SKL-NP / SK Bio - LARVOL DELTA

[VIRTUAL] A biocompatible nanoparticle-based approach to inhibiting renal ischemia reperfusion injury in mice by blocking thrombospondin-1 activity (TTS 2020) - "In line with this observation, severe tubular destruction and interstitial hemorrhage, which were clearly detected in kidneys from mice treated with PBS, free LSKL or NPs, were markedly ameliorated in LSKL/NP-treated mice (Fig... Our data demonstrate that LSKL/NPs provide an efficient means of adsorbing/neutralizing TSP1, hence inhibiting renal IRI. While other mechanisms may also be involved, protection against IRI by LSKL/NPs is assumed to be largely conferred by its ability to block TSP1-induced CD47 and TGF-β activation."

Preclinical • Hematological Disorders • Reperfusion Injury • Transplantation • THBS1