remimazolam tosylate (HR-7056) / Jiangsu Hengrui Pharma - LARVOL DELTA

Corrigendum to "The efficacy and safety of remimazolam tosilate compared with propofol for endoscopic retrograde cholangiopancreatography under monitored anesthesia care: A single-center randomized controlled clinical trial" [Heliyon Volume 10, Issue 19, October 2024, Article e38349]. (PubMed, Heliyon) - "[This corrects the article DOI: 10.1016/j.heliyon.2024.e38349.]."

Clinical • Anesthesia

The safety and efficacy of remimazolam, midazolam and propofol for perioperative sedation during percutaneous tracheostomy in critically ill neurological patients (ChiCTR) - P4 | N=40 | Recruiting | Sponsor: Beijing tiantan hospital, capital medical university; Beijing tiantan hospital, capital medical university

New P4 trial • Anesthesia • Brain Cancer • Cardiovascular • CNS Disorders • Vascular Neurology

Effects of Remimazolam Tosilate Combined with Esketamine on Anesthetic Efficacy and Psychiatric Symptoms in Patients Undergoing Ambulatory Surgery: A Randomized Controlled Study. (PubMed, Drug Des Devel Ther) - "The SAS scores decreased from T2 to T4 in Groups EM and ER than in Group E (p<0.05). The combination of remimazolam tosilate and esketamine effectively reduces postoperative psychiatric symptoms, enhances hemodynamic stability, and improves recovery quality, making it a viable anesthetic strategy for ambulatory surgery."

Clinical • Journal • Anesthesia • Pain • Psychiatry

The ED50 and ED95 of remimazolam tosilate to inhibit the gastroscopy reaction in elderly patients of varying ages: an up-and-down sequential allocation trial. (PubMed, Front Med (Lausanne)) - P4 | "The ED95 estimated by probit regression analysis was 0.199 (95% CI, 0.186-0.244) mg/kg in Group A and 0.188 (95% CI, 0.175-0.232) mg/kg in Group B. RT is a relatively safe sedative hypnotic that can provide a suitable sedative effect for elderly patients undergoing a gastroscopy. http://www.chictr.org.cn, identifier ChiCTR2200062842."

Journal

Effect of remimazolam tosilate on Propofol-related Euphoria in upper gastrointestinal endoscopy:a prospective, randomized, double-blind, controlled clinical trial (ChiCTR) - P=N/A | N=600 | Not yet recruiting | Sponsor: Northern Jiangsu People's Hospital; Northern Jiangsu People's Hospital

New trial • Gastrointestinal Disorder

The Median Effective Dose and studies on Pharmacokinetics of Afentanil combined with Remimazolam Tosilate for hysteroscopic Surgery (ChiCTR) - P4 | N=100 | Not yet recruiting | Sponsor: Qingdao Women and Children's hospital; Qingdao Women and Children's hospital

New P4 trial

Effects of remimazolam tosylate on early postoperative memory in young and middle-aged patients undergoing laparoscopic surgery (ChiCTR) - P4 | N=228 | Not yet recruiting | Sponsor: Department of Anesthesiology, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital); The First Af

New P4 trial • CNS Disorders • Cognitive Disorders • Developmental Disorders

Effect of Remimazolam Tosilate on Hemodynamics During Induction of Anesthesia in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting (ChiCTR) - P4 | N=168 | Not yet recruiting | Sponsor: Jining No.1 People's Hospital; Jining No.1 People's Hospital

New P4 trial • Anesthesia • Atherosclerosis • Cardiovascular • Coronary Artery Disease • Heart Failure

Comparison of EEG Burst Suppression and Hemodynamic Effects Between Remimazolam tosilate and Etomidate During General Anesthesia Induction (ChiCTR) - P=N/A | N=161 | Recruiting | Sponsor: The Second People’s Hospital of Guiyang/The Affiliated Jinyang Hospital of Guizhou Medical University, Guiyang, China; The Second People’s Hospit

New trial • Anesthesia • CNS Disorders

Comparison of Remimazolam and Propofol for Reducing Postoperative Delirium in Pediatric Otolaryngology Surgery: A Randomized Non-Inferiority Trial (ChiCTR) - P1 | N=80 | Recruiting | Sponsor: Affiliated Hospital of North Sichuan Medical College; Affiliated Hospital of North Sichuan Medical College

New P1 trial • CNS Disorders • Otorhinolaryngology • Pediatrics

Effect of remimazolam, cyclopofol and propofol in flexible ureteroscopic lithotripsy (ChiCTR) - P=N/A | N=123 | Not yet recruiting | Sponsor: Baoding NO.1 central hospital; Baoding NO.1 central hospital

New trial

Application of remimazolam tosylate-based anesthesia in enhanced recovery for liver transplantation (ChiCTR) - P=N/A | N=120 | Not yet recruiting | Sponsor: Affiliated Hospital of Qingdao University; Affiliated Hospital of Qingdao University

New trial • Anesthesia • Hepatology • Transplantation

Effect of remimazolam tosylate on the response to endotracheal intubation under general anesthesia in patients undergoing catheter placement for peritoneal dialysis. (PubMed, Am J Transl Res) - P=N/A | "Remimazolam tosylate is effective for inhibiting the systemic response to endotracheal intubation in patients undergoing peritoneal dialysis catheter placement. Additionally, the occurrence rate of hypotension and injection pain during anesthesia induction is significantly lower compared to propofol. The ED95 of remimazolam tosylate for inhibiting the endotracheal intubation response in peritoneal dialysis catheter placement patients is 0.332 mg/kg."

