naproxen / Generic mfg. - LARVOL DELTA

Symptomatic heterozygous Gitelman syndrome in a professional baseball player: a case report. (PubMed, J Osteopath Med) - "Management included individualized potassium and magnesium supplementation, naproxen sodium 220 mg daily, and pre-exercise iontophoresis to reduce sweating...This case highlights the diagnostic challenge posed by an incomplete GS phenotype in a high-performance athlete and the importance of correlating clinical, biochemical, and genetic findings. Heterozygous SLC12A3-associated salt-wasting physiology should be considered in athletes with persistent compatible symptoms and evidence of inappropriate renal electrolyte loss, while alternative acquired and endocrine causes are evaluated."

Journal • Endocrine Cancer • Fatigue • Metabolic Disorders • Nephrology • SLC2A3

Development of Sustained Release Chitosan/β-Glycerol Phosphate-Based Injectable Thermo-Gels Containing Naproxen Sodium: In-Vitro and In-Vivo Evaluation. (PubMed, Pharm Res) - "In-situ chitosan/β-glycerol gel-forming injectable formulation F6CGP provides sustained naproxen sodium release and shows potential as a therapeutic strategy for chronic inflammatory conditions such as arthritis. The results also indicate that this polymeric system can play a key role in modulating critical formulation parameters i.e. gelation time, gel fraction, injectability, drug release etc."

Journal • Preclinical • Immunology • Inflammation • Inflammatory Arthritis • Rheumatology

Drugs for acute treatment of migraine. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Migraine • Pain

Sensitive electrochemical sensor for selective detection of chiral amino acids based on covalent organic framework-cyclodextrin-gold nanocomposite. (PubMed, Anal Chim Acta) - "The enantioselectivity of the sensor was evaluated by monitoring methylene blue redox signals, enabling chiral discrimination of phenylalanine, tryptophan, tyrosine, histidine, propranolol, and naproxen. COF-V substrate enhanced electrode surface area and stability. Synergy of AuNPs-cyclodextrin and chitosan for improving chiral recognition."

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Determination of 33 non-steroidal anti-inflammatory drug residues in horse urine by QuEChERS-ultra performance liquid chromatography-tandem mass spectrometry (PubMed, Se Pu) - "The results revealed the presence of three NSAIDs， including ketorolac， lornoxicam and naproxen， with contents ranging from < LOQ to 6.87 μg/L. Lornoxicam is a banned substance and is strictly prohibited for use in horses at any time. The proposed method is simple， efficient and accurate， and is suitable for the simultaneous determination of the 33 NSAIDs residues in horse urine samples."

Journal • Inflammation • Pain

WHEN PAIN RELIEF LEAVES YOU BREATHLESS: A RARE CASE OF NAPROXEN-INDUCED EOSINOPHILIC PLEURAL EFFUSIONS (CHEST 2026) - No abstract available

Clinical • Pleural effusion • Pain • Respiratory Diseases

How Organ Manifestations Beyond the Bone May Guide Risk Stratification and Treatment Decisions in Chronic Nonbacterial Osteomyelitis. (PubMed, Paediatr Drugs) - "While chronic nonbacterial osteomyelitis limited to bones frequently responds to anti-inflammatory treatment with naproxen or, in more severe cases, tumor necrosis factor inhibitors and/or osteoclast inhibition with bisphosphonates, patients with additional symptoms may require additional/different treatments targeting effector T cells and associated cytokines (such as interleukin-17 blockers, Janus kinase inhibitors)...This article reviews the available literature, deciphering shared immune mechanisms between chronic nonbacterial osteomyelitis and associated diseases that may guide individualized care. It focuses on shared and disease-specific molecular and cellular patterns of chronic nonbacterial osteomyelitis and associated diseases, delivering arguments for disease stage and phenotype specific treatments, including cytokine blockers and synthetic small-molecule inhibitors."

Journal • Review • Hepatology • Inflammation • Oncology • Orthopedics • Pain

Pharmacological Interventions for the Prevention of Esophagitis in Lung Radiation: Systematic Review and Meta-Analysis (IASLC-WCLC 2026) - "Eight trials reported survival or treatment response outcomes, all of which showed no difference between trial arms Conclusions : Previous clinical trials have investigated the role of amofostine, epoetin-alpha, indomethacin, naproxen, glutamine and sodium alginate in preventing radiation-induced esophagitis in lung cancer. Pooled analysis demonstrates promising results for amfostine."

