naproxen / Generic mfg. - LARVOL DELTA

A Study to Evaluate the Pharmacokinetics and Food-effect of IN-M00002 Tablet in Healthy Adult Volunteers (clinicaltrials.gov) - P1 | N=74 | Not yet recruiting | Sponsor: HK inno.N Corporation

New P1 trial

Multibiomarker assessment of the ecotoxic effects of naproxen in African fresh water catfish (Clarias gariepinus) juveniles. (PubMed, Drug Chem Toxicol) - "The liver enzymes such as alanine aminotransferase, aspartate aminotransfearase and alkaline phosphatase showed a significantly increased level in all the groups exposed to naproxen. The observations from this study revealed that naproxen is toxic to Clarias gariepinus juveniles by the evidenced negative impact on the parameters studied and should, therefore, be closely monitored in the aquatic environment."

Biomarker • Journal • Hematological Disorders • CAT

The Association Between Common NSAID Use and Early Dental Implant Failure: A Large-Scale Retrospective Cohort Study. (PubMed, J Stomatol Oral Maxillofac Surg) - "The use of Ibuprofen and, to a lesser extent, Naproxen, is associated with a significantly increased risk of early dental implant failure, independent of other patient risk factors. Clinicians should consider these findings when formulating post-operative analgesic plans, particularly for patients with complex medical histories."

Journal • Retrospective data • Diabetes • Metabolic Disorders • Osteoporosis • Pain • Rheumatology

From physics to prediction: genetic algorithm-optimized neural network using hansen solubility parameters for pharmaceutical solubility in neat and mixed solvents. (PubMed, Eur J Pharm Biopharm) - "To ensure generality, the MLPANN was trained on 496 experimental solubility values of acetaminophen, diazepam, ibuprofen, lorazepam, and naproxen in both neat and binary solvent systems, including water, ethanol, isopropanol, dioxane, NMP, and propylene glycol. Two scenarios, using the optimized networks, achieved R2 values exceeding 0.99 across training, validation, and testing subsets. Graphical validation-an important aspect often overlooked in previous studies-demonstrated excellent predictive performance for unseen testing data of acetaminophen in isopropanol-water and naproxen in ethanol-water mixtures."

Journal

Removal of contaminants from wastewater using the bivalve Corbicula fluminea - Comparative assessment of biofiltration and biosorption. (PubMed, J Environ Manage) - "Clams were more effective than shells in removing fluoxetine, paracetamol, carbamazepine, metformin and diclofenac whereas the opposite was observed for caffeine and naproxen. Indeed, the remarkable toxicity reduction to the microalgae exposed to the biofiltered fluoxetine sample matches the pronounced removal %, confirming the beneficial effect of C. fluminea on the quality of water contaminated with this compound. Although biofiltration outperformed biosorption in general, the requirements for clams' maintenance and the risk of spreading this invasive species might constitute a drawback for the use of this species for bioremediation of contaminated wastewaters, highlighting the importance of analyzing the pros and cons of these approaches for each specific application."

Journal

Model-Based Meta-Analysis With MonolixSuite: A Tutorial for Longitudinal Categorical and Continuous Data. (PubMed, CPT Pharmacometrics Syst Pharmacol) - "Two case studies are presented: the first examining naproxen in osteoarthritis and the second evaluating canakinumab compared to existing treatments in rheumatoid arthritis. Furthermore, it illustrates how to use the model in Simulx to support the decision-making process, such as by simulating clinical trials. This step-by-step guidance offers practical insights for leveraging MBMA in model-informed drug development."

Journal • Retrospective data • Immunology • Osteoarthritis • Pain • Rheumatoid Arthritis • Rheumatology

Decoherence Principles and Algorithms for One-Dimensional Nonuniform Sampling Schedules for Multidimensional NMR. (PubMed, Anal Chem) - "These algorithms are implemented in a hands-free scheduler for one-dimensional NUS and tested with both iterative soft thresholding (IST) and iterative line shape (SMILE) reconstructions. While varying degrees of sampling noise are still expected, particularly in sparser NUS conditions, these methods reduce larger spectral artifacts and perform more consistent design of schedules for broader use, as illustrated with sodium naproxen, strychnine, and u-13C,15N-ubiquitin for weighted (e.g., quantile, Poisson gap, exponential), and random unweighted (RU) NUS, though limitations of sparse RU-NUS should be considered."

