valnivudine (FV-100) / Hepion Pharma - LARVOL DELTA

Hydrogen Bonding (Base Pairing) in Antiviral Activity. (PubMed, Viruses) - "Hydrogen bonding (base pairing) also seems to be involved in the inhibitory activity of Cf1743 (and its prodrug FV-100) against varicella-zoster virus (VZV) and in the activity of sofosbuvir against hepatitis C virus and that of remdesivir against SARS-CoV-2 (COVID-19). Base pairing based on hydrogen bonding also plays a key role in the mechanism of action of various acyclic nucleoside phosphonates (ANPs) such as adefovir, tenofovir, cidofovir and O-DAPYs, thus explaining their activity against a wide array of DNA viruses (human hepatitis B virus (HBV), human immunodeficiency (HIV) and human herpes viruses (i.e., human cytomegalovirus)). Base pairing based on hydrogen bonding has, since its inception, been crucial in the antiviral activity of arabinosyladenine, 2'-deoxyuridines (i.e., IDU, TFT, BVDU), acyclic nucleoside analogues (i.e., acyclovir) and nucleoside reverse transcriptase inhibitors (NRTIs). Hydrogen bonding (base pairing) may also explain the..."

Journal • Cytomegalovirus Infection • Epstein-Barr Virus Infections • Hepatitis B • Hepatitis C • Hepatology • Herpes Zoster • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Novel Coronavirus Disease • Respiratory Diseases • Varicella Zoster

COVID-19 Benefits and Dietary Behaviors Among Mothers From Low-Income, Food-Insecure Households. (PubMed, J Nutr Educ Behav) - "Coronavirus disease 2019 benefits may have reduced dietary inequities among low-income families. Associations between increased Supplemental Nutrition Assistance Program and unemployment benefits and decreased costs associated with the negative health outcomes linked to food insecurity and poor diets would be of value."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

The development of BVDU: An odyssey. (PubMed, Antivir Chem Chemother) - "It is contra-indicated in patients concomitantly treated by 5-fluorouracil (FU), since its degradation product, (E)-5-(2-bromovinyl)uracil, is inhibitory to the catabolism of FU, which may enhance the toxicity of the latter. A new compound, the bicyclic nucleoside analogue (BCNA) Cf-1743, has been described, which is a more potent inhibitor of VZV replication than BVDU and which does not interfere with the catabolism of FU. It is applicable orally, as its 5'-valine ester FV-100 (Fermavir), but has not (yet) been marketed for clinical use."

Journal • Review • Herpes Simplex • Herpes Zoster • Infectious Disease • Neuralgia • Pain • Varicella Zoster

Ex Vivo C5B9 Deposition Test as a Diagnostic and Monitoring Tool For Primary and Transplantation Associated AHUS (ERA-EDTA 2022) - "Images were taken using a FV100 Fluoroview Olympus Confocal Microscope at 40×...CONCLUSION The ex vivo C5b9 deposition test is an auspicious tool to diagnose and monitor aHUS response to eculizumab. We now demonstrated that the ex vivo C5b9 deposition test is also useful for HSC associated aHUS and for aHUS recurrence after kidney transplantation suggesting that it could be a useful diagnostic tool for any type of CM aHUS. These results expand the spectrum of patients that would benefit from a better diagnostic and treatment monitoring procedure."

Preclinical • Atypical Hemolytic Uremic Syndrome • Complement-mediated Rare Disorders • Glomerulonephritis • Nephrology • Transplantation

FV-100 for the Treatment of Varicella-Virus (VZV) Infections: Quo Vadis? (PubMed, Viruses) - "The anti-VZV activity of Cf1743 depends on a specific phosphorylation by the VZV-encoded thymidine kinase (TK). The target of antiviral action is assumed to be the viral DNA polymerase (or DNA synthesis in the virus-infected cells)."

