fosfomycin tromethamine / Generic mfg. - LARVOL DELTA

Building-Scale Wastewater Metagenomics Reveals Temporal Patterns in Resistance and Virulence Genes. (PubMed, Antibiotics (Basel)) - "Correlation and network analyses revealed modular ecological coupling between resistance and virulence functional categories, with metal/co-resistance and fosfomycin classes showing the strongest associations with virulence functions. At the community level, a Benjamini-Hochberg-corrected co-occurrence network resolved into taxa-anchored resistance modules and separate virulence-function clusters, with Acinetobacter and fluoroquinolone resistance as the principal connectors. These findings indicate that building-scale wastewater metagenomics can capture ecologically structured functional gene dynamics, highlighting its potential as a surveillance tool for monitoring AMR and virulence in built environments."

Journal • Infectious Disease • Novel Coronavirus Disease

The Evolving Clonal, Plasmid-Mediated Resistome, Virulome and Therapeutic Landscape of Carbapenem-Resistant Klebsiella pneumoniae in Oman. (PubMed, Antibiotics (Basel)) - "CRKP in Oman is characterised by convergent clonal expansion, plasmid-mediated resistance, retained virulence potential and narrowing therapeutic options. Integrated genomic surveillance with carbapenemase-directed susceptibility and synergy testing is essential to guide precision antimicrobial stewardship in high-risk healthcare settings and inform early infection prevention responses to emerging regional CRKP lineages."

Journal • Infectious Disease • Pneumonia • FOS

Antimicrobial Resistance Gene Profiles in Salmonella spp., Escherichia coli, and Enterococcus spp. from Conventional and Antibiotic-Free Chicken Meat. (PubMed, Pathogens) - "This difference was concentrated in isolates carrying the ionophore resistance genes narA and narB (CONV 41.9% vs. ATB-Free 5.9%; p < 0.001), which were not associated with transferable vancomycin or high-level aminoglycoside resistance determinants in this dataset. The resistance determinants associated with the clinically important antimicrobial classes, including blaCTX-M-8, quinolone resistance genes, and fosfomycin resistance genes, were detected in isolates from both production systems. Overall, the observed ARG profiles differed among the bacterial groups, indicating that the relationship between the production system and the resistome was not uniform. Since the sequenced isolates constituted a phenotypically selected subset, the observed ARG frequencies should not be interpreted as population-level prevalence estimates for either production system."

Journal

First Randomized Controlled Trial Comparing D-Mannose to Fosfomycin in Acute Uncomplicated Lower Urinary Tract Infections. (PubMed, Antibiotics (Basel)) - " Post hoc analysis indicated that D-mannose treatment is comparable to fosfomycin in uncomplicated cystitis in line with the prespecified non-inferiority criteria. These findings warrant confirmation in an adequately powered trial but suggest that D-mannose is a promising alternative to antibiotics given its favorable risk-benefit ratio."

Journal • Infectious Disease • Nephrology

Genomic Epidemiology, Antimicrobial Resistance, and Virulence of Clinical Enterococcus Isolates from Hat Yai, Thailand: Genomic Relatedness and Lineage Persistence. (PubMed, Antibiotics (Basel)) - " All isolates were susceptible to linezolid and oritavancin, whereas non-susceptibility to ampicillin, fosfomycin, vancomycin, and daptomycin was 60.0%, 57.5%, 12.5%, and 5.0%, respectively. High-level gentamicin resistance and MDR occurred in 37.5% and 22.5%, respectively...Three novel STs were identified, with E. faecium ST3096 exhibiting high-level ampicillin resistance, fosfomycin resistance, and reduced daptomycin susceptibility. These findings reveal emerging resistant lineages and spatiotemporal patterns of genomic relatedness, supporting continued genomic surveillance of clinical enterococci in Thailand."

Journal • Infectious Disease • LIAS

ESBL-Producing Klebsiella pneumoniae Bacteraemia with Renal Micro-Abscesses Treated with Cefepime-Enmetazobactam in a Neutropenic Allogeneic Transplant Recipient. (PubMed, Pathogens) - "We describe a profoundly immunocompromised patient with acute myeloid leukaemia after allo-HSCT, grade III steroid-refractory gastrointestinal graft-versus-host disease, and intestinal colonization by an ESBL-producing K. pneumoniae isolate resistant to ceftolozane-tazobactam...Meropenem was rapidly de-escalated to cefepime-enmetazobactam, with temporary adjunctive fosfomycin and subsequently tigecycline...Whole-genome sequencing identified K. pneumoniae ST307 carrying blaCTX-M-15, blaTEM-1, blaSHV-28, and blaOXA-1, together with multiple resistance determinants and a large conjugative plasmid. This case describes the use of cefepime-enmetazobactam as part of a targeted carbapenem-sparing strategy for invasive ESBL-producing K. pneumoniae infection in a highly immunocompromised allo-HSCT recipient."

