Cystistat (sodium hyaluronate) / China Medical System, Viatris - LARVOL DELTA

IC/BPS: Real-world Evidence Study on Cystistat (clinicaltrials.gov) - P=N/A | N=74 | Active, not recruiting | Sponsor: MEDA Pharma GmbH & Co. KG | Recruiting ➔ Active, not recruiting

Enrollment closed • HEOR • Real-world • Real-world evidence • Interstitial Cystitis • Musculoskeletal Pain • Pain

Cystoscopic application of PuraStat® in the treatment of radiation-induced haemorrhagic cystitis. (PubMed, Ann R Coll Surg Engl) - "We continue to monitor the effects in the medium and long term. Based on current data, PuraStat® haemostatic agent therapy may be considered for RHC, when traditional treatments are ineffective or infeasible, potentially eliminating the need for more aggressive therapy such as cystectomy."

Journal • Oncology

IC/BPS: Real-world Evidence Study on Cystistat (clinicaltrials.gov) - P=N/A | N=74 | Recruiting | Sponsor: MEDA Pharma GmbH & Co. KG | Not yet recruiting ➔ Recruiting | Trial completion date: Dec 2023 ➔ Mar 2025 | Trial primary completion date: Aug 2023 ➔ Jan 2025

Enrollment open • HEOR • Real-world • Real-world evidence • Trial completion date • Trial primary completion date • Interstitial Cystitis • Musculoskeletal Pain • Pain

IC/BPS: Real-world Evidence Study on Cystistat (clinicaltrials.gov) - P=N/A | N=74 | Not yet recruiting | Sponsor: MEDA Pharma GmbH & Co. KG

HEOR • New trial • Real-world evidence • Interstitial Cystitis • Musculoskeletal Pain • Pain

Effect of Glycosaminoglycan Replacement on Markers of Interstitial Cystitis In Vitro. (PubMed, Front Pharmacol) - " The data presented in this study reveal that commercial intravesical formulation support cell viability and migration. In addition, the commercial GAG formulations have a mild anti-inflammatory effect in the in vitro model of interstitial cystitis/bladder pain syndrome."

Journal • Immunology • Inflammation • Interstitial Cystitis • Musculoskeletal Pain • Pain • CXCL8 • ICAM1 • MMP2 • TIMP1 • TNFA

Intravesical sodium hyaluronate for treatment of cystitis & bladder pain in women with pelvic malignancies (ESGO 2019) - "All patients without history of malignancy (4/4) reported some improvement, and of these 75% (3/4) reported significant change. Conclusion Bladder instillation of sodium hyaluronate was effective in reducing the symptoms of radiation cystitis in women treated for gynaecological malignancies."

Clinical