tropicamide / Generic mfg. - LARVOL DELTA

Fluctuation of intraocular pressure in Chinese patients with pigment dispersion syndrome after drug-induced mydriasis. (PubMed, Medicine (Baltimore)) - "In this prospective cohort study, 26 PDS patients were identified and instilled with 0.5% tropicamide and phenylephrine twice randomly in one of the 2 eyes, after which IOP and pupil diameter (PD) were measured hourly for 8 hours...Drug-induced mydriasis appears relatively safe in the majority of Chinese PDS patients, with generally mild effect in most. However, caution remains warranted in eyes with prominent anterior chamber pigment shedding."

Journal • Ophthalmology

Comparison of microdrop administration using a bottle adapter of 2.5% phenylephrine and 0.8% tropicamide with standard drop for ROP examination: a randomized controlled noninferiority trial. (PubMed, Matern Health Neonatol Perinatol) - "Microdrop administration of phenylephrine and tropicamide achieved mydriasis comparable to standard drops, with no significant difference in adverse effects between the groups. This approach may represent a safer, clinically feasible and more physiologically appropriate strategy for ROP screening by reducing drug exposure in vulnerable preterm infants."

Head-to-Head • Journal • Ophthalmology • Retinal Disorders • Retinopathy of Prematurity

Extrinsic Modulation of the Zonular Tension Induces Calcium Influx in Lens Fiber Cells That Is Mediated by Mechanosensitive TRPV1 and TRPV4 Channels. (PubMed, Invest Ophthalmol Vis Sci) - "Changes in intracellular Ca²⁺ were monitored following pharmacological modulation of ciliary muscle contractility using Tropicamide to increase zonular tension and pilocarpine to decrease zonular tension. In this study, we have shown that extrinsic modulation of ciliary muscle contractility, through alterations in zonular tension, generates regionally specific influxes of Ca²⁺ mediated by mechanosensitive TRPV1/4 channels which in other studies have been shown to regulate lens water transport and lens power. These findings suggest that lens power may be influenced by extrinsic feedback regulation from other tissues in the eye."

Journal

Sublingual Tropicamide Eye Drops for the Management of Clozapine-Induced Hypersalivation: A Case Series of Seven Patients. (PubMed, Pharmacy (Basel)) - "Its short duration of action and local administration may offer practical advantages over systemic anticholinergics, though the mechanism remains unproven. Randomised trials with validated outcome measures are needed to establish its efficacy and safety."

Journal • CNS Disorders • Ophthalmology • Psychiatry • Schizophrenia

A trial to assess the short-term efficacy of contact lenses in myopic children (ANZCTR) - P=N/A | N=30 | Active, not recruiting | Sponsor: nthalmic Pty Ltd | Recruiting ➔ Active, not recruiting

Enrollment closed • Ophthalmology

The Effect of Pupil Dilation on Preoperative Optical Biometry Results for Phacoemulsification: A Meta-analysis. (PubMed, J Refract Surg) - "When compared to using tropicamide, cyclopentolate resulted in a greater increase in ACD (0.03 mm, P = .03) and greater reduction in LT (0.04 mm, P = .001), whereas phenylephrine resulted in less increase in ACD by 0.06 mm (P = .001). Pupil dilation significantly increases ACD and reduces LT, which in turn significantly increases IOL power recommendations by later generation IOL calculation formulas. It would be prudent to consider performing biometry without dilation to avoid its impact on IOL calculation and subsequently final refractive outcome."

Clinical • Journal • Retrospective data • Review

DL Models Predicting Cycloplegic Refractive Error Based on Non-Cycloplegic Parameters in Myopic Adults (clinicaltrials.gov) - P=N/A | N=2500 | Recruiting | Sponsor: Second Affiliated Hospital of Nanchang University

New trial • Ophthalmology

SOLMYD-PD: Pharmacodynamics of a Fixed Dose Combination of 0.34% Tropicamide and 2.5% Phenylephrine Hydrochloride, Eye Drop, Solution (clinicaltrials.gov) - P1/2 | N=20 | Completed | Sponsor: Unither Pharmaceuticals, France | Initiation date: Jul 2025 ➔ Nov 2025 | Not yet recruiting ➔ Completed

Trial completion • Trial initiation date • Ophthalmology

School and family based myopia education associations with myopia prevalence in Hefei high school students in the post-COVID-19 period. (PubMed, Sci Rep) - "Visual acuity was measured using a standard logarithmic eye chart, and refraction was assessed via non-cycloplegic autorefraction with tropicamide-induced mydriasis...Non-cycloplegic measurements may inflate estimates. These findings may inform targeted prevention strategies."

Journal • Infectious Disease • Novel Coronavirus Disease • Ophthalmology

Accuracy of Two Novel Self-Contained Darkroom Refractive Screeners Compared with Cycloplegic Retinoscopy and a Traditional Autorefractor in Schoolchildren. (PubMed, Clin Ophthalmol) - "Non-cycloplegic measurements were performed sequentially with the three devices, followed by CR after cycloplegia with 0.5% tropicamide...Columba 300 and YD-SX-A are portable, rapid, and sensitive for myopia screening, suitable for large-scale preliminary screening. A two-level "initial screening-confirmation" process is recommended for myopia prevention and control in children and adolescents."

Journal • Astigmatism • Ophthalmology

Near-infrared OCT imaging for the assessment of anisocoria. (PubMed, Eye (Lond)) - "Using NI-OCT photographs allows for reliable measurement of anisocoria and can aid in the detection of pathological anisocoria, especially in patients with dark irises and children."

Journal

Phase coupling between eye and brain pulsations is bidirectional and modulated by the parasympathetic system - An fMREye study. (PubMed, Acta Ophthalmol) - "The brain-eye pulsation connections express highly dynamic bi-directionality with frequency dependent net information transfer partly modulated by (para)sympathetic activity."

Journal

Clinical observation on the mydriatic effects of different doses of compound tropicamide eye drops during fundus examination of premature infants (PubMed, Zhonghua Yan Ke Za Zhi) - "Adverse events occurred 11 times after standard-dose administration and 3 times after low-dose administration. For fundus screening in preterm infants, low-dose (45 μl) compound tropicamide eye drops are non-inferior to the standard dose (90 μl) in terms of mydriatic efficacy, while offering advantages in safety profile."

Clinical • Journal • Ophthalmology • Retinal Disorders • Retinopathy of Prematurity

Impact of Pharmacologic Dilation on Anterior Segment Cell Density Using Semi-Automated Anterior Segment-Optical Coherence Tomography Quantification (ARVO 2026) - "Methods This was a prospective case series of patients who underwent pharmacologic pupil dilation with a dilating drop regimen consisting of a combination of 2.5% Phenylephrine/1% Tropicamide or 1% Tropicamide alone...Conclusions Our study demonstrates that pharmacologic dilation significantly increases AS-OCT cell density. While dilation status influences quantitative measurements, its effect on clinical assessment is likely minimal."

Ophthalmology

Impaired Neurovascular Coupling in Neurofibromatosis type 1 Optic Pathway Gliomas (NF1-OPG) with Vision Loss (ARVO 2026) - "After mydriasis with tropicamide, all participants underwent baseline ONHBF scans using laser speckle flowgraphy (Softcare Inc)...Conclusions Participants with NF1-OPGs and vision loss demonstrate impaired neurovascular coupling at the ONH and appear unable to sustain hyperemia during 60 seconds of continuous 10Hz flicker stimulation. It is conceivable that impairment of neurovascular coupling could impact the success of therapeutic response or neuroprotective strategies those with NF1-OPGs."

Ophthalmology • NF1

Two-Year Data from the FOCUS Study: Following Ocular Changes in US Optometry Students (ARVO 2026) - "At each visit, right eyes were dilated with 2.5% phenylephrine and 1% tropicamide, and cycloplegic autorefraction (WAM-5500) and ocular biometry (LenStar) were measured...Conclusions In this population known to have intense near work demands, axial length continued to increase into young adulthood, with a subset showing clinically meaningful myopic shifts. With ongoing enrollment and an expanded battery of tests (e.g., objective monitoring of visual activity), the FOCUS Study could elucidate which factors predict continued progression, with potential implications for intervention in young adults."

Ophthalmology

Association between Alzheimer's-related AB42/40 ratio and choroidal thickness in Down syndrome (ARVO 2026) - "Ocular imaging was performed after pupil dilation (Tropicamide 1%)...Conclusions Greater sCT is significantly associated with a lower Ab42/40 ratio. A lower Ab42/40 ratio is associated with higher beta-amyloid plaque deposition in the brain, that could trigger a secondary inflammatory process that could be responsible for choroidal thickening."

Ophthalmology

Evaluating Patient Preference and Visual Outcomes of Traditional Versus Modified Monovision Contact Lenses (ARVO 2026) - "Methods To simulate presbyopia in the participants, eyes were dilated with 1% tropicamide and 2.5% phenylephrine...These results suggest that MF and MM lenses provide comparable outcomes in both objective and subjective visual performance. Future research with larger sample sizes may help clarify whether specific subgroups benefit more from one modality over the other."

