cefadroxil / Generic mfg. - LARVOL DELTA

Subinhibitory concentrations of cefadroxil delay or prevent dalbavancin resistance and alter mutational pathways in S. aureus (ESCMID Global 2026) - No abstract available

Double Trouble… or Double Triumph? Dual Biologic Therapy in Refractory Hidradenitis Suppurativa (AAD 2026) - "Adalimumab, secukinumab, and bimekizumab are currently FDA-approved for moderate-to-severe HS, with adalimumab demonstrating response rates of 42–59%...He had minimal response to doxycycline, benzoyl peroxide wash, and clindamycin, and subsequently failed adalimumab, secukinumab, acitretin, dapsone, cefadroxil, prednisone, laser hair removal, and topical agents over two years. Given inadequate disease control, infliximab was added to ongoing secukinumab... Dual biologic therapy may represent a promising option for patients with severe, refractory HS unresponsive to monotherapy with currently available systemic treatments, including FDA-approved biologics used individually. Larger studies are needed to clarify long-term efficacy and safety."

Acne Vulgaris • Aesthetic Medicine • Conjunctivitis • Dermatology • Dry Eye Disease • Hidradenitis Suppurativa • Immunology • Infectious Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Henoch-Schönlein purpura induced by sitagliptin: a case report (AAD 2026) - "The patient was then treated with celecoxib, colchicine, and cefadroxil for wound infection. To our knowledge, this is the first case of sitagliptin-induced HSP and the third case of sitagliptin-induced LCV documented in the literature.3,4 Overall, this case highlights a new potential association of DPP-4 inhibitors with HSP, which may have systemic consequences."

Case report • Clinical • Diabetes • Infectious Disease • Metabolic Disorders • Respiratory Diseases • Type 2 Diabetes Mellitus • Vasculitis

Fat Necrosis with Secondary Abscess Formation at Foscarbidopa-Foslevodopa Infusion Sites: A Novel Cutaneous Adverse Reaction in Parkinson's Therapy (AAD 2026) - "Despite oral cefadroxil, topical clobetasol, and intralesional steroids, nodules recurred at additional sites. Continued nodule development in patients should prompt a risk-benefit discussion with the treating neurologist. Further research is needed to improve infusion site tolerability."

CNS Disorders • Infectious Disease • Mood Disorders • Movement Disorders • Obesity • Parkinson's Disease

Emergence of Dalbavancin, Vancomycin, and Daptomycin Cross-resistance in MRSA During Long-term LVAD Suppression With Vancomycin Followed by Dalbavancin: Genomic Insights and Synergy With Cefadroxil. (PubMed, Open Forum Infect Dis) - "This is the first report of dalbavancin nonsusceptibly associated with an LVAD infection, but dalbavancin resistance has been documented previously in association with treatment of endovascular infections. Combination therapy with synergistic and orally bioavailable agents like cefadroxil may be a reasonable strategy to enhance activity and possibly diminish emergence of resistance to dalbavancin."

Journal • Cardiovascular • Infectious Disease

Postoperative Extended Oral Antibiotic Prophylaxis Continues to Increase in Prevalence with Questionable Improvements in One-Year Periprosthetic Joint Infection Rates (AAOS 2026) - "All patients who underwent primary THA or TKA from January 1 st, 2016 to April 1st, 2024, had osteoarthritis as their primary diagnosis, and were given IV Ancef pre-operatively were included. We evaluated all patients who received at least 48-hours of oral cefadroxil or cephalexin and compared them to all patients who did not receive extended oral antibiotics postoperatively... The use of extended oral antibiotic prophylaxis following primary THA and TKA continues to increase in popularity, especially in high-risk patients. However, this large database study fails to demonstrate improvements in one-year PJI rates with EOAP in high-risk patients with obesity, diabetes, and CKD."

Chronic Kidney Disease • Diabetes • Genetic Disorders • Immunology • Infectious Disease • Metabolic Disorders • Nephrology • Obesity • Orthopedics • Osteoarthritis • Renal Disease

Atypical Methicillin Sensitive Staphylococcus Aureus (MSSA) Skin Infection Mimicking Malignancy in a Kidney Transplant Recipient (NKF-SCM 2026) - "Mycophenolate mofetil (MMF) was held. The patient completed a two-week course of cefadroxil with complete resolution of the lesions...CONCLUSION The differential diagnosis for skin lesions in transplant recipients is broad. This case underscores the importance of early detection, diagnosis with biopsy, and targeted therapy in the setting of immunosuppression."

