GH1581
/ Genhouse Bio
- LARVOL DELTA
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March 06, 2024
Discovery of GH1581, a potent and selective WRN inhibitor as a cancer therapy
(AACR 2024)
- "In SW48 xenograft model, it inhibited the tumor growth with 100% TGI at QD dosing of 10 mg/kg without severe adverse effect on body weight. In summary, we discovered GH1581 as a novel inhibitor of WRN with high in vitro and in vivo efficacy."
Colon Cancer • Colorectal Cancer • Endometrial Cancer • Microsatellite Instability • Oncology • Ovarian Cancer • Solid Tumor • MSI • WRN
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