LY4257496
/ Eli Lilly
- LARVOL DELTA
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October 31, 2025
A phase 1 study of LY4257496, a novel GRPR-targeted radioligand therapy, in patients with GRPR-positive metastatic ER+ breast cancer and other advanced solid tumors - OMNIRAY (Trial in Progress)
(SABCS 2025)
- "Dose expansion will enroll pts with ER+, HER2- MBC treated with LY4257496 monotherapy (cohort B1) and in combination with ET (cohort B2), capecitabine (cohort B3), or ET + abemaciclib (cohort B4)...Key exclusions include prior radiopharmaceutical (except 177Lu-PSMA-617 for mCRPC), recent pancreatitis, and untreated central nervous system metastases.Key study objectives: Evaluate safety, antitumor activity, optimal dose, PK, and biodistribution and dosimetry of LY4257496. Table ETa, fulvestrant or imlunestrant; ETb, investigators' choice of aromatase inhibitor, fulvestrant, or imlunestrant1Stoykow C, et al. Theranostics 2016, 6:1641-50"
Clinical • Metastases • P1 data • Breast Cancer • Estrogen Receptor Positive Breast Cancer • HER2 Breast Cancer • HER2 Positive Breast Cancer • Hormone Receptor Breast Cancer • Oncology • Solid Tumor • ER • GRP-10 • HER-2
August 18, 2025
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
(clinicaltrials.gov)
- P1 | N=421 | Not yet recruiting | Sponsor: Eli Lilly and Company
New P1 trial • Breast Cancer • Colorectal Cancer • Endometrial Cancer • Oncology • Prostate Cancer • Solid Tumor
August 21, 2025
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
(clinicaltrials.gov)
- P1 | N=421 | Recruiting | Sponsor: Eli Lilly and Company | Not yet recruiting ➔ Recruiting
Enrollment open • Breast Cancer • Colorectal Cancer • Endometrial Cancer • Oncology • Prostate Cancer • Solid Tumor
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