Retrospective data • Review • Gastrointestinal Disorder • Lung Cancer • Solid Tumor

Enzymatically triggered in situ gelation of a multifunctional peptide for localized controlled release and conformal fracture repair. (PubMed, J Control Release) - "Moreover, the resulting nanofibrous hydrogel, which presents peptide-bound naproxen and fluorinated motifs, was associated with a less inflammatory and more repair-supportive macrophage-associated marker profile, enhanced osteogenic marker expression, and improved radiographic and histological fracture repair in a murine model. This study adapts a promising ALP-instructed peptide self-assembly strategy to the fracture-repair microenvironment through a multifunctional precursor design, providing a local shape-conformal and bioactive hydrogel platform with potential for complex fracture repair."

Journal • Musculoskeletal Diseases • Orthopedics

Quantitative Environmental Monitoring of Pharmaceuticals in Complex Matrices using Isoreticular Ln-BDC Frameworks through Non-Covalent Interactions. (PubMed, Methods Appl Fluoresc) - "While exhibiting a maximum adsorption of 50.2% for naproxen on Dy 2 (BDC) 3 , highlighting the influence of EC functional groups, the materials demonstrate superior functionality as a luminescent sensor. Notably, ciprofloxacin adsorption induces a significant and specific luminescence enhancement (up to 202.24% for Eu-MOF), suggesting great potential for luminescence-based chemical sensing applications. The consistent fitting to the Freundlich model supports the occurrence of adsorption on energetically heterogeneous surfaces. These findings underscore the versatility of Ln-MOF for environmental monitoring through a mechanism that combines adsorption and modulated luminescence."

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Unraveling the R-Enantiomer Preference in Mirror-Image Cyclodextrin: An Integrated Multiscale Computational Study. (PubMed, J Chem Inf Model) - "Herein, a multiscale computational framework integrating high-throughput molecular docking, molecular dynamics (MD) simulations, and density functional theory (DFT) calculations was developed to elucidate the chiral recognition mechanism of L-CD toward three clinically drugs, namely baclofen (Bacl), naproxen (Nap), and propranolol (Prop). Energy decomposition analysis further reveals that reduced steric hindrance and favorable electrostatic interactions contribute to the enhanced stability of R-enantiomer complexes. This multiscale framework provides atomic-level insights into dynamic chiral recognition by L-CD and establishes a robust theoretical foundation for the rational design of next-generation L-CD-based chiral separation materials."

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PDM-01 - Kenvue Breakfast Double Down on Pain Relief: A New Option for Multimodal Approaches to Pain Relief (PAINWeek 2026) - "Get a first look at the clinical evidence behind a new FDA-approved OTC fixed-dose combination of acetaminophen and naproxen sodium for multimodal pain relief. Hear expert and patient perspectives on the full clinical program results, including considerations for the role of this non-opioid option in real-world pain management."

CNS Disorders • Pain

WRK-03 - Kenvue OTC Workshop Expert Roundtable - Double Down on Pain Relief: A New Fixed-dose Combination for Pain Management (PAINWeek 2026) - "Explore the clinical evidence behind a new FDA-approved OTC fixed-dose combination of acetaminophen and naproxen sodium, with multidisciplinary expert commentary on its implications for your pain management toolkit. Bring your questions - answered live by our expert panel."

CNS Disorders • Pain

Analgesic Effectiveness of a New Fixed-Dose Combination Acetaminophen/Naproxen Sodium: A Phase 3 Placebo-controlled, Randomized, Double-blind, Factorial Trial in Post-operative Dental Pain (PAINWeek 2026) - "Among 447 factorial trial participants, 59.5% reported severe pain and 93.7% had 4 third molars extracted. Among 279 POC trial participants, 65.5% reported severe pain and 90.3% had 4 third molars extracted. FDC Acet650/NPX220 participants in the factorial trial reported superior pain control compared to Acet650, NPX220, and PBO participants throughout 12 hours (mean SPID 0-12: 49.3, 24.0, 40.7, 4.1, respectively, each p≤0.003) and during the initial 6 hours (mean SPID 0-6: 27.1, 15.6, 20.3, 1.8, respectively, each p≤0.003)."