Journal • Targeted Protein Degradation

Duloxetine for LBP (clinicaltrials.gov) - P4 | N=120 | Recruiting | Sponsor: Montefiore Medical Center | Trial completion date: May 2026 ➔ May 2027 | Trial primary completion date: May 2026 ➔ May 2027

Trial completion date • Trial primary completion date • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Pain

Investigation of the pain reduction and migraine-associated symptoms in the treatment of migraine attack in a real-world setting of Austrian patients after the introduction of Sumatriptan 85mg/Naproxen-Natrium 500mg combination tablet (EHF-EHC 2025) - "Sumatriptan 85mg/Naproxen Natrium 500mg combination tablet was effective and generally well tolerated in the treatment of our patients presenting with migraine headaches. These data provide insights into real-word utilisation of the new combination tablet Sumatriptan 85mg/Naproxen Natrium 500mg in the treatment of acute migraine attacks."

Clinical • Real-world • Real-world evidence • CNS Disorders • Migraine • Musculoskeletal Pain • Pain

Paracetamol (Acetaminophen) and caffeine combination in headache management (EHF-EHC 2025) - "Two other TTH clinical trials have shown that the efficacy and safety of combination was comparable to Naproxen 550 mg and Ibuprofen 400 mg. One randomized, cross-over trial has shown a comparable efficacy/safety profile of the combination vs sumatriptan 50 mg in treatment of migraine attack. No data are available on the risk of medication overuse with the combination compared to paracetamol alone. Caffeine accelerates and prolongs the analgesic effect of paracetamol over time with a significant improvement of pain relief in patients with primary headaches without added safety issues."

CNS Disorders • Migraine • Pain • ADORA2A

Efficacy of JOINS Tablet for Lumbar Spinal Stenosis: Prospective, Randomized, Open-Label Clinical Trial. (PubMed, Medicina (Kaunas)) - "The control group was prescribed the usual spinal stenosis medications (Naproxen, Limaprost, and Pregabalin), while the test group was prescribed JOINS tablets in addition to the usual medications...At all follow-up periods, the functional outcomes did not show statistically significant differences between the test and control groups. The significant reduction in pain suggests that JOINS tablets may be an effective adjunct for pain relief, particularly in patients at high risk of adverse effects from long-term NSAID use."

Clinical • Journal • Back Pain • Inflammation • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

Design, In Silico, and Experimental Evaluation of Novel Naproxen-Azetidinone Hybrids as Selective COX-2 Inhibitors. (PubMed, Molecules) - "Molecular docking revealed high COX-2 binding affinities (-11.93 to -9.72 kcal/mol), while MM/GBSA analysis identified compound N4c (ΔG = -62.27 kcal/mol) as the most stable complex, surpassing meloxicam and naproxen. In vivo anti-inflammatory testing using an egg-white-induced rat paw edema model showed that N4d, N4e, and N4f achieved higher inhibition (19.22%, 16.98%, and 16.98%) than naproxen (4.3%). These results highlight 2-azetidinone-naproxen hybrids as promising selective COX-2 inhibitors with enhanced pharmacokinetic and electronic properties."

Journal

Corrosion-Modulating Effect of Pharmaceutical Agents in a Hybrid Coating System on Pure Magnesium. (PubMed, J Funct Biomater) - "Gentamicin, naproxen, streptomycin, ciprofloxacin and paracetamol were found to be corrosion accelerators with respect to bare h.p. Mg, whereas aspirin was found to be an inhibitor. Streptomycin-functionalized PEO/PCL system exhibited an active protection mechanism, triggered upon the release of the coating and substrate cations, associated with the coating defect-blocking action of the insoluble Me(II)-streptomycin chelates."

