cefadroxil / Generic mfg. - LARVOL DELTA

Increased Risk of Periprosthetic Joint Infection Following Aseptic Revision Hip and Knee Arthroplasty With the Use of Non-Cefazolin Alternative Antibiotics. (PubMed, J Arthroplasty) - "Perioperative cefazolin prophylaxis is a critical modifiable risk factor, providing a substantial protective effect against PJI in aseptic revision TJA. In contrast, extended oral antibiotic prophylaxis provided no additional benefit for culture-negative patients. While UPCs occurred in 4% of cases, only one case subsequently developed PJI with a concordant microorganism. These findings reinforce the importance of standardized cefazolin prophylaxis over alternative agents in aseptic revision TJA."

Journal • Infectious Disease • Orthopedics • Pain

Cefadroxil as Oral Transitional Therapy for Gram-Positive Bacteremia with or without Osteomyelitis: A Multicenter Retrospective Cohort Study (IDWeek 2026) - No abstract available

Gram positive • Retrospective data • Infectious Disease

Hybrid photoelectrocatalytic advanced oxidation systems for pharmaceutical wastewater treatment: mechanisms, reactive species, operational parameters, toxicity assessment and real wastewater treatment. (PubMed, RSC Adv) - "Representative PEC/PMS systems attained 98% sulfamethoxazole removal within 90 min, 100% norfloxacin removal within 25 min, and 91.3% tetracycline removal within 30 min...Ozone-assisted PEC achieved 96% cefadroxil removal and 57.6% TOC reduction, while a pilot-scale solar photoelectro-Fenton/ozone process achieved 60% pharmaceutical degradation and 41% COD removal in a four-drug mixture...Nevertheless, catalyst deactivation, oxidant consumption, mass-transfer limitations, incomplete mineralization, transformation-product toxicity, and energy demand remain critical barriers. Overall, hybrid PEC-AOPs offer highly tunable platforms for pharmaceutical wastewater treatment, but standardized energy, toxicity, mineralization, and long-term stability assessments under real-water conditions are required for practical scale-up."

Journal • Review

Haemophilus parainfluenzae as a Causative Organism in Periprosthetic Joint Infection: A Case Report. (PubMed, Case Rep Infect Dis) - "The patient underwent debridement, antibiotics, and implant retention (DAIR) and was discharged on intravenous (IV) ceftriaxone after H. parainfluenzae was isolated on culture, with no resistance reported on susceptibilities...He was treated with IV vancomycin and cefepime and placed on cefadroxil suppression therapy without additional surgery...Due to increasing resistance in this species worldwide, consideration should be taken when choosing antimicrobial therapy for H. parainfluenzae. From the limited data available, patients with PJI secondary to H. parainfluenzae have a better prognosis compared to PJI with other Gram-negative organisms."

Journal • Infectious Disease • Musculoskeletal Pain • Orthopedics • Pain • Respiratory Diseases

Cefadroxil-associated cholestatic liver injury presenting as vanishing bile duct syndrome: a case report. (PubMed, Front Med (Lausanne)) - "The patient was treated with ursodeoxycholic acid, with gradual biochemical recovery and subsequent normalization of liver tests. Clinicians should consider this diagnosis in patients who develop persistent jaundice and pruritus after antibiotic exposure, particularly when imaging is normal and competing causes have been excluded. Early recognition, drug withdrawal, close biochemical follow-up, and timely biopsy in persistent cases are essential to avoid delayed diagnosis of this potentially severe condition."

Journal • Autoimmune Hepatitis • Cholestasis • Dermatology • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Failure • Pruritus

Cefadroxil as Oral Transitional Therapy for Gram-Positive Bacteremia With or Without Non-Vertebral Osteomyelitis: A Multicenter Retrospective Cohort Study. (PubMed, Open Forum Infect Dis) - "Cefadroxil was well-tolerated without observed severe adverse events. In this multicenter, retrospective cohort study, cefadroxil was an effective and safe oral transitional therapy for bloodstream infections, with or without nonvertebral osteomyelitis."

Clinical • Journal • Retrospective data • Cardiovascular • Infectious Disease • Inflammation

Synergy between orally bioavailable antibiotics and dalbavancin against MRSA. (PubMed, J Antimicrob Chemother) - "Cefadroxil is a first-generation cephalosporin, like cephalexin, but with a longer half-life that allows for a typical 12-h dosing interval. In our study, we found that synergy between cefadroxil and dalbavancin was common regardless of susceptibility to cefadroxil or dalbavancin, suggesting that this might be a promising companion agent to add to dalbavancin in patients with deep-seated infections that may benefit from synergistic activity to enhance bactericidal effects. Trimethoprim/sulfamethoxazole and moxifloxacin may improve activity and are unlikely to be antagonistic. Clarithromycin and doxycycline seem least likely to offer a benefit."

Journal • Infectious Disease

The quantitative evaluation of antibiotic utilization in community health centers during the COVID-19 pandemic: a cross-sectional multicenter study. (PubMed, J Infect Dev Ctries) - "Antibiotic use in CHCs declined during the pandemic, but there was a significant increase in Azithromycin prescriptions."

