nitrofurantoin / Generic mfg. - LARVOL DELTA

A retrospective evaluation of antibiotic prescribing for recurrent urinary tract infection prophylaxis in adults in general practice. (PubMed, Fam Pract) - "This work has identified several opportunities to improve recurrent UTI management, including optimizing antimicrobial prescribing, ensuring regular clinical review, and accounting for resistant urinary isolates."

Journal • Retrospective data • Infectious Disease • Nephrology

Antimicrobial Susceptibility Pattern of Ceftriaxone-Sulbactam-EDTA Against Multidrug-Resistant Gram-Negative Bacilli From ICU Clinical Isolates. (PubMed, Cureus) - "High resistance was observed against meropenem (94.57%), netilmicin (93.48%), and ciprofloxacin (90.22%). Nitrofurantoin showed good activity among urinary isolates, with 35 (89.74%) susceptible. Co-trimoxazole showed susceptibility in 6 (14.63%) of 41 tested isolates, while tigecycline showed susceptibility in 5 (12.20%) of 41 tested isolates...CSE showed promising in vitro activity against MDR-GNB isolates and may be considered when guided by susceptibility testing. Strict infection control practices, routine resistance screening, and antimicrobial stewardship are essential in ICU settings."

Journal • Critical care • Infectious Disease • Pneumonia

Rapid point-of-care testing for urinary tract infections: diagnostic accuracy and clinical impact. (PubMed, BJGP Open) - "The PA-100 AST showed moderate diagnostic accuracy and may support management of suspected uUTI in primary care. However, its relatively low negative predictive value observed in our study population limits its ability to rule out bacteriuria. The test had a modest impact on prescribing decisions but further research is needed to determine its effectiveness in optimizing antibiotic use."

Journal • Infectious Disease • Nephrology

Prevalence and Antibiotic Resistance Pattern of Escherichia coli Isolated from Urine Samples of Pediatric Outpatients with Underlying Medical Conditions from Pakistan. (PubMed, Infect Drug Resist) - "The highest rates of resistance were observed against ampicillin (70.3%), cephalexin (60.1%), and trimethoprim-sulfamethoxazole (59.4%). Low resistance was noted to nitrofurantoin (2.8%) and amikacin (1.8%). Age was a significant predictor, with 1-year old children showing 2.1-fold 95% CI: 1.01-4.55) and 3.6‑fold (95% CI: 1.60-8.15) increased odds of ESBL production and MDR, respectively, compared to children aged 6-12 years. High rates of ESBL-producing and MDR E. coli in Pakistani children with underlying conditions underscore the critical need for antimicrobial stewardship and empirical therapy guided by local susceptibility patterns, particularly in younger children."

Journal • Infectious Disease • Nephrology • Pediatrics

Optimization of culture read times using full microbiology laboratory automation. (PubMed, J Clin Microbiol) - "Minor and major errors were rare; however, elevated error rates were observed for specific drugs (e.g., cefazolin, piperacillin/tazobactam, nitrofurantoin, and linezolid), largely due to a limited number of susceptible isolates and breakpoint-related challenges. These findings support the use of earlier culture read time points in MLA workflows, enabling faster turnaround of clinically actionable results. Implementation of optimized incubation times has the potential to improve laboratory efficiency and accelerate patient care decisions while maintaining diagnostic reliability."

Journal • Infectious Disease

Bacterial Contamination in Stored Blood for Transfusion and Associated Infectious Risks Among Patients with Cancer at Mbarara Regional Referral Hospital, in Uganda. (PubMed, J Blood Med) - "The isolates exhibited variable resistance to erythromycin, clindamycin, teicoplanin, vancomycin, tetracycline, nitrofurantoin, rifampicin, and trimethoprim-sulfamethoxazole. The four bacterial isolates were resistant to common antibiotics, which poses a risk of transmission of antibiotic-resistant strains to immunocompromised recipients with cancer. Notably, there was no infectious risk posed post-transfusion presumably due to the concurrent antibiotic therapy."

Journal • Infectious Disease • Oncology • Renal Cell Carcinoma

Antimicrobial resistance in Noma control: a costly neglect within existing neglect. (PubMed, Trop Med Health) - "AMR risks reversing gains in Noma control, and treatment centers may become AMR amplification sites without stewardship. Given limited microbiology data, we recommend adding AMR indicators to WHO and national Noma strategies, integrating anaerobic AMR surveillance at sentinel sites, generating Noma-specific antibiograms, and mandating antimicrobial stewardship in Noma programs. Mainstreaming AMR in Noma research and policy is essential to preserve therapeutic options."

