tropicamide / Generic mfg. - LARVOL DELTA

Lens Morphology in Cataract Patients with Zonula Dialysis by Anterior Segment Optical Coherence Tomography. (PubMed, J Cataract Refract Surg) - "Lens in ZD patients was characterized by steeper anterior curvature, and grater alterations of ACD, anterior curvature and decentration after cycloplegia. The comparison of lens morphologic parameters before and after cycloplegia might be the potential method to evaluate the stability of zonule."

Journal • Cataract • Ophthalmology

Cartwheeling of the Iris - Persistent pupillary membrane (SOE 2025) - "After dilating both the pupils with 1% tropicamide, a grade 1-2 nuclear sclerosis was noted, parts of the fundus was observable in the right eye and left eye fundus was noted to be within normal limits. Intraocular pressure and gonioscopic finding were well within normal limits. A clinical diagnosis of Total and Partial persistent pupillary membrane in the right and left eye was made respectively which looked like a cartwheel in the eyeMost Persistent pupillary membranes don't cause significant visual disturbance and can be managed with either mydriatic agents, surgical excision, or Nd-Yag laser membranectomy."

Achromatopsia • Cataract • Ophthalmology

Different facets of intraocular hemorrhage in hypertensive retinopathy (SOE 2025) - "On postoperative day 1 (POD1), the patient developed ocular pain, hyphema, and intraocular pressure of 33 mmHg in the left eye, being treated with Vigadex, Tropicamide and Britens...Optical coherence tomography of the macula was requested, and phacoemulsification of the left eye was indicated. This case exemplifies the different facets of intraocular hemorrhage in hypertensive retinopathy, allowing for imaging and therapeutic discussions."

Cataract • Ophthalmology • Retinal Disorders

Use of compression sutures and intracameral injection of C3F8 11% gas in the management of acute corneal hydrops in a pediatric patient: a case report (SOE 2025) - "Initially, clinical management was implemented to control edema and pain, with dimethylpolysiloxane eye drops, prednisolone 1%, and tropicamide 1%... Cases of acute hydrops, with extensive Descemet's membrane tears may benefit from surgical treatment combining compression sutures and injection of C3F8 gas, providing a faster recovery than clinical treatment, with reduced morbidity and fewer complications associated with the condition."

Case report • Clinical • Ophthalmology

Difference Between Cycloplegic and Non-Cycloplegic Refraction and Its Association with Longitudinal Refractive Changes in Chinese Children. (PubMed, Ophthalmic Epidemiol) - "Cycloplegia was achieved with 1% atropine or 0.5% tropicamide...Progression analysis of 752 children (mean age, 5.59 years; 46% girls) found no significant association between DSE and myopic shift. Younger and more hyperopic children exhibited larger DSE, DSE was not an independent risk factor for myopic shift."

Journal • Ophthalmology

Efficacy and safety of mydriasis in low-dose compound tropicamide eye drops: a non-inferior, randomized controlled study (ChiCTR) - P=N/A | N=42 | Recruiting | Sponsor: The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University

New trial • Ophthalmology • Retinal Disorders • Retinopathy of Prematurity

Retinal Vascular Changes in Patients After Coronavirus Disease 2019 (COVID-19) (clinicaltrials.gov) - P=N/A | N=34 | Completed | Sponsor: University Hospital Olomouc | Active, not recruiting ➔ Completed | Trial completion date: Mar 2024 ➔ Oct 2024

Trial completion • Trial completion date • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Can eye drops safely replace reading glasses in older adults? A short-term study. (ANZCTR) - P=N/A | N=24 | Not yet recruiting | Sponsor: The University of Auckland

New trial • Cardiovascular • Ophthalmology

Randomized Controlled Trial Comparing the Efficacy of Mydrin-P Microdrops Over Standard Dose Mydrin-P for Pupil Dilation in Retinopathy of Prematurity Examination. (PubMed, J Pediatr Ophthalmol Strabismus) - "Mydriatic Mydrin-P microdrops demonstrated similar efficacy compared to standard Mydrin-P eye drops and should replace standard Mydrin-P for ROP screening in preterm infants with potentially fewer side effects. [J Pediatr Ophthalmol Strabismus. 20XX;X(X):XXX-XXX.]."

Journal • Critical care • Ophthalmology • Retinal Disorders • Retinopathy of Prematurity • Strabismus

Metabolomic biomarkers in vitreous humor: unveiling the molecular landscape of diabetic retinopathy progression. (PubMed, Int J Retina Vitreous) - "Our findings suggest that metabolomic profiling could provide valuable insights into the underlying pathogenesis of DR and serve as a foundation for personalized therapeutic strategies."

Biomarker • Journal • Diabetes • Diabetic Retinopathy • Metabolic Disorders • Ophthalmology • Retinal Disorders

Diagnostic Eye Drops and Pain Sensitivity: A Marker for Dry Eye Syndrome? (PubMed, Cornea) - "This study highlights that pain sensitivity to commonly used diagnostic eye drops is a potential marker for the presence and severity of dry eye syndrome. Clinicians should consider evaluating pain responses during routine examinations as a simple, supplementary tool for identifying patients who may benefit from further diagnostic investigations and tailored management."

Journal • Dry Eye Disease • Ophthalmology • Pain

Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power. (PubMed, Acta Ophthalmol) - "The findings suggest parasympathetic activity is crucial in modulating physiological pulsations in both ocular and cerebral glymphatic pathways. This interplay may have implications for conditions involving impaired fluid dynamics, such as glaucoma and traumatic brain injury."

