citicoline / Generic mfg. - LARVOL DELTA

Efficacy of Alpha-Lipoic Acid Capsules in Diabetic Optic Neuropathy: A Randomized Controlled Trial (ChiCTR) - P4 | N=106 | Recruiting | Sponsor: Chinese People's Liberation Army General Hospital; Chinese People's Liberation Army General Hospital

New P4 trial • Diabetic Neuropathy • Ocular Inflammation • Ophthalmology • Optic Neuritis

CITADEL: Effectiveness of CITicoline in Preventing Cognitive Decline After DELirium (clinicaltrials.gov) - P2 | N=122 | Recruiting | Sponsor: University of Milano Bicocca

New P2 trial • CNS Disorders • Geriatric Disorders • Musculoskeletal Diseases • Orthopedics

Nutraceuticals and phytoceuticals for the treatment of major depressive disorder: a systematic review and network meta-analysis. (PubMed, Mol Psychiatry) - "Upon filtering low-quality evidence, only a few nutraceutical/phytoceuticals showed potential for depressive symptoms, warranting more rigorous trials."

Clinical • Journal • Retrospective data • Review • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Effect of citicoline on cognitive function and functional recovery in patients with mild-to-moderate traumatic brain injury: a randomized placebo-controlled trial. (PubMed, Neuroscience) - "These preliminary findings suggest that citicoline may be associated with better 90-day cognitive and functional outcomes after mild-to-moderate TBI. Confirmation in adequately powered multicenter randomized trials is required."

Journal • Cerebral Hemorrhage • CNS Disorders • Cognitive Disorders • Hematological Disorders • Vascular Neurology

Acute Binge Alcohol Consumption Presenting With a Cytotoxic Lesion of the Corpus Callosum (CLOCC) in a Young, Healthy Filipino Male: A Case Report With Features Overlapping the Proposed Marchiafava-Bignami Disease Spectrum. (PubMed, Cureus) - "The patient was managed with antiplatelet therapy, citicoline, and analgesics...Recognition of this entity is essential to avoid misdiagnosis and unnecessary long-term antithrombotic therapy. To our knowledge, this represents the first locally documented case of this presentation in the Philippines."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Ischemic stroke • Pain

Effects of Treatment with Citicoline Plus Nicotinamide Oral Solution on Retinal Ganglion Cells and Visual Pathways in Glaucomatous Impairment. (PubMed, Pharmaceuticals (Basel)) - "The HFA MD and RNFL-T changes were not significantly different (p > 0.05) between groups. In OAG patients, treatment with Citicoline plus Nicotinamide oral solution for three months induces RGC functional enhancement (increase in PERG amplitude) and improves the neural conduction along the visual pathways (shortening of VEP implicit time and increased amplitude), without significant changes in visual field or RNFL-T."

Journal • Glaucoma • Ophthalmology

Pharmacological interventions targeting cognition and related clinical outcomes in vascular dementia: a systematic review and meta-analysis of randomized controlled trials. (PubMed, Eur J Clin Pharmacol) - "Galantamine and memantine showed small short-term cognitive effects; EGb 761® suggested a fragile, very low-certainty signal; patient-important benefits remain uncertain."

Clinical • Clinical data • Journal • Retrospective data • Review • Alzheimer's Disease • CNS Disorders • Dementia

Neurovascular unit-targeted therapeutic strategies in diabetic retinopathy. (PubMed, Arch Soc Esp Oftalmol (Engl Ed)) - "Targeting NVU may represent a disease-modifying strategy, enabling earlier intervention and potentially preventing irreversible vision loss in DR. Further well-designed prospective and randomized studies are warranted to strengthen the level of evidence and validate this therapeutic approach."

Journal • Review • CNS Disorders • Diabetic Retinopathy • Retinal Disorders

Evaluation of Citicoline-loaded Lutrol 127/Carbopol/Hyaluronic acid-based gels for brain delivery by intranasal administration. (PubMed, Eur J Pharm Sci) - "Interestingly, none of the gels was cytotoxic against the primary nasal epithelial cells (pNEC) and also when pNEC were co-cultured with the neuronal SH-SY5Y cells in order to provide an in vitro model of nose-brain axis (NBA). Finally, by SIRT1 quantification in the NBA model, the gels evidenced an effective neuronal inflammatory modulation, so being promising for nerve cell protection."

