cefuroxime axetil / Generic mfg. - LARVOL DELTA

Cytotoxic and Apoptotic Effects of Sultamicillin and Cefuroxime Axetil and Their Potential Transformation Products in RTG-2 Fish Gonad Cells. (PubMed, Cell Biochem Biophys) - "Because both compounds are prodrugs that may undergo hydrolysis or transformation during incubation, the observed biological responses should be interpreted as effects associated with the exposure conditions rather than as evidence of the intrinsic toxicity of the intact parent compounds. These findings provide baseline information for future mechanistic studies and environmental risk assessment of antibiotic-related contaminants in aquatic ecosystems."

IO biomarker • Journal • BCL2 • TP53

Spectrum meets sustainability: green-validated novel simultaneous assays of antimicrobial fixed dose combination. (PubMed, BMC Chem) - "Herein, the first green spectrophotometric assay of pharmaceutical formulation of two antibiotics is done simultaneously; Cefuroxime Axetil and Ornidazole...As an environmental obligation, the proposed method's greenness was compared to the reported HPLC and HPTLC procedures using Analytical Eco-Scale and AGREE metrics. The first spectrophotometric simultaneous assay of CFUR-X and ORNI via isosbestic as well as 1D shows higher greenness scores preceding the previous chromatographic ones, which assures ecofriendly, simple and applicable analysis."

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Efficacy and safety of 24 antibiotics for group A streptococcal pharyngitis: a network meta-analysis of 64 randomized controlled trials. (PubMed, Front Public Health) - "For late bacterial eradication, cefprozil demonstrated greater efficacy compared with penicillin V (OR: 3.12; 95% CI: 1.03-11.25), whereas azithromycin exhibited suboptimal performance (OR: 0.38; 95% CI: 0.25-0.62). For early clinical response, cefdinir (OR: 2.01; 95% CI: 1.28-3.25) and cefuroxime axetil (OR: 2.14; 95% CI: 1.19-3.60) demonstrated significantly greater efficacy compared with penicillin V. For late clinical response, spiramycin showed superior efficacy to penicillin V (OR: 0.17; 95% CI: 0.02-0.94), although evidence was limited to a single small trial...Conversely, azithromycin should be avoided due to inferior efficacy and increased adverse risks. http://www.crd.york.ac.uk/prospero, identifier CRD420251104703."

Clinical • Journal • Retrospective data • Review

From complexity to cure: hybrid management of a giant Innominate artery pseudoaneurysm. (PubMed, Acta Cardiol) - "The patient recovered uneventfully, completed a two-week course of oral cefuroxime axetil, and remained afebrile at three-month follow-up with complete resolution of symptoms...The adopted hybrid strategy-combining carotid-subclavian bypass, endovascular exclusion, and adjunctive embolisation-represent a less invasive yet effective option for managing such complex supra-aortic lesions, potentially offering durable exclusion while maintaining cerebral perfusion. The uneventful recovery and symptom resolution at three months support hybrid repair as a viable strategy in select cases, though long-term surveillance remains essential given the risk of late graft infection or recurrence."

Journal • Cardiovascular • Infectious Disease • Inflammation • Thrombosis • CRP

C3 Glomerulopathy Associated With a CFHR5 Mutation in a Young Adult Non-Cypriot Case (ERA 2026) - "He had a history of ibuprofen and cefuroxime axetil use for an upper respiratory infection two months prior...The patient received three days of 500mg pulse methylprednisolone, followed by 1mg/kg/day steroid, intravenous diuretics, and mycophenolate mofetil(MMF)...After vaccination and azithromycin prophylaxis, eculizumab therapy was initiated...In patients with limited response to conventional immunosuppression, complement inhibitors such as eculizumab represent an important therapeutic option. Image"

Clinical • Complement-mediated Rare Disorders • Glomerulonephritis • Immunology • Infectious Disease • Lupus Nephritis • Respiratory Diseases • CRP

Sociodemographic and Clinical Correlates of Multidrug-Resistant Uropathogens in Hospitalized Children. (PubMed, Infect Drug Resist) - "Resistance to ampicillin, trimethoprim/sulfamethoxazole, amoxicillin/clavulanic acid, nitrofurantoin, cefuroxime-axetil, and cefuroxime-sodium was 33.8%, 12.4%, 9.4%, 3.9%, 3.2%, and 2.5%, respectively. The prevalence of MDR and non-susceptibility/resistance to 1-2 antibacterial categories in Gram-negative uropathogens is concerning. Our findings underscore the need for tailored empirical therapy and targeted antibiotic stewardship interventions."

