Pliaglis (lidocaine and tetracaine topical cream 7%/7%) / Miravo, Galderma - LARVOL DELTA

Efficacy and Safety of Combined Topical Lidocaine and Tetracaine Cream for Facial Fractional Laser Resurfacing Compared With Its Reference Product in Chinese Adults: A Multicenter, Randomized, Double-Blind Phase 3 Study. (PubMed, J Cosmet Dermatol) - "This study demonstrated the equivalent efficacy of CU-30101 to its reference product, Pliaglis, among Chinese adults undergoing facial fractional laser resurfacing. CU-30101 showed commendable local tolerability and safety profiles, consistent with those of Pliaglis."

Clinical • Journal • P3 data • Aesthetic Medicine • Anesthesia

The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment with QSwitched Laser (clinicaltrials.gov) - P1 | N=48 | Active, not recruiting | Sponsor: Northwestern University | Phase classification: P=N/A ➔ P1 | Trial completion date: Dec 2024 ➔ Dec 2025 | Trial primary completion date: Dec 2024 ➔ Dec 2025

Phase classification • Trial completion date • Trial primary completion date • Anesthesia • Pain

Efficacy and Safety of Lidocaine and Tetracaine Cream for Facial Laser Aesthetics in Chinese Adults (clinicaltrials.gov) - P3 | N=286 | Completed | Sponsor: Cutia Therapeutics（Wuxi）Co.,Ltd | Not yet recruiting ➔ Completed

Trial completion

The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - P=N/A | N=48 | Active, not recruiting | Sponsor: Northwestern University | Trial completion date: Dec 2023 ➔ Dec 2024 | Trial primary completion date: Dec 2023 ➔ Dec 2024

Trial completion date • Trial primary completion date • Anesthesia • Pain

Topical application of local anesthetics to melanoma increases the efficacy of anti-PD-1 therapy. (PubMed, Neoplasma) - "Therefore, we investigated the effect of topical application of the local anesthetic Pliaglis (7% lidocaine and 7% tetracaine) on the growth of melanoma induced by intradermal application of B16F0 cells in mice without treatment and in mice treated with the anti-PD-1 antibody. Our data suggest that Pliaglis reduces melanoma growth through a direct effect on melanoma cells as well as through modulation of the immune response. The involvement of nervous system-related signaling in the inhibitory effect of Pliaglis on melanoma is inconclusive from our data."

IO biomarker • Journal • Anesthesia • Melanoma • Oncology • Solid Tumor • CCL11 • IL1B • IL6 • ITGAM • MRC1 • NCR1 • NGF • NGFR • PTGS2

Efficacy and Safety of Lidocaine and Tetracaine Cream for Facial Laser Aesthetics in Chinese Adults (clinicaltrials.gov) - P3 | N=286 | Not yet recruiting | Sponsor: Cutia Therapeutics（Wuxi）Co.,Ltd

New P3 trial

The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - P=N/A | N=48 | Active, not recruiting | Sponsor: Northwestern University | Trial completion date: Dec 2022 ➔ Dec 2023 | Trial primary completion date: Dec 2022 ➔ Dec 2023

Trial completion date • Trial primary completion date • Anesthesia • Pain

The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser (clinicaltrials.gov) - P=N/A | N=48 | Active, not recruiting | Sponsor: Northwestern University | Trial completion date: Dec 2021 ➔ Dec 2022 | Trial primary completion date: Dec 2021 ➔ Dec 2022

Trial completion date • Trial primary completion date • Anesthesia • Pain

Real-life experience of a lidocaine/tetracaine self-occluding topical anesthetic for dermatological procedures. (PubMed, J Cosmet Dermatol) - "Pliaglis is an effective topical anesthetic for several dermatological procedures, with an excellent safety and tolerability profile."

Clinical • Journal • Aesthetic Medicine • Anesthesia • Dermatology • Pain

Transdermal Application of Anesthetic Preparations Is Effective in Increasing Mechanical Nociceptive Threshold at Perineural Injection Sites in Horses. (PubMed, J Equine Vet Sci) - "14 healthy horses were randomly divided in two groups of 7 horses each, one treated with EMLA and one with PLIAGLIS preparations. Furthermore, no significant difference of MNT values at sites distal to treatment was recorded between the two time points, both in the treated limb and control limbs. Both formulations are effective to obtain superficial skin desensitization."

Journal • Anesthesia • Cognitive Disorders • Pain