Journal • CNS Disorders • Inflammation • Movement Disorders • Parkinson's Disease • SIRT1

CEREBROVASCULAR EVENTS AND NEUROCOGNITIVE IMPAIRMENTS WITH ALTERATIONS IN POLYSOMNOGRAPHIC INDICATORS FOLLOWING CARDIAC SURGERY. (PubMed, Georgian Med News) - "The study demonstrates that polysomnography is a sensitive tool for detecting early neurocognitive dysfunction following cardiac surgery. The inclusion of Citicoline in the perioperative protocol significantly mitigates neurocognitive decline and facilitates the stabilization of sleep-wake cycles. PSG parameters may serve as reliable objective markers for predicting long-term neurological outcomes in cardiac surgery patients."

Journal • Alzheimer's Disease • Cardiovascular • Cognitive Disorders

Effect of Citicoline on Neurological Severity Score and Cerebral Doppler Resistive Index in Neonatal Hypoxic Ischemic Encephalopathy: A Randomized Control Trial (clinicaltrials.gov) - P=N/A | N=86 | Not yet recruiting | Sponsor: Khyber Girls Medical College

New trial • CNS Disorders

Contralateral venous thrombosis and intracerebral hemorrhage after resection of parasagittal meningioma: a case report and systematic review (PubMed, Zh Vopr Neirokhir Im N N Burdenko) - "Contralateral thrombosis of bridging vein after resection of parasagittal meningioma is unique and deserves attention. Timely diagnosis and anticoagulation can lead to complete regression of neurological symptoms."

Journal • Review • Brain Cancer • Cardiovascular • Cerebral Hemorrhage • Hematological Disorders • Meningioma • Oncology • Solid Tumor • Thrombosis

Role of Citicoline in Neonates with Hypoxic-Ischaemic Encephalopathy. (PubMed, J Coll Physicians Surg Pak) - "This study demonstrated the neuroprotective effects of citicoline in the treatment of HIE in neonates, with statistically significant earlier establishment of suck and Moro reflexes in the citicoline-treated group compared with the control group."

Clinical • Journal • CNS Disorders • Epilepsy • Pediatrics

Efficacy of citicoline as an add-on therapy in Parkinson's disease: a randomized, double-blind trial. (PubMed, Parkinsonism Relat Disord) - "Citicoline was well tolerated and associated with motor benefits compared with placebo in a highly compliant population. The results suggest a role of citicoline as a safe and possibly effective supportive therapy in PD treated with concomitant dopaminergic agents."

Clinical • Journal • CNS Disorders • Movement Disorders • Parkinson's Disease

Application of 13C MRS demonstrates carbohydrate feeding spares muscle but not liver glycogen utilisation during high-intensity interval exercise. (PubMed, Am J Physiol Endocrinol Metab) - "Following 24 h of standardised dietary intake, nine male cyclists completed 8 x 5-min intervals (1-min recovery), ingesting either placebo (PLA), 60 g maltodextrin (CHO) or 60 g maltodextrin plus caffeine, taurine, l-theanine, l-citrulline and citicoline (CHO+) in a randomised crossover design. These findings demonstrate preferential use of skeletal muscle glycogen during HIIT, which is attenuated under conditions of CHO feeding. This sparing effect is, however, not evident with the co-ingestion of a caffeine containing multi-ingredient blend, potentially due to an increased capacity to sustain higher power outputs resulting in greater glycogen utilisation."

Journal

The Impact of Citicoline/Phosphatidylserine Supplementation on Cognitive Performance and Executive Functions in Mental Disorders: A Systematic Review of Controlled Trials. (PubMed, Hum Psychopharmacol) - "Given methodological limitations and high risk of bias, current evidence does not support citicoline or PS-containing compounds as effective cognitive enhancers in mental disorders. Consequently, these agents should be positioned as adjunctive or investigational rather than as evidence-based treatments."

Journal • Review • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Mental Retardation • Mood Disorders • Psychiatry • Schizophrenia

Efficacy of Citicoline as an add-on therapy in Parkinson’s disease: the CITIPARK TRIAL trial (EAN 2026) - No abstract available

Clinical • CNS Disorders • Movement Disorders • Parkinson's Disease

Prospects for Neuroprotective Therapies in Glaucoma: Drug Targets and Emerging Clinical Strategies. (PubMed, Drug Des Devel Ther) - "Management of glaucoma is now at an inflection point with a new generation of therapeutic candidates, whilst targeting intraocular pressure-independent strategies is challenged by the landmark Phase III failure of memantine regarding trial design and endpoint sensitivity. Current clinical efforts are expanding into metabolic repurposing with agents (eg metformin and semaglutide), sustained-delivery systems with neurotrophic factors (eg ciliary neurotrophic factor implant), and functional enhancers (eg citicoline). To bridge the translational gap, the field is integrating new endpoints with higher sensitivity (eg advanced assessment of photopic negative response), AI-guided endpoint selection (eg graph attention neural network), novel biomarkers (eg detection of apoptotic retinal cells and neurofilament light chain in aqueous humor), and precision medicine frameworks (eg polygenic risk scores and multi-omics analysis) to develop the first clinically validated..."

