fosfomycin tromethamine / Generic mfg. - LARVOL DELTA

Whole-genome analysis of Lysinibacillus boronitolerans MSR1: A dairy-isolated multidrug-resistant and non-pathogenic strain. (PubMed, PLoS One) - "Antibiotic susceptibility testing revealed a high level of resistance in MSR1 to glycopeptides and aminoglycosides, while the strain remained susceptible to imipenem, with in silico analysis identifying key antimicrobial resistance (AMR) genes, including qacJ, vanW, vanT, and FosBx1, which confer resistance to disinfectants, vancomycin, and fosfomycin through efflux pumps and target modification mechanisms. Functional annotation of core, accessory, and unique genes revealed that core genes are predominantly associated with metabolic processes, while accessory and unique genes are involved in information processing, storage, and defence mechanisms. These findings enhance our understanding of the genomic diversity, evolutionary dynamics, and potential adaptive strategies of L. boronitolerans MSR1, providing new insights into its ecological and functional roles."

Journal • CAT

Antibiotics mechanism of action (PubMed, Med Sci (Paris)) - "They act by inhibiting peptidoglycan synthesis (β-lactams, glycopeptides and fosfomycin); protein synthesis (aminoglycosides, macrolides lincosamides and streptogramins -tetracyclines, tetracyclines, chloramphenicol, fusidic acid, oxazolidinones-); or nucleic acid synthesis (quinolones/ fluoroquinolones and rifamycins) or interfering with key metabolic pathways such as folate biosynthesis (cotrimoxazole). However, the extensive and sometimes inappropriate use of antibiotics has led to the emergence of resistance, progressively reducing their efficacy and highlighting the need for the development of new antibacterial agents. This review presents the origin, structure, mechanism of action, main clinical agents, and spectrum of activity of each class of antibiotic."

Journal • Review

Synergistic activity of fosfomycin combined with old and new oxazolidinones (linezolid, contezolid, delpazolid, and sutezolid) against bloodstream isolates of vancomycin-resistant Enterococcus faecium. (PubMed, Eur J Clin Microbiol Infect Dis) - "Our findings provide preclinical evidence supporting the use of fosfomycin in combination with novel oxazolidinones as a promising therapeutic strategy against VR E. faecium infections."

Journal • Infectious Disease

Determination of antimicrobial resistance pattern among post-operative orthopedic implant patients in a tertiary care hospital: A retrospective study. (PubMed, Int J Clin Pharmacol Ther) - "The critical challenges of antimicrobial resistance in orthopedic implant-related infections have been highlighted. Urgent institutional and policy level interventions are required for implementation of stringent infection control protocols and robust antibiotic stewardship programs to prevent a post-antibiotic crisis."

Journal • Retrospective data • Infectious Disease • Orthopedics

Metagenomic insights into microbial communities and antibiotic resistance in treated wastewater for urban irrigation. (PubMed, BMC Microbiol) - "This study underscores the ecological risks of using treated wastewater in urban environment, particularly due to the persistence of ARGs and pathogenic bacteria. Targeted removal of nutrients and heavy metals during wastewater treatment could help reduce microbial and resistance-related contamination, improving the safety of treated wastewater reuse."

Journal

Current Management Strategies of Difficult-to-Treat Resistant Pseudomonas aeruginosa Infections. (PubMed, Infect Dis Clin North Am) - "Although new active therapeutic options such as ceftolozane-tazobactam, ceftazidime-avibactam, imipenem-relebactam and cefiderocol are currently available, lack of randomized control trials, drug access limitations, and emerging resistance have a negative impact on the management of these infections. This review discusses the mechanisms of resistance, molecular epidemiology, clinical management, and current and future therapeutic strategies for DTR P aeruginosa infections."

Journal • Review • Infectious Disease

NextGen - Clinical Implication of Next Generation Sequencing (clinicaltrials.gov) - P4 | N=100 | Recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Dec 2026 ➔ Dec 2028 | Trial primary completion date: Dec 2026 ➔ Dec 2028

Biomarker • Trial completion date • Trial primary completion date • Infectious Disease • Nephrology

Case Report: Omadacycline in the Treatment of Community-Acquired Pneumonia in a Child With Multiple Antimicrobial Allergies. (PubMed, Clin Case Rep) - "This case report presents a 4-year-old girl with a mixed infection of CAP who exhibited hypersensitivity to multiple antimicrobial agents (piperacillin-tazobactam, ceftazidime, fosfomycin, meropenem, and levofloxacin), was treated with omadacycline followed by doxycycline, and underwent bronchoscopy with bronchoalveolar lavage. Potential adverse effects of omadacycline were evaluated, along with its utilization and dosage in children. Omadacycline has the potential to be a viable alternative anti-infective agent for the treatment of pediatric CAP in the absence of other drug options and with adequate safety evaluation and monitoring."

Journal • Allergy • Immunology • Infectious Disease • Pediatrics • Pneumonia • Respiratory Diseases

Rising trend of Enterococcus species as pathogen, and its antimicrobial susceptibility pattern in western Gujarat. (PubMed, J Infect Dev Ctries) - "The rising trend of enterococci and the alarming rates of resistance highlight the need for rational and restricted drug use, with early detection and use of the susceptibility report to prevent treatment failures and spread of resistance."

