tropicamide / Generic mfg. - LARVOL DELTA

A Study on Prevalence of Malarial Retinopathy among Malaria Cases and to Determine Its Presence as a Marker of Severe Malaria: Observations from Eastern India. (PubMed, J Assoc Physicians India) - "Malarial retinopathy may serve as an important clinical biomarker for predicting severe malaria. All clinicians should be appropriately trained in performing direct ophthalmoscopy to detect the retinopathy changes."

Journal • Allergy • Cardiovascular • Cataract • Chikungunya • Chronic Kidney Disease • CNS Disorders • Corneal Abrasion • Dengue Fever • Diabetes • Epilepsy • Glaucoma • Hematological Disorders • Hypertension • Immunology • Infectious Disease • Inflammation • Malaria • Metabolic Disorders • Ophthalmology • Renal Disease • Retinal Disorders • Septic Shock

Reversal of Pharmacologic Mydriasis in Pediatric Subjects with Ryzumvi (0.75% Phentolamine Ophthalmic Solution): A Post-Hoc Pooled Analysis from Three Randomized, Placebo-Controlled Phase 3 Trials. (PubMed, Clin Ophthalmol) - P3 | "Subjects received 1 or 2 drops of POS or placebo in each eye, administered 1 hour after pharmacologically induced mydriasis with 1% tropicamide, 2.5% phenylephrine, or Paremyd™ (0.25% tropicamide/1% hydroxyamphetamine)...Larger, prospectively powered pediatric studies are warranted. All three trials were registered with ClinicalTrials.gov (MIRA-2, NCT04620213; MIRA-3, NCT05134974; MIRA-4, NCT05223478)."

Clinical • Journal • P3 data • Retrospective data • Ophthalmology • Pediatrics

The Effect Of Polycystic Ovarian Syndrome Treatment On Ocular Surface. (clinicaltrials.gov) - P=N/A | N=90 | Completed | Sponsor: Cairo University

New trial • Polycystic Ovary Syndrome

Comparative Analysis of the Efficacy of 1% Tropicamide and 1% Cyclopentolate Eye Drops for Cycloplegic Refraction in Indonesian Paediatric Population. (PubMed, Br Ir Orthopt J) - "This randomised, double-blind, controlled non-inferiority trial compared the residual accommodation amplitude (AA) following two drops of 1% Tropicamide (TRP1%) or 1% Cyclopentolate (CYC1%), administered 5 min apart. Given its comparable efficacy and lower incidence of side effects, Tropicamide 1% may serve as a safer alternative for paediatric cycloplegic refraction. Further studies with larger samples are warranted to refine dosing strategies and enhance clinical outcomes."

Journal • Ophthalmology • Pediatrics

Efficacy of Tuina for Myopia in Children: Protocol for a Randomized Controlled Trial. (PubMed, JMIR Res Protoc) - "The primary outcome measures include uncorrected visual acuity and axial length, while secondary outcome measures include refractive power and accommodative amplitude. This study aims to evaluate the efficacy and safety of tuina therapy in the treatment of adolescents with myopia. We hypothesize that the therapeutic effect of tuina therapy is noninferior to that of tropicamide eye drops, with the additional advantages of fewer side effects and stable long-term efficacy, thereby providing reliable evidence and support for the application of tuina therapy in the management of myopia in adolescents."

Clinical • Clinical protocol • Journal • Ophthalmology • Pediatrics

Pharmacological and light-driven pupillary accommodation in guinea pigs: comparative effects of muscarinic modulators and illumination across developmental stages. (PubMed, Int J Ophthalmol) - "This study investigates pupillary responses in developing guinea pigs, revealing a direct pupillary light reflex (PLR) with light intensity-dependent responses, while indirect PLR was undetectable. The differential effects of muscarinic modulators on pupillary responses underscore the critical role of cholinergic signaling in ocular accommodation, with age-related variations in sensitivity. Additionally, a novel non-contact measurement methodology achieved a precision of 0.01 mm for pupillary quantification, enhancing accuracy in ocular studies."

Journal

Efficacy of Tuina for Myopia in children: A protocol for a randomized controlled trial. (PubMed, JMIR Res Protoc) - "This study aims to evaluate the efficacy and safety of Tuina therapy in the treatment of myopic adolescents. We hypothesize that the therapeutic effect of Tuina therapy is non-inferior to that of tropicamide eye drops, with the added advantages of fewer side effects and stable long-term efficacy, thereby providing reliable evidence and support for the application of Tuina therapy in the management of myopia in adolescents."

Clinical • Journal • Ophthalmology

Study of Stimulus Parameters in Flicker Electroretinogram (ERG) (clinicaltrials.gov) - P=N/A | N=18 | Completed | Sponsor: LKC Technologies, Inc. | Unknown status ➔ Completed

Trial completion • Retinal Disorders

Adaptive Optics (AO) Analysis of Retinal Arteries in Patients With Recent Stroke (STROKAO) (clinicaltrials.gov) - P=N/A | N=91 | Completed | Sponsor: Fondation Ophtalmologique Adolphe de Rothschild | Recruiting ➔ Completed

Trial completion • Cardiovascular

A Small Volume Topical Ophthalmic Spray for Pupillary Dilation in Children: A Randomized, Masked Non-inferiority Trial. (PubMed, Ophthalmology) - "Our study demonstrated that an ophthalmic spray containing 1% tropicamide and 2.5% phenylephrine was non-inferior to traditional eye drops for maximum pupil diameter and pupillary constriction percentage. Further work is needed to characterize the cycloplegic properties of this route of administration. Ophthalmic sprays have the potential to increase the acceptability of pupillary dilation in children while maintaining a similar mydriatic effect as eye drops."

Head-to-Head • Journal • Ophthalmology

Can eye drops safely replace reading glasses in older adults? A short-term study. (ANZCTR) - P=N/A | N=24 | Recruiting | Sponsor: The University of Auckland | Not yet recruiting ➔ Recruiting

Enrollment open • Trial initiation date • Cardiovascular • Ophthalmology

Assessing the Impact of Pharmacological Pupil Dilation on Anterior Chamber Cells Counting Using OCT. (PubMed, Ophthalmol Sci) - "The aim of this study was to evaluate the effect of pharmacological dilation with tropicamide 0.5% (T) or phenylephrine 2.5% + tropicamide 0.5% (PH + T) on the assessment of AC HRDs density measured in healthy eyes by AS-OCT...These findings suggest increased iris-lens friction and potential pigment release after dilation, providing critical considerations for standardizing AS-OCT-based assessments of AC inflammation. The author has no/the authors have no proprietary or commercial interest in any materials discussed in this article."

Journal • Inflammation • Ocular Inflammation • Ophthalmology • Uveitis

Myopia Prediction Using Machine Learning: An External Validation Study. (PubMed, Vision (Basel)) - "Chinese students (N = 614) aged 8-13 years underwent autorefraction before and after cycloplegia with 0.5% tropicamide (n = 505) or 1% cyclopentolate (n = 109). In this independent cohort of students, XGBoost and random forest performed very well for predicting cycloplegic SER and myopia status using non-cycloplegic data. This external validation study demonstrated that ML may provide a useful tool for estimating cycloplegic SER and myopia prevalence with heterogeneous clinical parameters, and study in additional populations is warranted."

Journal • Ophthalmology

Ultrasound Biomicroscopic Study of the Effects of 1% Tropicamide on the Anterior Segment and Ciliary Body in Cats. (PubMed, Vet Ophthalmol) - "These findings suggest that tropicamide-induced IOP elevation in cats results from anterior chamber angle narrowing, emphasizing the need for caution when using mydriatics in patients at risk for ocular hypertension."

Journal • Cardiovascular • Glaucoma

Acute Angle Closure Incidence in a Large Countywide Safety Net Teleretinal Screening Program. (PubMed, JAMA Ophthalmol) - "Dilation with tropicamide, 1.0%, or tropicamide, 0.5%...AAC risk was less than 1 in 40 000 per dilation in a high-volume TDRS program serving a diverse safety net population, supporting the overall safety of dilation in this setting. Further discussion about AAC risk as a contraindication to dilation is warranted."

Journal • Diabetic Retinopathy • Glaucoma • Ophthalmology • Pain • Retinal Disorders

RAM-TF-IOCV: Clinical Determinants and Adverse Reactions to Tropicamide/Phenylephrine in Hospitalized Patients. (clinicaltrials.gov) - P=N/A | N=1000 | Recruiting | Sponsor: Instituto de Oftalmología Fundación Conde de Valenciana

Adverse drug reaction • New trial • Cardiovascular • Hypertension • Ophthalmology

Changes in corneal topography and corneal biomechanics in keratoconus after mydriasis. (PubMed, Ophthalmic Physiol Opt) - "Mydriasis produced significant alterations in corneal topographic and biomechanical parameters in participants with KC. Although these changes do not affect the diagnosis of the condition, clinicians should be aware of them and adjust their treatment planning accordingly."

