nitrofurantoin / Generic mfg. - LARVOL DELTA

Janibacter melonis bacteremia following autologous stem cell mobilization in lymphoma: a case report and literature review. (PubMed, BMC Infect Dis) - "This case highlights the importance of considering rare infections in immunocompromised patients, especially those with hematologic malignancies. Prompt microbiological and molecular diagnosis, combined with targeted therapy, is essential for good outcomes. This report also provides useful insights for managing Janibacter melonis infections."

Journal • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Disorders • Hematological Malignancies • Infectious Disease • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology

GD04 (P064) A study of multidrug resistance pattern in scabies-associated infections in endemic communities. (PubMed, Br J Dermatol) - "High resistance was noted for erythromycin (91.6%) and ciprofloxacin (53.7%). Gentamicin and clindamycin had moderate susceptibility rates of 57.4% and 51.9%, respectively. Nitrofurantoin and rifampicin maintained high susceptibility (98.1% and 92.6%). Among bacterial strains, methicillin-resistant S. aureus (MRSA) was most prevalent (46.3%), followed by coagulase-negative staphylococci (5.6%) and vancomycin-resistant S. aureus (5.6%)...The high prevalence of MRSA highlights the urgent need for improved infection control measures and the judicious use of antibiotics. While newer drugs like tigecycline, linezolid and daptomycin offer alternative treatment options, robust surveillance and targeted antibiotic stewardship programmes are crucial to address this growing challenge and ensure effective patient care.TableBacteria isolated from 55 patients with scabiesOrganism isolatedn (%)Staphylococcus aureus47 (97)Staphylococcus haemolyticus2 (4)Staphylococcus epidermidis2..."

Journal • Infectious Disease

P064 A study of multidrug resistance pattern in scabies-associated infections in endemic communities. (PubMed, Br J Dermatol) - "High resistance was noted for erythromycin (91.6%) and ciprofloxacin (53.7%). Gentamicin and clindamycin had moderate susceptibility rates of 57.4% and 51.9%, respectively. Nitrofurantoin and rifampicin maintained high susceptibility (98.1% and 92.6%). Among bacterial strains, methicillin-resistant S. aureus (MRSA) was most prevalent (46.3%), followed by coagulase-negative staphylococci (5.6%) and vancomycin-resistant S. aureus (5.6%)...The high prevalence of MRSA highlights the urgent need for improved infection control measures and the judicious use of antibiotics. While newer drugs like tigecycline, linezolid and daptomycin offer alternative treatment options, robust surveillance and targeted antibiotic stewardship programmes are crucial to address this growing challenge and ensure effective patient care.TableBacteria isolated from 55 patients with scabiesOrganism isolatedn (%)Staphylococcus aureus47 (97)Staphylococcus haemolyticus2 (4)Staphylococcus epidermidis2..."

Journal • Infectious Disease

Autoimmune-like hepatitis induced by drugs: Still many unanswered questions. (PubMed, World J Hepatol) - "Several drugs, including nitrofurantoin, minocycline, hydralazine, methyldopa and infliximab, have a well-documented capacity to induce DI-ALH. International collaborative studies are needed to further characterize DI-ALH. In this review, we update current controversies, present emerging concepts, and outline future challenges in the diagnosis and management of this complex condition learned so far."

Journal • Review • Autoimmune Hepatitis • Fibrosis • Hepatology • Immunology • Inflammation • Liver Failure

Impact of Plant Growth Promoting Rhizobacteria Exiguobacterium Acetylicum RGK and Enterobacter Mori RGK1 on Growth Parameters and Phytochemicals of Asparagus Racemosus. (PubMed, Curr Microbiol) - "Additionally, has shown antibiotic susceptibility to antibiotics such as Amikacin, Netilin, Co-trimaxazole, Streptomycin, Furazolidone, Kanamycin, Nalidixic acid, Nitrofurantoin, Tobramycin, Oxytetracyclin, Chloramphenicol, Gentamycin and their ability to withstand salt concentration (NaCl) up to 5-6%. As compared to the untreated plants, PGPR-treated plantlets showed higher amounts of secondary metabolites, primarily Diosgenin. The main focus is on the use of multiple microbial strains in a single formulation, an emerging trend in sustainable agriculture."

