GH1581 / Genhouse Bio - LARVOL DELTA

Discovery of GH1581, a potent and selective WRN inhibitor as a cancer therapy (AACR 2024) - "In SW48 xenograft model, it inhibited the tumor growth with 100% TGI at QD dosing of 10 mg/kg without severe adverse effect on body weight. In summary, we discovered GH1581 as a novel inhibitor of WRN with high in vitro and in vivo efficacy."

Colon Cancer • Colorectal Cancer • Endometrial Cancer • Microsatellite Instability • Oncology • Ovarian Cancer • Solid Tumor • MSI • WRN