Journal • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Gastrointestinal Disorder • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Nephrology • Neutropenia • Oncology • Pneumonia • Transplantation

Evaluation of the Excretion of Fosfomycin Into Breast Milk Following a Single Intravenous Dose of ZTI-01 (6 g) in Healthy Lactating Women (clinicaltrials.gov) - P4 | N=24 | Recruiting | Sponsor: Meitheal Pharmaceuticals, Inc. | Not yet recruiting ➔ Recruiting

Enrollment open

Perspectives for pharmaceutical screening at XFEL sources using the example of Lassa virus endonuclease. (PubMed, Acta Crystallogr D Struct Biol) - "We collected serial fixed-target X-ray diffraction data at Linac Coherent Light Source and at the synchrotron source PETRA III for comparison and solved the crystal structures of 2,4-dioxo-4-phenylbutanoic acid (DPBA) and baloxavir acid (BXA) binding to the active site of LASVendoN...To analyse the sample throughput in a compound-screening experiment at an XFEL, we further present data for the bacterial fosfomycin-resistance protein A with six ligands previously identified in a synchrotron screening experiment. In summary, the XFEL and synchrotron data-collection approaches have proven to be useful for compound screening with minor differences in achievable data quality and resolution. The individual experimental setup, detector and potentially the use of beam sweeping at XFELs at close-to-physiological temperatures combined with reasonable sample consumption and minimized radiation damage are considered to be advantageous for high-throughput drug development."

Journal • Infectious Disease

Urbanization impacts the environmental microbial community and its antibiotic phenotypic resistance potential by reshaping the diversity and network complexity. (PubMed, Environ Res) - "This phenotypic resistance potential, structured around nodes of cefalexin, amoxicillin, and fosfomycin, exhibited increased topological robustness, a doubling of inter-domain connectivity (bacterial-fungal), and an increase in positive correlation. To conclude, this study reveals that urbanization induces a trade-off between the overall cohesion of microbial ecosystems and the topological robustness of specialized AMR-networks. It highlights the interest of integrating high-resolution network analysis into One Health surveillance of AMR, to accurately predict and intercept the AMR spread in anthropized landscapes, even if this AMR-network constructed using culture-based methods have limitations."

Journal

Characterization of the microbial resistome in a prospective trial of CBM588 in metastatic renal cell carcinoma (mRCC) offers mechanism for interplay between antibiotic (abx) use and immune checkpoint inhibitor (ICI) activity. (ASCO 2022) - P1 | " Pts with newly diagnosed mRCC with clear cell and/or sarcomatoid histology and intermediate/high risk disease per IMDC criteria were randomized to nivolumab/ipilimumab (nivo/ipi) or nivo/ipi/CBM588 in a 1:2 ratio...More specifically, nivo/ipi/CBM588 treatment led to a significant reduction in fosfomycin RGs and nitroimidazole (e.g., metronidazole) RGs in both pts with R (p = 0.019 and 0.042, respectively) and NR (p = 0.031 and p = 0.031, respectively). A multitude of other clinically relevant abx RGs were downregulated in pts receiving CBM588, including those mediating resistance to glycopeptide (e.g., vancomycin) and lincosamide (e.g., clindamycin) abx... In the first interrogation of the resistome in mRCC, we demonstrate that CBM588 decreases abx RGs associated with multiple commonly used classes of abx. Abx clear commensals and increase pathogenic (abx resistant) bacteria in the gut. Based on our data, we formulate the hypothesis that combining abx with CBM588..."