Clinical • Chronic Kidney Disease • Dermatology • Diabetic Nephropathy • Genetic Disorders • Infectious Disease • Leukopenia • Nephrology • Oncology • Renal Disease • Skin Cancer • Solid Organ Transplantation • Transplantation

How does the antibiotic cefadroxil work in treating serious Staph infections? A first look (clinicaltrialsregister.eu) - P1/2 | N=25 | Not yet recruiting | Sponsor: UZ Brussel

New P1/2 trial • Infectious Disease

Structure-dependent transformation of cephalosporin antibiotics at MnO2 surface mediated by iodide and formation of highly toxic iodinated products. (PubMed, Water Res) - "These RIS facilitate the degradation of cefoperazone (CFP) and cefadroxil (CFX) through electrophilic substitution at phenolic hydroxyl groups, while their formation competes for the active sites at MnO2 surface, thereby hindering the direct oxidation of cefalexin (CEX) and cefazolin (CFZ) that lack such reactive moieties. Toxicity assessments using luminescent bacteria test and ECOSAR predictions indicate that the I-TPs exhibit higher toxicity than the parent compound and its non-iodinated products. These findings underscore that reactions between MnO2 and I- can profoundly alter the environmental fate and potential toxicity of cephalosporins in iodine-rich water environments."

Journal

Amoxicillin-induced Erythema Scarlatiniforme Desquamativum Recidivans with cross-reactivity to cefadroxil in a child: A case report and review of literature. (PubMed, Br J Clin Pharmacol) - "This case establishes the first report of generalized ESDR triggered by amoxicillin in a paediatric patient. It emphasizes a unique pattern of drug hypersensitivity, characterized by cross-reactivity to cefadroxil and tolerance to other tested penicillins (phenoxymethylpenicillin and oxacillin). It is essential to conduct a complete allergy work-up, which includes OPTs, to conduct a customized cross-reactivity assessment. This assessment is essential for the safe guidance of future therapeutic decisions in patients with drug-induced ESDR."

Journal • Allergy • Dermatology • Immunology • Pediatrics

Resistance of uropathogens to gepotidacin: a systematic review of in vitro antimicrobial susceptibility studies. (PubMed, Int J Antimicrob Agents) - "Gepotidacin has very good antimicrobial activity against a variety of pathogens that cause uUTIs. Importantly, it retains activity against uropathogen isolates that exhibit resistance to other antibiotics commonly used for UTIs making it a useful addition to a physician's therapeutic arsenal."

Journal • Preclinical • Review • Infectious Disease • Nephrology • Pneumonia

ESBL and Integron Profiles in Pediatric EPEC/STEC. (PubMed, Pediatr Infect Dis J) - "DEC is a significant cause of pediatric diarrhea in Egypt, with STEC and tEPEC predominating. The high prevalence of antimicrobial resistance, ESBL production and integron carriage underscores the urgent need for surveillance programs, antimicrobial stewardship and improved infection control to limit resistance dissemination in pediatric populations."

Journal • Infectious Disease • Pediatrics

Gepotidacin (Blujepa) - a new antibiotic for uncomplicated UTI. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Infectious Disease • Nephrology

Cefadroxil-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome After Double Mastectomy for Ductal Carcinoma In Situ: A Case Report. (PubMed, Cureus) - "Typical causal agents of DRESS syndrome include allopurinol, aromatic anticonvulsants, and antibiotics. The signs and symptoms of DRESS syndrome may be indolent and persistent even after stopping the offending agent, as seen in this patient. Therefore, prompt treatment is necessary to prevent detrimental complications of the disease."

Journal • Eosinophilia • Hematological Disorders • Hepatology • Immunology • Liver Failure • Musculoskeletal Pain • Oncology • Pain

Antibiotics in Tactical Combat Casualty Care 2025: TCCC Change 25-1. (PubMed, J Spec Oper Med) - "The panel recommends changing the oral antibiotic to cefadroxil (preferred) or cephalexin (alternative) and the parenteral antibiotic to ceftriaxone. In light of these changes in TCCC antibiotics, considerations should be made within Prolonged Casualty Care guidelines for the narrower spectrum of antibiotics and surveillance for unanticipated in-creases in specific injury patterns such as post-traumatic en-dophthalmitis, open fractures, or abdominal injuries."

Journal • Musculoskeletal Diseases • Ophthalmology • Orthopedics

Fluoroquinolones vs Amoxicillin-Clavulanate or Cefadroxil as Oral Step-down Therapy For Gram-Negative Bloodstream Infections (ASHP 2025) - No abstract available

Gram negative • Infectious Disease

Henoch-Schönlein purpura induced by sitagliptin: A case report. (PubMed, SAGE Open Med Case Rep) - "Sitagliptin was discontinued, and the patient was treated with celecoxib, colchicine, and cefadroxil for wound infection. However, urinalysis revealed new 0.3 g/L protein. Overall, this case highlights a new potential association of dipeptidyl peptidase-4 inhibitors with Henoch-Schönlein purpura, which may have systemic consequences."

Journal • Diabetes • Infectious Disease • Metabolic Disorders • Type 2 Diabetes Mellitus • Vasculitis

Primary Genital HSV-2 Infection in a Resource-Limited Setting: Diagnostic Challenges and Clinical Implications. (PubMed, Cureus) - "Treatment with oral acyclovir, cefadroxil, and mefenamic acid, supplemented by topical gentamicin and counselling on recurrence risk and safe sexual practices, led to complete lesion resolution within 14 days and no recurrence at six-week follow-up. These limitations hinder accurate case identification and contribute to the underrecognition of HSV-2 prevalence. Early clinical recognition, prompt antiviral initiation, and strengthened patient education remain essential for mitigating morbidity, preventing recurrence, and reducing transmission in low-resource environments."

