dicyclomine / Generic mfg. - LARVOL DELTA

Severe Nirogacestat-Induced Colitis Responsive to Budesonide After Failure of Standard Therapies (ACG 2026) - "Despite treatment with cholestyramine, loperamide, dicyclomine, tincture of opium, octreotide, and high-dose hydrocortisone, diarrhea persisted at 3-5 L/day. Budesonide's potent local anti-inflammatory activity and limited systemic absorption may make it a valuable treatment option for inflammatory chemotherapy-related colitis, particularly when associated with targeted therapies. Further studies are needed to evaluate its efficacy in similar cases."

Desmoid Tumors • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Immunology • Sarcoma • Solid Tumor • CRP

Breaking the Collagen Barrier: Successful Treatment of Collagenous Gastritis With Oral Budesonide (ACG 2026) - "Medications included sumatriptan, ondansetron, dicyclomine, and magnesium oxide...Pantoprazole was continued, and a budesonide taper was initiated...Our case adds to the growing evidence for the use of steroids and PPI for the treatment of Collagenous gastritis. Figure: Stomach - Gross Finding: Nodular Gastritis Figure: Biopsy findings"

Barrett Esophagus • CNS Disorders • Colonic Polyps • Colorectal Cancer • Crohn's disease • Dyspepsia • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Bowel Disease • Migraine • Rare Diseases • Solid Tumor

Persistent Pathogens: A Case of Chronic Enteropathogenic E. coli Diarrhea in an Adult (ACG 2026) - "Symptoms were partially controlled with dicyclomine and as needed hyoscyamine...Subsequent GI pathogen panel testing was positive for enteropathogenic Escherichia coli (EPEC) and sapovirus in the setting of persistent diarrhea, and the patient was treated with azithromycin 500 mg daily for three days...The patient was also co-infected with sapovirus, which may have increased susceptibility to persistent bacterial infection. Additionally, this case underscores the value of repeat infectious testing in patients with ongoing diarrhea despite initially negative studies."

Clinical • Autism Spectrum Disorder • CNS Disorders • Epilepsy • Genetic Disorders • Infectious Disease • Obesity • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

Pan-Enteric Dysmotility and Small Bowel Malabsorption: A Multidisciplinary Challenge in a Patient With LADA and Hashimoto's (ACG 2026) - "Despite extensive medical therapy which included prokinetics (prucalopride, erythromycin, azithromycin) , intestinal secretagogues (lubiprostone, plecanatide), antiemetics (ondansetron, prochlorperazine) and antispasmodics (dicyclomine), (proton pump inhibitors and H2 blockers), symptoms persisted . An integrated neuro-immuno-gastroenterological approach is essential in such complex presentations. Figure: Smallbowel Figure: Autoimmune"

Clinical • Constipation • Crohn's disease • Diabetes • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Secondary Hyperparathyroidism • IL13 • IL6

Delayed Diagnosis of Crohnâs Disease Following Ileal Pouch-Anal Anastomosis: A Diagnostic Challenge (ACG 2026) - "Colonoscopy confirmed severe colitis, and he was started on 6-mercaptopurine with good response. In 2016, elevated liver enzymes and worsening psoriasis prompted transition to adalimumab, which was discontinued after suspected drug-induced lupus...With infliximab and methotrexate initiation, he achieved clinical and endoscopic quiescence...Post-operative diarrhea and bowel urgency were unresponsive to ciprofloxacin, loperamide, cholestyramine, and dicyclomine...He remains on vedolizumab for luminal disease and risankizumab for psoriasis with sustained remission...In our case, delayed recognition contributed to a complicated clinical course, including bacterial infection, pouch-related complications, and poorer quality of life. Hence, this case highlights the importance of maintaining diagnostic flexibility at the onset of suspected IBD and the need for prudent treatment reassessment in refractory or atypical disease courses."

Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Inflammatory Bowel Disease • Lupus • Psoriasis • Ulcerative Colitis

A Case of Post-Infectious Diarrhea Predominant Irritable Bowel Syndrome Lasting Over a Decade Following Ciguatera Poisoning (ACG 2026) - "Over multiple years, the patient was treated with methscopolamine, dicyclomine, rifaximin, metronidazole, and selective serotonin reuptake inhibitors with marginal improvement. Seven years ago, he started taking eluxadoline (Viberzi) with some relief...Prevalence, Risk Factors, and Outcomes of Irritable Bowel Syndrome After Infectious Enteritis: A Systematic Review and Meta-analysis. Gastroenterology 2017;152:1042-1054.e1."

