PerFoam Five (permethrin 5% foam) / Vyne Therap - LARVOL DELTA

Better Disease Control by Multidrug Regimen in Scabies (clinicaltrials.gov) - P=N/A; N=212; Completed; Sponsor: B.P. Koirala Institute of Health Sciences

Clinical • New trial • Infectious Disease

Evaluation of Susceptibility of Aedes caspius (Diptera: Culicidae) to Insecticides in a Potent Arboviral-Prone Area, Southern Iran. (PubMed, J Arthropod Borne Dis) - "The adult susceptibility test was assessed to Bendiocarb 0.1%, DDT 4%, Deltamethrin 0.05%, Lambda-cyhalothrin 0.05%, Malathion 5% and, Permethrin 0.75% at different interval times as well as at discriminative dose recommended by WHO...caspius to Temephos were 0.000068, and 0.000130ppm, the figures for B. thuringiensis was 111.62 and 210.2ppm, respectively. A routine and continuous study for monitoring and evaluation of different species of Aedes to insectides is recommend at different parts of country for decision making."

Journal

Susceptibility of Dermanyssus gallinae from China to acaricides and functional analysis of glutathione S-transferases associated with beta-cypermethrin resistance. (PubMed, Pestic Biochem Physiol) - "Four field isolates of CBP-1, CBP-3, CBY-2 and CBH-1 had developed high or extremely high level of resistance (resistance ratio ≥ 40.0) to beta-cypermethrin or permethrin...HPLC analysis indicated that rGST-1 protein could metabolize phoxim directly, but rGSTs could not directly metabolize beta-cypermethrin. Our results indicated that some field isolates of D. gallinae from China had developed high level of resistance to pyrethroids, and elevated GSTs activity as well as increased GSTs expression levels were involved in beta-cypermethrin resistance, but the three evaluated GSTs did not play a direct role in the metabolism of beta-cypermethrin."

Journal

Multivariate optimization of a dispersive liquid-liquid microextraction method for the determination of six antiparasite drugs in kennel effluent waters by using second-order chromatographic data. (PubMed, Talanta) - "The developed method allowed the quantitation of the target analytes, even in the presence of unexpected compounds from dirty water samples. The following maximum levels of veterinary drugs were found (in ng mL): imidaclopril, 7; albendazole, 46; fenbendazole, 21; praziquantel, 29; fipronil, 29 and permethrin, 217."

Journal

Pesticide exposure among Latinx children: Comparison of children in rural, farmworker and urban, non-farmworker communities. (PubMed, Sci Total Environ) - "The most frequently detected pesticide classes were organochlorines (85.7%), pyrethroids (65.4%), and organophosphates (59.4%), with the most frequently detected specific pesticides being alpha-chlordane (69.2%), trans-nonachlor (67.7%), gamma-chlordane (66.2%), chlorpyrifos (54.9%), cypermethrin (49.6%), and trans-permethrin (39.1%)...Children in urban, non-farmworker families had greater concentrations of alpha-chlordane (geometric mean (GM) 18.98, 95% CI 14.14, 25.47 vs. 10.25, 95% CI 7.49, 14.03; p= 0.0055) and dieldrin (GM 17.38, 95% CI 12.78 23.62 vs. 8.10, 95% CI 5.47, 12.00; p= 0.0034) than did children in rural, farmworker families. These results support the position that pesticides are ubiquitous in the living environment for children in vulnerable, immigrant communities, and argue for greater effort in documenting the widespread nature of pesticide exposure among children, with greater effort to reduce pesticide exposure."

Clinical • Journal

Insecticide Resistance Development in the Filth Fly Pupal Parasitoid, Spalangia cameroni (Hymenoptera: Pteromalidae), Using Laboratory Selections. (PubMed, J Econ Entomol) - "A comparison of several parasitoid strains collected from different U.S. states indicated that permethrin susceptibility was not significantly different between a baseline strain and more recently established field strains. The potential implications of this previously unrecognized nontarget insecticide exposure effect on filth fly parasitoids are discussed."

Journal

Photodegradation kinetics, mechanism and aquatic toxicity of deltamethrin, permethrin and dihaloacetylated heterocyclic pyrethroids. (PubMed, Sci Total Environ) - "The ECOSAR program displayed that pyrethroids and most of their photodegradation products were toxic to fish, daphnid, green algae. Particularly, some photodegradation products were more harmful to aquatic organisms than their parents."

Journal

The first implementation of allele-specific primers for detecting the knockdown and acetylcholinesterase target site mutations in malaria vector, Anopheles sacharovi. (PubMed, Pestic Biochem Physiol) - "Many populations have begun to have resistance against permethrin and deltamethrin...sacharovi field populations suggesting that populations might gain resistance against all possible insecticide in the future. Therefore, insecticide resistance management strategies are urgently needed for effective vector control implementation."