Clinical • Journal • Infectious Disease • Novel Coronavirus Disease

Unlocking biomedical potential of eco-friendly polyhydroxyurethane hydrogel: controlled release of cefadroxil antibiotic. (PubMed, J Biomater Sci Polym Ed) - "The controlled drug release behavior of drug loaded hydrogel followed the Fickian mechanism of diffusion (R2 = 0.9909 at pH 7.4) as suggested by the Korsmeyer-Peppas model. These findings underscore the potential of PHU hydrogels as effective, biocompatible materials for controlled, pH-sensitive drug delivery, contributing to safer and more efficient biomedical applications."

Journal

Incidence of toxigenic Bacillus cereus in ready-to-eat fermented foods in Osogbo, Nigeria: a potential health risk. (PubMed, BMC Microbiol) - "The three B. cereus isolates were resistant to β-lactam antibiotics (penicillin, cefadroxil, cefoxitin, and amoxicillin/clavulanic acid), trimethoprim, and fusidic acid; however, they were susceptible to gentamicin, linezolid, and chloramphenicol, and had a multiple antibiotic resistance (MAR) index of 0.64. This study identified the presence of enterotoxigenic genes in B. cereus recovered from RTE fermented foods sold in Osogbo, Nigeria, a potential food safety risk that requires in-depth surveillance."

Journal • Hematological Disorders

Antibiotic Prophylaxis in High-Risk Arthroplasty Patients (clinicaltrials.gov) - P4 | N=4618 | Enrolling by invitation | Sponsor: Mayo Clinic | Trial completion date: Jun 2026 ➔ Jan 2028 | Trial primary completion date: Jun 2026 ➔ Jan 2027

Trial completion date • Trial primary completion date • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Genetic Disorders • Immunology • Infectious Disease • Inflammation • Metabolic Disorders • Nephrology • Nicotine Addiction • Obesity • Orthopedics • Renal Disease

Synergistic coagulation/flocculation and UV254 photo-assisted electrochemical advanced oxidation process for the efficient treatment of municipal influent wastewater. (PubMed, Chemosphere) - "This study evaluates a synergistic treatment combining coagulation-flocculation with a UV254 photo-assisted electrochemical advanced oxidation process (AOP) producing HOCl-•OH for domestic wastewater collected from the influent of a municipal wastewater treatment plant in Mexico, and fortified with ciprofloxacin (CIP), cefadroxil (CFX), sulfamethoxazole (SMX), and carbamazepine (CBZ) at 20 mg L-1 each. Complete elimination of total coliforms was achieved; while Daphnia magna bioassays revealed null toxicity at shorter treatment times than 0.5 h. Overall, this hybrid process demonstrates high mineralization efficiency for municipal wastewater conditions while identifying operational constraints relevant for pilot-scale implementation."

Journal

Getting It Right the Second Time: How Can we Optimize First-Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century? (PubMed, Pharmacotherapy) - "Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. Although some clinical data support lower doses in mild SSTIs, higher doses optimize PK/PD parameters in moderate-severe SSTIs, especially due to Staphylococcus aureus. Further prospective clinical and PK/PD studies, especially in obese adults, would be beneficial."

Journal • Review • Infectious Disease • Obesity

Erysipelothrix rhusiopathiae Prosthetic Joint Infection of the Knee in an Immunocompromised Patient. (PubMed, Cureus) - "He completed six weeks of intravenous daptomycin, followed by oral cefadroxil to complete a total of six months of antimicrobial therapy from the time of surgery. He had an excellent functional outcome with no recurrent infection at two years."

Journal • Infectious Disease • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

A Case of Urothelial Carcinoma in Situ of the Bladder in Local Dog in Bali, Indonesia. (PubMed, Arch Razi Inst) - "Prior to release the histopathological results, post-cystotomy the dog was treated with cefadroxil as antibiotics at 20 mg/kg BW b.i.d for 14 days, carprofen as anti-inflammatory at 2 mg/kg BW s.i.d. for 5 days, and tramadol as analgesics at 2 mg/kg BW b.i.d...The patient was managed palliatively with the administration of piroxicam at 0.3 mg/kg BW s.i.d as monotherapy. Until day 190, the dog showing a stable disease. To the best of the authors' knowledge, this is the first documented case of canine urothelial carcinoma in Indonesi."