Clinical • P3 data • CNS Disorders • Pain

Pharmacokinetic and Mechanistic Rationale for Combining Acetaminophen with Naproxen Sodium: A Systematic Analysis of Temporal and Mechanistic Complementarity (PAINWeek 2026) - "A total of 576 publications were identified for acetaminophen, 351 for aspirin, 294 for ibuprofen, and 75 for naproxen sodium - of which 35 studies for acetaminophen,14 studies for aspirin, 26 studies for ibuprofen, and 4 for naproxen sodium were selected for evaluation based on the inclusion/exclusion criteria. Naproxen sodium was associated with fewer qualifying publications possibly due to limited available formulations and doses compared to multiple APAP and ibuprofen doses/formulations. Sample sizes ranged from 5 to 50 subjects."

PK/PD data • CNS Disorders • Migraine • TRPV1

A Phase 3 Multiple-dose Efficacy and Safety Trial of a Novel Fixed Dose Combination of Acetaminophen and Naproxen Sodium in a Post-surgical Bunionectomy Pain Model (PAINWeek 2026) - "Postsurgical bunionectomy pain is a well-established and reliable pain model that has been used to assess moderate- and high-potency analgesics and support regulatory agency review and approval of many prescription analgesics, including, suzetrigine and hydrocodone bitartrate/acetaminophen... Among 143 randomized participants, mean baseline pain intensity score was 7.6 on PI-NRS with 86 (60.1%) reporting moderate and 57 (39.9%) severe pain. FDC Acet650/NPX220 participants reported greater reductions in pain intensity compared with placebo throughout the trial (SPID 0-12, 15.2 and 2.6, respectively; SPID 0-24 [primary endpoint], 48.4 and 14.2, respectively; SPID 0-48, 151.5 and 68.3, respectively; each p< 0.001). FDC Acet650/NPX220 participants reported significantly greater PID compared with placebo from 3-48 hours (p< 0.05 across timepoints)."

Clinical • P3 data • CNS Disorders • Pain

National Survey of Pharmacists' Practices in OTC Pain Management (PAINWeek 2026) - "[Carrasco-Labra 2024, Qaseem 2020, Dowell 2022] In a population-based online survey of U.S. adults, over-the-counter (OTC) medications were among the most prevalent medications used, with acetaminophen, ibuprofen, aspirin, and naproxen sodium as the most utilized pharmacologic agents... 201 U.S. retail pharmacists who currently counsel patients on OTC pain medications completed the online survey. Most of the respondents practice in chain community pharmacy settings (53%, n=106) and suburban locations (51%, n=102). Over half reported more than 10 years of practice (58%, n=117) and 51% (n=103) counseled more than 50 patients weekly on OTC medications."

Back Pain • CNS Disorders • Musculoskeletal Pain • Pain

Safety of Acute Naproxen Use: A Systematic Review of Secondary Analyses (PAINWeek 2026) - "Of the nine reviews that met the inclusion criteria, four were Cochrane reviews, two were academic meta-analyses, and three were large industry-sponsored pooled analyses. AMSTAR-2 ratings ranged from low to high. An estimated 14,000 patients were included across indications, including postoperative pain, migraine, dysmenorrhea, osteoarthritis, sore muscle, and ankle sprain, with trial overlap across reviews."

Clinical • Review • Addiction (Opioid and Alcohol) • CNS Disorders • Migraine

2026 Taiwan guidelines for the acute pharmacologic treatment of migraine in adults. (PubMed, J Chin Med Assoc) - "Non-specific agents include acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs: diclofenac, ibuprofen, naproxen). Injectable prochlorperazine is also strongly recommended. Ergotamine/caffeine combinations are less effective and are second-line agents, while high-dose aspirin is limited by gastrointestinal risk. Considering the potential risk of dependency, tramadol or tramadol/paracetamol combinations should be reserved until all other agents fail, and should be limited to oral forms. Other opioids, such as morphine, butorphanol, etc., lack evidence and are not recommended...Acetaminophen remains first-line for children and pregnant women. To prevent medication-overuse headache, acute treatments, including NSAIDs, acetaminophen, triptans, ergot derivatives, and combination analgesics, should not exceed two days per week, probably with the exception of rimegepant."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Migraine • Pain

Paraneoplastic Fever in a Patient With Cervical Carcinoma: A Diagnostic Challenge and Management Approach. (PubMed, Case Rep Oncol Med) - "Neoplastic fever should be considered early in cancer patients with persistent unexplained fever, particularly in tuberculosis- and malaria-endemic settings. Following exclusion of infection, the naproxen challenge may provide a simple and affordable diagnostic step to distinguish neoplastic fever from infectious causes, reduce unnecessary antimicrobial use, shorten diagnostic delays, and facilitate timely cancer-directed therapy."