Journal • Retrospective data • Infectious Disease • Nephrology

Fosfomycin-based combinations against carbapenemase-producing Klebsiella pneumoniae bloodstream infections: Correlating in vitro synergy with clinical outcomes. (PubMed, Int J Antimicrob Agents) - "FOF AD MIC value may have potential as a predictive marker for FOF-C treatment response in CP-Kp BSI and could aid in guiding combination therapy decisions. Larger, prospective studies using standardized synergy testing methods are needed."

Clinical data • Journal • Preclinical • Infectious Disease • Pneumonia

Infection risks and biopsy-associated complications in prostate cancer diagnosis: a review of recent literatures. (PubMed, Prostate Cancer Prostatic Dis) - "Modern evidence supports a paradigm shift toward TP-Bx combined with targeted or multidrug prophylaxis to mitigate infectious risks. Imaging-guided and robotic-assisted techniques enhance diagnostic accuracy and safety but remain limited in resource-constrained settings. TRUS-Bx retains utility where TP access is unavailable; however, adapting infection prevention strategies is critical. Future large-scale trials and cost-effectiveness analyses are needed to optimize biopsy protocols globally."

Journal • Review • Anesthesia • Genito-urinary Cancer • Infectious Disease • Nephrology • Oncology • Prostate Cancer • Septic Shock • Solid Tumor

Overcoming the drug resistance barrier: progress in fosfomycin combination therapy against multidrug-resistant pathogens. (PubMed, Front Microbiol) - "The preclinical and clinical evidence of key combination regimens (including β-lactams, aminoglycosides, fluoroquinolones, polymyxins, and daptomycin) has been comprehensively evaluated, with detailed discussions of the mechanistic foundations for the observed synergistic effects. Although in vitro and animal models show substantial promise, we critically examine the translational gap between positive preclinical results and clinical realities, discussing major barriers to clinical advancement. Finally, we outline a prospective research agenda, encompassing pharmacokinetic/pharmacodynamic (PK/PD)-guided precision dosing, exploring non-antibiotic adjuvants, and developing more predictive preclinical models to unlock the full potential of fosfomycin-based combinations against MDR infections."

Journal • Review • Infectious Disease

Calcite solubilizing, Multi-metal Tolerant Strain Isolated from Dolomite Affected Tea Garden Shows Plant Growth Promoting Activity. (PubMed, Curr Microbiol) - "Also, displayed resistance against antibiotics, including streptomycin, colistin, cefuroxime, methicillin and fosfomycin. Significant increases in plant height, root length, leaf length and biomass were noted for Phaseolus vulgaris and Vigna radiata on its soil application, with similar effects on increases in chlorophyll content. Overall findings displayed the potentiality of this strain may be used as a bioinoculant in dolomite affected tea gardens for sustainable agriculture."

Journal

Phenotypic and Molecular Analysis of Fosfomycin Resistance Among P. aeruginosa Isolates from Cystic Fibrosis Patients. (PubMed, Infect Drug Resist) - "Based on AST, significant antibiotic resistance was observed, particularly against fosfomycin (77.2%), imipenem, and amikacin (53.5%). The presence of resistance genes suggests a genetic basis for these patterns, emphasizing the importance of developing new strategies to manage P. aeruginosa infections effectively. Future studies should focus on targeted inhibitors for these genes to overcome resistance and improve clinical outcomes."

Biomarker • Journal • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Formulation, development and characterization of fosfomycin tromethamine pessaries for the treatment of vaginal infections. (PubMed, Sci Rep) - "The antibacterial results of the Fosfomycin pessaries showed significant activity against E. coli using in vitro and in vivo studies. Conclusion The in vitro and in vivo results revealed that Fosfomycin pessaries have improved pharmacokinetics and increased antibacterial activity."

Journal • Infectious Disease • Nephrology • Vaginitis

Molecular Characterization of KPC-2 and CMY AmpC Beta Lactamases in Ceftazidime-Avibactam Resistant Klebsiella pneumoniae in a Tertiary Care Hospital. (PubMed, Cureus) - "Introduction Multidrug-resistant (MDR) Klebsiella pneumoniae poses significant treatment challenges, particularly in intensive care settings. Sanger sequencing confirmed 99.3% similarity with bla CMY-2. Conclusion CMY AmpC β-lactamase emerged as the predominant mechanism of CZA resistance in K. pneumoniae, highlighting the need for routine AmpC screening, prudent use of alternatives such as cefiderocol, tigecycline, or fosfomycin, and sustained genomic surveillance to guide therapy and infection control."

