nitrofurantoin / Generic mfg. - LARVOL DELTA

Nitrofurantoin for Neisseria gonorrhoeae urethritis? an in vitro and in vivo study in Galleria mellonella (ESCMID Global 2026) - No abstract available

Preclinical • Infectious Disease

Impact of the National Health Service (NHS) pharmacy first service on general practice dispensing of nitrofurantoin in England: a time series analysis (ESCMID Global 2026) - No abstract available

Nitrofurantoin efficacy against E. coli in a dynamic bladder infection model (ESCMID Global 2026) - No abstract available

Clinical • Infectious Disease

Methenamine and nitrofurantoin antibiotic prescribing: is there evidence of an antibiotic-sparing effect in England, 2018 to 2025 (ESCMID Global 2026) - No abstract available

Photochromic Heterometallic Metal-Organic Framework as a Multifunctional Platform for Antibiotic Sensing and Sulfide Photooxidation. (PubMed, Inorg Chem) - "Moreover, LCU-118 demonstrates the efficient detection of nitrofurantoin (NFT) and nitrofurazone (NZF) through a fluorescence quenching mechanism...Additionally, LCU-118 displays excellent catalytic activity toward the oxidation of methyl phenyl sulfide (MPS) at room temperature, offering a novel strategy for the efficient utilization of green energy. Mechanistic investigations reveal that the generation of superoxide radicals in the suspensions is involved in endowing LCU-118 with such multifunctional properties.."

Journal

Why Do We Avoid Using Nitrofurantoin for Pyelonephritis? (PAS 2026) - "Sponsored By: PHM"

Nephrology

"Where Did This Come From?": Questioning Dogma with JPIDS (PAS 2026) - "In this session, we plan to discuss 4 infectious disease topics that are of high relevance to the pediatric audience of PAS. Learning Objectives: Upon completion, participants will be able to evaluate the current relevance of the original rationale for using high-dose amoxicillin for otitis media Upon completion, participants will be able to discuss the rationale for not using nitrofurantoin to treat pyelonephritis Upon completion, participants will be able to discuss the rationale for the timing of 1-2 month intervals for dosing of common vaccines Upon completion, participants will be able to discuss the rationale for recommending less than 10 days of antibiotic treatment for Group A Streptococcal pharyngitis"

Infectious Disease • Nephrology • Otorhinolaryngology

Hemoglobin Zurich: A Rare Hemoglobin Anomaly With Hemolytic Crisis in the ICU (SCCM 2026) - "We present a case illustrating the diagnostic and clinical challenges in managing Hgb Zurich crisis.Description: A 53-year-old woman with a remote diagnosis of Hemoglobin Zurich and no prior hemolytic episodes presented with acute dyspnea, fatigue, and chest tightness after treatment for a urinary tract infection with nitrofurantoin and over-the-counter phenazopyridine...This case highlights the need for thorough medication review and heightened awareness of oxidant-induced hemolysis. Prompt recognition and targeted supportive care can prevent deterioration, optimize ICU resource use, and improve patient outcomes."

Hematological Disorders • Hepatology • Immunology • Infectious Disease • Nephrology • Pulmonary Disease • G6PD • HP

A two-dimensional nanomaterial-based substrate for the simultaneous SERS detection of three antibiotic substances. (PubMed, Talanta) - "When combined with the optimized pretreatment protocol, the resulting hybrid substrate enables the simultaneous detection of three residual antibiotics-nitrofurantoin, tetracycline, and sulfadiazine-in milk samples within 10 min, achieving a detection limit as low as 8.6-15.3 ng g-1. Compared to national standard methods, the established SERS method enhances analytical efficiency while maintaining detection performance, demonstrating substantial potential for practical application."

Journal

Synthesis, Characterization, and Bioactivity Investigation of Novel Benzimidazole Derivatives as Potential Antibacterial and Antifungal Agents. (PubMed, Molecules) - "Antibacterial activity was evaluated in vitro using the agar well diffusion method against Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Klebsiella pneumoniae, with nitrofurantoin (300 µg/mL) as the positive control...The SEM analysis of bacteria treated with 6h revealed marked morphological damage, including cell deformation and membrane disruption, supporting a bactericidal mode of action. Collectively, these results highlight benzimidazole derivatives as promising scaffolds for the development of broad-spectrum antibacterial and antifungal agents."