Journal • Review • Glaucoma • Metabolic Disorders • Ophthalmology • NEFL

Repurposing citicoline for single prolonged stress-induced behavioral and hippocampal molecular abnormalities in male mice: novel mechanistic attenuation of endoplasmic reticulum stress, mitochondrial dysfunction, oxidative stress, and apoptosis. (PubMed, Neuropharmacology) - "Citicoline also normalized mitochondrial biogenesis by upregulating peroxisome proliferator-activated receptor gamma coactivator 1-alpha and prevented neuronal apoptosis by suppressing caspase-3. Collectively, these findings establish citicoline as a promising multi-targeted therapeutic candidate for behavioral and hippocampal molecular abnormalities after SPS in male mice."

Journal • Preclinical • CNS Disorders • Mental Retardation • Metabolic Disorders • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry • ATF6 • CASP3 • PTEN • XBP1

Evaluation of the efficiency of combined neuroprotection and high-intensity magnetotherapy in the medical rehabilitation of patients with ischemic stroke (PubMed, Zh Nevrol Psikhiatr Im S S Korsakova) - "The findings suggest that a multimodal approach to restorative treatment, combining neuroprotective medications with high-intensity magnetic therapy, demonstrates considerable therapeutic efficacy in the medical rehabilitation of patients with ischemic stroke."

Journal • Cardiovascular • CNS Disorders • Ischemic stroke • Movement Disorders

Probiotic Fermentation Enhances Anti-Diabetic Effects of Chlorella pyrenoidosa in Mice by Modulating Gut Microbiota and Short-Chain Fatty Acids. (PubMed, Foods) - "Furthermore, untargeted metabolomics analysis revealed that fermentation significantly altered the metabolite profile of C. pyrenoidosa, leading to the enrichment of potential anti-diabetic compounds such as acetylcholine and citicoline...Additionally, CH-F modulated the gut microbiota and improved the levels of short-chain fatty acids (SCFAs) in the intestines of T2DM mice. We demonstrate that CH-F exerts anti-diabetic effects via gut microbiota modulation and SCFA regulation, highlighting its great potential as a functional food ingredient and dietary supplement for the adjuvant management of T2DM."

Journal • Preclinical • Diabetes • Dyslipidemia • Metabolic Disorders • Type 2 Diabetes Mellitus

The Use of Citicoline in Ophthalmology: A systematic review. (PubMed, Beyoglu Eye J) - "This review aims to evaluate and summarize the current evidence on the neuroprotective effects of citicoline in ophthalmologic diseases. Findings from various clinical studies suggest that it may have a beneficial effect on the treatment of conditions including amblyopia, glaucoma, and non-arteritic ischemic optic neuropathy."

Journal • Review • CNS Disorders • Glaucoma • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Psychiatry

Longitudinal changes of BOLD-CSF coupling and its association with the clinical assessments in subcortical ischemic stroke. (PubMed, Brain Res Bull) - "These findings indicate that antiplatelet plus citicoline therapy promotes BOLD-CSF coupling restoration, and regional BOLD-CSF coupling in the SMA and precentral gyrus may serve as a neuroimaging biomarker for post-stroke motor recovery."

Journal • Cardiovascular • Ischemic stroke

N-acetylcysteine, Acetyl-L-carnitine, and Citicoline: A Potential Synergism in Neurological and Psychiatric Disorders. (PubMed, Curr Neuropharmacol) - "These agents act on complementary pathways-redox regulation, mitochondrial support, and membrane integrity-potentially enhancing each other's neuroprotective effects. The purpose of this review is to explore the fields (psychiatric, neurological, and also rheumatological), in which the combination of these compounds may benefit patient management, starting with preclinical evidence and focusing on clinical trials conducted over the years."

Journal • Alzheimer's Disease • Cardiovascular • CNS Disorders • Cognitive Disorders • Fatigue • Mental Retardation • Mood Disorders • Pain • Psychiatry • Rheumatology • Schizophrenia

Left eye optic neuropathy and right eye retinopathy after embolization of middle cerebral artery aneurysm: a case report (PubMed, Zhonghua Yan Ke Za Zhi) - "Based on the medical history, the diagnosis was confirmed as: left eye surgery-associated posterior ischemic optic neuropathy, and right eye Purtscher retinopathy. After treatment with mecobalamin tablets, citicoline sodium capsules, and compound vitamin B tablets, the ocular symptoms in the right eye showed some improvement."

Journal • Achromatopsia • Cardiovascular • Hematological Disorders • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Retinal Disorders • Subarachnoid Hemorrhage