Journal • Herpes Simplex • Human Immunodeficiency Virus • Infectious Disease • Pain

Bacillus mycoides bacteremia after dog bite trauma in a patient on chronic suppressive antibiotics. (PubMed, IDCases) - "The patient, who had a chronic Left Ventricular Assist Device (LVAD) in place and was on a chronic suppressive regimen of doxycycline and cefadroxil for a preexisting driveline infection, developed B. mycoides bacteremia despite ongoing antibiotic therapy. She was successfully treated with intravenous ampicillin-sulbactam plus vancomycin, followed by oral ciprofloxacin upon discharge. The patient's recovery was uncomplicated and the final susceptibility testing confirmed pan-susceptibility to all tested agents. This case highlights the potential pathogenicity of B. mycoides in humans and raises questions on the risk factors for infection and optimal management of B. mycoides infections in the setting of relatively limited clinical data."

Journal • Cardiovascular • Infectious Disease • Mood Disorders

Chitosan coated yeast microcapsules for efficient delivery of cefadroxil for the treatment of inflammatory bowel disease. (PubMed, Int J Biol Macromol) - "Cefadroxil-loaded YM coated with chitosan showed significant therapeutic activity in the IBD animal model and also achieved colon targeting. Therefore, this cefadroxil-loaded YM coated with chitosan could be used as a targeted oral drug delivery system for the treatment of IBD."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease

Pro-inflammatory secreted virulence factors of Staphylococcus capitis causing a rare occurrence of severe native hip joint infection. (PubMed, ASM Case Rep) - "The patient was treated with intravenous cefazolin (6 weeks), after which he was transitioned to oral cefadroxil. The organism secreted a neutrophil pro-inflammatory autolysin protease and an analog of the immunodominant antigen B of S. aureus, previously with no known biological function. Our data suggest that the inflammatory lesion in the patient's right hip was due to S. capitis subspecies capitis, and furthermore, it is likely that two secreted proteins (autolysin and an analog of immunodominant antigen B) contributed to the inflammation."

Journal • Immunology • Infectious Disease • Inflammation • Mood Disorders • Orthopedics • Osteoarthritis • Pain • Rheumatology • CRP

Sulopenem etzadroxil/probenecid (Orlynvah) for uncomplicated UTIs. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Infectious Disease • Nephrology

Acute Hepatitis During Dalbavancin Infusion: A Rare Adverse Reaction With Implications for Repeat Dosing (ACG 2025) - "He subsequently completed therapy with cefazolin and linezolid and was placed on oral cefadroxil plus doxycycline suppression in view of retained hardware. In pooled data from 2,120 adults across phase 1–3 studies, 17 patients (0.8%) developed post-baseline ALT elevations >3× ULN; within this group, 5 (0.2%) had ALT >10× ULN and one phase 1 subject exhibited ALT >20× ULN—each reversible on follow-up (Table 2)...In this case likely mechanisms include immune-mediated hypersensitivity, similar to vancomycin-induced hepatotoxicity, although rate of cross-reactivity between dalbavancin and vancomycin appears to be very low to negligible...Laboratory Values Pre-infusion and Post-infusion of Dalbavancin Figure: Table 2. ALT Elevation Secondary to Dalbavancin Infusion Regiments"

Fatigue • Hepatology • Immunology • Infectious Disease • Inflammation

Medical Management of an Infusion Site Extravasation Injury After Peripheral Intravenous Infusion of Ado-Trastuzumab Emtansine in a 38-Year-Old Woman with Breast Cancer: A Case Report. (PubMed, Am J Case Rep) - "She was treated with a topical steroid (clobetasol), topical calcineurin inhibitor (tacrolimus), oral antibiotic (cefadroxil), high-dose vitamin D (ergocalciferol), and pain management (gabapentin) with almost complete resolution in 4 weeks. CONCLUSIONS This case report describes a T-DM1 skin extravasation treated with multimodal medical measures as opposed to a more conservative approach. We reaffirm that the use of port access when administering T-DM1 is critical to prevent extravasation, and we recommend multimodal management, including antibiotics and topical therapies, to prevent infection and expedite wound healing if extravasation occurs."

Journal • Breast Cancer • Dermatology • Hormone Receptor Breast Cancer • Infectious Disease • Oncology • Pain • Solid Tumor

Prevalence, Serotypes, and Antimicrobial Resistance of Salmonella Species in Ready-to-Eat Foods in Erbil, Iraq. (PubMed, Microorganisms) - "All isolates were susceptible to colistin, cefadroxil, and gentamicin, while showing high resistance to streptomycin (52%) and levofloxacin (48%). Contamination peaked during the warmer months, particularly in June (15.4%) and May (11.5%), when compared to the other sampling months. These findings highlight significant food safety concerns related to Salmonella contamination and AMR in RTE foods, emphasizing the urgent need for enhanced hygiene practices and regulatory oversight especially among street vendors."

Journal • Infectious Disease