intranasal Glutathione ((in)GSH) / University of Washington, Bastyr University - LARVOL DELTA

Intranasal insulin increases brain glutathione (GSH) and enhances antioxidant capacity in healthy participants, but not in those with early psychotic disorders. (PubMed, Biol Psychiatry Cogn Neurosci Neuroimaging) - "Intranasal insulin increases brain GSH in healthy participants, but not in early psychotic disorders. These novel findings demonstrate that intranasal insulin enhances antioxidant capacity and resilience to oxidative stress in healthy individuals, in contrast to an absent antioxidant response in those with early psychotic disorders."

Journal • Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry • Schizophrenia

Amelioration of oxidative stress utilizing nanoemulsion loaded with bromocriptine and glutathione for the management of Parkinson's disease. (PubMed, Int J Pharm) - "The levels of GSH, superoxide dismutase (SOD), and catalase (CAT) were significantly enhanced; and the level of thiobarbituric acid reactive substances (TBARS) was significantly reduced after the intranasal administration of nanoemulsion in the haloperidol-induced model of PD...A higher value of AUC of nanoemulsion in the brain after intranasal administration revealed that BRM and GSH remained in the brain for a longer period due to sustained release from nanoemulsion. According to the findings, BRM and GSH loaded nanoemulsion has the potential to provide a combined and synergistic anti-oxidant effect for efficient management of PD."

Journal • CNS Disorders • Movement Disorders • Oncology • Parkinson's Disease • CAT • IL6 • TNFA

CCRD based development of bromocriptine and glutathione nanoemulsion tailored ultrasonically for the combined anti-parkinson effect. (PubMed, Chem Phys Lipids) - "The outcomes of the behavioural studies revealed that BRM and GSH loaded nanoemulsion treatment showed significant improvement in behavioural activities of PD (haloperidol-induced) rats after intranasal administration. This study concluded that BRM and GSH loaded nanoemulsion could be promising for the combined and synergistic anti-parkinson effect for the effective management of PD."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease • Solid Tumor