Clinical • Dyspepsia • Gastrointestinal Disorder

Incidental Wolff-Parkinson-White Syndrome Discovered Following Dicyclomine Use: A Case Report. (PubMed, Clin Pract Cases Emerg Med) - "This case highlights the potential importance of cardiac monitoring, even in patients with non-cardiac chief complaints, particularly when anticholinergic agents are administered."

Journal • Cardiovascular • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Movement Disorders

Ethnopharmacological Validation of Capparis spinosa L. in Gastrointestinal and Respiratory Disorders: Evidence from In Vitro, In Vivo, and In Silico Models. (PubMed, J Ethnopharmacol) - "C. spinosa L. exerts potent antispasmodic, bronchodilator, and antidiarrheal effects and may involve Ca2+ channel blockade and muscarinic antagonism, demonstrating pharmacological justification for its traditional use in gut and airway dysfunctions."

Journal • Preclinical • Asthma • Immunology • Pulmonary Disease • Respiratory Diseases

The efficacy and safety of hyoscyamine, dicyclomine, and desipramine in the treatment of irritable pouch syndrome-a retrospective cohort study. (PubMed, Crohns Colitis 360) - "Adverse events were infrequent and consistent with known safety profiles. Antispasmodic agents and low-dose neuromodulators are associated with meaningful symptom improvement in patients with irritable pouch syndrome, supporting their role as adjunctive therapies for pouch-related functional symptoms."

Journal • Retrospective data • Gastrointestinal Disorder • Inflammation • Pain

Effects of Roughage Combinations of Sugarcane Dry Leaves and Peanut Vine on the Rumen Microbial Community and Metabolites of Weaned Buffalo Calves. (PubMed, Microorganisms) - "By PLS-DA analysis, significantly higher levels of Bentyl and 3-Methoxytyramine-betaxanthin were observed in the S22.5PV group compared to the S15PV and S30PV groups, respectively. Positive correlations were observed between Succiniclasticum and NDFD, ADFD, acetic acid, propionic acid, isovaleric acid, as well as 3-Methoxytyramine-betaxanthin (p < 0.05). In conclusion, the rumen microbial diversity was not altered by the roughage combinations of dried sugarcane leaves and peanut vine, but the abundance of Succiniclasticum and the level of 3-Methoxytyramine-betaxanthin were significantly correlated with NDFD and ADFD, which enriched ruminal AA and PA, and may thus be associated with improved growth performance."

Journal

Petroleum ether fraction of Myrica nana roots relieves spasmodic abdominal pain in mice by inhibiting intestinal smooth muscle spasm (PubMed, Nan Fang Yi Ke Da Xue Xue Bao) - "PEFM has spasmolytic and analgesic effects in mice with neostigmine-induced spastic abdominal pain, mediated primarily by its main active component ST, which upregulates cGMP, enhances ileal VASP phosphorylation, activates NO/sGC/cGMP/PKG pathway, promotes opening of voltage-gated potassium channels, and antagonizes L-type calcium channels."

Journal • Preclinical • Pain

SemInERCP: Effects of Pre-procedure and Intra-procedure Simethicone and Dicyclomine Administration in Improving Quality of Endoscopic Reterograde Cholangipancreaticography (ERCP) (clinicaltrials.gov) - P4 | N=90 | Completed | Sponsor: CMH Lahore Medical College and Institute of Dentistry | Active, not recruiting ➔ Completed

Trial completion • Gastrointestinal Disorder

Association Between Real-Time Alerts in Electronic Prescribing Systems and Potentially Inappropriate Prescribing Among Older Adults. (PubMed, J Am Geriatr Soc) - "A national, real-time, non-interruptive alert system was associated with meaningful reductions in PIM prescribing among older adults. Scalable CDSS tools may enhance medication safety in resource-constrained settings."

Journal • Pain

Effectiveness of the extensively hydrolyzed formulas in the management of infantile colic: A systematic review and meta-analysis. (PubMed, World J Clin Pediatr) - "eHF appear significantly more effective than standard formulas and pharmacologic comparators in reducing colic-related symptoms. These findings support eHF as a viable dietary intervention for IC, though larger, well-controlled trials are warranted to confirm long-term outcomes."

Journal • Retrospective data • Allergy • Immunology

A multihued sustainable appraisal of the electrochemical method for synchronized micro-estimation of the household drug Paracetamol with Aceclofenac or Dicyclomine. (PubMed, Sci Rep) - "The results demonstrate that the proposed voltammetric approach is simple, rapid, cost-effective and suitable for routine quality control analysis of paracetamol-based binary mixtures. The online version contains supplementary material available at 10.1038/s41598-026-41215-w."