Journal • Infectious Disease • Pneumonia

LONG-TERM SAFETY AND EFFICACY OF CHRONIC NITROFURANTOIN PROPHYLAXIS IN POST-MENOPAUSAL WOMEN WITH RECURRENT URINARY TRACT INFECTIONS (AUA 2026) - No abstract available

Clinical • Infectious Disease • Nephrology

Non-Antibiotic Herbal Therapy (BNO 1045) versus Antibiotic Therapy (Nitrofurantoin) for the Treatment of Localised Urinary Tract Infections in Women: A Retrospective, Real-World, Multicentre Study (AUA 2026) - No abstract available

Real-world • Real-world evidence • Retrospective data • Infectious Disease • Nephrology

Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals. (PubMed, Nat Med) - "Clindamycin, fluoroquinolones and flucloxacillin accounted for most of the associations with the abundance of individual species. Use of these antibiotics 4-8 years earlier was associated with altered abundance of 10-15% of the species studied; penicillin V, extended-spectrum penicillins and nitrofurantoin were associated with only a few species. Similar results were found comparing one antibiotic course 4-8 years before sampling versus none in the past 8 years. These findings indicate that antibiotics may have long-lasting consequences for the gut microbiome."

Journal • Cardiovascular • Metabolic Disorders

Nitrofurantoin-induced immune-mediated vasculitis with auto-immune haemolytic anaemia and pigment nephropathy: A rare adverse drug reaction. (PubMed, Trop Doct) - No abstract available

Adverse drug reaction • Journal • Anemia • Autoimmune Hemolytic Anemia • Hematological Disorders • Immunology • Renal Disease • Vasculitis

PREVALENCE, PHYLOGENETIC DIVERSITY, AND ANTIMICROBIAL RESISTANCE OF UROPATHOGENIC ESCHERICHIA COLI IN GEORGIA. (PubMed, Georgian Med News) - "UPEC strains circulating in Georgia exhibit marked phylogenetic diversity but relatively low levels of multidrug resistance. Continued surveillance is warranted to support evidence-based antimicrobial therapy and stewardship."

Journal • Infectious Disease • Nephrology • Urology

Prevalence and Antimicrobial Susceptibility of Multi-Drug Resistant Uropathogens in a Tertiary Hospital in Nepal: A One-Year Audit. (PubMed, JNMA J Nepal Med Assoc) - "coli, Klebsiella, Enterococcus, Citrobacter, Pseudomonas, and Acinetobacter showed resistance to Ceftriaxone (74.61-92.20%), Amoxycillin+Clavulanate (67.58-97%), and Nitrofurantoin (52.29-89.55%) across selectively tested isolates. Urine samples demonstrated a high prevalence of multidrug resistance to routinely prescribed antibiotics, even among second-line parenterally administered antibiotics. Only costly third-line antibiotics exhibited low resistance."

Journal • Retrospective data • Infectious Disease • Nephrology

Antibiotic Susceptibility Profile of Carbapenem Resistant Escherichia Coli and Klebsiella Pneumoniae in Urinary Isolates from a Tertiary Care Hospital: An Observational Study. (PubMed, JNMA J Nepal Med Assoc) - "Both the Carbapenem resistant E. coli and K. pneumoniae showed susceptibility to fosfomycin and nitrofurantoin. Urinary tract infections caused by Escherichia coli and Klebsiella pneumoniae are frequent, but Carbapenem resistant strains pose an emerging therapeutic challenge. This study highlights the prevalence and effective antibiotic options."

Journal • Observational data • Infectious Disease • Nephrology • Pneumonia

Advances in the Development of Antibiotic Drug Candidates for Urinary Tract Infection Therapy. (PubMed, Chem Asian J) - "Existing antibiotics for UTI treatment include trimethoprim/sulfamethoxazole, nitrofurantoin, fosfomycin, ciprofloxacin, levofloxacin, cephalexin, ceftriaxone, amoxicillin/clavulanate, doxycycline, and piperacillin/tazobactam. Nonantibiotic strategies, such as mannosides, curli inhibitors, and FimH antagonists, are also being explored as promising anti-adhesion and biofilm-targeting therapies. This review emphasizes the urgent need for novel, resistance-resilient antibacterial agents and highlights recent chemical and biological innovations that could transform future UTI prevention and therapy."

