terbutaline oral / Generic mfg. - LARVOL DELTA

β2-Adrenergic Receptor Agonist Terbutaline Regulates Macrophage Polarization Via HMGB1 in Immune Thrombocytopenia (ASH 2024) - "Conclusions : Terbutaline could modulate abnormal macrophage polarization and inhibit macrophage phagocytosis toward platelets via HMGB1. To our knowledge, this is the first report indicating that terbutaline can effectively ameliorate thrombocytopenia by regulating macrophage polarization via HMGB1 in ITP."

Hematological Disorders • Immune Thrombocytopenic Purpura • Immunology • Thrombocytopenia • Thrombocytopenic Purpura • CD14 • CD163 • HMGB1 • IL10 • TNFA

START CARE: STep-wise Anti-inflammatory Reliever Therapy Children’s Asthma REsearchn: A Randomised Controlled Trial of the efficacy and safety of an Inhaled Corticosteroid and Long Acting Beta Agonist maintenance and/or reliever therapy versus standard maintenance with separate reliever therapy in children with mild, moderate and severe asthma. (ANZCTR) - P3 | N=400 | Active, not recruiting | Sponsor: Medical Research Institute of New Zealand | Recruiting ➔ Active, not recruiting

Enrollment closed • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

Patients with asthma reminded of the increased risk of severe asthma attacks from overusing blue inhalers (GOV.UK) - "The Medicines and Healthcare products Regulatory Agency (MHRA) is reminding patients with asthma of the importance of using their preventer (anti-inflammatory) inhaler regularly as prescribed, and to avoid relying on their blue inhaler alone. This is because without regular use of a preventer inhaler, symptoms could worsen and increase the risk of severe asthma attacks. This reminder follows updates to product information and the National Institute for Health and Care Excellence (NICE) guidance for short-acting beta 2 agonists (SABAs), including salbutamol and terbutaline, which are used to relieve sudden asthma symptoms such as chest tightness, wheezing, coughing and breathlessness."

NICE • Asthma

Terbutaline for Management of Relative Bradycardia Post-Orthotopic Heart Transplant: A Single Center Experience. (PubMed, Clin Transplant) - "This study's overall low PPM placement rate suggests that early sinus node dysfunction can be treated with pharmacotherapy without committing to a permanent device, and that terbutaline can be used safely in early post-heart transplant recipients. If patients require long-term chronotropic support, the risk-benefit of PPM placement versus continued terbutaline should be considered."

Journal • Retrospective data • Cardiovascular • Transplantation

Cooperation of aquaporin 5 and the adrenergic system in the initiation of birth in rat model. (PubMed, Heliyon) - "Pharmacological influence on AQP5 expression and uterine contraction was investigated by treatment with terbutaline (10 mg/kg, subcutaneously) and doxazosin (5 mg/kg, orally) in vivo; and mercuric chloride (HgCl2), in vitro...In conclusion, our findings elucidate the collaborative role of aquaporin 5 (AQP5) and adrenergic systems in the regulation of uterine contractions in late-pregnant rats. Our findings suggest this may be a good starting point for developing a new tocolytic therapy."

Journal • Preclinical

Prenatal broad-spectrum cannabidiol administration prevents an autism-like phenotype in male offspring from a maternal stress/terbutaline rat model. (PubMed, Brain Behav Immun Health) - "Broad-spectrum cannabidiol oil given during pregnancy decreased scores for all three ASD-related behavioral responses, resulting in an overall significant prevention of the ASD-like phenotype. These findings highlight the potential of broad-spectrum cannabidiol oil as a complementary and integrative approach for prevention of stressor-induced sequelae relevant to development of an ASD-like phenotype."

Journal • Preclinical • Autism Spectrum Disorder • Genetic Disorders • Inflammation • Mood Disorders • Psychiatry

The Impact of Airway Allergic Diseases on Children's and Parents' Quality of Life (clinicaltrials.gov) - P=N/A | N=600 | Recruiting | Sponsor: Wenjing Zhou

HEOR • New trial • Allergy • Asthma • Immunology • Inflammation • Pediatrics • Pulmonary Disease • Respiratory Diseases

Under Pressure: A Case of Systemic Capillary Leak Syndrome and Monoclonal Gammopathy of Undetermined Significance With Pulmonary Arterial Hypertension (ATS 2024) - "We propose that the patient herein has WSPH group V pulmonary hypertension related to underlying hemopathy with concomitant systemic capillary leak syndrome. We share our treatment strategy, with a positive response to cautious application of pulmonary vasodilator therapy."