Journal

NextGen - Clinical Implication of Next Generation Sequencing (clinicaltrials.gov) - P4 | N=100 | Recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Dec 2026 ➔ Dec 2028 | Trial primary completion date: Dec 2026 ➔ Dec 2028

Biomarker • Trial completion date • Trial primary completion date • Infectious Disease • Nephrology

Community-acquired pneumonia-causing bacteria and antibiotic resistance rate among Syrian patients. (PubMed, J Infect Dev Ctries) - "These findings underscore the importance of being able to adapt the general World Health Organization recommendations according to local evidence. It is crucial to emphasize the need for continuous local monitoring, functioning and well-equipped laboratories, and well-trained specialists in infectious diseases in hospitals to be able to make these decisions."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Rising trend of Enterococcus species as pathogen, and its antimicrobial susceptibility pattern in western Gujarat. (PubMed, J Infect Dev Ctries) - "The rising trend of enterococci and the alarming rates of resistance highlight the need for rational and restricted drug use, with early detection and use of the susceptibility report to prevent treatment failures and spread of resistance."

Journal • Retrospective data • Infectious Disease • Nephrology

Prevalence of antibiotic-resistant Escherichia coli isolates from healthy chicken droppings. (PubMed, PLoS One) - "The high prevalence of multidrug-resistant E. coli in broiler chickens underscores the urgent need for stricter antibiotic stewardship in poultry farming. The findings support Sustainable Development Goals (SDGs) 3 (Good Health and Well-being), 12 (Responsible Consumption and Production), and 15 (Life on Land) by promoting antimicrobial surveillance and sustainable livestock management."

Journal

Characteristics of Patients with Type 2 Diabetes Mellitus with Sodium-Glucose Cotransporter Protein-2 Inhibitor-Related Urinary Tract Infections: Pathogen Distribution and Drug Resistance. (PubMed, Arch Esp Urol) - "The distribution of pathogenic bacteria complicated by UTI in patients with T2DM treated with SGLT-2 inhibitors was dominated by Gram-negative bacteria such as E. coli, some Gram-positive bacteria, and a small number of fungi. Antibiotics should be used appropriately in this population because of the pharmacological mechanism of SGLT-2 inhibitors."

Journal • Retrospective data • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Pneumonia • Type 2 Diabetes Mellitus

The Prevalence of Asymptomatic Bacteriuria Among Jordanian Pregnant Women. (PubMed, Int J Womens Health) - "Furthermore, the antibiotic sensitivities of the isolated E. coli showed high percentages (≥90%) to nitrofurantoin, aminoglycosides, and some types of cephalosporins, but low (56%) to amoxicillin-clavulanic acid. These findings emphasized the importance of routine screening for ASB during pregnancy, particularly in the third trimester and in grand multiparous women. Although no significant association was found with maternal age or common comorbidities such as diabetes and hypertension, further extensive studies are needed."

Journal • Cardiovascular • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology

Target product profiles for paediatric formulations of azithromycin and nitrofurantoin. (PubMed, Bull World Health Organ) - "If scoring is feasible, a 10 mg unit dose should be developed for dosing flexibility across paediatric age groups. These profiles aim to support regulatory authorities, pharmaceutical developers, health programmes and other stakeholders in advancing safer, effective and child-appropriate antibiotic formulations."

Journal • Infectious Disease • Pediatrics

Morganella morganii Urinary Tract Infection in Jordanian Children: Case series from a Tertiary Hospital. (PubMed, Infect Chemother) - "M. morganii should be considered in pediatric UTIs, especially among children with urinary tract anomalies or catheter use. Awareness of its distinct resistance profile is critical for selecting appropriate empiric therapy."