Journal • Bladder Cancer • Genito-urinary Cancer • Hematological Disorders • Infectious Disease • Nephrology • Oncology • Pain • Palliative care • Solid Tumor • Urothelial Cancer

Evaluation of the Safety and Effectiveness of ARTIA Reconstructive Tissue Matrix Breast Reconstruction (ADORA) in Adult Participants (clinicaltrials.gov) - P3 | N=264 | Recruiting | Sponsor: AbbVie | N=783 ➔ 264 | Trial completion date: Dec 2029 ➔ Feb 2031 | Trial primary completion date: Dec 2029 ➔ Feb 2031

Enrollment change • Trial completion date • Trial primary completion date

Flavobacterium psychrophilum as an Important Pathogen Associated with Overwintering Mortality Syndrome in Grass Carp (Ctenopharyngodon idella): Isolation, Characterization, and Pathogenicity. (PubMed, Animals (Basel)) - "Strain Hbh25210 exhibited high-level resistance to multiple antibiotics, including ciprofloxacin, cefadroxil, neomycin, florfenicol, sulfamethoxazole, doxycycline, trimethoprim-sulfamethoxazole, and flumequine. Conversely, it was relatively sensitive to enrofloxacin, gentamicin, and amikacin...In conclusion, this study indicates that Flavobacterium psychrophilum is an important pathogen associated with overwintering mortality syndrome in grass carp. Our research findings can provide a basis for the effective prevention and control of overwintering mortality syndrome in major freshwater fish species."

Journal • Infectious Disease

A 30-Year-Old Woman With a Lactational Breast Abscess Managed With Adjunctive Negative Pressure Wound Therapy (Vacuum-Assisted Closure). (PubMed, Am J Case Rep) - "Despite initial needle aspiration and empirical antibiotic therapy with cefadroxil, symptoms persisted...CONCLUSIONS This case suggests that NPWT may be a safe and effective therapeutic option for managing lactational breast abscesses, especially in cases resistant to standard treatments. In this patient, NPWT did not interfere with ongoing lactation and breastfeeding."

Journal • Pain

Atypical Methicillin Sensitive Staphylococcus Aureus (MSSA) Skin Infection Mimicking Malignancy in a Kidney Transplant Recipient (NKF-SCM 2026) - "Mycophenolate mofetil (MMF) was held. The patient completed a two-week course of cefadroxil with complete resolution of the lesions...CONCLUSION The differential diagnosis for skin lesions in transplant recipients is broad. This case underscores the importance of early detection, diagnosis with biopsy, and targeted therapy in the setting of immunosuppression."

Clinical • Chronic Kidney Disease • Dermatology • Diabetic Nephropathy • Genetic Disorders • Infectious Disease • Leukopenia • Nephrology • Oncology • Renal Disease • Skin Cancer • Solid Organ Transplantation • Transplantation

Extended Oral Antibiotic Prophylaxis in Diabetic Fracture Patients (clinicaltrials.gov) - P4 | N=40 | Recruiting | Sponsor: Texas Tech University Health Sciences Center, El Paso

New P4 trial • Diabetes • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics

Postoperative Oral Antibiotics Continue to Increase in Prevalence Without Associated Improvements in One-Year Periprosthetic Joint Infection Rates. (PubMed, J Arthroplasty) - "Extended postoperative oral antibiotics after primary THA and TKA have become increasingly common. However, this database study showed no reduction in one-year PJI rates or risk among those who received them, despite accounting for key risk factors."

Journal • Chronic Kidney Disease • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Orthopedics • Pain • Renal Disease

How does the antibiotic cefadroxil work in treating serious Staph infections? A first look (clinicaltrialsregister.eu) - P1/2 | N=25 | Recruiting | Sponsor: UZ Brussel | Not yet recruiting ➔ Recruiting

Enrollment open • Infectious Disease

Double Trouble… or Double Triumph? Dual Biologic Therapy in Refractory Hidradenitis Suppurativa (AAD 2026) - "Adalimumab, secukinumab, and bimekizumab are currently FDA-approved for moderate-to-severe HS, with adalimumab demonstrating response rates of 42–59%...He had minimal response to doxycycline, benzoyl peroxide wash, and clindamycin, and subsequently failed adalimumab, secukinumab, acitretin, dapsone, cefadroxil, prednisone, laser hair removal, and topical agents over two years. Given inadequate disease control, infliximab was added to ongoing secukinumab... Dual biologic therapy may represent a promising option for patients with severe, refractory HS unresponsive to monotherapy with currently available systemic treatments, including FDA-approved biologics used individually. Larger studies are needed to clarify long-term efficacy and safety."

Acne Vulgaris • Aesthetic Medicine • Conjunctivitis • Dermatology • Dry Eye Disease • Hidradenitis Suppurativa • Immunology • Infectious Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Henoch-Schönlein purpura induced by sitagliptin: a case report (AAD 2026) - "The patient was then treated with celecoxib, colchicine, and cefadroxil for wound infection. To our knowledge, this is the first case of sitagliptin-induced HSP and the third case of sitagliptin-induced LCV documented in the literature.3,4 Overall, this case highlights a new potential association of DPP-4 inhibitors with HSP, which may have systemic consequences."

Case report • Clinical • Diabetes • Infectious Disease • Metabolic Disorders • Respiratory Diseases • Type 2 Diabetes Mellitus • Vasculitis

Subinhibitory concentrations of cefadroxil delay or prevent dalbavancin resistance and alter mutational pathways in S. aureus (ESCMID Global 2026) - No abstract available