amoxicillin / Generic mfg. - LARVOL DELTA

Effectiveness and Safety of First-Line Non-Bismuth Quadruple Concomitant Therapy Versus Single-Capsule Bismuth Quadruple Therapy. (PubMed, Aliment Pharmacol Ther) - "Sc-BQT is more effective, better tolerated, and more broadly applicable than 14-day CT. Both regimens achieved ≥ 90% success, but Sc-BQT's stewardship-friendly profile further supports its use as first-line therapy for H. pylori eradication."

Journal • Infectious Disease

On paper; in practice: measuring compliance with official pricing policies in a large field study of essential medicines in Indonesia. (PubMed, J Pharm Policy Pract) - "Five essential medicines (allopurinol, amlodipine, amoxicillin, cefixime, dexamethasone) were purchased from randomly selected health facilities, retail pharmacies and online outlets in Indonesia. Rules restricting permitted MRPs for unbranded generics, irrational since their inception, while they never set any limits at all on the price of branded medicines. This showed not enough evidence that the policy contributed to its objective of ensuring affordability."

Compliance • Journal • Pricing

Prevalence and antimicrobial susceptibility of Salmonella enterica Typhi in febrile patients: a cross-sectional study. (PubMed, J Infect Dev Ctries) - "Azithromycin and carbapenem were a suitable empirical therapy choice. However, the isolates were highly resistant to conventional first-line antibiotics (ampicillin, amoxicillin), second generation fluoroquinolones (ciprofloxacin), and third-generation cephalosporins (ceftriaxone, cefotaxime), that are considered vital in typhoid treatment."

Journal • Observational data • Retrospective data • Infectious Disease

Cost of non-antimicrobials for prophylaxis in the management of recurrent UTIs. (PubMed, Scott Med J) - "Trimethoprim was the cheapest of the antimicrobials for 6 months of prophylaxis (£5.08), followed by Cefalexin (£7.97), Amoxicillin (£10.71) and Nitrofurantoin (£16.32).ConclusionThe cost of antimicrobial management options for the prophylaxis of UTIs was found to be generally cheaper across the board, in comparison to non-antimicrobial products. However, the continuing public health crisis with regards to overprescribing of antimicrobials, growing resistance and the need for antimicrobial stewardship makes non-antimicrobials an ever-important consideration."

Journal

Whole-Genome Sequencing and Bioinformatics Analysis of ESBL- producing Klebsiella pneumoniae in a Ghanaian teaching hospital. (PubMed, BMC Microbiol) - "This study highlights the prevalence of MDR ESBL-producing K. pneumoniae in both hospital environments and patients, emphasizing the potential for cross-transmission within healthcare settings. These findings reinforce the urgent need for strengthened infection prevention and control measures, enhanced antimicrobial stewardship, and continuous genomic surveillance to mitigate the spread of resistant K. pneumoniae in healthcare settings."

Journal • Infectious Disease • Pneumonia • ACO1

Effect of therapeutic plasma exchange on amoxicillin, clindamycin, midazolam, and morphine pharmacokinetics in a critically ill child. (PubMed, Pediatr Nephrol) - "Despite theoretical predictions, clinically significant reductions in plasma drug concentrations of amoxicillin, clindamycin, and midazolam were observed following therapeutic plasma exchange. This case report emphasizes the necessity of therapeutic drug monitoring to adjust dosing appropriately and optimize patient outcomes."

Journal • PK/PD data • Critical care • Septic Shock

Antibiotics use and ethnoveterinary practices in pig farming: an insight from federal capital territory, Nigeria. (PubMed, BMC Vet Res) - "Antibiotic use was widespread, 90% of farmers administered antibiotics, with oxytetracycline, penicillin, and amoxicillin being most commonly used. Addressing these issues may support sustainable livestock production and AMR mitigation in similar low-and middle-income settings. These findings add to the understanding of antimicrobial practices in localised settings which cumulatively influence the global AMR burden."

Journal

Helicobacter Rescue Therapy With Vonorazon and Amoxicillin Dual Therapy Versus Bismuth-containing Quadruple Therapy (clinicaltrials.gov) - P4 | N=688 | Completed | Sponsor: Yongquan Shi | Recruiting ➔ Completed

Head-to-Head • Trial completion • Dyspepsia • Gastric Cancer • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Oncology • Peptic Ulcer • Solid Tumor

Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line Eradication (clinicaltrials.gov) - P4 | N=558 | Completed | Sponsor: Xijing Hospital of Digestive Diseases | Not yet recruiting ➔ Completed | Trial completion date: Oct 2025 ➔ Jun 2025 | Trial primary completion date: Sep 2025 ➔ Apr 2025

Trial completion • Trial completion date • Trial primary completion date • Gastrointestinal Disorder • Infectious Disease

Prevalence and antimicrobial resistance patterns of nontyphoidal Salmonella in Ghana: a systematic review and meta-analysis. (PubMed, Trop Med Health) - "Despite ongoing interventions, NTS remains a significant public health challenge in Ghana, with high AMR levels. The continued rise in resistance to critical antibiotics highlights the need for a One Health approach, improved diagnostics, enhanced surveillance, and targeted public health measures to control NTS and mitigate AMR."