Journal

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Use Is Associated With an Increased Risk of Femoral Osteonecrosis in Migraine Patients: A Retrospective, TriNetX Database-Based Study. (PubMed, Cureus) - "The first cohort included patients aged 18 to 50 who had a diagnosis of migraine, no history of femoral neck fractures, and were prescribed any of the following NSAID medications: naproxen, aspirin, diclofenac, or ibuprofen. Similarly, stratified analyses showed significant findings in males (RR = 3.897, 95% CI: 2.986-5.086; OR = 3.902, 95% CI: 2.989-5.094) and females (RR = 3.441, 95% CI: 2.872-4.122; OR = 3.443, 95% CI: 2.874-4.124; all p < 0.0001). Conclusions These findings are concerning, given the widespread use of NSAIDs for migraine management, as they may contribute to reduced blood flow to the femur and eventual ischemia."

Journal • Retrospective data • Cardiovascular • CNS Disorders • Migraine • Musculoskeletal Diseases • Orthopedics • Pain

Naproxen printlets for extemporaneous dispersion: Designing new medicines for drug delivery through the enteral route. (PubMed, Eur J Pharm Biopharm) - "Re-dispersed printlets had reduced vascular event compared to positive controls in Hen's Egg Test - Chorioallantoic Membrane (HET-CAM) assay (in vitro alternative model) and were classified as slight irritants. This study provides an innovative route for drugs presenting gastric irritation, advancing SSE 3D printing for personalised EFT medicines."

Journal • Gastrointestinal Disorder • Otorhinolaryngology

REB methodology application on topical and oral NSAIDS' therapeutic benefit evaluation on acute pain related to musculoskeletal injuries (PubMed, Therapie) - "According to REB methodology, topical NSAIDs, unlike oral formulations, have demonstrated efficacy in managing acute pain related to musculoskeletal injuries. These results reinforce recent meta-analyses favoring topical NSAIDs and recommending to limit the use of oral NSAIDs due to a lack of proof in this indication. Finally, NSAIDs impact on tissue healing has not been objectively studied by RCTs in humans, so further research is warranted. The use of NSAIDs in trauma care may potentially evolve as new data and knowledge emerge."

Journal • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Enantioseparation by Thin-Layer Chromatography. (PubMed, Methods Mol Biol) - "Both pre-coated and custom-prepared TLC plates have been used. (-)-Quinine, (-)-erythromycin, L-(+)-tartaric acid, (S)-naproxen, bovine serum albumin (BSA), and L-amino acids were used as chiral reagents/selectors in different manners for the enantioseparations of (±)-ketamine, (RS)-ketorolac, certain β-adrenergic drugs, and DL-dansyl amino acids, as examples."

Journal

Development of a methodology in an automated system for analysis of naproxen and bezafibrate in in-situ formation using a deep eutectic solvent by liquid chromatography. (PubMed, J Chromatogr A) - "The precision results were lower than 15.9% and recoveries ranged from 71 to 102%. The greenness of the methodology was confirmed using the AGREEprep tool, demonstrating that the proposed strategy offers a sustainable, selective, and high-throughput alternative for the determination of emerging pharmaceutical contaminants in aquatic environments."

Journal

Tailoring adsorption properties of Kekulene nanoring via functionalization for pharmaceutical pollutant removal. (PubMed, J Mol Graph Model) - "Pharmaceutical pollutants such as Diclofenac and Naproxen are emerging environmental contaminants due to their persistence and potential biological hazards...Compared to benchmark materials such as PTX@rGO and FPV@GN, KNR-based adsorbents demonstrated competitive or superior tunability and desorption potential. These results suggest that functionalized KNRs-particularly KNR-NO2-N-are promising candidates for efficient, reversible pharmaceutical pollutant capture in both gas and aqueous environments."