Journal • Review

TO BURN OR TO BREATHE: NITROFURANTOIN-INDUCED CHRONIC LUNG DISEASE MISDIAGNOSED AS RECURRENT INFECTION (CHEST 2026) - No abstract available

Infectious Disease • Pulmonary Disease • Respiratory Diseases

NITROFURANTOIN-INDUCED EOSINOPHILLIC PLEURAL EFFUSION: A RARE ADVERSE DRUG REACTION (CHEST 2026) - No abstract available

Adverse drug reaction • Pleural effusion • Respiratory Diseases

Rethinking Long-Term Nitrofurantoin Prophylaxis in Older Adults: A Clinical Pharmacist-Led Stewardship Approach (IDWeek 2026) - No abstract available

Clinical • Infectious Disease

Identification of Nitrofurantoin In Vitro Susceptibility Test Interpretive Criteria (STIC) for Escherichia coli and Klebsiella pneumoniae (IDWeek 2026) - No abstract available

Preclinical • Infectious Disease

Urine Good Hands: Nitrofurantoin Performs Comparably to Alternative Antibiotics for Cystitis in Kidney Transplant Recipients (IDWeek 2026) - No abstract available

Clinical • Infectious Disease

Detection and antimicrobial susceptibility patterns of Salmonella enterica subsp. arizonae and Proteus spp. associated with gastrointestinal disease in rescued hedgehogs (Erinaceus europaeus). (PubMed, Comp Immunol Microbiol Infect Dis) - "isolates were susceptible to cefotaxime, nalidixic acid, ciprofloxacin, levofloxacin, norfloxacin, amikacin, gentamicin, tobramycin, aztreonam, cefoxitin, ceftazidime and fosfomycin. However, resistance was observed to amoxicillin-clavulanic acid, ampicillin, ertapenem, meropenem, trimethoprim-sulfamethoxazole, cefuroxime, piperacillin-tazobactam, colistin and nitrofurantoin, with the latter two showing resistance in all Proteus spp...from hedgehog samples may display relevant antimicrobial resistance (AMR) patterns. Therefore, continuous bacteriological monitoring and antimicrobial susceptibility testing are important in wildlife rehabilitation settings to guide treatment decisions and support One Health surveillance."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease

Molecular epidemiology of multidrug-resistant uropathogenic Escherichia coli: Virulence, biofilm formation, phylogenetic distribution, and genetic diversity. (PubMed, J Infect Public Health) - "These findings highlight the alarming spread of MDR and XDR E. coli strains with high virulence potential, emphasizing the need for continuous monitoring and judicious antibiotic use."

Journal • Infectious Disease • Nephrology

Antimicrobial susceptibility patterns of commensal fecal bacteria isolated from pigs with an intentional genomic alteration that included the selectable marker gene nptII. (PubMed, Front Microbiol) - "Higher resistance rates in GalSafe™ pigs were observed only for quinolones in Campylobacter coli (ciprofloxacin and nalidixic acid) and nitrofurantoin in Enterococcus spp. However, the positive isolate did not appear to contain nptII derived from the GalSafe™ pig genome as the sequences flanking the gene did not match the IGA. We did not detect evidence of nptII gene transformation into bacterial species of potential human health importance in this population of GalSafe™ pigs."

Journal • Gene Therapies

Optimizing urinary tract infection outcomes: nitrofurantoin versus fluoroquinolones. (PubMed, Bioinformation) - "The adverse reaction rate was significantly lower for nitrofurantoin (10% versus 26.7%), though both groups reported similar side effects. Thus, data shows the nitrofurantoin also maintained a lower failure rate (5% versus 15%), supporting its prioritization as a first-line empirical therapy."

Journal • Infectious Disease • Nephrology

Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli. (PubMed, Nat Commun) - "Under flow, shear stress promoted bacterial elongation, attachment and intracellular community formation, while reducing nitrofurantoin and combination therapy efficacy despite increased drug exposure. These findings demonstrate that the bladder microenvironment profoundly influences UPEC infection dynamics and therapeutic outcomes, underscoring the need for advanced models to guide treatment strategies in the antibiotic resistance era."

Journal • Infectious Disease • Nephrology

Comparative efficacy of oral antibiotics against intracellular populations of uropathogenic Escherichia coli and bladder cell inflammatory response. (PubMed, Eur J Clin Microbiol Infect Dis) - "Here we investigated the efficacy of oral agents (nitrofurantoin, doxycycline, and gepotidacin) in intracellular bacterial clearance and proinflammatory signaling in bladder epithelial cell infection in-vitro. Our findings suggested variable and strain-dependent host inflammatory responses to UPEC infection and that mechanistically distinct oral antibiotics differentially affected the expression of proinflammatory mediators (TNFα and PTGS2) and efficacy in clearing intracellular bacteria."