Intubation • Journal • Anesthesia • Hypotension • Pain

Comparison of remimazolam tosylate and propofol in hemodynamic stability, postoperative cognitive function, and recovery in general anesthesia combined with regional nerve blocks: a retrospective cohort study. (PubMed, BMC Anesthesiol) - "Remimazolam tosylate was associated with more stable hemodynamic parameters, lower rates of postoperative cognitive dysfunction, and shorter recovery times compared to propofol in patients undergoing GA combined with RA, suggesting it may be a safer alternative for patients."

Clinical • Journal • Retrospective data • Anesthesia • Cognitive Disorders • Hypotension

Effect of remimazolam tosilate for injection (HR7056) versus sevoflurane on the incidence of postoperative delirium in older patients undergoing total hip arthroplasty: study protocol for a prospective, multicentre, two-arm, parallel-group, randomised controlled trial. (PubMed, BMC Geriatr) - P=N/A | "The findings will be published in an international peer-reviewed medical journal. The trial has been registered at the Chinese Clinical Trial Registry: ChiCTR2200062455; date of registration: 2022-08-08."

Journal • Anesthesia • CNS Disorders • Orthopedics • Pain

Effect of remimazolam tosylate on cognitive function after major abdominal surgery in older adults (ChiCTR) - P4 | N=534 | Sponsor: The First People's Hospital of Lianyungang; The First People's Hospital of Lianyungang

New P4 trial • Cognitive Disorders

Evaluation of the effect of remimazolam tosylate on anesthesia for prostate biopsy in the elderly (ChiCTR) - P4 | N=200 | Sponsor: The First Affiliated Hospital of Xi'an Jiaotong University; The First Affiliated Hospital of Xi'an Jiaotong University

New P4 trial • Anesthesia

Comparison of the hemodynamic effects of remimazolam tosilate and etomidate for anesthetic induction in elderly frail patients (ChiCTR) - P=N/A | N=96 | Completed | Sponsor: Fuyang People's Hospital; Fuyang People's Hospital

New trial • Anesthesia • Geriatric Disorders

Procedural sedative effect of remimazolam in ICU patients on invasive mechanical ventilation: a randomised, prospective study. (PubMed, Ann Intensive Care) - "Remimazolam is a novel benzodiazepine that has demonstrated promising applications in general anaesthesia and procedural sedation; however, its use in ICU sedation is still in the early stages of research. Current evidence suggests that remimazolam is a safe sedative that is particularly well suited for patients with haemodynamic instability. Large sample-size randomised clinical trials are warranted."

Journal • Anesthesia • CNS Disorders • Critical care • Dyslipidemia • Mood Disorders • Pain • Psychiatry

Safety and efficacy of remimazolam tosilate for general anaesthesia in paediatric patients undergoing elective surgery: a multicentre, randomised, single-blind, controlled trial. (PubMed, Anaesthesia) - "Remimazolam was well tolerated for the induction and maintenance of general anaesthesia in pre-school-age children and was non-inferior to propofol."

Journal • Surgery • Anesthesia • CNS Disorders • Pain • Pediatrics

Efficacy and safety of remimazolam tosylate for patients undergoing off-pump coronary artery bypass grafting: a study protocol for a non-inferiority randomised controlled trial in China. (PubMed, BMJ Open) - P4 | "The trial results will be submitted to an international peer-reviewed journal. ChiCTR.gov.cn: ChiCTR2400079615."

Head-to-Head • Journal • Anesthesia • Cardiovascular • CNS Disorders • Coronary Artery Disease • Critical care • Depression • Heart Failure • Psychiatry

Efficacy and safety of remimazolam tosilate in anesthesia for short otolaryngology surgery. (PubMed, BMC Anesthesiol) - P4 | "Remimazolam tosilate is effective on anesthesia for short otolaryngology surgery. Remimazolam shows the rapid onset, stable circulation, fast postoperative recovery, no increase in perioperative AEs, and high satisfaction with anesthesia experience compared with midazolam."

Clinical • Journal • Surgery • Anesthesia • Hypotension • Otorhinolaryngology

Efficacy and safety of remimazolam tosilate in obese patients undergoing mechanical ventilation: a single-center randomized, controlled study (ChiCTR) - P4 | N=60 | Not yet recruiting | Sponsor: Dazhou Central Hospital; Dazhou Central Hospital

New P4 trial • Obesity

Comparative analysis of the therapeutic efficacy of remimazolam tosylate and propofol in older adults undergoing painless endoscopic retrograde cholangiopancreatography. (PubMed, Front Pharmacol) - P4 | "Post-surgery levels of epinephrine (E), norepinephrine (NE), and cortisol (Cor) at 24 h were lower in the remimazolam group than in the propofol group (P < 0.05). These attributes suggest that remimazolam has potential for widespread clinical application and adoption. clinicaltrials.gov, identifier ChiCTR2400080926."

Journal • Anesthesia • Pain

Comparison of the anesthetic effects of remimazolam tosilate and remimazolam besylate in daytime hysteroscopic surgery. (PubMed, BMC Anesthesiol) - "There was no significant difference in the anesthetic effect of remimazolam tosilate and remimazolam besylate in daytime hysteroscopic surgery."

Clinical • Journal • Surgery • Anesthesia • Cardiovascular • Cough • Gynecology • Hypertension • Hypotension • Respiratory Diseases