TP-6076
/ Innoviva
- LARVOL DELTA
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February 02, 2022
An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii.
(PubMed, mBio)
- "We then compare the differences in binding modes between TP-6076 and the related tetracycline antibiotic eravacycline in both targets. In this work, we use cryo-EM to show how AdeJ recognizes the experimental tetracycline antibiotic TP-6076 and prevents this drug from interacting with the A. baumannii ribosome. Since AdeJ and the ribosome use different binding modes to stabilize interactions with TP-6076, exploiting these differences may guide future drug development for combating antibiotic-resistant A. baumannii and potentially other strains of MDR bacteria."
Journal • Infectious Disease
December 17, 2021
Phase 1, Safety and Bronchopulmonary PK Study in Healthy Volunteers
(clinicaltrials.gov)
- P1; N=8; Completed; Sponsor: Tetraphase Pharmaceuticals, Inc.; Active, not recruiting ➔ Completed
Clinical • Trial completion
November 01, 2019
In-vitro activity of the novel fluorocycline TP-6076 against carbapenem-resistant Acinetobacter baumannii.
(PubMed, Int J Antimicrob Agents)
- "The susceptibility of 323 non-duplicate CRAB isolates to TP-6076, amikacin, ampicillin/sulbactam (SAM), cefepime, colistin, doxycycline, eravacycline, imipenem, levofloxacin, meropenem, minocycline, rifampicin, sulbactam, tigecycline, tobramycin and trimethoprim/sulfamethoxazole (SXT) was determined by the broth microdilution method. Compared to other compounds, TP-6076 was the most active antimicrobial against carbapenem-resistant A. baumannii, including isolates that were resistant to other anti-Acinetobacter reference drugs including ampicillin/sulbactam, colistin, amikacin/tobramycin, and levofloxacin. TP-6076 is a promising new agent that may offer a useful addition to the limited armamentarium of drugs targeting this problem pathogen."
Journal • Preclinical
April 05, 2019
In vivo efficacy of TP-6076 in murine thigh and lung infection models challenged with Acinetobacter baumannii
(ECCMID 2019)
- "Female CD-1 mice (22 ± 2 g) were rendered neutropenic by intraperitoneal injection of cyclophosphamide at 150 mg/kg (Day -4) and 100 mg/kg (Day -1) pre-infection. TP-6076 demonstrated potent in vivo efficacy in murine neutropenic thigh/lung infection models challenged with carbapenem-resistant A. baumannii. Further PK/PD modeling to predict percentage of target attainment (PTA) in patients is warranted.e"
Preclinical • Neutropenia
December 12, 2018
Phase 1, Safety and Bronchopulmonary PK Study in Healthy Volunteers
(clinicaltrials.gov)
- P1; N=20; Recruiting; Sponsor: Tetraphase Pharmaceuticals, Inc.; Not yet recruiting ➔ Recruiting
Enrollment open • Biosimilar
May 15, 2017
TP-6076, a Fully Synthetic Tetracycline Antibacterial Agent, is Highly Potent against a Broad Range of Pathogens, Including Carbapenem-Resistant Enterobacteriaceae
(ASM Microbe 2018)
- "Fully synthetic tetracycline analogs with novel substitutions at C4, C7, and C8 were designed and synthesized using the total synthesis approach, and their antibacterial activity-structure relationships were systematically studied. A number of these new tetracyclines displayed high in vitro potency against a broad range of clinically important pathogens, including carbapenem-resistant Enterobacteriaceae (CRE). TP-6076, a lead compound from this novel chemical series, is currently being evaluated in phase 1 clinical studies."
Biosimilar
October 02, 2018
BAL: Phase 1, Safety and Bronchopulmonary PK Study in Healthy Volunteers
(clinicaltrials.gov)
- P1; N=20; Not yet recruiting; Sponsor: Tetraphase Pharmaceuticals, Inc.
New P1 trial • Biosimilar
September 11, 2019
Phase 1, Safety and Bronchopulmonary PK Study in Healthy Volunteers
(clinicaltrials.gov)
- P1; N=8; Active, not recruiting; Sponsor: Tetraphase Pharmaceuticals, Inc.; Recruiting ➔ Active, not recruiting; N=20 ➔ 8; Trial completion date: May 2019 ➔ Feb 2020; Trial primary completion date: Mar 2019 ➔ Jun 2019
Clinical • Enrollment change • Enrollment closed • Trial completion date • Trial primary completion date
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