Deflux (dextranomer microspheres) / Bausch Health - LARVOL DELTA

Limosilactobacillus Reuteri (Lr) in Its Biofilm State Protects against Hyperactivity Disorder in Survivors of Murine Necrotizing Enterocolitis (NEC) (ACS-CLINCON 2026) - "Introduction: We have developed a novel enteral therapeutic in which Lr is adhered to dextranomer microspheres containing maltose (Lr-DM-maltose) to facilitate biofilm development, leading to improved protection of the intestines from experimental NEC... Lr in its biofilm state protects against hyperactivity in survivors of experimental NEC. Future experiments will evaluate the mechanisms by which by Lr in its biofilm state exerts these neuroprotective effects."

Preclinical • ADHD (Impulsive Aggression) • Gastrointestinal Disorder • Psychiatry

Preoperative predictors for endoscopic Deflux injection therapy for vesicoureteral reflux: a single-center experience during 10 years. (PubMed, Pediatr Surg Int) - "Constipation was an independent risk factor for failure after the first injection and remained associated with failure after repeated injections, even after exclusion of clinically evident BBD. It may serve as a clinically relevant and easily assessable predictor, particularly in young children in whom bladder function is difficult to assess."

Journal • Retrospective data • Constipation • Gastroenterology • Gastrointestinal Disorder • Inflammatory Bowel Disease

Comparative Analysis of Ureteral Reimplantation and Dextranomer/Hyaluronic Acid Injection Between Two Centers with Systematic Review and Meta-Analysis. (PubMed, J Urol) - "Ureteral reimplantation has lower likelihood of reoperation and with possibly postoperative UTI risk, while Dx/HA offers meaningful perioperative advantages. These trade-offs support individualized, risk-adapted surgical decision-making for pediatric VUR."

Journal • Retrospective data • Infectious Disease • Nephrology • Pediatrics

Era and indication-matched comparison of vesicoureteral reflux management between institutions: high-volume ureteral reimplantation center vs. preferential Deflux® center (AUA 2026) - "Compared to reimplantation, Deflux® carries higher short-term recurrent UTI risk. However, as a minimally invasive procedure, post-operative pain, length of stay, cost, patient/parental preference must also be weighed, highlighting need for counseling and risk-stratification."

Clinical • Gastrointestinal Disorder • Infectious Disease • Inflammatory Bowel Disease • Nephrology

Variation in price transparency for pediatric urologic procedures (AUA 2026) - "Payer-specific prices were similar for Deflux injections ($1,457-4,906; p=0.15), distal hypospadias repair ($3,000-4,228, p=0.21), inguinal hernia repair ($2,288-6,692; p=0.35), hydrocelectomy ($2,176-4,308; p=0.069), laparoscopic/robotic pyeloplasty ($3,600-8,919; p=0.23), and vaginoplasty ($3,487-4,445; p=0.31)... Even four years after the implementation of the Price Transparency Final Rule, almost half of children's hospitals do not report pricing data for common pediatric urology procedures. There is not much variation in reimbursement rates by payers save for open pyeloplasty and open ureteral reimplantation. This underscores the need for continued reporting of healthcare prices to understand the variations in prices for commonly performed urologic procedures."

Clinical • Gastroenterology • Pediatrics • Urology

Endoscopic Deflux Injection for Vesicoureteral Reflux in a Renal Allograft Complicated by Recurrent Acute Pyelonephritis: A Case Report. (PubMed, Cureus) - "Follow-up voiding cystography demonstrated resolution of VUR, and no further episodes of acute pyelonephritis occurred during 52 months of clinical follow-up, with stable allograft function. This case suggests that endoscopic Deflux injection can be a safe and effective minimally invasive option for managing transplant kidney VUR complicated by recurrent acute pyelonephritis, potentially preserving renal allograft function while avoiding more invasive reconstructive surgery."

Journal • Infectious Disease • Nephrology • Transplantation

Acute bilateral ureteric obstruction after Deflux injection: a case report. (PubMed, J Surg Case Rep) - "The patient remained asymptomatic without hydronephrosis after 5 years. This case highlights the uncommon but significant risk of ureteral obstruction following endoscopic bulking agent injection and emphasizes the need for careful post-procedural monitoring."

