GT-055
/ Geom Therap
- LARVOL DELTA
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September 16, 2021
In vitro and in vivo activity of GT-1, a novel siderophore cephalosporin, and GT-055, a broad-spectrum β-lactamase inhibitor, against biothreat and ESKAPE pathogens.
(PubMed, J Antibiot (Tokyo))
- "Here, we demonstrated sub-4 µg ml efficacy against a number of pathogens in vitro. We further determined that in mice infected via aerosol route with Yersinia pestis, efficacy of GT-1/GT-055 treatment is at least equivalent to the comparator antibiotic, ciprofloxacin."
Journal • Preclinical • Infectious Disease
April 05, 2019
Pharmacokinetics-pharmacodynamics of the novel beta-lactamase inhibitor GT-055 in combination with the siderophore cephalosporin GT-1
(ECCMID 2019)
- "When GT-055 is paired with the novel siderophore cephalosporin, GT-1 (formerly LCB10-0200), the BLI has been shown to improve the in vitro activity up to 8-fold against a variety of Gram-negative organisms including Enterobacteriaceae. Results of GT-1 + GT-055 in vitro studies provided insight about the activity of the inhibitor when utilized in combination with GT-1 and will serve to guide future studies."
Combination therapy • PK/PD data
April 05, 2019
Penicillin-binding protein activity of beta-lactamase inhibitor GT-055
(ECCMID 2019)
- "Other antibiotics (ceftriaxone and mecillinam) and BLIs (avibactam and OP0595) were used as controls. BLI GT-055 was found to bind PBP2, but not other PBPs in E. coli and K. pneumoniae. GT-055 bound to PBP2 with slightly higher affinity than the other diazabicyclooctane-class BLIs, avibactam and OP0595. Therefore, these results suggest that BLI GT-055 bind to and inhibit PBP2."
Infectious Disease • Pneumonia • Respiratory Diseases
May 24, 2020
In Vitro Activity of a Novel Siderophore-Cephalosporin, GT-1 and Serine-Type β-Lactamase Inhibitor, GT-055, against Escherichia coli, Klebsiella pneumoniae and Acinetobacter spp. Panel Strains.
(PubMed, Antibiotics (Basel))
- "This study investigates GT-1 (also known as LCB10-0200), a novel-siderophore cephalosporin, inhibited multidrug-resistant (MDR) Gram-negative pathogen, via a Trojan horse strategy exploiting iron-uptake systems...Compared with CAZ-AVI, GT-1/GT-055 exhibited lower MICs against E. coli and K. pneumoniae isolates. GT-1 demonstrated potent in vitro activity against clinical panel strains of E. coli, K. pneumoniae and Acinetobacter spp. GT-055 enhanced the in vitro activity of GT-1 against many GT-1-resistant strains."
Journal • Preclinical • Infectious Disease • Pneumonia • Respiratory Diseases
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