Journal • Infectious Disease • Nephrology • Pediatrics

Nitrofurantoin as a preferred first-line therapy for urinary tract infection: A comparison using urinary tract infection-specific antibiograms. (PubMed, Bladder (San Franc)) - "The susceptibility data were consistent across the two institutions, suggesting that NF can continue to be considered a first-line therapy for uncomplicated urinary tract infections in women. This report highlights the importance of clinicians consulting their local antibiograms to inform empiric antibiotic therapy."

Journal • Infectious Disease • Nephrology

Asymptomatic Bacteriuria, their Related Risk Factors and Antibiotic Susceptibility Pattern of Isolates Among Hemodialysis Patients. (PubMed, J Nepal Health Res Counc) - "This study demonstrates high prevalence of asymptomatic bacteriuria among hemodialysis patients. Routine screening of asymptomatic bacteriuria aids in early detection and management of complications along with optimization of antibiotic use."

Journal • Cardiovascular • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease

An observational study on multidrug resistance in pediatric patients with urinary tract infections. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Escherichia coli demonstrated high resistance to nalidixic acid (84.4%), ampicillin (78.1%), and ciprofloxacin (78.1%), while maintaining high susceptibility to fosfomycin (90.6%), ertapenem (81.3%), gentamicin (71.9%), and nitrofurantoin (71.9%)...exhibited high resistance to tetracycline (64.3%), and levofloxacin (63%). but remained sensitive to linezolid (93.27%), vancomycin (85.71%), teicoplanin (78.57%), and tigecycline (71.4%)...Fosfomycin, nitrofurantoin, and carbapenems retain efficacy, though over-reliance may accelerate resistance. Regular, pediatric-specific AMR surveillance and antimicrobial stewardship programs are essential to preserve treatment efficacy and improve outcomes in this vulnerable population."

Journal • Observational data • Infectious Disease • Nephrology • Pediatrics • Pneumonia

Phenyllactic Acid as a Marker of Antibiotic-Induced Metabolic Activity of Nosocomial Strains of Klebsiella pneumoniae In Vitro Experiment. (PubMed, Microorganisms) - "Doxycycline, nitrofurantoin, rifampicin, and tigecycline significantly suppressed metabolic activity, confirmed by decreased PhLA levels. Conversely, meropenem, cephalosporins (ceftriaxone, cefepime, cefotaxime, and ceftazidime), ciprofloxacin, and amikacin stimulated PhLA production, suggesting that bacterial metabolic activity was maintained despite the presence of antibiotics. PhLA is a promising biomarker for quantifying K. pneumoniae's metabolic response to antibiotics. This potentially introduces a novel approach for future investigations into resistance mechanisms and has the potential to increase the effectiveness of therapies for multidrug-resistant K. pneumoniae infections by providing an additional analytical tool to traditional susceptibility testing methodologies."

Journal • Preclinical • Infectious Disease • Pneumonia • Septic Shock

Antimicrobial Resistance Profiles of Bacteria Isolated from the Animal Health Sector in Zambia (2020-2024): Opportunities to Strengthen Antimicrobial Resistance Surveillance and Stewardship Programs. (PubMed, Antibiotics (Basel)) - "The findings of this study reveal rising resistance to commonly used antibiotics in the animal health sector. Despite the lack of molecular analysis, our findings underscore the urgent need for AMS programs and integrated AMR surveillance under Zambia's One Health strategy."

Journal • Infectious Disease • Pneumonia

Bacterial Agents and Antimicrobial-Resistance Patterns in Canine Otitis Externa. (PubMed, Animals (Basel)) - "These results highlight the significant role of S. pseudintermedius in the pathogenesis of otitis externa in dogs, as well as the relevance of Gram-negative opportunistic pathogens like P. aeruginosa, which exhibits the highest recurrence rate, with 90% of the cases associated with highly resistant to β-lactams (93% for amoxicillin-clavulanic acid; >70% for third-generation cephalosporins). mirabilis showed complete resistance to tetracycline, partial resistance to doxycycline, and reduced susceptibility to carbapenems, nitrofurantoin, and polymyxin B. S. canis exhibited limited resistance to erythromycin and clindamycin, while S. epidermidis displayed extensive multidrug resistance, including β-lactams, fluoroquinolones, sulfonamides, and polymyxins. These findings highlight the high prevalence of multidrug-resistant pathogens in canine otitis externa, emphasizing the need for culture-guided therapy and raising concerns regarding One Health, due to potential zoonotic..."