Journal • Retrospective data • Review • Infectious Disease

Feasibility of serial measurement of nitrite for pharmacodynamic monitoring and precision prescribing in urinary tract infections. (PubMed, Commun Med (Lond)) - "Here we show that nitrite generation by E. coli may have clinical relevance as a biomarker for infection progression and antimicrobial treatment outcomes, offering a valuable tool for monitoring the pharmacodynamic responses to antimicrobial therapy in UTIs."

Journal • PK/PD data • Infectious Disease • Nephrology

Recommendations and Adjuvant Therapies to Mitigate Clarithromycin-Resistant Helicobacter pylori-Associated Infections in Africa. (PubMed, Infect Drug Resist) - "In Africa, first-line therapy combines antimicrobials (eg, amoxicillin and clarithromycin) with proton pump inhibitors (PPIs), whereas second-line therapies (levofloxacin-based triple therapy, sequential non-bismuth quadruple therapy, or bismuth-based quadruple therapy) combine antimicrobials (amoxicillin, clarithromycin, nitroimidazole, levofloxacin, or tetracycline) with PPIs and bismuth compounds. The recommendations included the implementation of prevention measures, standardized antimicrobial susceptibility testing methods, strengthening the surveillance, and promoting antimicrobial stewardship, while phytotherapy and probiotics were discussed as potential adjuvant therapies to conventional antimicrobial treatments. While awaiting the full implementation of these measures, the treatment of H. pylori infections should be based on the guidelines of the AHMSG First Lagos Consensus."

Journal • Review • Gastric Cancer • Infectious Disease • Oncology • Solid Tumor

What is the appropriate antibiotic administration to prevent MRONJ development after tooth extraction? (PubMed, J Bone Miner Metab) - "A single preoperative dose of AMPC may be sufficient for tooth extractions in patients on low-dose BPs. However, teeth with radiopaque changes around the root require careful monitoring postextraction."

Journal

Azithromycin as adjunctive treatment for uncomplicated severe acute malnutrition (AMOUR): study protocol for a double-masked randomised controlled trial. (PubMed, BMJ Open) - P4 | "Amoxicillin is recommended for children with uncomplicated severe acute malnutrition (SAM). The results of this study will be disseminated to the Ministry of Health, community stakeholders and via peer-reviewed publications and academic conferences. NCT06010719."

Clinical • Clinical protocol • Journal

Efficient Sulfamethoxazole Removal by an Isolated Strain Microbacterium esteraromaticum S13. (PubMed, Curr Microbiol) - "The results showed that the strain can tolerate high SMX concentrations up to 150 mg/L and achieved the best removal efficiency at 35 °C, pH 8.0, with an initial SMX concentration of 100 mg/L and the addition of 5 g/L glucose, achieving a removal efficiency of 50.31% within 72 h. The strain also showed good removal potential for other sulfonamide antibiotics (SAs), including sulfadiazine, sulfamethazine, and sulfadimidine, with removal efficiencies all exceeding 61%, and also demonstrated a removal efficiency of 53% for amoxicillin. Nearly 100% removal of 100 mg/L SMX was achieved within 24 h, and S13-immobilized gel beads maintained a degradation rate of over 85% even after four consecutive rounds of degradation. These results strongly demonstrated the potential of the S13 strain to degrade antibiotics and provided a solid foundation for advancing the removal of SAs in the environment."

Journal

Novel Animal Model of Enterobacteria Pathogenicity, Virulence, and Amoxicillin-Biosurfactant Synergic Using Nsombé (Rhynchophorus phoenicis Larvae). (PubMed, Microbiologyopen) - "In contrast, amoxicillin alone demonstrated variable and less sustained efficacy. These findings underscore the potential of R. phoenicis larvae as a valuable alternative model for exploring host-pathogen interactions and assessing the synergistic efficacy of combined antimicrobial treatments involving antibiotics and biosurfactants."

Journal • Preclinical • Infectious Disease • Pneumonia • HSPD1

Anti-Inflammatory and Antibacterial Properties of Curcuma longa Extract Against Helicobacter pylori. (PubMed, Mol Nutr Food Res) - "In vitro experiments demonstrated that CLE completely inhibited the growth of H. pylori Sydney strain 1 (SS1) in a dose-dependent manner and exhibited synergistic effects when combined with amoxicillin...Furthermore, CLE attenuated inflammatory cell infiltration in the gastric mucosa of infected mice and significantly reduced the expression of proinflammatory cytokines and matrix metalloproteinases in H. pylori-infected AGS cells, a human gastric cancer cell line. These findings suggest that CLE is a promising candidate for the treatment of H. pylori infection, exhibiting potent antibacterial and anti-inflammatory properties."

