naproxen / Generic mfg. - LARVOL DELTA

In Silico, In Vitro, and In Vivo Antinociceptive Potential of S-Naproxen Derivatives. (PubMed, ChemistryOpen) - "The molecular simulation studies showed that all the tested compounds had good binding interactions with COX-1/COX-2, except GMO-I-9a. In conclusion, the tested naproxen derivatives might have a significant analgesic effect."

Journal • Preclinical • Pain

What's in a Name: Interesting and Challenging Entities of the Tubular GI Tract (USCAP 2026) - "She was diagnosed with likely irritable bowel syndrome (IBS) and treated with amitriptyline and Buscopan...She was also prescribed a combination tablet of naproxen and esomeprozole to take during menstrual cycles...Examples from each of these categories will be reviewed with an emphasis on pitfalls that my lead to an erroneous diagnosis of IBD. Evening Specialty Presentation (PDF): Click to View"

Constipation • Crohn's disease • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Inflammatory Bowel Disease • Ulcerative Colitis • IL17A

Impacts of non-steroidal anti-inflammatory drugs on Phragmites australis root exudation throughout plant life cycle: Defense responses and phytoremediation potential. (PubMed, J Environ Sci (China)) - "This study investigated the root exudate profiles of Phragmites australis across its life cycle under exposure to an environmental-level mixture of NSAIDs (diclofenac, ibuprofen, indomethacin, ketoprofen, and naproxen; 100 ng/L each). The decline in root-exudated amino acids, such as glutamate, glutamine, proline, γ-aminobutyric acid, serine, threonine, valine, glycine, and isoleucine, suggests their increased utilization within plants to counteract NSAIDs-induced oxidative stress. Conversely, the enhanced secretion of organic acids, including quinate, tartrate, citrate, propanoate, malonate, malate, and oxalate, likely reduces root uptake of NSAIDs by increasing root-pollutant repulsion mediated by these compounds and recruiting bacteria capable of NSAID degradation via quinate co-metabolism."

Journal

Dual-Action NSAID-Gold(I) Alkynyl Hybrids for Synergistic Anti-Inflammatory and Anticancer Therapy of Colorectal Cancer. (PubMed, Inorg Chem) - "Complexes based on naproxen, ibuprofen, and salicylic acid derivatives display potent antiproliferative activity against Caco-2/TC7 colon cancer cells, outperforming oxaliplatin and being comparable to auranofin, while showing markedly reduced cytotoxicity in breast cancer lines and nonmalignant cells, thus indicating promising selectivity. Additionally, complex 1 selectively inhibits the enzyme cyclooxygenase-2 (COX-2) over COX-1 and reduces IL-8 expression without affecting PTGS2 transcription, highlighting a post-transcriptional anti-inflammatory action. These results support NSAID-derived alkynyl gold(I) complexes as promising multitarget agents for colorectal cancer intervention, combining disruption and COX-2 modulation."

Journal • Breast Cancer • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor • CXCL8 • PACERR • PTGS2

High- and low-field NMR in binary solvent gradients. (PubMed, Analyst) - "On a benchtop instrument, we demonstrate how our approach enables the transfer of resonance assignments between spectra of the same compound (asarone) acquired in different solvents (methanol and DMSO). We also show that the method can boost the spectral resolution of complex molecular mixtures (naproxen tablet) via the differential solubility of the components in the two solvents."

Journal

Renal Tubular Acidosis Leading to Severe Hypokalemia: An Uncommon Adverse Effect of Nonsteroidal Anti-inflammatory Drugs. (PubMed, Cureus) - "Her medical history was significant for osteoarthritis, for which her pain was controlled with ibuprofen and naproxen. This case emphasizes the importance of considering RTA in the differential diagnosis in the setting of unexplained hypokalemia and metabolic acidosis, especially in the absence of gastrointestinal losses or diuretic use. Discontinuation of NSAIDs with correction of electrolytes is crucial for recovery."

Adverse events • Journal • Fatigue • Immunology • Metabolic Disorders • Osteoarthritis • Pain • Rheumatology

Engineered MnO2/UiO-66-x Heterostructure with Tailored Interfaces for Efficient Capture of NSAIDs: Performance and Mechanistic Insights. (PubMed, Langmuir) - "Structure-activity relationships indicated that NSAIDs adsorption efficiency (naproxen ≈ ibuprofen ≈ ketoprofen > indomethacin > paracetamol) was governed by molecular structure, size, and pKa values. This study establishes a new paradigm for metal-organic-framework-based adsorbent design through precise control of metal-organic interfaces and defect engineering. With 87% capacity retention after 5 regeneration cycles, MnO2/UiO-66-x shows strong potential for practical water remediation applications."

Journal

A Study of SJP-001 in Comparison With Fexofenadine and Naproxen Administered With Alcohol (clinicaltrials.gov) - P1/2 | N=47 | Completed | Sponsor: Sen-Jam Pharmaceutical

New P1/2 trial

Study of Nonsteroidal Anti-inflammatory Drugs in People With Painful Knee Osteoarthritis (clinicaltrials.gov) - P4 | N=20 | Active, not recruiting | Sponsor: Northwestern University | Trial completion date: Sep 2026 ➔ Sep 2027 | Trial primary completion date: Jun 2026 ➔ Jun 2027

Trial completion date • Trial primary completion date • Immunology • Musculoskeletal Pain • Osteoarthritis • Pain • Rheumatology

Severe Drug-Induced Anaphylaxis After Naproxen Sodium Administration: A Case Report (EAACI 2026) - No abstract available

Case report • Clinical • Immunology

CFA-1042-1-24: Single dose, open-label, laboratory blinded, randomized, 2-treatment, 2-period, 2-sequence, crossover, pivotal study to assess the relative bioavailability of Test Product Naproxen sodium 660 mg modified release tablets to Reference Product Actromadol 660 mg Modified-Release tablets in healthy adult male and female subjects under fed conditions. (clinicaltrialsregister.eu) - P1 | N=32 | Recruiting | Sponsor: Laboratorios Cinfa S.A. | Not yet recruiting ➔ Recruiting

Enrollment open

Analytical Quality by Design-Guided Optimisation and Validation of a Short-Run Stability-Indicating Reverse-Phase Ultra-Fast Liquid Chromatography (RP-UFLC) Method for the Quantitation of Nonivamide. (PubMed, Biomed Chromatogr) - "Naproxen served as the internal standard...Stress studies revealed NON stability under most conditions, except alkaline and oxidative stress, whereas specificity was confirmed by detection in the presence of degradants. Overall, the developed method is robust, reproducible, reliable and environmentally considerate, enabling accurate NON quantification from pharmaceutical bulk."

Journal • Pain

Intentional Naproxen Overdose Causing Metabolic Acidosis: A Case Report. (PubMed, Cureus) - "We describe the case of a 24-year-old female who presented to the Emergency Department after an intentional multidrug overdose involving naproxen, hydroxyzine, and clonazepam. This case report aims to illustrate that large doses of naproxen may contribute to metabolic acidosis in overdose situations. In cases of intentional ingestions involving multiple substances, clinicians should consider NSAIDs as potential contributors to acid-base abnormalities, particularly when more common causes are excluded."

Journal • Metabolic Disorders

Adverse events related to drug-drug interactions in tocilizumab combination therapy: a retrospective analysis and clinical implications. (PubMed, Front Med (Lausanne)) - "The most significant DDI-related AEs identified for specific TCZ drug combinations were as follows: with DMARDs (e.g., methotrexate, hydroxychloroquine, and leflunomide), occurrence of anti-cyclic citrullinated peptide (CCP) positivity, hand deformity, and pemphigus were observed; with glucocorticoids (specifically prednisone), pemphigus, hand deformity, glossodynia, and pericarditis should be monitored; with NSAIDs (specifically diclofenac), heightened vigilance is warranted for anti-CCP positive, rheumatic fever, duodenal ulcer perforation, and Helicobacter infections. Age and sex influence DDI risks: adults (≥18 years) were more susceptible to infusion reactions with TCZ + hydroxychloroquine or TCZ + sulfasalazine, and to joint swelling with TCZ + naproxen. Male patients demonstrated a higher incidence of stomatitis with TCZ + methotrexate, and of joint swelling with TCZ + ibuprofen or TCZ + naproxen. Female patients were more susceptible to infusion-related reactions..."

Adverse events • Journal • Retrospective data • Cardiovascular • Dental Disorders • Immunology • Infectious Disease • Musculoskeletal Diseases • Peptic Ulcer • Rheumatology • Stomatitis

Chronic nonbacterial osteomyelitis: a typical case and review. (PubMed, Front Pediatr) - "Treatment included NSAIDs, intravenous antibiotics, and oral medications such as diclofenac sodium, naproxen, methotrexate, and calcitriol...After escalation to intravenous pamidronate and subcutaneous adalimumab, the patient achieved sustained clinical remission...This case underscores the complexity of diagnosing and managing CNO, highlighting the need for a multidisciplinary approach. Further research is essential to establish standardized diagnostic criteria and optimize treatment strategies for this rare condition."