Journal • Critical care • Infectious Disease • Pneumonia

Giants in Infectious Diseases: Prof. Jose M. Miro's translational research in infective endocarditis. (PubMed, Clin Microbiol Infect) - No abstract available

Journal • Cardiovascular • Colon Cancer • Colorectal Cancer • Infectious Disease • Oncology • Solid Tumor

An observational study on multidrug resistance in pediatric patients with urinary tract infections. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Escherichia coli demonstrated high resistance to nalidixic acid (84.4%), ampicillin (78.1%), and ciprofloxacin (78.1%), while maintaining high susceptibility to fosfomycin (90.6%), ertapenem (81.3%), gentamicin (71.9%), and nitrofurantoin (71.9%)...exhibited high resistance to tetracycline (64.3%), and levofloxacin (63%). but remained sensitive to linezolid (93.27%), vancomycin (85.71%), teicoplanin (78.57%), and tigecycline (71.4%)...Fosfomycin, nitrofurantoin, and carbapenems retain efficacy, though over-reliance may accelerate resistance. Regular, pediatric-specific AMR surveillance and antimicrobial stewardship programs are essential to preserve treatment efficacy and improve outcomes in this vulnerable population."

Journal • Observational data • Infectious Disease • Nephrology • Pediatrics • Pneumonia

Ceftazidime-Avibactam Resistance in Carbapenem-Resistant Klebsiella pneumoniae Bloodstream Infections: Risk Factors and Clinical Outcomes. (PubMed, Antibiotics (Basel)) - "CAZ-AVI resistance in CRKP bacteremia is associated with specific clinical risk profiles and contributes to high mortality. Identifying high-risk patients and optimizing antimicrobial stewardship are essential to improve prognosis."

Clinical data • Journal • Infectious Disease • Pneumonia

Resistance Trends in Klebsiella pneumoniae Strains Isolated from Bloodstream Infections in a Tertiary Care Hospital over a Period of 7 Years. (PubMed, Microorganisms) - "Overall resistance rates to other antibiotics were 47.1% to ciprofloxacin, 31.4% to gentamicin, 25.7% to amikacin, 20.9% to colistin, 19.6% to Fosfomycin, and 44.5% to trimethoprim/sulfamethoxazole. The most frequently co-harboring carbapenemases were NDM and OXA-48. Local antibiotic resistance rates are crucial in implementing an effective antibiotic stewardship strategy."

Journal • Infectious Disease • Pneumonia

Fosfomycin in Complicated Intra-Abdominal Infections in an Intensive Care Setting: Does It Improve the Outcome? A Retrospective Observational Study. (PubMed, Antibiotics (Basel)) - "Univariate and multivariate analysis highlighted Charlson Comorbidity Index (CCI) (p = 0.04) and septic shock (p = 0.029) as risk factors, and effective empirical therapy (p = 0.04) as the protective factor; fosfomycin was not directly associated with outcome improvement. The outcome was comparable between groups; clinicians preferred to administer a combination regimen including fosfomycin in patients with statistically significant greater severity of illness and without early source control."

Journal • Observational data • Retrospective data • Critical care • Infectious Disease • Septic Shock

From Crisis to Cure: A Breathtaking Journey through Persistent Complicated Pneumonia (APSR 2025) - "Bronchoscopy revealed inflammatory lesions and tracheomalacia, with BAL culture confirming MDR Klebsiella pneumoniae followed by treatment with a combination of Fosfomycin, Polymyxin B, and Tigecycline after extensive literature review. Further BAL analysis identified NTM infection, prompting initiation of azithromycin, rifampicin, and ethambutol...Timely escalation of therapy, bronchoscopy-guided diagnostics, and multi-modal treatment strategies were crucial in achieving recovery. Early identification of atypical pathogens, including NTM, is essential in managing non-resolving pneumonia."

Asthma • Cough • Immunology • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases • Respiratory Syncytial Virus Infections

Isolation and characterization of Salmonella enterica serovars from poultry in Egypt: a comprehensive genetic analysis of ESBLs, MCR, integron and other resistance genes. (PubMed, BMC Vet Res) - " Based on serological identification, this study reports the detection of rare Salmonella enterica serovars, such as S. Colorado and S. Jerusalem, with extensive drug resistance (XDR) in broiler farms in Egypt. These isolates carried critical resistance genes, including intI1, mcr-1, and various β-lactamases. The findings underscore the urgent need for surveillance, biosecurity, and antimicrobial stewardship to protect public health and poultry production."

Journal

Molecular characterisation of fosfomycin resistant Enterococci faecalis isolated from a tertiary care medical hospital in northern India. (PubMed, Indian J Med Microbiol) - "To our knowledge this study is the first to explore FOS resistance in E. faecalis isolates from this part of the country. Increased resistance to FOS as compared to what has been reported previously calls for strict implementation of infection control protocols as well as heightened surveillance studies."

Journal • Infectious Disease • FOS

Dual chitosan hydrogel and polylactic acid microparticle delivery system reduces Staphylococcal osteomyelitis and soft tissue infection. (PubMed, NPJ Biofilms Microbiomes) - "Notably, only the CH + PLA biomaterial treatment led to a reduction in bone defect area, plasma haptoglobin level, and bacterial burden in bone and soft tissue, compared to hydrogel only. Local treatment of osteomyelitis with the chitosan+microparticle vehicle loaded with fosfomycin mitigated S. aureus pathogenesis and may serve as an effective alternative to systemic antibiotics."

Journal • Infectious Disease • Inflammation • HP