amoxicillin / Generic mfg. - LARVOL DELTA

Different Amoxicillin Treatment Regimens in Erythema Migrans Patients (clinicaltrials.gov) - P3 | N=200 | Recruiting | Sponsor: University Medical Centre Ljubljana | Phase classification: P=N/A ➔ P3 | N=510 ➔ 200

Enrollment change • Phase classification • Dermatology • Lyme Disease

DEPLETION OF GUT MICROBIOTA ALLEVIATES PROTEINURIA IN PUROMYCIN AMINONUCLEOSIDE-INDUCED NEPHROSIS IN RATS (ISN-WCN 2026) - "Rats were divided into three groups (n=6 each): a control group (oral PBS for 10 days followed by a single subcutaneous injection of PAN (50 mg/kg) on day 0, an antibiotic-treated group (oral amoxicillin, cefotaxime, vancomycin, and metronidazole) for 10 days, followed by PAN injection on day 0, and an indoxyl sulfate (IS)-treated group (antibiotics for 10 days followed by intraperitoneal IS and PAN injection on day 0). The protective effects of antibiotics were associated with the loss of indole-producing bacteria and reduced urinary IS, suggesting that pathogenic gut-derived metabolites drive podocyte injury. Targeting indole-producing bacteria or their metabolites may represent a novel therapeutic approach for MCNS, potentially reducing reliance on corticosteroids."

Gut Microbiota • Preclinical • Chronic Kidney Disease • Glomerulonephritis • Nephrology • Renal Disease

Optimized green zinc oxide/chitosan/amoxicillin nanocomposite against Pseudomonas aeruginosa. (PubMed, Appl Microbiol Biotechnol) - "These findings demonstrate that the ZnO/CS/AMX nanocomposite acts through a synergistic, multimodal mechanism, effectively overcoming bacterial resistance and biofilm recalcitrance, while also exhibiting favorable biocompatibility. KEY POINTS: RSM-Box-Behnken optimized green biosynthesis of ZnO NPs using cell-free metabolites of P. aeruginosaGreen synthesis of zinc oxide/chitosan/amoxicillin nanocomposite to combat MDR P. aeruginosaThe nanocomposite markedly enhances bactericidal and antibiofilm efficacy at low doses with high mammalian cell safety and synergistic action."

Journal • Infectious Disease

Dramatic increase in consumption of antibiotics in Colombia, 2020-2023. (PubMed, Biomedica) - "The progressive increase in consumption and spending on antimicrobials in Colombia requires a set of interventions that include promoting changes in medical prescribing behaviour and a public education campaign that leads to the adoption of a sustainable public health policy."

Journal

Emerging Antimicrobial Resistance in Klebsiella pneumoniae: A Molecular and Antibiogram Insight From the Beef Value Chain in Bangladesh. (PubMed, Microbiologyopen) - "The antibiogram profile depicted diverse resistance patterns with the highest resistance pattern to ampicillin (100%), amoxicillin (100%), and cefoxitin (87.12%). Phenotypic characterization, utilizing Congo red agar and microtiter plate tests, identified 25 out of 132 (19%) isolates as biofilm producers, with 7 (28%) classified as strong producers, and 3 (12%) and 15 (60%) as intermediate and weak producers, respectively. This study addresses the alarming emergence of antimicrobial resistance within the beef value chain in Bangladesh, posing an alarming threat to food safety and public health associated with biofilm-producing foodborne pathogens, underscoring the necessity for improved hygiene practices to mitigate the public health risk posed by these pathogens."

Journal • Infectious Disease • Pneumonia

Antibiotic prescribing and antimicrobial resistance: An evaluation of clinical teachers' knowledge, attitude and practices at a South African dental school. (PubMed, PLoS One) - "The results reveal a range of knowledge, attitudes, and practices related to antibiotic prescribing and AMR awareness among clinical teachers, and indicate acceptable levels of knowledge and practice in various clinical scenarios, however certain identified prescribing practices may require targeted educational intervention. By strengthening antibiotic stewardship principles among clinical teachers, undergraduate prescribing practices can be further enhanced."

Journal • Allergy • Immunology

Dual-layer tissue scaffolds with antibacterial and regenerative properties: Integration of melt electrowriting and electrospray technologies. (PubMed, J Pharm Sci) - "The paper discusses the development of dual-layer tissue scaffolds (DLS) using poly (lactic acid) (PLA) and amoxicillin (AMOX) nanoparticles at different concentrations (0.5% w/v and 1% w/v)...MTT assays confirmed cytocompatibility of the scaffold, showing enhanced cell viability for the DLS-0.05 AMOX scaffold. Considering the obtained results, dual-layer tissue scaffolds with antibacterial properties present significant potential for a wide range of wound care applications."

Journal

Comparison of Adverse Events Associated With Six Common Antibiotics in Lower Respiratory Tract Infections Using the United States Food and Drug Administration Adverse Event Reporting System. (PubMed, Cureus) - "Ciprofloxacin exhibited the highest reporting proportion, with 89 of 809 patients (11.0%), followed by clarithromycin (129/1,572; 8.2%), azithromycin (132/2,048; 6.4%), amoxicillin (90/1,796; 5.0%), levofloxacin (198/4,604; 4.3%), and doxycycline (26/693; 3.8%). Fluoroquinolones (levofloxacin, ciprofloxacin) and macrolides (clarithromycin, azithromycin) showed elevated serious AE reporting relative to amoxicillin, underscoring the need for careful benefit-risk assessment. These drug‑specific patterns and temporal characteristics may help inform targeted clinical monitoring and guide future pharmacoepidemiological research to verify these hypothesis‑generating findings."