Journal • Infectious Disease • Nephrology • Pediatrics • CRP

Artesunate ameliorates Staphylococcus aureus-induced mandibular osteomyelitis and promotes osteogenic differentiation via NOD2/p65 signaling pathway. (PubMed, Int Immunopharmacol) - "AS attenuated inflammation and promoted osteogenic differentiation in rBMSCs by inhibiting the NOD2/p65 pathway. In vivo, AS facilitated the healing of chronic suppurative mandibular osteomyelitis in rats."

Journal • Inflammation • RELA

Electrochemical Removal of Cephalosporin Antibiotic-Cefuroxime Axetil from Aquatic Media Using Boron-Doped Diamond Electrodes: Process Optimization, Degradation Studies and Transformation Products Characterization. (PubMed, Molecules) - "Their potential aquatic toxicity was subsequently evaluated in silico using fish and algae models. Finally, energy consumption analysis was conducted to evaluate the impact of various factors on the process's economic efficiency."

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Microbiological Monitoring and Microbial Susceptibility of Salmonella from Aquacultured Tambaqui Hybrids (Colossoma macropomum): Implications for Food Safety. (PubMed, Antibiotics (Basel)) - "Identification and susceptibility profiling were performed using the VITEK®2 Compact automated system (BioMérieux, Marcy l'Étoile, France), testing 14 commonly used antimicrobials, including amoxicillin-clavulanic acid, piperacillin-tazobactam, cephalexin, cefuroxime axetil, ceftriaxone, cefepime, meropenem, ertapenem, amikacin, gentamicin, ciprofloxacin, and sulfamethoxazole-trimethoprim. Nevertheless, ongoing microbiological monitoring remains essential, particularly in light of regulatory standards that prohibit the presence of Salmonella spp. in fish products and the potential emergence of MDR strains."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease

Quality evaluation of cephalexin, cefuroxime, and ceftriaxone medicines marketed in Addis Ababa city, Ethiopia with three tier level approach and anti-microbial assays. (PubMed, BMC Pharmacol Toxicol) - "The tested medicinal products were of good quality. However, there are differences in the antimicrobial activity effectiveness results against tested bacterial strains. It implies that resistance to Cephalosprins' is emerging in the study area."

Journal • Infectious Disease

Clinical Characteristics and Antibiotic Susceptibility of Staphylococcus aureus-Infected Dermatoses. (EADV 2025) - "Resistance rates were highest for benzylpenicillin (81.8%), levofloxacin (54.9%), and erythromycin (39.4%). Resistance to fusidic acid, clindamycin, mupirocin, and tetracycline was observed in 38.2%, 20.6%, 16.9%, and 10.3% of isolates, respectively...Among all patients, 16.2% were immunosuppressed, receiving medications such as oral prednisolone (45.4%), methotrexate (27.3%), azathioprine (18.2%), and mycophenolate mofetil (9.1%). Treatment regimens included topical fusidic acid (27.9%), mupirocin (16.2%), and clindamycin (8.8%), while systemic therapy involved oral doxycycline (14.7%), amoxicillin/clavulanic acid (13.2%), and cefuroxime axetil (10.3%)... This study highlights the significant burden of MRSA in outpatient dermatology settings and underscores the necessity for local antimicrobial resistance surveillance. The findings emphasize the importance of informed empirical antibiotic selection to optimize treatment strategies for S. aureus-associated ID and improve..."

Clinical • Atopic Dermatitis • Dermatology • Dermatopathology • Hidradenitis Suppurativa • Immunology • Infectious Disease

Green Nail Syndrome from Serratia marcescens in a 62-Year-Old Filipino Female (EADV 2025) - "Materials & We report the case of a 62-year-old female with a history of hypertension and a seven-year history of non-insulin- dependent diabetes mellitus, maintained on Gliclazide 60 mg once daily and a combination of Linagliptin and Empagliflozin after dinner...However, culture and sensitivity tests demonstrated a heavy growth of Serratia marcescens, sensitive to amikacin, cefepime, ceftazidime, ciprofloxacin, gentamicin, trimethoprim-sulfamethoxazole, ceftriaxone, ertapenem, and meropenem; but resistant to cefuroxime, amoxicillin/clavulanic acid, cefoxitin, and cefuroxime axetil... This report documents a rare case of green nail syndrome attributed to Serratia marcescens, a pathogen uncommonly associated with this condition. It highlights the importance of considering less common pathogens in the differential diagnosis of green nail syndrome, particularly in patients with underlying comorbidities such as diabetes mellitus. Accurate microbiological identification..."

