nitrofurantoin / Generic mfg. - LARVOL DELTA

Incidence and pattern of antimicrobial resistance of main bacterial isolates from patients with communityacquired urinary tract infections in North of Iraq. (PubMed, Arch Ital Urol Androl) - "Community-acquired UTI pathogens in Sulaimani  showed high resistance to widely used oral antibiotics, while carbapenems and nitrofurantoin remained effective. Higher resistance was especially noted among older adults, men, and patients with diabetes or renal disease. These findings highlight the need for improved empirical therapy and ongoing resistance surveillance."

Journal • Cardiovascular • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease

Characterization of a conjugative IncFII/IncR plasmid harboring blaKPC-2 in a clinical ST91 Citrobacter freundii isolate. (PubMed, BMC Microbiol) - "To our knowledge, this is the first characterization of an IncFII(pBK30683)/IncR plasmid carrying blaKPC-2 in a clinical C. freundii ST91 isolate. The findings highlight plasmid lineages as drivers of carbapenem resistance dissemination and underscore the need for plasmid-focused genomic surveillance, particularly for monitoring transferable resistance vehicles across clinically relevant hosts."

Journal

Predicting the Ototoxic Risk of Fda-Approved Drugs Through Machine Learning and in Vivo Approaches (ARO 2026) - "To date, we have experimentally tested eight compounds and confirmed that two drugs, Dantrolene and Nitrofurantoin, were ototoxic. A third, Fruquintinib, showed hair cell loss only at the highest dose, suggesting general cytotoxicity... Preliminary findings demonstrate that ML–based predictions for unrecognized ototoxic compounds need improvement, as 2 out of 8 tested drugs were confirmed as ototoxins in zebrafish. Further experiments will explore whether the confirmed ototoxic drugs from the predicted list enter via mechanotransduction (MET) channels, affect ribbon synapses, and ultimately impact hair cell function. Our future work will focus on refining the model to achieve >90% prediction confidence and developing it into an accessible, robust screening tool for drug-induced ototoxicity."

Machine learning • Preclinical • Otorhinolaryngology • POU4F3

A Mysterious Case of Autoimmune Hepatitis Triggered by Herpes Zoster Virus Versus Drug-Induced Liver Injury. (PubMed, Cureus) - "While evaluating a patient with suspected autoimmune hepatitis, common causes such as viral hepatitis, Epstein-Barr virus, and medications like amoxicillin-clavulanic acid, statins, nitrofurantoin and methyldopa must be ruled out. She was observed with findings typical of cholestatic liver disease, and an extensive workup, including imaging and liver biopsy, was done to determine the cause of liver injury. Her clinical presentation, laboratory and Imaging findings favored Herpes Zoster virus as the likely culprit for autoimmune hepatitis."

Journal • Autoimmune Hepatitis • Cholestasis • CNS Disorders • Diabetes • Endocrine Disorders • Epstein-Barr Virus Infections • Gastroenterology • Gastrointestinal Disorder • Hepatitis C • Hepatology • Herpes Zoster • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Inflammatory Bowel Disease • Keratitis • Liver Failure • Metabolic Disorders • Neuralgia • Ocular Inflammation • Ophthalmology • Pain • Rheumatoid Arthritis • Rheumatology • Scleritis • Type 1 Diabetes Mellitus • Ulcerative Colitis • Uveitis • Varicella Zoster

Nitrofurantoin for Neisseria gonorrhoeae urethritis? An in vitro and in vivo study in Galleria mellonella (ESCMID Global 2026) - No abstract available

Preclinical • Infectious Disease

Nitrofurantoin efficacy against E. coli in a dynamic bladder infection model (ESCMID Global 2026) - No abstract available

Clinical • Infectious Disease

Impact of the National Health Service (NHS) pharmacy first service on general practice dispensing of nitrofurantoin in England: a time series analysis (ESCMID Global 2026) - No abstract available

Methenamine and nitrofurantoin antibiotic prescribing: is there evidence of an antibiotic-sparing effect in England, 2018 to 2025 (ESCMID Global 2026) - No abstract available

In vitro activity of furazidin and comparator agents against bacterial isolates from urinary tract infections. (PubMed, Eur J Clin Microbiol Infect Dis) - "Our study demonstrates that furazidin exhibits potent in vitro activity against a broad spectrum of organisms responsible for UTIs. These data support furazidin as an effective alternative for treatment of UTIs."