Adverse events • Journal • CNS Disorders • Infectious Disease • Nephrology • Pulmonary Disease • Renal Disease • Respiratory Diseases

In vitro analysis of biofilm formation and synergistic antibiotic-phage therapy for amoxicillin-resistant Escherichia coli (ESCMID Global 2026) - No abstract available

Preclinical

Prevalence of dual resistance of Helicobacter pylori to clarithromycin and amoxicillin and emergence of novel genetic mutations among clinical isolates from adult patients with gastritis in Tehran, Iran, 2023–2024 (ESCMID Global 2026) - No abstract available

Clinical • Gastrointestinal Disorder • Infectious Disease

A hit with a scar: amoxicillin alters the infant gut microbiome long-term but without fungal expansion (ESCMID Global 2026) - No abstract available

Gastrointestinal Disorder

Amoxicillin dosages in adult patients with streptococcal endocarditis: a PK/PD reappraisal (ESCMID Global 2026) - No abstract available

Clinical • PK/PD data • Cardiovascular

Unpredictable amoxicillin exposure under high-dose therapy: evidence supporting individualised-guided TDM (ESCMID Global 2026) - No abstract available

Clinical

Treatment of early Lyme borreliosis with amoxicillin for ten vs 14 days: a randomised open-label clinical trial (ESCMID Global 2026) - No abstract available

Clinical • Inflammatory Arthritis • Lyme Disease

Lack of synergy between amoxicillin and cefazolin against Enterococcus faecalis: reassessment of a proposed empirical regimen for infective endocarditis (ESCMID Global 2026) - No abstract available

Cardiovascular

Klebsiella pneumoniae hypervirulent clonal complex 66 among amoxicillin-susceptible strains (ESCMID Global 2026) - No abstract available

Infectious Disease • Pneumonia

Green manufacturing of amoxicillin trihydrate: a malic acid-assisted crystallization framework enhanced by Taguchi-ANN optimization. (PubMed, RSC Adv) - "Under optimized conditions (2.5 M malic acid, pH 5.5, 60 min, 1500 rpm), AMCT crystals were obtained with 99.21% purity and 61.82% yield. These results demonstrate a robust, data-driven framework for sustainable AMCT production, providing a high-performance alternative to conventional mineral-acid-based crystallization methods."

Journal

Microbial contamination of ART culture media with Enterococcus faecalis: case report of a live birth following blastocyst transfer. (PubMed, Reprod Biomed Online) - "Treatment with prophylactic amoxicillin resulted in a healthy live birth from a blastocyst contaminated with E. faecalis, questioning the systematic discarding of embryos from contaminated culture medium."

Journal

Amoxicillin and copper affect humification during compost: Insight into dissolved organic matter and bacterial community succession. (PubMed, Environ Res) - "During the cooling period, the complex pollution inhibited amino acid metabolism and carbohydrate metabolism, and suppressed the expression of GHs and GTs. This study provides data support for regulating HA formation during composting under combined pollution."

Journal

Ornamental coral pests and parasites: a biosecurity alert for aquarium trade. (PubMed, Braz J Biol) - "Chemical treatments (e.g., levamisole, praziquantel, KCl, milbemycin, amoxicillin) show partial efficacy, yet many are limited to adult stages and risk disrupting coral microbiota. In an era of climate change and increasing demand for captive-bred corals, integrating science-based management with aquarist practices is essential. Preventive measures, rapid diagnostics, and biotechnological innovation will be key to ensuring coral health and advancing the aquarium hobby as a tool for marine conservation."

Journal • Review

Case Report: Diagnosis and detection of amoxicillin-induced immune hemolytic anemia. (PubMed, Front Immunol) - "A combination of detailed drug history, serological testing, and drug-specific assays is essential for accurate diagnosis. Immediate withdrawal of the implicated drug remains critical for clinical recovery."

Journal • Anemia • Hematological Disorders

Salmonella Osteomyelitis with Cutaneous Fistula in an Immunocompetent Adult Presenting as a Tumor-Like Bone Lesion: A case report. (PubMed, Intern Med) - "The patient was treated with ceftriaxone and de-escalated to ampicillin, followed by oral amoxicillin. This case demonstrates that chronic osteomyelitis caused by NTS can present as a cutaneous fistula. Furthermore, it underscores the importance of obtaining a bone culture to identify the causative organism and ensure an accurate diagnosis."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Inflammation • Oncology • Pain

Prevalence of Inducible Clindamycin Resistance Staphylococcus aureus Associated with Wound Infection in Central Nepal. (PubMed, J Nepal Health Res Counc) - "A high rate of inducible clindamycin resistance among MRSA was observed. To identify the status of antibiotic resistance among S. aureus, further genomic-based studies are required."

Journal • Infectious Disease

A 5-year review of Helicobacter pylori isolated from gastric biopsies at the UK Health Security Agency Gastrointestinal Bacteria Reference Unit. (PubMed, J Med Microbiol) - "Antimicrobial susceptibility to metronidazole, clarithromycin, levofloxacin, amoxicillin and tetracycline was determined phenotypically by E-test.Results. There is an urgent need to establish UK primary resistance rates in treatment-naïve patients to support a review of regional first-line treatment regimes. These results support a need for rapid, local isolation of H. pylori by clinical microbiology laboratories to maximize patient benefit due to delays in testing, significantly reducing the likelihood of recovering viable strains for susceptibility testing, and demonstrate that implementation of molecular tests could support better patient management."

Journal • Gastric Cancer • Infectious Disease • Oncology • Peptic Ulcer

FORMaT-EVOLVE: Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial (clinicaltrials.gov) - P2 | N=300 | Not yet recruiting | Sponsor: The University of Queensland

New P2 trial • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Nontuberculous Mycobacterial Disease • Pulmonary Disease • Respiratory Diseases