Journal • Infectious Disease • Nephrology • Pain • Pediatrics • Urology

Deflux as a Minimally Invasive Solution for Vesicoureteral Reflux Following Ureteral Reimplantation. (PubMed, J Emerg Trauma Shock) - "Posttreatment results showed a significant reduction in VUR severity, reduction of her recurrent UTIs, and resolution of chronic flank pain. This case report demonstrates a successful utilization of this approach for symptomatic reflux following ureteral reimplantation in an adult."

Journal • Infectious Disease • Nephrology • Pain

Targeted hysteroscopic methotrexate injection for caesarean scar pregnancy: insights from a single-center case series (ESGE 2025) - "A 3.7F Deflux metal needle was introduced into the myometrial tissue at four separate points around the implantation site...Moreover, it enabled high local drug concentrations while minimizing the risk of intra- and post-operative bleeding. Further studies with larger cohorts are required to assess long-term fertility and pregnancy outcomes."

Clinical • Anesthesia • Hematological Disorders

Enhanced Facial Rejuvenation: Biostimulatory Effects of Hylan Gel Dermal Filler DX on Collagen Synthesis and Tissue Regeneration. (PubMed, Aesthetic Plast Surg) - "HA + DX exhibited considerable benefits in collagen stimulation, wound healing, and cytokine modulation. Its favorable rheological characteristics and regenerative potential make it a promising option for facial rejuvenation and tissue regeneration."

Journal • Aesthetic Medicine • IL10 • IL1B • IL6 • TGFB1 • TNFA

The Deflux Injection Reduced the Incidence of Urinary Tract Infections in Children with Vesicoureteral Reflux (UAA 2025) - "The Deflux injection could reduce the incidence of febrile urinary tract infections in children with vesicoureteral reflux. The Deflux injection affords a choice of bridge therapy between conservative and surgical treatment for vesicoureteral reflux."

Clinical • Infectious Disease • Nephrology

Long-Term Effectiveness of Onabotulinum Toxin-A in a Combined Total Endoscopic Management of Pediatric Vesicoureteral Reflux in Neurogenic Bladder Dysfunction. (PubMed, Toxins (Basel)) - "Total endoscopic management (TEM), combining intradetrusor Onabotulinum Toxin-A (BTX-A) and subureteric dextranomer/hyaluronic acid (Deflux(R)) injection, offers a minimally invasive alternative. Mean follow-up: 3.2 years (range 1-4.7). In selected patients, TEM appears to be a safe and effective strategy, potentially delaying or avoiding major reconstructive surgery."

Journal • Retrospective data • Fibrosis • Immunology • Infectious Disease • Inflammation • Nephrology • Pediatrics • Urology

Exploratory trial of urethral submucosa injection therapy of deflux for stress urinary incontinence after radical prostatectomy. (PubMed, Int J Surg Protoc) - "The secondary endpoint is efficacy on both SUI volume and patients' QOL. The importance of this clinical trial is to propose a new minimally invasive treatment option for male SUI patients after RARP."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • Urinary Incontinence • Urology

Bulking agent treatment of incontinent catheterizable channels in pediatric patients and young adults. (PubMed, J Pediatr Urol) - "Endoscopic injections offer a minimally invasive option and can be considered a first-line approach for treating CCC incontinence. However, surgical correction remains necessary for some patients. In our material, re-injections were ineffective."

Journal • Pediatrics • Urology

Robotic Assisted Laparoscopic Female Artificial Urinary Sphincter: An Underutilized Tool for Severe Stress Urinary Incontinence (AUA 2025) - "The patient reported leakage throughout her entire childhood and adult life despite multiple bladder neck and urethral bulking with Deflux... AUS in females with severe SUI provides a long-term efficacious solution over repeat sling and bulking procedures, especially in patients with history of multiple interventions. Robotic surgery provides significant advantages in placement of the AUS due to excellent optics, decreased risk of infection, and improved time to recovery. Therefore, robotic female AUS is an important treatment option for severe female SUI and should be considered earlier in the algorithm for female SUI."

Cough • Infectious Disease • Nephrology • Pediatrics • Respiratory Diseases • Urinary Incontinence • Urology

Acute kidney injury caused by ureteral obstruction after Deflux® injection treatment for vesicoureteral reflux after pediatric kidney transplantation: a case report. (PubMed, BMC Urol) - "Ureteral obstruction after Deflux® injection treatment for VUR after transplantation is a serious complication; therefore, treatment indications and timing should be carefully considered."