Clinical • Ophthalmology • Retinal Disorders

Translational animal adaptive optics ophthalmoscopy: from proof-of-principle to a preclinical tool (ARVO 2026) - "1) with 6 manual linear stages and 2 motorized rotational (gimbal) stages was demonstrated by imaging adult C57BL/6J mice, after anesthesia (ketamine-HCl/xylazine), pupil dilation and cycloplegia (1% tropicamide drop), and with a rigid PMMA contact lens (1.6 mm base curvature, 3 mm diameter)...The AOSLO has been used to image mice using 800 nm confocal reflectance and non-confocal quadrant detection, non-invasively revealing the photoreceptor mosaic, photoreceptor cell somas, capillaries, blood vessel walls and other cellular/subcellular structures throughout the retina using a single contact lens without optical power. Conclusions Improved AOSLO optical design, large navigational FOV, and motorized steering will enable high throughput and consistent longitudinal studies in small animals for biomarker discovery and assessment of retinal cell structure and function relevant to neuroprotective therapeutic development in degenerative disease."

Preclinical • Ophthalmology

Shorter fluorescence lifetimes in a retinitis pigmentosa mouse model observed in comparison to healthy mice (ARVO 2026) - "Mice were anesthetized with ketamine/xylazine, dilated with 1 drop each of 2.5% phenylephrine and 1% tropicamide, and fit with a +10 D contact lens...Conclusions It is thought that the LSC reflects lipofuscin fluorescence while the SSC is also impacted by metabolites. These results suggest that during the rod death phase of retinitis pigmentosa in mice, there are changes in the relative lipofuscin and metabolite concentrations."

Preclinical • Inherited Retinal Dystrophy • Ocular Inflammation • Ophthalmology • Retinal Disorders • Retinitis Pigmentosa

Segmental Outflow Patterns in Rats Using Fluorescent Tracer Beads (ARVO 2026) - "All injections were performed under isoflurane with tropicamide for pupil dilation...Concordantly, the median number of hotspots was lowest in the superior quadrant (0), intermediate in nasal (1) and temporal quadrants (1), and highest in the inferior quadrant (3). Conclusions Regional tracer patterns showed consistent spatial organization across animals, with higher inferiornasal flow than superiortemporal flow."

Preclinical • Glaucoma • Ophthalmology

Safety of FRX-001, a high concentration topical formulation of ciclopirox in cyclodextrin, to increase drug solubility and penetration of drug to the retina (ARVO 2026) - "Animal eyes were checked for pupillary reflex using a transilluminator prior to pupillary dilation with a suitable mydriatic agent (ex: tropicamide)...Postmortem histopathology showed a normal choroidal epithelium without inflammatory cells, no inflammatory material in the anterior chamber, and no abnormal pathology in the lens, iris, ciliary body, or poster segment. Conclusions Repeat daily ocular instillation of FRX-001 for up to 14 and 28 days by topical bilateral ocular application to Dutch-belted rabbits or C57BL/6 mice respectively resulted in no toxicity in this study."

Clinical • Age-related Macular Degeneration • Ophthalmology • GPX4

Effects of Tropicamide-Phenylephrine Dilation on Refraction Accuracy (ARVO 2026) - "Based on these implications, it is recommended that optometric physicians refract patients as soon as 5 minutes post dilation with tropicamide and phenylephrine for myopes and hyperopes alike for stable, accurate refractions. Due to limitations in sample size and refractive error variety, further research is needed to determine the reliability of post-dilation refractions."

Ophthalmology

Short-Term Choroidal Responses to Full-Field and Mid-Peripheral Myopic Defocus in Emmetropic and Myopic Young Adults (ARVO 2026) - "Methods Participants attended two visits (≥3 days apart) at the same time, with cycloplegia induced using two drops of 1% tropicamide...These preliminary results are promising but limited by the small sample. Final analyses will clarify whether emmetropic and myopic eyes differ in their short-term responses to full-field and mid-peripheral myopic defocus."

Clinical • Ocular Inflammation • Ophthalmology

Mast cell activation syndrome-related unusual periocular inflammation associated with mydriatic eyedrops during cataract surgery. (PubMed, Am J Ophthalmol Case Rep) - "Despite prophylactic treatment with oral and intravenous (IV) antihistamines, intraoperative subconjunctival dexamethasone, and postoperative anti-inflammatory medications, the patient developed periocular swelling and erythema, on the first postoperative day, following uneventful cataract surgery during which intraprocedural tropicamide was administered for dilation. This unusual presentation, previously not well described in the context of MCAS, highlights the critical need for ophthalmologists to recognize the heightened risk of severe periocular inflammation in MCAS patients undergoing procedures involving routine mydriatic agents. The case underscores that such reactions may be excipient-driven rather than drug-specific, emphasizes the complex interplay between MCAS, ocular surface conditions, and ophthalmic medications, and necessitates increased awareness among healthcare providers to tailor management to prevent potentially severe outcomes."

Journal • Allergy • Cardiovascular • Cataract • Dermatology • Dry Eye Disease • Immunology • Inflammation • Ocular Inflammation • Ophthalmology