assessment, and extended observation."

Anesthesia • Breast Cancer • Fibromyalgia • Gynecology • Musculoskeletal Pain • Oncology • Ovarian Cancer • Pain • Rheumatology • Solid Tumor

A Rare Case of Catecholamine-induced Tetany and Novel Approach for Management (ATS 2025) - "This abstract is funded by: None Introduction A catecholamine surge is a rapid release of epinephrine, norepinephrine, and dopamine hormones into the bloodstream...The patient had an episode of vomiting which led to aspiration necessitating re-intubation with sevoflurane...Vecuronium was given which improved the rigidity...The novel approach of using Dantrolene to relax the muscle was effective and sustained. Therefore, dantrolene should be considered in patients who develop tetany due to catecholamines."

Clinical • Anesthesia • Cardiovascular • Gastroenterology • Gastroesophageal Reflux Disease • Hematological Disorders • Hypertension • Pain • Psychiatry • Thrombosis • Urinary Incontinence • Urology

When Two Complications Collide: Navigating Wooden Chest Syndrome and Propofol Infusion Syndrome in the ICU (ATS 2025) - "Initial sedation included etomidate (20 mg IV), fentanyl (100 mcg), propofol (50 mg at 35 mcg/kg/min), succinylcholine (100 mg IV), and ketamine (500 mg)...Prompt discontinuation of fentanyl and vecuronium administration enabled successful WCS management...This case underscores the importance of vigilant monitoring for rare complications like WCS and PRIS in critically ill patients. Early recognition and evidence-based intervention played a crucial role in managing this patient's complex ICU course. Continued research is essential to improve understanding and prevention strategies for these complications in critical care."

Anesthesia • Asthma • Dyslipidemia • Immunology • Infectious Disease • Metabolic Disorders • Pneumonia • Pulmonary Disease • Respiratory Diseases • Septic Shock