Journal • Cervical Cancer • Infectious Disease • Malaria • Oncology • Pulmonary Disease • Respiratory Diseases • Solid Tumor • Tuberculosis

Avoiding Breakthrough Pain Following Dental Implant Surgery. (PubMed, Compend Contin Educ Dent) - "Because dental implant post-surgical pain is mainly driven by inflammation, nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (eg, Advil'ae, Motrin'ae IB) or naproxen sodium (Aleve'ae) are logical choices to address it. Implant surgeons must be able to identify those patients in whom a short course of NSAIDs can be used safely and employ dosing strategies that provide optimal analgesic efficacy while limiting untoward events. This article discusses current recommendations for postoperative pain management in dental implant patients, emphasizing the role of NSAIDs while addressing patient-specific safety considerations."

Journal • Review • Anesthesia • Inflammation • Pain

Opioid Therapy vs. Multimodal Analgesia in Head and Neck Cancer (OPTIMAL-HN): Results of a Randomized Clinical Trial (ASTRO 2024) - P2 | "HNC patients receiving curative-intent RT/CRT and experiencing moderate 4/10 RIM pain were randomized 1:1, stratified by RT vs. CRT, to opioids alone per institutional standard or MMA (Pregabalin, Acetaminophen, Naproxen, and opioids if required)...Median weekly opioid use was numerically higher in the opioid arm (99.2 mg oral morphine equivalent dose [OMED], IQR: 16.3-173.1) compared to the MMA arm (50.5 mg OMED; IQR: 8.4-126.3), although nonsignificant (p=0.435)... MMA demonstrates non-inferiority to opioid analgesia alone in managing RIM pain during the last week of RT and superiority when analyzing the post-RT time period. MMA is therefore an effective analgesic regimen and should be considered for use in HNC patients."

Clinical • Acute Kidney Injury • Head and Neck Cancer • Mucositis • Nephrology • Oncology • Pain • Renal Disease • Solid Tumor

Enhancement of antibacterial activity and controlled drug release in Polyalphaolefins via chitosan-PAO Nanohybrid strategy. (PubMed, Int J Biol Macromol) - "Furthermore, X-CSPAO nanocomposite was utilized for the drug delivery of Naproxen...These characteristics enhance the potential biomedical applications of X-CSPAO nanohybrid in targeted drug delivery systems. Grafting a silane agent onto the CS surface is a simple, functional, and cost-effective modification."

Journal • Infectious Disease

Effect of Multimodal Pre-emptive Analgesia with Pregabalin Versus Naproxen on Post-Thoracotomy Pain and Opioid Consumption: A Randomized Clinical Trial. (PubMed, Turk J Anaesthesiol Reanim) - "Pregabalin reduced opioid requirement: fewer patients required rescue analgesia (46.2% vs. 69.2%; P=0.042), time to first rescue was longer (7.6±3.1 vs. 5.4±2.8 h; P=0.001), and 24-hour opioid consumption was lower (6.2±3.0 vs. 8.6±3.4 mg morphine equivalents; P=0.001). Dynamic pain during deep breathing and coughing was lower with pregabalin at early time points; sedation was slightly higher at 2 hours, without significant adverse neurocognitive events. Pre-emptive pregabalin improved functional analgesia and produced an opioid-sparing effect compared with naproxen after thoracotomy, with acceptable short-term safety, thereby supporting enhanced recovery pathways."

Clinical • Journal • Anesthesia • Pain

Toxicity of Some Natural Products in the Treatment of Rheumatoid Arthritis. (PubMed, Life (Basel)) - "Additionally, we applied in silico methods to predict pharmacokinetic and toxicological parameters using ADMET Predictor® (Simulation Plus) and compared the results with those of commercial drugs such as diclofenac, ibuprofen, and naproxen. In conclusion, natural products represent viable alternatives for RA therapy. However, further studies are essential to better understand their safety, pharmacokinetics, and drug interactions to ensure their clinical applicability."

Journal • Review • Immunology • Inflammation • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology