remimazolam tosylate (HR-7056) / Jiangsu Hengrui Pharma - LARVOL DELTA

Efficacy and safety of remimazolam tosilate in elderly patients undergoing general anesthesia for bronchoscopy. A randomized controlled trial. (PubMed, BMC Anesthesiol) - P=N/A | "Remimazolam tosilate demonstrated non-inferior safety and efficacy to propofol for general anesthesia during bronchoscopy in elderly patients. Remimazolam was associated with a lower incidence of injection pain and hypotension. Additionally, when reversed with flumazenil, remimazolam provided significantly faster recovery times compared to propofol, potentially enhancing bronchoscopy efficiency."

Clinical • Journal • Anesthesia • Cardiovascular • Hypertension • Hypotension • Pain

Comparison of the clinical effects of remimazolam tosylate and propofol in elderly patients undergoing laparoscopic cholecystectomy: Exploring optimized anesthesia strategies and improving postoperative recovery (ChiCTR) - P1 | N=84 | Recruiting | Sponsor: The First Affiliated Hospital of Kunming Medical University; The First Affiliated Hospital of Kunming Medical University

New P1 trial • Anesthesia

Feasibility Study of the Use of Remimazolam Tosylate During Cardiopulmonary Bypass (ChiCTR) - P=N/A | N=76 | Not yet recruiting | Sponsor: WeiHai Municipal Hospital; WeiHai Municipal Hospital

New trial • Anesthesia

Remimazolam tosilate combined with remifentanil hydrochloride alleviates dental phobia in patients undergoing tooth extraction surgeries. (PubMed, Odontology) - "Moreover, the postoperative systolic blood pressure (122.3 ± 10.5 vs 135.6 ± 12.3 mmHg), heart rate (72.5 ± 8.3 vs 85.6 ± 9.7 beats/min), and other vital signs of the EG were more stable, and the incidence of angina (0.76% vs 2.29%) and hypertension (1.53% vs 3.82%) were significantly reduced (P < 0.05). The combination of RT and RH can effectively alleviate dental phobia in patients undergoing extraction, enhance the effects of sedation and analgesia as well as patient comfort, and has good safety, which is worthy of clinical application and promotion."

Journal • Anesthesia • Cardiovascular • Hypertension • Pain • Psychiatry

Safety and efficacy of repeated remimazolam tosilate sedation in patients receiving interstitial brachytherapy for cervical cancer and its impact on sleep quality (ChiCTR) - P4 | N=100 | Not yet recruiting | Sponsor: Sichuan Cancer Hospital; Sichuan Cancer Hospital

New P4 trial • Anesthesia • Cervical Cancer • Oncology • Solid Tumor

Effects of Remimazolam Tosilate on Postoperative Sleep Disturbances and Recovery Quality in Elderly Obese Patients Undergoing Total Knee Arthroplasty (ChiCTR) - P4 | N=108 | Not yet recruiting | Sponsor: The First Affiliated Hospital of the University of Science and Technology of China(Anhui Provincial Hospital); The First Affiliated Hospital of the Un

New P4 trial • CNS Disorders • Obesity • Orthopedics • Pain • Sleep Disorder

New Application of Remimazolam Tosilate in ICU Ventilation: Benefits in Reducing Iatrogenic Stress and Maintaining Stable Immune Function. (PubMed, Ann Ital Chir) - "Compared with propofol, remimazolam tosilate may offer potential benefits in mitigating iatrogenic stress and preserving immune homeostasis, while ensuring adequate sedation during ICU mechanical ventilation. It could be a promising sedative agent for use in the ICU setting."

Biomarker • Journal • Retrospective data • Anesthesia • Critical care • CD4 • CD8

Efficacy of Different Doses of Remimazolam Tosilate Combined with Esketamine in Painless Abortion Patients: A Prospective, Double-Blind, Randomized Controlled Trial. (PubMed, Drug Des Devel Ther) - "No significant differences were observed among groups for ΔHR, induction time, surgical duration, hypertension, body movement, injection pain, postoperative pain, or patient/surgeon/anesthesiologist satisfaction. Low-dose RT (0.2 mg/kg) combined with esketamine significantly shortens recovery and discharge times, ensures hemodynamic stability, and reduces adverse events, making it the recommended sedation strategy for painless abortion procedures."

Clinical • Journal • Anesthesia • Cardiovascular • CNS Disorders • Depression • Hypertension • Hypotension • Pain • Psychiatry

Prediction Model for Remimazolam Dosing Based on Patient Characteristics to Enhance Anesthesia Management (ASA 2025) - "Background:The combination of alfentanil and remimazolam tosylate is widely used in painless gastroscopy anesthesia. While Logistic Regression performed best, Random Forest is preferred for stability and generalization. BMI and heart rate are key factors in optimizing remimazolam dosing, with gender and administration time having moderate effects. Incorporating patient characteristics into predictive models enhances safety and anesthesia efficacy."

Clinical • Anesthesia • CNS Disorders • Depression • Immunology • Infectious Disease • Psychiatry • Respiratory Diseases

Comparison of remimazolam tosylate and sevoflurane for anesthesia induction with preserved spontaneous respiration during tracheal intubation: a prospective, single-center, randomized controlled trial. (PubMed, Perioper Med (Lond)) - "Compared with sevoflurane, remimazolam can be safely and effectively used for intubation while preserving spontaneous breathing, with a shorter time to achieve conditions for topical anesthesia and intubation."

Intubation • Journal • Anesthesia • CNS Disorders • Cough • Depression • Psychiatry • Respiratory Diseases

Commentary: Determination of the 95% effective dose of remimazolam tosylate in anesthesia induction inhibits endotracheal intubation response in senile patients. (PubMed, Front Pharmacol) - No abstract available

Intubation • Journal • Anesthesia

Comparison of EEG Burst Suppression and Hemodynamic Effects Between Remimazolam Tosilate and Etomidate During General Anesthesia Induction: A Retrospective Analysis. (PubMed, Drug Des Devel Ther) - "Remimazolam tosilate demonstrated notable differences compared to etomidate during general anesthesia induction, including the absence of ESR and different hemodynamic response patterns. While these findings suggest potential advantages for certain patient populations, the retrospective design and ASA classification imbalance limit definitive conclusions, warranting prospective validation studies."

Clinical • Journal • Retrospective data • Anesthesia • Cardiovascular • CNS Disorders • Hypertension

A Study of Remimazolam Tosilate for Prolonged Sedation in the ICU (clinicaltrials.gov) - P1/2 | N=24 | Completed | Sponsor: Jiangsu HengRui Medicine Co., Ltd. | Recruiting ➔ Completed | Trial completion date: Nov 2023 ➔ Mar 2025 | Trial primary completion date: Nov 2023 ➔ Mar 2025

Trial completion • Trial completion date • Trial primary completion date • Anesthesia • Critical care

The Impact of Remimazolam Tosilate on Oxygenation and Postoperative Cognitive Function in Elderly Patients Undergoing Thoracoscopic Lobectomy (clinicaltrials.gov) - P1/2 | N=150 | Not yet recruiting | Sponsor: Jinqiao Qian

New P1/2 trial • Cognitive Disorders

Evaluation of the Impact of Remimazolam Tosylate on Cardiac Function during Anesthesia Induction and Maintenance in Patients Undergoing Abdominal Surgery Based on Transesophageal Echocardiography (ChiCTR) - P=N/A | N=64 | Not yet recruiting | Sponsor: Zigong Fourth People's Hospital; Zigong Fourth People's Hospital

New trial • Anesthesia

Study on the efficacy, safety and postoperative cognitive dysfunction of continuous infusion of remimazolam toluesulfonate in PFNA surgery for elderly patients (ChiCTR) - P4 | N=80 | Recruiting | Sponsor: The Fourth People's Hospital of Zigong City; The Fourth People's Hospital of Zigong City

New P4 trial • Cognitive Disorders • Musculoskeletal Diseases • Orthopedics

Comparative Analysis of Serum and Urine Metabolomics: The Impact of Remimazolam Tosilate Application During General Anesthesia on Postoperative Delirium (ChiCTR) - P=N/A | N=160 | Not yet recruiting | Sponsor: The Affiliated Hospital of Guizhou Medical University; The Affiliated Hospital of Guizhou Medical University

New trial • Anesthesia • CNS Disorders

A Study Assessing Heart Rate Variability During Anesthesia Induction with Remimazolam Besylate and Remifentanil Coadministration in Elderly Patients. (ChiCTR) - P=N/A | N=152 | Not yet recruiting | Sponsor: The Affiliated Hospital of Guizhou Medical University; The Affiliated Hospital of Guizhou Medical University

New trial • Anesthesia

Efficacy and Safety of Remimazolam Tosilate Plus Lidocaine in Elderly Patients Undergoing Painless Gastroscopy (ChiCTR) - P=N/A | N=211 | Not yet recruiting | Sponsor: Ya 'an People's Hospital; Ya 'an People's Hospital

New trial • Pain

Remimazolam Tosylate Combined with Remifentanil for Painless Bronchoscopy in Children: A Randomized Controlled Clinical Trial (ChiCTR) - P4 | N=96 | Not yet recruiting | Sponsor: Boai Hospital of Zhongshan; Boai Hospital of Zhongshan

New P4 trial • Pain

Anesthetic effects of different doses of remimazolam tosylate in gynecological laparoscopic surgery and their impact on patient recovery quality (ChiCTR) - P=N/A | N=212 | Not yet recruiting | Sponsor: Suzhou Municipal Hospital; Suzhou Municipal Hospital

New trial • Anesthesia

Effects of Esketamine Combined With Remimazolam Tosylate on Hemodynamics During Cardiovascular Anesthesia. (PubMed, Clin Transl Sci) - "Seventy-eight patients were randomized to Group C (dexmedetomidine hydrochloride) or Group R (esketamine + remimazolam tosylate). The combination of esketamine and remimazolam tosylate offers hemodynamic stability, enhances cerebral oxygen metabolism, improves cognitive function, and reduces myocardial injury in patients undergoing heart valve replacement surgery. This approach might provide significant benefits in cardiovascular anesthesia."

Journal • Anesthesia • Cardiovascular • CNS Disorders

Impact of Remimazolam on Prognosis After Bladder Cancer Surgery (clinicaltrials.gov) - P4 | N=1128 | Recruiting | Sponsor: Peking University First Hospital | Trial completion date: Oct 2025 ➔ Oct 2026 | Trial primary completion date: Oct 2024 ➔ Oct 2025

Trial completion date • Trial primary completion date • Anesthesia • Bladder Cancer • CNS Disorders • Genito-urinary Cancer • Oncology • Solid Tumor

Anesthetic Effects and Safety of Remimazolam Tosilate in Elderly Patients With Hip Fractures: A Retrospective Cohort Study. (PubMed, Ann Ital Chir) - "RT provides effective anesthesia with faster recovery and enhanced hemodynamic stability compared to propofol in elderly patients undergoing hip fracture surgery. Additionally, its lower incidence of injection pain further supports its safety, suggesting that RT is a promising alternative for anesthesia in this patient population."

Clinical • Journal • Retrospective data • Anesthesia • Musculoskeletal Diseases • Orthopedics • Pain

Study on the Safety and Effectiveness of Remimazolam Tosilate for Injection for Short-term Elective Surgery in Adults (clinicaltrials.gov) - P4 | N=650 | Completed | Sponsor: Tongji Hospital | Trial completion date: Jan 2023 ➔ May 2025 | Trial primary completion date: Dec 2022 ➔ Mar 2025

Intubation • Trial completion date • Trial primary completion date • Anesthesia • Hypotension