Journal • Preclinical • Infectious Disease • Nephrology • Pneumonia

Resistance of uropathogens to gepotidacin: a systematic review of in vitro antimicrobial susceptibility studies. (PubMed, Int J Antimicrob Agents) - "Gepotidacin has very good antimicrobial activity against a variety of pathogens that cause uUTIs. Importantly, it retains activity against uropathogen isolates that exhibit resistance to other antibiotics commonly used for UTIs making it a useful addition to a physician's therapeutic arsenal."

Journal • Preclinical • Review • Infectious Disease • Nephrology • Pneumonia

Antibacterial resistance in urinary samples from long term care-facility and community-dwelling older people in Gauteng, South Africa. (PubMed, J Glob Antimicrob Resist) - "LTCF residence was independently associated with higher AMR in several common urinary pathogens. These findings suggest that empirical UTI regimens commonly used in community-dwelling older adults may be inadequate for LTCF residents. Setting-specific antibiograms, improved diagnostic stewardship, and strengthened AMS interventions are needed to support appropriate prescribing. Further studies incorporating patient-level clinical factors are warranted to refine empirical treatment recommendations for older adults across care settings."

Journal • Infectious Disease • Nephrology

ABLE: Asymptomatic Bacteriuria in Pregnancy in Low- and Middle-IncomE Countries (clinicaltrials.gov) - P3 | N=1134 | Recruiting | Sponsor: NICHD Global Network for Women's and Children's Health | Not yet recruiting ➔ Recruiting

Enrollment open • Small for Gestational Age

Intravesical Gentamicin to Prevent Recurrent UTI (clinicaltrials.gov) - P4 | N=30 | Recruiting | Sponsor: Women and Infants Hospital of Rhode Island | Trial completion date: Dec 2025 ➔ May 2026

Trial completion date

pH-dependent efficacy of nitrofurantoin against uropathogenic Escherichia coli: Implications for personalized urinary tract infection treatment. (PubMed, Indian J Urol) - "Current susceptibility testing at neutral pH may underestimate the in vivo performance. Integrating urinary pH considerations into antimicrobial susceptibility testing and patient management could optimize the treatment outcomes and support personalized UTI therapy."

Journal • Infectious Disease • Nephrology

Antimicrobial susceptibility and risk factors of asymptomatic bacteriuria among pregnant women attending antenatal care at public health facilities in Debre Markos town, Northwest Ethiopia. (PubMed, BMC Microbiol) - "ASB prevalence was 16.2%; E. coli was the predominant isolate; the MDR rate was 40%. Diabetes, vaginal douching, catheterization, and prior UTI were associated with ASB. Routine urine culture should be considered for targeted screening and culture-guided therapy for high-risk groups. Further studies are needed to evaluate prophylaxis and treatment outcomes."

Journal • Diabetes • Metabolic Disorders • Nephrology

Safety and efficacy of gepotidacin in urinary tract infection: a GRADE-assessed systematic review and meta-analysis. (PubMed, J Antimicrob Chemother) - "Gepotidacin provides superior composite and microbiological outcomes relative to nitrofurantoin for female uUTI but is associated with increased mild-to-moderate gastrointestinal toxicity. Long-term tolerability and resistance surveillance are recommended."

Clinical • Journal • Retrospective data • Review • Infectious Disease • Nephrology

Molecular characterization and antimicrobial resistance of Yersinia enterocolitica isolated from raw chicken meat in Iran: polymerase chain reaction ribotyping insights. (PubMed, Ital J Food Saf) - "Ceftazidime and ampicillin resistance, however, was 100%. Notably, there were also notable levels of resistance to trimethoprim-sulfamethoxazole and nitrofurantoin. Pathogenic strains (IRT1 and IRT2) were grouped independently from non-pathogenic strains (IRT3) using PCR ribotyping. The detection of highly pathogenic Y. enterocolitica (1B/O:8) in Iran may pose a serious public health concern."

Journal • Polymerase Chain Reaction • Gastrointestinal Disorder

Antibiotic Resistance Patterns in Uropathogens Isolated from Pregnant Women: A Tertiary Hospital Study. (PubMed, J Pharm Bioallied Sci) - "Resistance was found in about three-quarters of isolates to ampicillin and co-trimoxazole, but most isolates were still sensitive to nitrofurantoin and fosfomycin. Resistance to different antibiotics was found in 47.3% of the isolates, more commonly in E. coli strains. It was shown in the study that a large number of pregnant women with UTIs are infected by bacteria resistant to many commonly used drugs."