Journal • Infectious Disease • Malaria • KDR

Scabies-Renaissance of an ectoparasite infection : Diagnosis and therapy-How to proceed in practice (PubMed, Hautarzt) - "In the event of repeated nonresponse to topical (permethrin) and/or oral antiscabious treatment, alternative topical preparations-benzyl benzoate or crotamiton-should be used. Combination with ivermectin is mandatory."

Journal • Review • Dermatology • Infectious Disease • Pruritus

Permethrin exposure from wearing fabric-treated military uniforms in high heat conditions under varying wear-time scenarios. (PubMed, J Expo Sci Environ Epidemiol) - "Differences related to wear-time under the ambient conditions (Group 3 vs. Group 4) were not statistically significant. Findings suggest that wearing permethrin-treated clothing in heat conditions results in higher internal dose of permethrin above that observed under ambient conditions."

Biomarker • Journal

Insecticide resistance status of Aedes aegypti in Bangladesh. (PubMed, Parasit Vectors) - "The detection of widespread pyrethroid resistance and multiple resistance mechanisms highlights the urgency for implementing alternate Ae. aegypti control strategies. In addition, implementing routine monitoring of insecticide resistance in Ae. aegypti in Bangladesh will lead to a greater understanding of susceptibility trends over space and time, thereby enabling the development of improved control strategies."

Journal • Chikungunya • Dengue Fever • Infectious Disease

Presence of the knockdown resistance (kdr) mutations in the head lice (Pediculus humanus capitis) collected from primary school children of Thailand. (PubMed, PLoS Negl Trop Dis) - "Currently, the mainstay of treatment for pediculosis is chemical insecticides such as permethrin...PCR-RFLP is an easy technique to demonstrate the kdr mutation in head louse. The data obtained from this study would increase awareness of increasing of the kdr mutation in head louse in Thailand."

Clinical • Journal • CNS Disorders • Pruritus • Sleep Disorder • PCR

Permeable reactive surface-biobarriers. Testing and evaluation of an ecotechnology for the removal of agrotoxic compounds carried by agricultural runoffs. (PubMed, J Environ Health Sci Eng) - "showed the capacity to accumulate the insecticides permethrin and cypermethrin...in the aerobic barriers was the bioaccumulation of pyrethroids, meaning that biosorption is also a valuable removal mechanism operating in the aerobic PRBs. In this aspect, they behave analogously to subsurface constructed wetlands but, instead of superficial plant life, aerobic PRSBs host microalgae."

Journal

Susceptibility of Anopheles gambiae from Côte d'Ivoire to insecticides used on insecticide-treated nets: evaluating the additional entomological impact of piperonyl butoxide and chlorfenapyr. (PubMed, Malar J) - "Low mosquito mortality was found for pyrethroids alone, and while PBO increased mortality, it did not restore full susceptibility. The vector was not fully susceptible to chlorfenapyr in one third of the sites tested. However, vector susceptibility to chlorfenapyr seems to be considerably higher than for pyrethroids alone or with PBO. These data should be used cautiously when making ITN procurement decisions, noting that bioassays are conducted in controlled conditions and may not fully represent field efficacy where the host-seeking behaviours, which include free-flying activity are known to enhance pro-insecticide chlorfenapyr intoxication to mosquitoes."

Journal

Widespread Multiple Insecticide Resistance in the Major Dengue Vector Aedes albopictus in Hainan Province, China. (PubMed, Pest Manag Sci) - "This study provides evidence of widespread resistance to multiple insecticides in Ae. albopictus in Hainan Province, China. Both kdr mutations and metabolic detoxification were the potential causes of insecticide resistance for Ae. albopictus. Our findings highlight the need for insecticide resistance management and mosquito control measures that do not entirely depend on synthetic insecticides."

Journal • Chikungunya • Dengue Fever • Infectious Disease

Resistance to insecticides and synergism by enzyme inhibitors in Aedes albopictus from Punjab, Pakistan. (PubMed, Sci Rep) - "In conclusion, field strains of Ae. albopictus from Punjab exhibit resistance to temephos, deltamethrin and permethrin, which might be associated with metabolic mechanisms of resistance."

Journal • Dengue Fever

Highly stable and thermo-responsive gel foams by synergistically combining glycyrrhizic acid nanofibrils and cellulose nanocrystals. (PubMed, J Colloid Interface Sci) - "Such ultra-stable gel foams display tunable thermo-responsive behavior and a rapid on-demand destabilization upon heating by inducing a phase transition of the bulk composite network. Our work opens up new scenarios on the use of a novel combination of all-natural, sustainable nanoscale building blocks to develop aqueous "superfoams" which are highly stable, stimulable and processable."