Checkpoint inhibition • Clinical • Genito-urinary Cancer • Immune Modulation • Inflammation • Lung Cancer • Oncology • Renal Cell Carcinoma • Sarcoma • Solid Tumor

Purine and pyrimidine analogs differentially regulate cell wall precursor biosynthesis to control β-lactam susceptibility in methicillin-resistant Staphylococcus aureus. (PubMed, mBio) - "We previously showed that the pyrimidine analogs 5-fluorouracil (5-FU) and 5-fluorouridine (5-FUrd) synergize with β-lactams...Gemcitabine (Gem) and mitomycin C (Mito), such as 5-FU and 5-FUrd, exhibited intrinsic anti-MRSA activity and potentiated β-lactams, whereas the purine analog 6-thioguanine (6-TG) showed distinct, often antagonistic effects...Consistent with this, pyrimidine analogs also suppressed GlmS expression, potentially limiting UDP-GlcNAc production required for cell wall synthesis, and synergized with fosfomycin...Additionally, glutathione-mediated attenuation of killing implicated reactive oxygen species in the bactericidal activity of cloxacillin combinations. Finally, these agents displayed strong antibiofilm activity, further enhanced in combination with daptomycin and rifampicin...These drugs altered the bacterial cell wall and other metabolic pathways linked to antibiotic susceptibility. Our findings reveal the potential to repurpose certain..."

Journal • Infectious Disease • Oncology

In Vitro antibacterial, anti-biofilm, and virulence-modulating activity of Cinnamomum verum-mediated iron oxide nanoparticles against carbapenem-resistant uropathogenic Escherichia coli. (PubMed, Int Microbiol) - "These proof-of-concept findings indicate that C. verum-mediated Fe₂O₃-NPs show potent in vitro multi-mechanism antibacterial activity against two clinically confirmed CRE UPEC isolates, combining promising antibacterial potency with transcriptional suppression of key virulence determinants; validation in a larger isolate panel is required to confirm generalisability. These findings identify the nanoparticle preparation as a promising in vitro candidate for further antibacterial and anti-virulence investigation. However, cytotoxicity, biocompatibility, validation using a larger collection of clinical isolates, and in vivo studies are required before any therapeutic application can be considered."

Journal • Preclinical • Infectious Disease • Nephrology

Rapid point-of-care testing for urinary tract infections: diagnostic accuracy and clinical impact. (PubMed, BJGP Open) - "The PA-100 AST showed moderate diagnostic accuracy and may support management of suspected uUTI in primary care. However, its relatively low negative predictive value observed in our study population limits its ability to rule out bacteriuria. The test had a modest impact on prescribing decisions but further research is needed to determine its effectiveness in optimizing antibiotic use."

Journal • Infectious Disease • Nephrology

Microbiological Profile of Pathogens Among Patients at a Tertiary Care Hospital in Mumbai, India. (PubMed, Cureus) - "Gram-negative bacteria were the predominant pathogens isolated with a substantial burden of MDROs. The observed antimicrobial resistance patterns emphasize the need for continuous microbiological surveillance, regular updating of institutional antibiograms, and implementation of robust antimicrobial stewardship programs to optimize empirical antimicrobial therapy and improve patient outcomes."

Journal • Critical care • Infectious Disease • Pneumonia

Prevalence of Fosfomycin-Resistant Escherichia coli from Livestock, Companion Animals, and the Environment in Japan, and Genomic Characterization of Transferable fos Genes. (PubMed, Microb Drug Resist) - "The genetic structures of fosA3-carrying plasmids were almost identical to those reported in Japan and China. Herein, we report the prevalence of fosfomycin resistance in Japan, including fosfomycin-nonapproved fields, showing that these may serve as reservoirs of fosfomycin-resistant bacteria and fos genes carried on globally disseminated mobile genetic elements."

Journal • Gene Therapies • FOS

Spectrum, Clinical Characteristics, and Outcomes of Infections in Renal Allograft Recipients: A Three-Year Prospective Study (TTS 2026) - "UTIs were treated requently with broad-spectrum antibiotic,meropenem and ceftriaxone, followed by piperacillin–tazobactam, colistin, fosfomycin, and oral cephalosporins...Gram-positive infections were managed with linezolid, teicoplanin, or vancomycin.Skin and soft-tissue infections clinically significant, including herpes zoster (3.0%), cutaneous aspergillosis, viral warts (HPV), non-tuberculous mycobacterial wound infection,and multiple staphylococcal abscesses... Infections are a major contributor to morbidity in renal allograft recipients. Strengthening infection surveillance, preventive measures, and prompt treatment may help improve patient survival and long-term outcomes."