Cardiovascular • Dermatology • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Mood Disorders • Pruritus

The efficacy and safety of containning vonoprazan-minocycline quadruple therapy for Helicobacter pylori eradication:A Prospective, Multicenter, Randomized, Controlled Clinical Study (ChiCTR) - P4 | N=316 | Recruiting | Sponsor: Fuzhou University Affiliated Provincial Hospital; Fuzhou University Affiliated Provincial Hospital

New P4 trial • Infectious Disease

Cefuroxime axetil dosing regimens and probability of target attainment in adults and children. (PubMed, Br J Clin Pharmacol) - "Our analysis provides insight into the performance of different doses and dosing regimens for cefuroxime axetil for key pathogens. As resistance patterns evolve, and differ between countries or regions, cefuroxime doses may require adjustments considering local bacterial susceptibility."

Journal • Infectious Disease • Nephrology

Rising Threats and Evolving Trends: Five Years of Urinary Tract Infection Prevalence in a Portuguese Hospital. (PubMed, Clin Pract) - "For E. coli, resistance ranged from 2% (amikacin) to 41% (ampicillin), with increasing resistance to ertapenem and fosfomycin and decreasing resistance to several key antibiotics...pneumoniae showed 4-36% resistance across antimicrobials, with notable increases for fosfomycin, meropenem, and cefuroxime axetil...Identified risk factors may inform targeted prevention strategies. Ongoing surveillance and antimicrobial stewardship are crucial to mitigate the rising burden of UTIs and resistance."

Journal • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Pneumonia

'Unlocking the potential of cefuroxime axetil metal complexes: a multifaceted approach to discovering β-glucosidase inhibitors through MD simulations, POM analyses, and pharmacophore site identification'. (PubMed, J Biomol Struct Dyn) - "MD simulations unveiled a robust binding affinity between the inhibitors and the active site of β-glucosidase, inducing notable structural conformational alterations within the protein. Conclusively, These metal complexes have a greater capacity to block β-glucosidase activity than standard drugs, as evidenced by their binding energy and interaction pattern inside the active pocket, making them a better drug candidate."

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Variation of healthcare associated infections at a tertiary hospital in Southwest China over a 5-year period (2019-2023): a retrospective observational study. (PubMed, BMC Infect Dis) - "The incidence rates of HAIs fluctuated over the years, peaking in 2019, suggesting potential shifts in infection control dynamics. Klebsiella pneumoniae, Escherichia coli, and Acinetobacter baumannii were the predominant pathogens, and tigecycline may be considered as a potential option against these pathogens. The study highlights the importance of enhancing infection control measures in high-risk departments and sites, optimizing antibiotic stewardship, and continuously monitoring HAI trends to inform evidence-based infection control policies."

Journal • Observational data • Retrospective data • Cardiovascular • Hematological Disorders • Infectious Disease • Novel Coronavirus Disease • Pneumonia

PREVALENCE AND CORRELATES OF URINARY TRACT INFECTION CAUSED BY MULTIDRUG-RESISTANT BACTERIA AMONG CHILDREN AND ADOLESCENTS (ESPID 2025) - "Resistance rate to ampicillin, trimethoprim/sulfamethoxazole, amoxicillin/clavulanic acid, nitrofurantoin, cefuroxime-axetil, and cefuroxime-sodium was 33.8%, 12.4%, 9.4%, 3.9%, 3.2%, and 2.5%, respectively, and 6.8% [95% CI (4.84-9.37)] were MDR bacteria. Conclusions/Learning Points The prevalence of MDR Gram-negative uropathogens was low, with recent antibiotic treatment being the main risk factor. No difference was found in LOS and costs of UTI hospitalizations caused by MDR and non-MDR bacteria."