Clinical • Amyloidosis • Cardiovascular • Congestive Heart Failure • Heart Failure • Hematological Malignancies • Hypertension • Inflammation • Monoclonal Gammopathy • Obstructive Sleep Apnea • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Rheumatology • Sleep Disorder • HIF1A

Terbutaline for Chronotropic Incompetence in Orthotopic Heart Transplant Recipients (ATC 2024) - "A bicaval anastomosis technique was used in 221 (96.5%) patients and 163 (71%) had amiodarone exposure within 90 days before transplant (Table 1)... To our knowledge, this is the largest study to date investigating oral terbutaline use post heart transplantation. Our overall PPM placement rate was low suggesting that early sinus node dysfunction can be treated with pharmacotherapy without committing to a PPM. We conclude that terbutaline can be used safely early post heart transplant."

Clinical • Atrial Fibrillation • Cardiovascular • Multiple Sclerosis • Solid Organ Transplantation • Transplantation

metformin induced lactic acidosis in elderly patients (EUSEM 2023) - "metformin lactic acidosis is a rare complication and its formation is the result of a multifactorial process.we report the case of a 74-year-old patient, diabetic on metformin and janumet, hypertensionand heart rhythm disorder on antiarrhythmic; anticoagulant and beta-blocker.consulting the emergency room for deterioration of general condition for a month with diarrhea.arrived at the emergency room, the patient was conscious, polypneic with normal pulmonary ausculation and normal pulsed oxygen saturation,good hemodynamic constants contrasting with cyanosis of the extremities and HR at 60 bpm.Initial ECG showed bifascicular block at 60 (ECG1). afterwords ,the patient presented a bradycardia at 30 with wide QRS (ECG 2), we had time to take a blood gas which showed deep acidosis at 7.08with lactates at 8.4, hyperkalemia at 7.5 bicarbonates at 7 and hypocapnia at 26.while waiting for the results of the rest of the biology, a hyperkalemia corection protocol has been initiated..."

Clinical • Acute Kidney Injury • Anemia • Cardiovascular • Diabetic Nephropathy • Hematological Disorders • Hypertension • Metabolic Disorders • Renal Disease

A Randomised Controlled Trial of the efficacy and safety of an Inhaled Corticosteroid and Long Acting Beta Agonist maintenance and/or reliever therapy versus standard maintenance with separate reliever therapy in children with mild, moderate and severe asthma. (ANZCTR) - P3 | N=400 | Recruiting | Sponsor: Medical Research Institute of New Zealand | Initiation date: Dec 2000 ➔ Dec 2022

Trial initiation date • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

Systemic capillary leak syndrome secondary to decompression sickness. (PubMed, BMJ Case Rep) - "No pharmacological therapy has substantial evidence in the treatment of acute systemic capillary leak syndrome. By review of current recommendations for acute management, we also emphasise an observed positive response to judicious fluid resuscitation and an oral cyclic AMP-elevating agent (ie, terbutaline)."

Journal • Cardiovascular • Critical care

Impact of Terbutaline on Hemodynamics Following Heart Transplantation [Board No. B284] (ATC 2023) - "Subgroup analyses were also conducted to determine if terbutaline dose and pre-transplant amiodarone use impacted the overall efficacy... Terbutaline is a safe and modestly effective therapy to treat sinus node dysfunction and bradyarrhythmias after heart transplantation. This analysis suggests that the use of terbutaline may allow for more rapid discontinuation or removal of pacing wires and titration of IV chronotropic agents. This, in turn, may facilitate more rapid transfer out of the ICU in patients experiencing sinus node dysfunction."

Atrial Fibrillation • Cardiovascular • Transplantation

Clinical pharmacokinetics of terbutaline in humans: a systematic review. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "The addition of theophylline to terbutaline did not affect the PK of terbutaline; hence, both can be used without dose adjustment. This review summarizes all the available PK parameters of terbutaline, and it may be helpful for researchers in the development and evaluation of PK models as well as in designing optimal dosage regimens in different clinical conditions."