Clinical • Chronic Kidney Disease • Glomerulonephritis • Herpes Zoster • Infectious Disease • Lupus Nephritis • Nephrology • Nontuberculous Mycobacterial Disease • Pneumonia • Respiratory Diseases • Tuberculosis • Varicella Zoster

Genomic Insights Into Multidrug-Resistant Foodborne Serratia liquefaciens Strains Carrying mcr-9 and Comparative Genomic Analysis of Novel Biosynthetic Gene Clusters. (PubMed, Int J Food Sci) - "The strains were screened for the presence of β-lactamases, plasmid-mediated mobile colistin resistance (mcr) genes, and carbapenemase-encoding genes using PCR...The strains exhibited multidrug resistance (MDR) phenotypes to third-generation cephalosporins, cephamycin, fosfomycin, and other clinically important antimicrobials...Although the presence of mcr-9 in Serratia may not be of clinical significance because of natural resistance of the strain to polymyxins, we shed light on the genomic characteristics of this MDR pathogen and the potential spread of mcr-9 among other bacterial species. The emergence of mcr-9 in drug-resistant S. liquefaciens provides significant insights, underscoring the need for increased surveillance of this pathogen."

Journal • Metabolic Dysfunction-Associated Steatohepatitis • BAG4

Staphylococcus pettenkoferi: an underrecognized species with clinically relevant antimicrobial resistance. A comprehensive genomic European study. (PubMed, Emerg Microbes Infect) - "Susceptibility rates were below 70% for cefoxitin, erythromycin, and levofloxacin, whereas high susceptibility (>90%) was observed for vancomycin, teicoplanin, dalbavancin, aminoglycosides, oxazolidinones, trimethoprim-sulfamethoxazole, fusidic acid, and tetracycline. Nearly all isolates (92.1%) were fosfomycin-resistant...This study provides a comprehensive genomic and phenotypic assessment of antimicrobial resistance in S. pettenkoferi, revealing widespread multidrug-resistant lineages, including ceftobiprole- and daptomycin-resistant isolates across distinct clades. These findings underscore the need for continued surveillance and improved diagnostics for this increasingly encountered CoNS species."

Journal • Infectious Disease • Inflammation

Global genomic surveillance uncovers emergence and spatiotemporal patterns of World Health Organization priority antibiotic resistance in invasive Salmonella. (PubMed, Nat Commun) - "29 (37.7%) of 77 countries identified at least one isolate with resistance or decreased susceptibility to ciprofloxacin, 25 (32.5%) and 29 (37.7%) countries resistance or decreased susceptibility to ceftriaxone and cefixime, 8 (10.4%) countries resistance to azithromycin, 15 (19.5%) countries resistance to fosfomycin, 10 (13.0%) countries resistance to colistin. We generated a global map of clinically key antibiotic resistance genes in invasive Salmonella infections worldwide. This retrospective, global, longitudinal genomic epidemiology study on invasive Salmonella provides evidence-based data for clinical guidelines, genomic surveillance, AMR control, and public health policies."

Journal • Infectious Disease

Activity of Fosfomycin against Enterobacterales Collected from US Medical Centers during 2020-2023 (IDWeek 2026) - No abstract available

Infectious Disease

Clinical Outcomes of Intravenous Fosfomycin in Managing Multidrug-Resistant Gram-Negative Infections: Insights from a Matched Cohort Study (IDWeek 2026) - No abstract available

Clinical • Clinical data • Gram negative • Infectious Disease

Oral Fosfomycin as an Intravenous-Sparing Strategy for Resistant Bacterial Prostatitis: A 15-Year Retrospective Comparative Cohort Study (IDWeek 2026) - No abstract available

Retrospective data • Infectious Disease

Timing, Severity, and Duration of Hypokalemia in Adults with Complicated Urinary Tract Infection Treated with Intravenous Fosfomycin (Contepo): Post Hoc Analysis of the ZEUS Trial (IDWeek 2026) - No abstract available

Clinical • Retrospective data • Infectious Disease

CONTEPO® (IV fosfomycin): Exploring unmet needs and clinical evidence (IDWeek 2026) - "Supported by Meitheal Pharma"

Clinical • Infectious Disease

Endoscopic Application of GM-CSF, Fosfomycin, and Metronidazole in Pouchitis, a Phase I Safety and Pilot Study. (PubMed, Dig Dis Sci) - P1/2 | "The administration of GM-CSF, fosfomycin, and metronidazole in the pouch appears to be safe in patients with pouchitis and results in immunological changes suggesting a reduction in inflammation, ClincialTrials.gov number, NCT04979832."

Journal • P1 data • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • CSF2