Journal • Review • Infectious Disease • Inflammation • Oncology • Orthopedics • Pain

CARDIORENAL SAFETY OF NSAIDS IN PATIENTS WITH ARTHRITIS: A NETWORK METANALYSIS (ACC 2026) - " We included 23 studies (19 RCTs, 4 cohort) with 1245,108 patients,NSAIDs evaluated were Naproxen (n=69,209),Ibuprofen(n=535,651), Celecoxib(n=107,493),oral Diclofenac (n=335,154),Rofecoxib (n=105,102), Nabumetone (n=507),Valdecoxib (n=5,075), Meloxicam (n=27,713),Piroxicam (n=14,585),Mefenamic acid (n=13,856),Indomethacin (n=26,254),placebo (n=4192), Acetaminophen (n=287),and Amtolmetin guacil (n=30).Compared to placebo, Valdecoxib had highest odds of MACE [OR: 2.96 (95%CI:1.80-4.85)] and Rofecoxib highest odds of renal AEs [OR: 5.11 (95%CI: 2.58-10.10)].League tables showed no differences between different NSAIDs, SUCRA rankings identified Celecoxib with highest MACE and Rofecoxib with highest renal risk (Figure). Valdecoxib and Rofecoxib confer the highest cardiorenal risks. SUCRA rankings ranked Celecoxib as highest for MACE risk and Rofecoxib for renal risk, underscoring the importance of NSAID-specific safety profiles to guide arthritis treatment decisions."

Clinical • Cardiovascular • Immunology • Rheumatology

Sweet Syndrome Masquerading as Sporotrichosis: A Novel Association with Adrenal Adenoma (AAD 2026) - "She received repeated courses of itraconazole, cephalexin, and naproxen from infectious disease specialists, yet lesions recurred independent of gardening exposures...Lesions temporarily resolved with triamcinolone 0.1% ointment...Given the absence of other causes, we propose this functional adrenal adenoma, with potential for hormone dysregulation and neutrophilic infiltration, as the most likely driver of her recalcitrant SS. To our knowledge, this represents the first reported case of sweet syndrome secondary to an adrenal adenoma."

Dermatitis • Dermatology • Discoid Lupus Erythematosus • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Musculoskeletal Pain • Rare Diseases • Sarcoidosis • Vasculitis

Lightning strikes thrice: a case report of triple positive ANCA associated vasculitis (UKKW 2026) - "She had taken short courses of traditional Chinese medicine herbal remedies, ibuprofen, naproxen, and omeprazole for treatment of her joint stiffness...She was treated for Anca-Associated Vasculitis (AAV) with rituximab and cyclophosphamide: the prednisolone was later converted to avacopan. Hepatitis B core antibody was positive so she was also started on lamivudine prophylaxis...Few cases have been described where other autoantibodies are also positive. Patient’s consent: the patient has given verbal documented consent and written consent for publication."

Case report • Clinical • ANCA Vasculitis • Glomerulonephritis • Hepatitis B • Hepatitis C • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Lupus Nephritis • Nephrology • Renal Disease • Vasculitis

Chloride ions accelerated the removal of naproxen in Cu(II)/peracetic acid system: Promotion of copper cycling through the formation of copper-chloride complexes. (PubMed, Water Res) - "In addition, the Cl-/Cu(II)/PAA system was remarkably resistant to common water matrices. In summary, this study presents a simple yet viable strategy to enhance the oxidizing capacity of the Cu(II)/PAA system across a wide pH range, demonstrating its potential applicability in treating high-salinity wastewater."

Journal

Periconceptional Use of Analgesics and Severity of Structural Birth Defects. (PubMed, Clin Pharmacol Ther) - "aORs for each severity group in association with use of acetaminophen combined with oxycodone approximated the null and those for ibuprofen, naproxen, and aspirin ranged between 1.15 and 1.28. In consideration of severity of birth defects, our findings indicate both safer and riskier analgesic medication options are available."