Journal • CNS Disorders • Glaucoma • Ophthalmology • Vascular Neurology

Peripheral Iridotomy-Less Approach in Descemet's Membrane Endothelial Keratoplasty Using Pupil-Dilating Eye Drops, a Retrospective Case-Control Study. (PubMed, Clin Ophthalmol) - "Postoperatively, mydriatic eye drops were administered for three days 4x/d (phenylephrine 25 mg/mL, tropicamide 5 mg/mL)...PI-less triple DMEK in particular might improve accessibility, reduce surgical complexity, or lower costs, making it attractive in resource-limited settings. Close postoperative IOP monitoring is advised in PI-less DMEKs."

Journal • Retrospective data • Ophthalmology • Transplantation

The Effect of Eyedrop Size on Pupillary Dilation Using the Nanodropper Bottle Adapter. (PubMed, Clin Ophthalmol) - "One eye was randomly selected and dilated with the Nanodropper, and the fellow eye dilated with the standard bottle with a 50/50 mixture of 1% tropicamide and 2.5% phenylephrine...The Nanodropper is non-inferior to the standard eyedrop bottle for pupillary dilation. Small volume eyedrops may reduce medication waste and side effects and improve affordability and patient compliance."

Journal • Ophthalmology

Assessing Patient Comfort, Anxiety, and Satisfaction During CR Comparing Conventional Drops With ROC (clinicaltrials.gov) - P=N/A | N=74 | Active, not recruiting | Sponsor: Superior University

New trial • Mood Disorders • Psychiatry

Fluorescence lifetime imaging ophthalmoscopy (FLIO) is repeatable in healthy adults under dark and white light acquisition (ARVO 2025) - "Initial test images were acquired 10 min after participant's pupils were dilated using 1% tropicamide...Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Clinical • Ophthalmology

Gender-Related Variations in Canine Anterior Chamber Dimensions: Implications for Glaucoma Research (ARVO 2025) - "After pupil dilation with a 0.5% tropicamide, each eye underwent a comprehensive UBM (VuPAD®, Sonomed Escalon) examination to measure the following parameters: peripheral anterior chamber depth (ACD), iridocorneal angle (ICA), angle-opening distance (AOD), ciliary cleft width (CCW), length (CCL), and area (CCA), as well as the thickness of the ciliary muscle's longitudinal fibers (Lf-CMT) and the combined thickness of longitudinal and radial fibers with the choroid (LRf-CMT)...Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Glaucoma • Ophthalmology

The effects of cyclopentolate 1.0% versus tropicamide 0.5% on autorefraction and ocular biometry in young adults (ARVO 2025) - "Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Clinical • Ocular Inflammation • Ophthalmology

Visual electrophysiological characteristics of the porcine model of oculocutaneous albinism type 1 (ARVO 2025) - "Pigs were anesthetized with zoletil, and 1% tropicamide was applied for mydriasis...Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Preclinical • Ophthalmology

Machine Learning for Predicting Future Myopia Progression, Cycloplegic Refraction, and Axial Length (ARVO 2025) - "Children (n=591) aged 6-9 years at baseline underwent autorefraction before and after cycloplegia with 0.5% tropicamide, with assessment of ocular biometric measures, uncorrected visual acuity (UCVA), and intraocular pressure (IOP) at baseline and 3 years later...Machine learning (ML) models have previously demonstrated potential for predicting cycloplegic spherical equivalent refraction (SER) and myopia status using noncycloplegic refractive error and ocular biometric data. We evaluated the performance of multiple ML models for predicting myopia progression, cycloplegic SER, and axial length after 3 years using baseline data including ocular biometric data as well as noncycloplegic and cycloplegic SER."

Machine learning • Ophthalmology

Gnotobiotic operations and assembly for development of germ-free animal model of light-induced retinal degeneration, a commonly used model for geographic atrophy. (ARVO 2025) - "C57BL/6J GF mice were transferred in cages inside the sterile hood and underwent 16 hours of dark adaptation followed by bilateral dilation using sterile tropicamide 0.5% and phenylephrine 2.5% ophthalmic solutions...Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Preclinical • Age-related Macular Degeneration • Dry Age-related Macular Degeneration • Macular Degeneration • Ophthalmology • Retinal Disorders

Comparison of blue light-induced damage (BLD) in albino and pigmented mice (ARVO 2025) - "After an overnight dark adaptation and pupil dilation with tropicamide 30 min prior to induction, the mice were exposed to blue light (454 nm, 1000 lux) for 1 hour (albino) or 3 hours (pigmented).Scotopic flash electroretinography (ERG)(Celeris, Diagnosys LLC) and spectral-domain optical coherence tomography (SD-OCT)(Envisu R2200, Bioptigen Inc./Leica Microsystems) were performed at baseline and on Day 7 after induction...Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Preclinical • Ophthalmology

Outcomes of a pilot ophthalmic screening program for a Refugee population (ARVO 2025) - "Tropicamide drops were used for dilated examinations, allowing attending ophthalmologists to assess for conditions such as cataracts, retinal pathologies, and non-refractive conditions...Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Clinical • Cataract • Ophthalmology

Comparison and Repeatability of Refraction Measurements in Awake vs. Anesthetized Mice (ARVO 2025) - "Mouse eyes were dilated with 1% tropicamide and tear supplements were applied regularly to prevent corneal desiccation when anesthetized...Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Preclinical • Cataract • Ophthalmology

The Regulatory Role of Optic Nerve Conduction in Refractive Development in Murine Model (ARVO 2025) - "The refraction was detected with retinoscopy after pupils dilated with compound tropicamide and ocular biological parameters were measured by optical coherence tomography in vivo at baseline and 2 weeks after the intervention...The big picture of this research is understanding the fundamental role of optic nerve conduction in refractive development in mice. The reason behind this might have something to do with the HIF-1 signaling pathway and the higher parts of the nervous system."

Preclinical • Ocular Inflammation • Ophthalmology • HIF1A