Journal • PK/PD data • Review • Asthma • Chronic Kidney Disease • Chronic Obstructive Pulmonary Disease • Immunology • Nephrology • Pulmonary Disease • Renal Disease • Respiratory Diseases

"SMILE Study design- Symbicort 1 inhalation BID with either Bricanyl PRN, Formoterol PRN or Symbicort PRn - Symbicort plus Symbicort PRN best at reducing exacerbations" (@DrAnneEllis)

Conservative and medical treatments of non-sickle cell disease-related ischemic priapism: a systematic review by the EAU Sexual and Reproductive Health Panel. (PubMed, Int J Impot Res) - "Conservative methods including ice pack, exercise, cold enema and ejaculation depicted lower effectiveness in resolving priapism (1-55%). Longer time interval from the onset to the resolution of IP was associated with higher rate of erectile dysfunction at follow-up (30-70%), especially after 24 h."

Journal • Review • Erectile Dysfunction • Genetic Disorders • Hematological Disorders • Sickle Cell Disease

The Combination of Terbutaline and Danazol as the Treatment of Corticosteroid-resistant/Relapse Immune Thrombocytopenia (clinicaltrials.gov) - P2 | N=228 | Not yet recruiting | Sponsor: Peking University People's Hospital

Monotherapy • New P2 trial • Hematological Disorders • Thrombocytopenia • Thrombocytopenic Purpura

Innovative pulmonary targeting of terbutaline sulfate-laded novasomes for non-invasive tackling of asthma: statistical optimization and comparative in vitro/in vivo evaluation. (PubMed, Drug Deliv) - "The pharmacokinetic studies divulged 3.88-fold accentuation in TBN bioavailability from the optimum TBN-NVS versus the oral TBN solution. Concisely, the results proposed that NVS are an auspicious nanovector for TBN pulmonary delivery with integral curbing of the disease owing to target specificity."

Journal • Preclinical • Asthma • Immunology • Pediatrics • Pulmonary Disease • Respiratory Diseases

Inhaled Terbutaline Increases High Density Lipoprotein Cholesterol (ATS 2022) - "A similar mechanism may result in an increase in HDLC by inhaled beta agonists, and duration of action may play an important role. Modulation of lipid metabolism by beta adrenergic agents has important implications in the potential induction (beta blocker) or therapy (beta agonist) of the metabolic syndrome, a condition partially defined by low HDLC levels, and is associated with increased cardiovascular disease risk."

Asthma • Cardiovascular • Immunology • Metabolic Disorders • Respiratory Diseases • SLC51B

Ambulatory electrocardiography, heart rate variability, and pharmacologic stress testing in cats with subclinical hypertrophic cardiomyopathy. (PubMed, Sci Rep) - "Male cats had significantly higher HRV (SDNN: p = 0.0001) and lower mean heart rates (p = 0.0001). HRV decreased post-terbutaline (SDNN: p = 0.0008) and changes in HRV observed between sexes were attenuated by terbutaline."

Journal • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Hypertrophic Cardiomyopathy

Hot Flashes and Neurovascular Function in Women (clinicaltrials.gov) - P=N/A; N=120; Recruiting; Sponsor: Mayo Clinic

Clinical • New trial

Drugs for asthma. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Asthma • Immunology • Respiratory Diseases

[VIRTUAL] Efficacy of oral terbutaline for positive chronotropic support in patients with bradycardia (ASHP 2020) - "The primary objective is to evaluate the effect of oral terbutaline on median heart rate from baseline to 2-4 hours, 20-28 hours, and 68- 76 hours after initiation of terbutaline. Secondary objectives include patient symptomatic improvement, starting or discontinuation of inotropes, effect of terbutaline on pacemaker status, incidence of intermittent bradycardia while on terbutaline, and safety of terbutaline."

Clinical • Cardiovascular • Fatigue

A novel nanogel loaded with chitosan decorated bilosomes for transdermal delivery of terbutaline sulfate: artificial neural network optimization, in vitro characterization and in vivo evaluation. (PubMed, Drug Deliv Transl Res) - "These findings support the prospect use of BLS as active and safe transdermal carrier for TBN in the treatment of asthma. Graphical Abstract."

Journal • Preclinical • Asthma • Respiratory Diseases

"@AstraZenecaFR Comment est-il possible qu'il y ait des ruptures de stocks sur des médicaments utiles aux #insuffisantsrespiratoires ! Comment pouvons-nous nous traiter correctement sans #bricanyl et #symbicort turbuhalers ? #DCP #traitementmédical #PCD" (@Peuchamiel1)