Journal

[VIRTUAL] Crusted Scabies in a Patient with Hematopoietic Stem Cell Transplant (ASDP 2020) - "He was diagnosed with crusted scabies and was treated with topical permethrin followed by systemic therapy of ivermectin. To our knowledge, this is the third reported case of crusted scabies in patients who have undergone stem cell transplant. Being aware of this entity and making early diagnosis is essential to improve clinical outcomes and prevent an outbreak of scabies in the community."

Clinical • CNS Disorders • Dermatology • Diabetes • Immunology • Infectious Disease • Mental Retardation • Metabolic Disorders • Pruritus • Respiratory Diseases • Transplantation • Tuberculosis

Insecticide Resistance Profiling of Anopheles coluzzii and Anopheles gambiae Populations in the Southern Senegal: Role of Target Sites and Metabolic Resistance Mechanisms. (PubMed, Genes (Basel)) - "Pre-exposure to the PBO (Piperonyl butoxide) synergist induced a partial recovery of susceptibility to permethrin and full recovery to deltamethrin...coluzzii sympatric population. PBO or Duo nets and IRS (Indoor Residual Spraying) with organophosphates could be used as an alternative measure to sustain malaria control in the study area."

Clinical • Journal • Infectious Disease • Malaria • KDR

[VIRTUAL] Seizure-Independent Long-Term Cognitive Dysfunction and Emotional Impairments in an Experimental Model of GWI Chemical Neurotoxicity (AES 2020) - " GWI is linked to exposure to GWI-related chemicals during highly stressful Gulf war (pyridostigmine-bromide or PB and pesticides DEET, permethrin). These results confirm that chronic GWI chemical exposure led to cognitive and mental disorders, especially without obvious seizure activity, demonstrating the role of divergent etiological mechanisms in epilepsy and its comorbidity. Funding: DOD Award # W81XWH1910702 and NIH CounterACT Grants U01-NS083460 & R21 NS099009."

Cardiovascular • CNS Disorders • Cognitive Disorders • Depression • Epilepsy • Mental Retardation • Mood Disorders • Psychiatry • Vascular Neurology

Insecticide susceptibility of Anopheles gambiae s.l and identification of some resistance mechanisms in Kwilu Province in the Democratic Republic of Congo. (PubMed, Pan Afr Med J) - "Bioassays showed phenotypic resistance to the main insecticides used in the region, notably pyrethroids (deltamethrin, permethrin) and organochlorine (DDT)...PBO significantly improved the effectiveness of deltamethrin. The results of this study can be helpful to policy makers in decision making for vector control programmes in the region."

Journal • Infectious Disease • Malaria

Toxicological Characterization of Pesticide Residue in Phaseolus vulgaris. (PubMed, Pak J Biol Sci) - "The research work had shown that the two samples had contamination rates higher than both the ADI and MRL, this could pose health hazards to the populace if consumed and it is recommended that the applications of pesticides in foods should be regulated and MRL and ADI should be adhered to."

Journal • Oncology

Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model. (PubMed, Toxicology) - "For permethrin, a process similar to the excretion in a human in vivo study could be simulated which was remarkably comparable to the in vivo situation. These results support the use of the Chip2 model to provide information on parent and metabolite disposition that may be relevant to risk assessment of topically applied cosmetics ingredients."

Journal • PK/PD data • Metabolic Disorders • CYP3A4

GALECRUSTED: Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies (clinicaltrials.gov) - P3; N=130; Recruiting; Sponsor: Assistance Publique - Hôpitaux de Paris; Not yet recruiting ➔ Recruiting; Trial completion date: Mar 2019 ➔ May 2021; Trial primary completion date: Mar 2019 ➔ Apr 2021

Clinical • Enrollment open • Trial completion date • Trial primary completion date • Infectious Disease

Exposure to multiclass pesticides among female adult population in two Chinese cities revealed by hair analysis. (PubMed, Environ Int) - "The concentrations of 38 chemicals (e.g., p-nitrophenol, diethyldithiophosphate, λ-cyhalothrin, permethrin, carbendazim and tebuconazole) were significantly different between women in Baoding and Dalian, indicating the regional differences in exposure to pesticide. Using a multiple regression analysis, we found that concentrations of a few dominant pesticides were associated with age, body mass index (BMI), cooking frequency and regions. These results can provide baseline information on exposure of female adult Chinese population to multiple pesticides and support future studies focused on the health effects associated with pesticide exposure."

Clinical • Journal