Journal • Review • Herpes Zoster • Infectious Disease • Neuralgia • Pain • Varicella Zoster

Advances and Perspectives in the Management of Varicella-Zoster Virus Infections. (PubMed, Molecules) - "We also focus on acyclovir, valacyclovir, and famciclovir (FDA approved drugs to treat VZV infections), brivudine (used in some European countries) and amenamevir (a helicase-primase inhibitor, approved in Japan) that augur the beginning of a new era of anti-VZV therapy. Valnivudine hydrochloride (FV-100) and valomaciclovir stearate (in advanced stage of development) and several new molecules potentially good as anti-VZV candidates described during the last year are examined. We reflect on the role of antiviral agents in the treatment of VZV-associated diseases, as a large percentage of the at-risk population is not immunized, and on the limitations of currently FDA-approved anti-VZV drugs. Their low efficacy in controlling HZ pain and post-herpetic neuralgia development, and the need of multiple dosing regimens requiring daily dose adaptation for patients with renal failure urges the development of novel anti-VZV drugs."

Journal • Review • Herpes Zoster • Infectious Disease • Neuralgia • Pain • Peripheral Neuropathic Pain • Renal Disease • Varicella Zoster

Heterokaryon formation and nuclear fusion of hybridizing cancer cells visualized in real time by color-coded imaging (AACR 2018) - "...The fused cells were cultured on plastic and observed using an Olympus FV1000 confocal microscope. Multi-nucleate (heterokaryotic) cancer cells, in addition to hybrid cancer cells with a single fused nucleus undergoing mitosis, were observed by confocal microcopy... Cell fusion with subsequent heterokaryon formation followed by nuclear hybridization may be an important natural phenomenon between cancer cells that may make them more malignant. The ability to image the complex processes following cell fusion using reciprocal color-coded cancer cells will allow greater understanding of the genetic basis of malignancy."

Sarcoma

Metastasis-resistant fatty liver induced by a choline-deficient diet (AACR 2018) - "...Using the Olympus SZX7 microscope and the Olympus FV1000 confocal microscope, metastases in mice with fatty liver or normal liver were imaged. EL4-RFP tumors were observed to metastasize to the liver and bone marrow as well as form ascites... The relative metastatic resistance of the fatty liver may be due to the reduced number of CAFs in the fatty liver. The fatty liver may not be a suitable environment for CAFs which may be due to re-programmed methionine metabolism which may have occurred during the time the animals were on the CDD."

Hepatocellular Cancer • Lymphoma

Tandem Homometallic or Multimetallic Catalysis for Assembly of Base-Modified Nucleosides. (PubMed, Curr Protoc Nucleic Acid Chem) - "© 2020 Wiley Periodicals LLC. Basic Protocol 1: Double tandem one-pot Sonogashira/cyclization of 5-IdU for the synthesis of FV-100 and analogs Basic Protocol 2: Double tandem one-pot Heck/Suzuki-Miyaura of 5-IdU for the synthesis of fluorescent nucleoside analogs Basic Protocol 3: Double tandem one-pot Suzuki-Miyaura cross-coupling of 5-IdU for the synthesis of fluorescent nucleoside analogs Basic Protocol 4: Double tandem one-pot amination/amidation for the synthesis of Sangivamycin precursor Basic Protocol 5: Triple tandem one-pot chemoselective etherification/Sonogashira coupling/cyclization for synthesis of BCNA analogs Basic Protocol 6: Triple tandem one-pot sequential Heck/borylation/Suzuki-Miyaura reaction"

Journal

FV-100 versus valacyclovir for the prevention of post-herpetic neuralgia and the treatment of acute herpes zoster-associated pain: A randomized-controlled trial. (PubMed) - J Med Virol - "Adverse event and SAE profiles of the 2 FV-100 and the valacyclovir groups were similar and no untoward signals or trends were evident. These results demonstrate a potential for FV-100 as an antiviral for the treatment of shingles that could both reduce the pain burden of the acute episode and reduce the incidence of PHN compared with available treatments."

Journal • Biosimilar • Demo Pain • Immunology • Pain