Clinical • Infectious Disease

Successful Treatment of Pyogenic Liver Abscess Caused by Klebsiella Pneumoniae Using Antibiotics Alone: A Case Report. (PubMed, Infect Drug Resist) - "Despite unsuccessful drainage, the patient received 22 days of intravenous anti-infective treatment with meropenem, levofloxacin, and cefoperazone/sulbactam. After discharge, the patient continued oral treatment with levofloxacin and cefuroxime axetil for another 21 days until the abscess completely disappeared. The PLA took a total of 48 d from detection to complete resolution."

Journal • Gastrointestinal Disorder • Hepatology • Infectious Disease • Pneumonia • Respiratory Diseases

Exploring potential drug-drug interactions in discharge prescriptions: ChatGPT's effectiveness in assessing those interactions. (PubMed, Explor Res Clin Soc Pharm) - "The most frequent major interaction was between Cefuroxime Axetil and Pantoprazole Sodium. pDDIs are prevalent in internal medicine discharge prescriptions, with polypharmacy heightening the risk. While ChatGPT 4.0 accurately identifies pDDI occurrence, its limitations in predicting severity, onset, and documentation underscore healthcare professionals' need for careful oversight."

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Antibiotic resistance in community-acquired urinary tract infections. Did the COVID-19 pandemic cause a change? (PubMed, J Infect Dev Ctries) - "Ceftriaxone and Cefixime resistance rates and ESBL positivity among the uropathogens E. coli and K. pneumoniae increased during the pandemic compared with the pre-pandemic period. ESBL positivity was higher in males."

Journal • Infectious Disease • Nephrology • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

Synthesis, Characterization, Bioavailability and Antimicrobial Studies of Cefuroxime-Based Organic Salts and Ionic Liquids. (PubMed, Pharmaceutics) - "Cefuroxime is usually administered in its prodrug form, cefuroxime axetil...Cefuroxime organic salts have a water solubility 8-to-200-times greater than the original drug at 37 °C. The most soluble compounds have a very low octanol-water partition, similar to cefuroxime, while more lipophilic salts partition predominantly to the organic phase."

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Development of bacterial resistance in Germany from 2008 to 2022 - major culprit pathogens, antibacterial drugs, and prescribing practices. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "We identified cefuroxime axetil, sulfamethoxazole-trimethoprim and nitrofurantoin as the most problematic drugs. In aggregate, our findings support irrational prescribing behaviour and underscore the urgent need for improved prescribing practices to counter rising bacterial resistance in Germany. Moreover, therapeutic guidelines for bacterial infections, the "holy grail" of pharmacotherapy, must be updated more frequently."

Journal • Infectious Disease • Pneumonia

Antimicrobial Susceptibility of 687 Escherichia coli Isolates from Urinary Tract Infection in Brazil (AAP-NCE 2024) - "E.coli is still highly susceptible to amoxicillin-clavulanate (84%), piperacillin-tazobactam (95%), second-generation cephalosporin (cefuroxime axetil-91%, cefuroxime-94%), third-generation cephalosporin (ceftriaxone-95%), fourth-generation cephalosporin (cefepime-96%), aminoglycoside (gentamicin-93%, amikacin-99%), carbapenems (meropenem-100%, ertapenem-100%), nitrofurantoin (97%), fosfomycin (100%) and fluoroquinolones (norfloxacin-88%, ciprofloxacin-90%). E.coli isolates from Brazilian patients younger than 15 years old with UTI have low susceptibility to cotrimoxazole, ampicillin, cefalotin, and nalidixic acid. E.coli isolates from Brazilian patients younger than 15 years old with UTI have low susceptibility to cotrimoxazole, ampicillin, cefalotin, and nalidixic acid. Second-generation cephalosporins and amoxicillin-clavulanate are appropriate empiric antibiotic choices to treat uncomplicated febrile UTIs. Nitrofurantoin and fosfomycin are suitable oral alternatives..."

Infectious Disease • Nephrology • Pediatrics

Daily defined dose-costs have a stronger influence on antibacterial drug prescriptions in Germany than bacterial resistance: economic factors are more important than scientific evidence. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Our data point to irrational prescribing behavior for amoxicillin, cefuroxime axetil, doxycycline, nitrofurantoin, ciprofloxacin, and clarithromycin. For amoxicillin clavulanic acid and sulfamethoxazole-trimethoprim, data point to semi-rational prescribing...It will be important to conduct similar studies on the prescription of antibacterial drugs in other countries. It will also be important to study the relation between DDD-costs and -prescriptions for other drug classes and assess the scientific basis for these relations."

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