Journal • Ophthalmology

Superior visual quality outcomes with compound tropicamide eye drops in treating juvenile pseudomyopia. (PubMed, Am J Transl Res) - "Compound Trop Eye Drops effectively enhances visual function and quality of life in juvenile pseudomyopia patients, with a safety profile comparable to low-dose atropine, offering potential clinical value."

Journal • Cardiovascular • Ophthalmology • Xerostomia

A case of rare fungal keratitis caused by Pseudoshiraia conidialis. (PubMed, Medicine (Baltimore)) - "We report the first case of fungal keratitis caused by P conidialis. Microbial culture remains the gold standard for diagnosing fungal keratitis. This case provides a reference for the clinical treatment of fungal keratitis caused by P conidialis."

Journal • Keratitis • Ocular Inflammation • Ophthalmology

The Prevalence of Myopia in Finnish Conscripts Has not Increased in Recent Decades and Is Lower Than in Many East and Southeast Asian Countries. (PubMed, Invest Ophthalmol Vis Sci) - "Refraction was performed on 1522 participants under tropicamide-induced cycloplegia...Higher education, prolonged near work, reduced time outdoors, and increased smartphone use (in the higher-educated group) were factors associated with myopia prevalence. The reduced educational pressure may be attributed to the lower prevalence of myopia among Finnish conscripts compared to many East and Southeast Asian countries, where myopia is much more prevalent."

Journal • Ophthalmology

Efficacy and influencing factors of preoperative pharmacological mydriasis in type 2 diabetic patients undergoing cataract surgery (PubMed, Zhonghua Yi Xue Za Zhi) - "The pupil diameter and compliance rate were observed at eight time points: 20 min (T1), 30 min (T2), 40 min (T3), 50 min (T4), 60 min (T5), 70 min (T6), 80 min (T7) and 90 min (T8) after mydriasis with compound tropicamide before cataract surgery... The compliance rate of pupil diameter within 60 min after pharmacological mydriasis before cataract surgery in patients with type 2 diabetes increased significantly with time, and the expansion effect tended to be stable after 60 min. The duration of diabetes, HbA1c levels, and BMI were factors affecting mydriasis achievement in patients with type 2 diabetes."

Journal • Cataract • Diabetes • Metabolic Disorders • Ophthalmology • Type 2 Diabetes Mellitus

Subthreshold Micropulse Laser Therapy (SML) in Retinitis Pigmentosa (clinicaltrials.gov) - P=N/A | N=60 | Enrolling by invitation | Sponsor: Marta P. Wiącek

New trial • Conjunctivitis • Genetic Disorders • Inherited Retinal Dystrophy • Ocular Inflammation • Ophthalmology • Retinal Disorders • Retinitis Pigmentosa

SOLMYD-PD: Pharmacodynamics of a Fixed Dose Combination of 0.34% Tropicamide and 2.5% Phenylephrine Hydrochloride, Eye Drop, Solution (clinicaltrials.gov) - P1/2 | N=20 | Not yet recruiting | Sponsor: Unither Pharmaceuticals, France

New P1/2 trial • Ophthalmology

Comparison of cycloplegic effects of atropine and tropicamide in children with refractive error. (PubMed, Transl Pediatr) - "The cycloplegic effect of 4 g/L of tropicamide eye drops on spherical and cylindrical lenses was less than that of 8 g/L of atropine eye ointment. In the mixed astigmatism group, among spherical lenses, 14 eyes had differences, accounting for 100.0% of cases, with the maximum difference being 1.25 D; among cylindrical lenses, 5 eyes had the same results between the two pupil dilation methods, accounting for 35.7% of cases, and 64.3% had a difference of 0.25-0.5 D. In children under 12 years old with mixed astigmatism and hyperopia, cycloplegic refraction using atropine is preferred over tropicamide."

Journal • Astigmatism • Ophthalmology • Pediatrics

Heart failure temporally associated with tropicamide and phenylephrine eye drops in a premature infant: A case report and literature review. (PubMed, SAGE Open Med Case Rep) - "This case illustrates the potential for severe cardiovascular complications associated with mydriatic agents in neonates with undiagnosed congenital heart defects. It underscores the need for individualized risk assessment, vigilant monitoring, and cautious application of mydriatic protocols to ensure patient safety in high-risk preterm populations."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Hepatology • Retinal Disorders • Retinopathy of Prematurity