deuterium containing levodopa (SD-1077) / Teva - LARVOL DELTA

The Psychological Impact of Hand Injuries Among Foreign Workers in Singapore. (PubMed, Cureus) - "The majority were male (97.5%), married (60%), and had a salary of less than SGD1500 (USD1077) per month (81.3%)...We recommend that the psychological impact of hand injuries be factored into holistic management and rehabilitation with adequate time and resource allocation. An ancillary benefit is the improvement of productivity and overall contribution to Singapore's economy."

Journal • CNS Disorders • Depression • Pain • Psychiatry

STING antagonists, synthesized via Povarov-Doebner type multicomponent reaction. (PubMed, RSC Med Chem) - "At concentrations as low as 20 nM, HSD1077 suppressed type-1 interferon expression in both murine RAW macrophages and human THP-1 monocytes upon treatment with 100 μM 2'-3' cGAMP. Compounds containing the 3H-pyrazolo[4,3-f]quinoline moiety have the potential to be translated into anti-inflammatory compounds via STING inhibition."

Journal • CNS Disorders • Diabetic Nephropathy • Gastroenterology • Gastrointestinal Disorder • Immunology • Nephrology • Oncology • Renal Disease • STING-Associated Vasculopathy with Onset in Infancy • Vascular Neurology • STING

Pharmacokinetics, Metabolism and Safety of Deuterated L-DOPA (SD-1077)/Carbidopa (CD) Compared to L-DOPA/CD following single oral dose administration in Healthy Subjects. (PubMed, Br J Clin Pharmacol) - "SD-1077/CD demonstrated the potential to prolong exposure to central DA at comparable peripheral PK and safety to the reference LD/CD combination. A single dose of SD-1077 is safe for further clinical development in Parkinson's disease patients."

Clinical • Journal • PK/PD data