Journal • Infectious Disease • Nephrology • Pneumonia

Non-Antibiotic Herbal Therapy (BNO 1045) versus Antibiotic Therapy (Nitrofurantoin) for the Treatment of Localised Urinary Tract Infections in Women: A Retrospective, Real-World, Parallel-Group, Multicentre Study (EAU 2026) - No abstract available

Real-world • Real-world evidence • Retrospective data • Infectious Disease • Nephrology

Epidemiological characteristics and antibiotic resistance of pathogens in urinary tract infection in Chengdu 2019-2023, China. (PubMed, BMC Microbiol) - "The main pathogens of UTIs were Escherichia coli. Changes in UTIs risk and antibiotic resistance may be associated with the COVID-19 pandemic. Meanwhile, we have observed a gradual increase in antibiotic resistance among certain pathogens. Therefore, to ensure optimal therapeutic efficacy, antimicrobial susceptibility testing and bacterial culture should be performed prior to antibiotic administration, thus ensuring rational and effective use."

Journal • Infectious Disease • Nephrology • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases

Gepotidacin (Blujepa) - a new antibiotic for uncomplicated UTI. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Infectious Disease • Nephrology

Early symptom response in patients with uncomplicated urinary tract infection treated with gepotidacin or nitrofurantoin: pooled analysis from two pivotal Phase 3 studies. (PubMed, Clin Infect Dis) - P3 | "Gepotidacin and nitrofurantoin provide meaningful and similar early relief from uUTI symptoms."

Journal • P3 data • Retrospective data • Infectious Disease • Nephrology

Applying international urinary tract infection guidelines in Poland: epidemiologic insights from Southern Poland. (PubMed, Pol Arch Intern Med) - "coli) was 73% susceptible to co-trimoxazole and ≥86.9% to cephalosporins only in premenopausal women, but ~76.6% in men and postmenopausal women. Outpatient E. coli isolates showed 91.9% susceptibility to nitrofurantoin, but most other Access group agents fell below 60%, except gentamicin (92%). Resistance was frequent: Extended-Spectrum Beta-Lactamases occurred in 12.8% of outpatient and 32.9% of inpatient Enterobacterales and High-Level Aminoglycoside Resistance in 56.5% of inpatient Enterococcus faecalis and 63.7% of Enterococcus faecium.   Due to the high potential risk of empirical therapy ineffectiveness based on current guidelines, its coherence to clinical reality should be further evaluated using more locally derived data."

Clinical • Journal • Infectious Disease • Nephrology • Pneumonia

Efflux pump-associated antimicrobial resistance genes in Staphylococcus spp. from dairy and meat samples. (PubMed, Turk J Biol) - "The administration of reserpine reduced minimum inhibitory concentration (MIC) values across all cefuroxime-resistant isolates and in a subset of tetracycline- and nitrofurantoin-resistant strains, suggesting the potential involvement of efflux pumps. These results suggest efflux-mediated resistance can significantly impact antibiotic tolerance and biocides in foodborne isolates. Continued surveillance and control strategies are essential to limit the spread of these resistance genes in the food chain."

Journal

Infection after cesarean delivery: diagnosis, pathophysiology, management, and prevention. (PubMed, Am J Obstet Gynecol) - "The appropriate antibiotic therapy for endometritis is either a combination regimen, such as clindamycin plus gentamicin or metronidazole plus ampicillin plus gentamicin, or single agents such as extended-spectrum penicillins, cephalosporins, or carbapenems that provide coverage against the broad range of pelvic pathogens. For wound infection, the addition of a specific antistaphylococcal antibiotic such as vancomycin or linezolid, and, in some instances, surgical drainage are indicated. For a lower urinary tract infection, the oral antibiotics, nitrofurantoin monohydrate macrocrystals or trimethoprim-sulfamethoxazole, are preferred. For pyelonephritis, ceftriaxone is an excellent choice for therapy...It also provides a brief overview of the diagnosis and management of the potentially very serious complications that may arise from the original infection at the operative site, namely pelvic abscess, septic pelvic vein thrombophlebitis, and septic shock. The review..."

Journal • Review • Diabetes • Endometriosis • Genetic Disorders • Infectious Disease • Metabolic Disorders • Nephrology • Obesity • Pneumonia • Respiratory Diseases • Rheumatology • Septic Shock • Type 1 Diabetes Mellitus