Journal • Gastric Cancer • Gastrointestinal Disorder • Infectious Disease • Inflammation • Oncology • Peptic Ulcer • Solid Tumor

Trends in Antimicrobial Resistance of Major Mastitis-Causing Pathogens: A Nine-Year Study. (PubMed, Vet Med Sci) - "This study highlighted key factors contributing to MDR in mastitis pathogens. The findings emphasised the complex nature of antimicrobial resistance and the necessity for tailored strategies-such as improved farm management, seasonal interventions, and targeted antimicrobial use-to effectively mitigate resistance."

Journal • Retrospective data

Adsorptive Removal of Amoxicillin Using Green-Synthesized SiNH2@FeNP Nanocomposite: Characterization, Optimization, and Modeling. (PubMed, ACS Omega) - "These results demonstrate the high potential of SiNH2@FeNP as a low-cost, eco-friendly adsorbent for pharmaceutical removal from water, providing a scalable and sustainable alternative for wastewater treatment applications. This approach represents a novel combination of green nanotechnology and statistical optimization for AMX removal."

Journal

Antimicrobial Sensitivity Pattern of Sputum and Nasopharyngeal Swab in Children with Cystic Fibrosis: A Lesson from a Specialized Shishu (Children) Hospital in Bangladesh. (PubMed, Mymensingh Med J) - "In contrast, nearly all isolates were resistant to amoxicillin, erythromycin and rifampicin. Levofloxacin is the most effective agent to treat CF patients. Active surveillance of the resistance pattern should always continue to be promoted."

Journal • Observational data • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pediatrics • Pneumonia • Pulmonary Disease • Respiratory Diseases

Gastroenterologists' perspectives of high-dose dual therapy for Helicobacter pylori infection in China: Results of a China survey. (PubMed, Medicine (Baltimore)) - "Amoxicillin was the most commonly used antibiotic in HDDT, followed by clarithromycin, furazolidone, levofloxacin, metronidazole, cefuroxime and tetracycline. HDDT maybe the main treatment of H pylori eradication, but the application of the HDDT among gastroenterologists in China is insufficient. Better education should be carried out in future to improve the ability of gastroenterologists to standardize the treatment of H pylori infection."

Journal • Gastroenterology • Infectious Disease

Drug-induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Ten-year Retrospective Study of 103 Cases. (PubMed, Clin Exp Dermatol) - "In our study, carbamazepine, levofloxacin, ibuprofen, aspirin, amoxicillin, metronidazole and lamotrigine were the most common triggers for SJS/TEN. If combined with high-risk factors such as pneumonia, renal insufficiency, gastro-intestinal disorder, cardiac involvement and sepsis, SJS/TEN patients might have a higher risk of mortality."

Journal • Retrospective data • Gastroenterology • Gastrointestinal Disorder • Hepatology • Infectious Disease • Liver Failure • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases • Septic Shock • Steven-Johnson Syndrome

Improving ratiometric-based analysis via designing intense bi-ligand metal-organic frameworks: dual-mode for detection of amoxicillin in milk and pharmaceutical samples. (PubMed, Food Chem) - "The spectrofluorometric method achieved a detection range of 5.0-250 μM with a detection limit of 0.34 μM, while the smartphone-based approach reached a detection limit of 3.3 μM. The BiL-Eu-MOF demonstrated high accuracy (98.1-102.7 %) and precision (RSD < 2 %) in milk and pharmaceutical samples, highlighting its potential as a simple, effective, and modification-free sensing platform."

Journal

Microbiota profiles and antimicrobial resistance genes in sow fecal samples from farms with and without antibiotic use. (PubMed, Anim Biosci) - "Sows were randomly divided into two groups: one was fed a commercial diet with antibiotics for 3 weeks from mating to day 21 of gestation, before the farrowing stage (amoxycillin 300 mg/kg and tiamulin 150 mg/kg: control group, ABO), and the other was fed the same diet without antibiotics (treatment group, NOABO)...Our investigations discovered that the core microbiota of withdrawal antibiotics may be related to the gut microbiota and AMR. Therefore, understanding the gut microbiota composition and function in animals could enable strategies for its modulation to improve sows' gut microbiota and minimize the negative impact of antibiotics."

Journal

Genetically Engineered Yeast for Enhanced Biodegradation of Β-lactam Antibiotics. (PubMed, Appl Biochem Biotechnol) - "Over 90% of 10 µM ampicillin was degraded within 0.5 h using 250 nM α-factor and a cultivation period of 24 h. Finally, the transferability to other β-lactam antibiotics was investigated, resulting in complete degradation of amoxicillin, penicillin G and piperacillin within 24 h."

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