Journal • Acute Kidney Injury • Chronic Kidney Disease • Infectious Disease • Nephrology • Pediatrics • Renal Disease • Transplantation • Urology

Vesicoureteral reflux of a solitary kidney treated with endoscopic injection therapy comprising tandem injections administered with the assistance of a ureteral guidewire in a young girl. (PubMed, Urol Case Rep) - "A reduced volume of dextranomer-hyaluronic acid copolymer (Deflux®) was required to construct an effective anti-reflux tunnel. A voiding cystourethrogram confirmed VUR resolution. This technique avoided complications associated with a solitary kidney."

Journal

Factors Influencing Success in Endoscopic Treatment of Grade 4-5 Primary Vesicoureteric Reflux (VUR) in Infancy and Childhood. (PubMed, J Pediatr Surg) - "Endoscopic Dx/HA injection is a safe first-line, day-case treatment for Grade 4-5 VUR in children of any age, with a low complication rate. Two-thirds of patients are asymptomatic after one injection; 84 % do not require further procedures after one injection, and 98 % after 2 injections."

Journal • Infectious Disease • Nephrology • Pediatrics • Urology

Rectal Prolapse in the Pediatric Population. (PubMed, Curr Gastroenterol Rep) - "15% hypertonic saline, 50% dextrose, and Deflux are additional safe alternatives...Transabdominal rectopexy with sigmoidectomy, the recommended operation in the adult population for patients with prolapse and constipation, appears only to be preferred in the pediatric population for postoperative recurrences. While outcomes of medical treatment for pediatric rectal prolapse are excellent, sclerotherapy and transabdominal rectopexy are effective options for refractory disease preferred by most pediatric surgeons."

Journal • Review • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Mental Retardation • Pediatrics • Psychiatry

Asymmetrical primary vesicoureteral reflux: Which is the best surgical strategy? (PubMed, J Pediatr Urol) - "The combined Lich-Gregoir extra-vesical ureteral reimplantation and sub-ureteric Deflux® injection for the treatment of primary asymmetrical VUR is an effective alternative to the gold standard cross-trigonal ureteral reimplantation. Moreover, the position of the ureteric orifice is not modified in the eventuality of endourological procedures into adulthood."

Journal • Infectious Disease • Nephrology • Pain • Pediatrics • Urology

Unraveling the Veil: Deflux Injection Masquerading as Calculus at the Vesicoureteric Junction. (PubMed, Indian J Radiol Imaging) - No abstract available

Journal

Recurrence of vesico-ureteral reflux in children: is still the endoscopic injection the best option? (PubMed, Transl Androl Urol) - "Thanks to its low costs and the acceptable recurrence rate, Deflux EI should be proposed as the first therapeutic approach for children affected by VUR, especially in those with low and moderate grades of VUR. Multiple injections could be contraindicated only in older children thank 1 year with high-grade VUR (IV symptomatic and V grade)."

Journal

FLUX trial: 3-month outcome of female urethral bulking with DEFLUX bulking agent (UAA 2024) - No abstract available

Vantris vs. deflux for treatment of paediatric vesicoureteral reflux: Efficacy and obstruction risk. (PubMed, Fr J Urol) - "Despite a similar success rate after PPC and Dx/Ha injections for endoscopic treatment of VUR, there may be a greater risk of postoperative ureteral obstruction after PPC injections. The benefit of using PPC to prevent febrile UTI and renal scarring in children with low-grade VUR does not seem to outweigh the risk of chronic ureteral obstruction."

Clinical • Journal • Retrospective data • Infectious Disease • Nephrology • Pediatrics

The use of a Deflux needle to remove renal keratinizing desquamative metaplasia during PCNL surgery (AUA 2024) - "Renal KDSM represents a rare condition that can be challenging for a Urologist to manage when symptoms are refractory to conservative measures. Use of a deflux needle for hydrodissection during PCNL surgery can facilitate easier removal of these lesions."

Surgery • Cardiovascular • Diabetes • Hypertension • Metabolic Disorders • Nephrology • Pain • Renal Calculi