Journal

Structural and functional insights into helical antimicrobial peptide-drug conjugates: a dual-action strategy against infection and inflammation. (PubMed, Bioorg Chem) - "We report the synthesis of twelve α-helical AMP conjugates, which are each composed of one of three AMPs (LL-I, LK6, ATRA-1) covalently linked to ibuprofen (IBF) or naproxen (NPX) via 8-aminooctanoic acid (C8) or 10-aminodecanoic acid (C10) spacers, selected based on prior lipidation-activity correlations. All lead conjugates demonstrated potent, broad-spectrum antimicrobial activity with negligible cytotoxicity at bactericidal concentrations. These results highlight NSAID conjugation as a tunable strategy to modulate AMP structural dynamics and introduce dual antimicrobial-anti-inflammatory functionality."

Journal • Infectious Disease • Inflammation

Fluorescent Carbon Dots Decorated with ONN Donor Sites by Using Schiff Base Silatrane for Selective Recognition of Mefenamic Acid in Environmental Samples. (PubMed, Langmuir) - "The ONN donor sites in CDs@SBONN interact with the mefenamic acid (MA) selectively out of different drugs (such as ibuprofen, acetylsalicylic acid, naproxen, diclofenac, and ketoprofen), amino acids (like glycine, valine, and alanine), excipients (like glucose and urea), cations (like Cd2+, Cu2+, Fe3+, and Cr3+), and anions (like Cl-, AcO-, NO3-, and SO42-), and display a quenching signal at λems = 460 nm (λexc = 360 nm). The standardization of the analytical method offers applicability of CDs@SBONN for the evaluation of MA with high accuracy and recovery range in pharmaceutical samples (89.42-102.55) and river water (98.05-100.79) with a relative standard deviation of <5%. Thus, CDs@SBONN can have a promising potential application in environmental and biological analysis."

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Box-Behnken design approach for optimizing the removal of non-steroidal anti-inflammatory drugs from environmental water samples using magnetic nanocomposite. (PubMed, Sci Rep) - "This study investigated the removal of naproxen (NAP) and diclofenac (DIC) from aqueous solutions using an Fe3O4/ZnO/GO magnetic composite...Finally, the FZG composite was tested on tap water, wastewater, and river water, achieving removal efficiencies of 81.53-97.91%. Our findings revealed that the FZG composite is an efficient, reusable, and practical adsorbent for removing NAP and DIC from real water sources, highlighting its high potential for sustainable water treatment applications."

Journal

Symptomatic Management of Lyme Arthritis (clinicaltrials.gov) - P3 | N=3 | Terminated | Sponsor: Desiree Neville, MD | N=300 ➔ 3 | Trial completion date: Dec 2030 ➔ May 2025 | Suspended ➔ Terminated | Trial primary completion date: Dec 2030 ➔ May 2025; Study with overlapping patient population

Enrollment change • Trial completion date • Trial primary completion date • Trial termination • Immunology • Infectious Disease • Inflammatory Arthritis • Lyme Disease • Rheumatology

Pain rating variability and response to treatment in osteoarthritis clinical trials. (PubMed, J Pain) - "We retrospectively analyzed data from 345 knee OA patients enrolled in two randomized, double-blind trials comparing naproxen (500 mg BID; n=190) to placebo (n=155)...Its consistent association with treatment response-regardless of intervention-supports its value as a predictive marker. Incorporating variability into clinical trial design may enhance outcome sensitivity and improve patient stratification."

Clinical • Journal • Immunology • Musculoskeletal Pain • Osteoarthritis • Pain • Rheumatology

Patient Information Awareness and NSAID Usage Patterns in Mexico: Insights from an Online Survey (Neuroscience 2025) - "Respondents reported high familiarity with paracetamol (96%), ibuprofen (91%), and aspirin (81%), but low recognition of naproxen (0.8%). Notably, several reported symptoms (such as lethargy and anxiety), may reflect effects on the central nervous system, suggesting that NSAIDs are also used in neurological contexts, such as migraine management and neuroinflammation modulation. These results emphasize the need for improved communication of neurological risks in patient-directed informational materials."

Clinical • CNS Disorders • Migraine • Mood Disorders • Psychiatry