Journal • Cough • Pain • Respiratory Diseases

Comparing the Effect of Drug, Sodium Carboxymethyl Cellulose and Other Excipients on Shape, Size and Drug Release from the Matrices. (PubMed, Int J Pharm Compd) - "The swelling rate of the different matrices was constrained only by NaCMC. The ratio of anionic NaCMC primarily controlled the release rate of drugs. The shape and size of the matrices, according to the solubility and charge of these drugs. Other excipients, such as surfactants, lactose, and magnesium stearate, affected the release rate of the drugs, shape and size of the matrices but did not influence their swelling rate."

Clinical • Journal

Engineered Peptide Coassembly Enables Precision Delivery of As(III)-Peptide Complexes and Counteracts Inflammation-Dependent Therapeutic Resistance in High-Risk Neuroblastoma. (PubMed, ACS Nano) - "While arsenic trioxide (As(III)) demonstrates therapeutic potential through ferroptosis induction, its clinical application is severely constrained by dose-limiting systemic toxicity and consequent inflammation-mediated COX2/PGE2 pathway activation, which confers ferroptosis resistance...TCADS comprises two rationally designed self-assembling peptides incorporating As(III)-binding domains, tumor-selective targeting moieties (MMP9-responsive and Tenascin C-targeting motifs), and the COX2 antagonist naproxen (NPX)...This precision-targeted approach empowers TCADS to effectively disrupt the deleterious inflammation-ferroptosis resistance cycle, thereby successfully overcoming treatment resistance and suppressing tumor progression by 85.0% and 95.4% in subcutaneous and orthotopic tumor models, respectively. This integrated paradigm of precision-targeted delivery coupled with microenvironment modulation establishes a compelling therapeutic framework for chemoresistant HR-NB..."

Journal • Inflammation • Neuroblastoma • Oncology • Pediatrics • Solid Tumor • MMP9 • MYCN

Cryogenic auriculotherapy reduces pain and opioid use in patients undergoing endoscopic carpal tunnel release surgery: a retrospective analysis. (PubMed, Front Pain Res (Lausanne)) - "The primary end points were overall consumption-expressed as the area under the curve (AUC) for oral morphine equivalent (OME) in mg-and pain scores between POD1 and POD3...Naproxen consumption was not significantly different...Our study suggests that cryogenic AT is an effective complementary alternative to opioids to control postoperative pain following CTR. Further investigations are required to confirm these findings."

Journal • Retrospective data • Anesthesia • Pain

Nonsteroidal Anti-Inflammatory Drug Use in Orthopaedic Surgery Practice is Increasing: A Review of Medicare Part D Claims from 2013 to 2021 (AAOS 2026) - "The use of ketorolac, meloxicam, diclofenac, celecoxib, and ibuprofen significantly increased with time while the use of naproxen, nabumetone, etodolac, sulindac, piroxicam, and indomethacin significantly decreased (Table 2). Outpatient NSAID prescriptions by orthopaedic surgery providers increased between 2013 and 2021and is likely underestimated by these data as the majority of NSAIDs are available as over the counter medications. Further study is needed to identify if these practice patterns represent rising use in the setting of fracture surgery as historically this has been the subspecialty where their use was most limited."

Medicare • Reimbursement • Review • Surgery • US reimbursement • Musculoskeletal Diseases • Orthopedics

Synthetic Tetrahydrocannabinol (THC) is a Safe Adjunct to the Treatment of Postoperative Pain after Arthroscopic Knee Surgery: A Pilot Randomized Safety Trial (AAOS 2026) - "Exclusion criteria included patients under the age of 18, patients unable to provide consent, patients who are pregnant, breastfeeding, or trying to become pregnant, patients with an allergy to any of the study drugs, patients undergoing revision surgery or open surgery, patients with a history of mania, depression, or schizophrenia, patients currently diagnosed with alcohol or drug abuse, patients who cannot or will not abide by the medication regimen, or patients taking any of the following drugs: anticholinergic agents, benzodiazepines, central nervous system depressants, droperidol, hydroxyzine, levomepromazine, methotrimeprazine, monoamine oxidase inhibitors, ritonavir, selective serotonin reuptake inhibitors, sympathomimetics, St...Primary outcome for this pilot study was safety of the test drug with the secondary outcome being pain control and number of opioid tablets (hydrocodone-acetaminophen 5-325mg) consumed at 3 different time intervals: 24 hours, 48 hours,..."

Clinical • Surgery • Addiction (Opioid and Alcohol) • Bipolar Disorder • Depression • Immunology • Orthopedics • Pain • Schizophrenia • Xerostomia