Journal • Infectious Disease • Inflammation • Nephrology • PACERR • PTGS2 • TNFA

Clinical Characteristics and Modifiable Factors of Urinary Tract Infections in Infants and Toddlers: A Case-Control Study. (PubMed, Arch Esp Urol) - "UTIs in infants and toddlers often present with non-specific symptoms; therefore, standardised urine specimen collection combined with comprehensive testing is crucial for early identification. Low birth weight, non-exclusive breastfeeding, constipation, and improper perineal hygiene were associated with UTI, among which feeding pattern, bowel habits, and perineal care are potentially modifiable. For empirical anti-infective therapy, cephalosporins or nitrofurantoin may be preferred. Further imaging evaluation should be individualised, with ultrasonography as the first-line assessment and voiding cystourethrography or dimercaptosuccinic acid scintigraphy reserved for selected children with recurrent febrile UTI, abnormal ultrasound findings, poor treatment response, or suspected renal scarring. Strengthening breastfeeding, constipation management, and perineal care may help reduce UTI occurrence."

Journal • Retrospective data • Constipation • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Nephrology • Pediatrics

In women with uncomplicated urinary tract infection, nitrofurantoin leads to clinical and bacteriological cure more often than fosfomycin and pivmecillinam. (PubMed, Recenti Prog Med) - No abstract available

Journal • Infectious Disease • Nephrology

Real-World Safety Signals of Fluoroquinolone-Associated Peripheral Neuropathy: Analysis of US and Canadian Databases Combined with Mechanistic Exploration. (PubMed, Int J Antimicrob Agents) - "This study provides a comprehensive pharmacovigilance characterization of FQ-associated PN, revealing significant differences in reporting frequencies among FQs. These results underscore the need for a careful benefit-risk assessment when prescribing FQs, particularly for long-term oral therapy, and highlight the importance of further research to validate these associations."

Journal • Real-world evidence • Pain

Emergence of a novel NDM-4-producing Citrobacter freundii complex species in a complicated urinary tract infection treated with cefiderocol. (PubMed, IDCases) - "Antimicrobial susceptibility testing demonstrated resistance to most tested agents, with susceptibility limited to nitrofurantoin, cefiderocol, aztreonam, doxycycline, and tigecycline. This case underscores the critical role of drainage and access to newer antibiotic agents in management of complex intra-abdominal infections. Genome sequencing aids the detection of novel reservoirs of antibiotic resistance genes in carbapenemase-producing Enterobacterales that may emerge during prolonged antimicrobial exposure."

Journal • Infectious Disease • Nephrology

Drug-Induced Vanishing Bile Duct Syndrome Resembling Pancreaticobiliary Malignancy (ACG 2026) - "Cephalexin was thus permanently discontinued, and he improved on ursodeoxycholic acid (UDCA)...Because nitrofurantoin is structurally unrelated to cephalexin, this response suggests an idiosyncratic hypersensitivity to these antibiotics; his symptoms have since resolved with strict avoidance of all hepatotoxic medications...Figure: High-power (400Ã) view of a portal tract demonstrating ductopenia. The portal tract contains a small hepatic artery and portal vein; however, the bile duct is absent, consistent with loss of the interlobular bile duct."

Biliary Cancer • Cholangiocarcinoma • Cholestasis • Hepatology • Immunology • Infectious Disease • Liver Failure • Nephrology • Oncology • Solid Tumor

ACUTE HEPATOCELLULAR INJURY AFTER SHORT‑TERM NITROFURANTOIN THERAPY IN AN ELDERLY PATIENT (UEGW 2026) - No abstract available

Clinical

Pediatric Urinary Antimicrobial Resistance Patterns in a Tertiary Hospital of Northern Greece: A Retrospective Laboratory-Based Surveillance Study. (PubMed, Antibiotics (Basel)) - "E. coli showed very high ampicillin resistance, low resistance to gentamicin and amikacin, and moderate resistance to guideline-relevant cephalosporins. P. aeruginosa retained low resistance to key antipseudomonal agents. K. pneumoniae showed the highest burden of cephalosporin resistance and of presumptive ESBL and carbapenem resistance phenotypes. These data support guideline-based empirical coverage more strongly for E. coli than for K. pneumoniae in this setting."

Journal • Retrospective data • Infectious Disease • Nephrology • Pediatrics • Pneumonia