Journal • Review • Infectious Disease • Nephrology • DHFR

Susceptibility of carbapenem-resistant Klebsiella pneumoniae in urinary tract infections: clinical efficacy of fosfomycin. (PubMed, J Infect Dev Ctries) - "Clinical experience may be feasible and needed to assess the efficacy of nitrofurantoin and TMP-SMX. Fosfomycin-including regimens may serve as a salvage treatment option for CR-Kp UTI in selected patients. However, the retrospective and single-center design of the study should be considered as a limitation."

Journal • Infectious Disease • Nephrology • Novel Coronavirus Disease • Pneumonia

Profibrotic predictive toxicology in the lung. (PubMed, Front Pharmacol) - "For drug-induced fibrosis modeling, cell viability assays defined 20% inhibitory concentrations of nitrofurantoin (NF, 5 μM) and amiodarone (AD, 20 μM), which were then used to treat MiLO for assessment of MDA, invasion area on collagen-coated plates, and expression of fibrotic and signaling markers. Environmental toxicant (Cd) and drug (AD or NF) treatments drove the development of hallmark fibrotic features in lung organoids, characterized by increased collagen deposition, oxidative stress, and profibrotic gene activation. These findings demonstrate that mouse lung organoids effectively recapitulate key molecular and pathological aspects of drug- and toxin-induced pulmonary fibrosis and represent a powerful model for mechanistic investigation and preclinical screening of compounds with potential pro-fibrotic effects."

Journal • Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases • ACTA2 • AKT1 • CD31 • COL1A1 • FN1 • MMP9 • PECAM1 • TGFB1

A COMPREHENSIVE EVALUATION OF EMPIRICAL ANTIBIOTIC THERAPY, DE-ESCALATION PRACTICES, AND ANTIMICROBIAL RESISTANCE TRENDS IN HOSPITALIZED PATIENTS: A HOSPITAL-BASED OBSERVATIONAL STUDY (ISPOR 2026) - "Resistance was highest against ceftriaxone, amoxicillin-clavulanate, and ciprofloxacin. Carbapenems, linezolid, vancomycin, and nitrofurantoin remained largely effective. Early culture testing, appropriate empirical selection, and timely de-escalation were associated with better antibiotic use and clinical outcomes. Continued focus on these practices and regular AMR monitoring remains essential."

Clinical • Observational data • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Respiratory Diseases

Antimicrobial resistance and carbapenemase production among gram-negative bacteria in a newly established hospital. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Community-acquired isolates showed high susceptibility to carbapenems, aminoglycosides, and nitrofurantoin, while hospital-acquired isolates exhibited significantly higher resistance to β-lactams and fluoroquinolones...Carbapenemase production was detected predominantly in hospital-acquired isolates, with OXA-48-like and NDM enzymes being the most common, although sporadic carbapenemase-producing community-acquired isolates were also identified. The early detection of multidrug-resistant Gram-negative bacteria, including carbapenemase producers, shortly after hospital opening underscores the necessity of early antimicrobial resistance surveillance and robust infection prevention and control strategies."

Journal • Infectious Disease • Pneumonia

Comparative in vitro activity of furazidin and nitrofurantoin and assessment of resistance mechanisms in Escherichia coli isolates from urinary tract infections. (PubMed, Folia Microbiol (Praha)) - "These results underscore the need for region-specific evaluation of nitrofuran susceptibility and caution against extrapolating nitrofurantoin MICs to furazidin efficacy in clinical practice. Moreover, the findings highlight the need for improved standardization of nitrofuran susceptibility testing and further investigation of resistance mechanisms to guide optimal UTI therapy, particularly in outpatient populations where nitrofurans remain first-line empirical agents."

Journal • Preclinical • Infectious Disease • Nephrology

Three Strikes with Nitrofurantoin: A Case of Recurrent Delayed Hypersensitivity (AAAAI 2026) - "Nitrofurantoin is a first line antibiotic for uncomplicated urinary tract infections but is an uncommon cause of hypersensitivity reactions. We present a case of recurrent, delayed onset urticaria and angioedema following nitrofurantoin exposure."

Clinical • Cardiovascular • Dermatology • Immunology • Infectious Disease • Nephrology • Urticaria

Recognizing the Rare but Real: Nitrofurantoin-Induced Pneumonitis (ATS 2026) - No abstract available

Inflammation • Pneumonia