WBMP-4
/ Welt Bio-Molecular Pharma
- LARVOL DELTA
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October 03, 2025
The development of directly active monoclonal antibodies: monotherapies with combined antibody-dependent cellular cytotoxic and tyrosine kinase inhibitory effects
(SITC 2025)
- "WBMP-4's global kinase inhibition encompasses the effects of approved inhibitor drugs (i.e. BTK, PI3K, and Bcl-2 inhibitors), and should be more tumor-restrictive; WBMP-4 only affects IgM-expressing B-cells, sparing healthy B-cells that express other classes of Ig. This tumor specificity and potent inhibitory effects make WBMP-4 a promising clinical candidate."
IO biomarker • Hematological Malignancies • Lymphoma • Oncology • CD79B • ZAP70
March 26, 2025
A novel drug discovery platform identifies epitopes on driver receptors that can be targeted to induce widespread kinase inhibition and cancer cell death
(AACR 2025)
- "WBMP-4's global kinase inhibition encompasses the effects of approved kinase inhibitor drugs (i.e. BTK, PI3K, and Bcl-2 inhibitors), and is designed to be more tumor-restrictive; WBMP-4 only affects IgM-expressing B-cells, sparing healthy B-cells that express other classes of Ig (i.e. IgG, IgA, IgD, or IgE). This tumor specificity and potent inhibitory effects make WBMP-4 a promising clinical candidate."
IO biomarker • Hematological Malignancies • Lymphoma • Oncology • CD79B • ZAP70
March 06, 2024
Membrane protein expression and activity following inhibition of B-cell receptor-initiated signaling by WBMP-4, a therapeutic antibody for leukemia/lymphoma
(AACR 2024)
- "This work will be considered in the context of our ongoing research on WBMP-4's inhibition of intracellular signaling pathways, and the resulting biologic effects, and will contribute to the continued development of WBMP-4 by providing an understanding of the effects achieved (cell growth inhibition, cell differentiation, apoptosis) at different dosages and if these effects are maintained over time. As a novel, efficacious, and low toxicity treatment strategy for B-cell leukemia and lymphoma, WBMP-4 has significant clinical potential."
IO biomarker • Burkitt Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Oncology • BCL2 • CD20 • CD21 • CD22 • CD79A • CD79B • CD81 • CXCR4 • EBF1 • FCGR2A • MYC • PAX5 • STAT5
March 14, 2023
Anti-membrane IgM monoclonal antibody, WBMP-4, induces apoptosis in B-cell malignancies by modulation of kinase expression and phosphorylation
(AACR 2023)
- "These data support the concept that WBMP-4 binds an epitope on mIgM that is critical to its signal transduction to CD79a/b.Due to WBMP-4’s specific targeting of IgM-expressing B-cells, we expect that the toxicities associated with approved therapies upon their interaction with non-lymphatic tissue (e.g. bleeding, infection, cytopenia, arrhythmia, secondary malignancies) will be avoided. With potent anti-tumor activity and expected reduced toxicities, WBMP-4 is a compelling candidate for clinical development."
Burkitt Lymphoma • Hematological Malignancies • Leukemia • Lymphoma • Oncology • CD79A • CD79B • ZAP70
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