Journal • Infectious Disease • Otorhinolaryngology

Comparative analysis of virulence genes, biofilm production, and antibiotic resistance in Escherichia coli from dogs and humans using rep-PCR. (PubMed, BMC Vet Res) - "The results suggest that E. coli from humans and dogs share the same pathogenic characteristics, with notable differences in biofilm production and antibiotic resistance. The genetic relatedness between some isolates highlights the risk of zoonotic transmission, emphasizing the need for continuous surveillance and a One Health approach to control infections."

Clinical • Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease

Rapid enrichment and determination of fishery drugs residue in fishes and shrimps by ZnO-Ag SERS substrate. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "The enhancement mechanisms were simulated using the finite-difference time-domain method and a charge-transfer model. The strategy was successfully applied for rapid SERS analysis of nitrofurantoin and methylene blue in aquatic products with recoveries of 91.6 %-113.2 % and RSDs of 0.5 %-7.8 % (n = 3)."

Journal

Identifying high-risk drugs and demographic patterns in drug-induced liver injury from FAERS and CVARD analyses. (PubMed, Sci Rep) - "Our analysis of 21,738 cases from FAERS identified 172 drugs with significant DILI signals, including high-risk drugs such as dapsone, isoniazid, and nitrofurantoin, which showed the strongest associations (BCPNN > 3). While these findings provide valuable insights into drug safety and clinical decision-making, the study's limitations, including potential biases from the spontaneous reporting nature of FAERS and CVARD, should be acknowledged. Overall, the findings highlight the importance of personalized monitoring and risk stratification to enhance medication safety and improve patient outcomes."

Journal • Hepatology • Liver Failure • Oncology

Cranberry Tablets Versus Nitrofurantoin Prophylaxis for Urinary Tract Infection Prevention After Urogynecologic Surgery (clinicaltrials.gov) - P=N/A | N=142 | Active, not recruiting | Sponsor: Brigham and Women's Hospital | Trial completion date: Jan 2024 ➔ Dec 2026

Trial completion date • Gynecology • Infectious Disease • Nephrology • Urinary Incontinence • Urology

Antimicrobial resistance and virulence gene patterns of Staphylococcus aureus in infectious mastitis: implications for inflammatory myopathies of the lactating breast. (PubMed, Eur J Transl Myol) - "Both MRSA and MSSA showed high resistance to penicillin G, erythromycin, and Clindamycin, while all isolates were susceptible to nitrofurantoin, linezolid, vancomycin, and rifampicin. aureus, particularly MRSA, is the main pathogen in lactating mastitis. Specific virulence genes may influence the severity of local inflammation and myopathic changes, highlighting implications for inflammatory myopathies in the lactating breast."

Journal • Infectious Disease • Inflammation • Myositis

Phylogenetic analysis of bla NDM genes of carbapenem resistant uropathogens isolated from federal tertiary care hospital, Pakistan: insights into the evolution and dissemination of drug resistance. (PubMed, Iran J Microbiol) - "Uropathogenic CRE, harboring bla NDM, revealed susceptibility of 34.78%, 60.87%, and 65.22% to amikacin, nitrofurantoin, and fosfomycin respectively...Phylogenetic analysis revealed that bla NDM variants exhibit diverse relationships with Pakistani and worldwide sequences. The significant presence of bla NDM in uropathogens, along with extensive antibiotic resistance, underscores the urgent need for continuous monitoring and antibiotic stewardship programs to manage the growing threat of CRE infections."

Journal • Infectious Disease • Pneumonia