Journal • Pain

SemInERCP: Effects of Pre-procedure and Intra-procedure Simethicone and Dicyclomine Administration in Improving Quality of Endoscopic Reterograde Cholangipancreaticography (ERCP) (clinicaltrials.gov) - P4 | N=90 | Active, not recruiting | Sponsor: CMH Lahore Medical College and Institute of Dentistry

New P4 trial • Gastrointestinal Disorder

Chronic, Noninfectious Diarrhea: A Review. (PubMed, JAMA) - "For general treatment of chronic diarrhea, dietary modifications, such as consuming a diet low in fermentable oligosaccharides (legumes, wheat, onions, garlic), disaccharides (lactose), and monosaccharides (fructose), and polyols (sorbitol, mannitol), or medications, such as opiate agonists (loperamide), anticholinergics (hyoscyamine, dicyclomine), or 5-hydroxytryptamine 3 receptor (5-HT3) antagonists (ondansetron), can be prescribed. Diagnostic testing should include consideration of celiac disease, inflammatory bowel disease, and microscopic colitis. Empiric therapies for chronic diarrhea include lifestyle and dietary modifications and medications, including opiate agonists, anticholinergics, and 5-HT3 antagonists."

Journal • Celiac Disease • Colorectal Cancer • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Inflammatory Bowel Disease • Oncology • Pain • Solid Tumor

Discovery of Genes Related to Cuproptosis and Mitophagy to Improve Myocardial Infarction Diagnosis and Treatment. (PubMed, Curr Gene Ther) - "The core genes (GPCPD1, S100A8, and CD55) identified in this study not only served as potential diagnostic markers but were also functional nodes in copper-dependent cell death, contributing to MI treatment."

Journal • Cardiovascular • Inflammation • Metabolic Disorders • Myocardial Infarction • CD55 • S100A8

Gastric Schwannoma versus Gastrointestinal Stromal Tumor: A Case Report and the Future of Artificial Intelligence in Differentiating Subepithelial Gastric Lesions (ACG 2025) - "Dicyclomine and a proton pump inhibitor (PPI) were started, but with no relief of symptoms...(D) Endoscopic ultrasound (EUS) identifying a well-defined, hypoechoic mass originating from the muscularis propria layer (red arrow).Figure: Figure 2. Comparison of conventional EUS and AI-assisted EUS in key diagnostic capabilities, highlighting the superior performance of AI-assisted imaging in lesion differentiation, early detection, and data integration.*EUS = Endoscopic Ultrasound"

Case report • Clinical • Stroma • Brain Cancer • Gastric Cancer • Gastrointestinal Cancer • Gastrointestinal Stromal Tumor • Melanoma • Oncology • Sarcoma • Solid Tumor • Spindle Cell Sarcoma • CD34 • KIT • PRAME

Diagnostic Dilemma: Overlap Syndrome in the Young—Antimitochondrial Antibodies Meet NAFLD (ACG 2025) - "We present a case of a young, obese male with AMA-positive MASLD who underwent liver biopsy for further evaluation.Case Description/ A 27-year-old obese male (BMI 40) with hypertension and prior robotic cholecystectomy for symptomatic cholelithiasis presented with persistently elevated liver enzymes (ALT 67, AST 72), proteinuria (albumin/creatinine: 101, 50, 301), and thrombocytosis...Medications included lisinopril, Flonase, azelastine, meclizine, and dicyclomine...AMA positivity, proteinuria, and cholestatic features may indicate advanced disease and serve as diagnostic/prognostic markers for MASH. Emerging therapies include tirzepatide (a GIP/GLP-1 agonist) for weight and fat reduction, and resmetirom, the first FDA-approved treatment for MASH with fibrosis (F2–F3).Figure: fibroscan"

Brain Cancer • Cardiovascular • Fibrosis • Gastroenterology • Glioblastoma • Hematological Disorders • Hepatology • Hypertension • Immunology • Infectious Disease • Metabolic Disorders • Metabolic Dysfunction-Associated Steatohepatitis • Metabolic Dysfunction-Associated Steatotic Liver Disease • Musculoskeletal Pain • Obesity • Otorhinolaryngology • Primary Biliary Cholangitis • Renal Disease • Solid Tumor • Thrombocytosis • Vertigo

Diarrhea with Depression: Sertraline-Induced Microscopic Colitis (ACG 2025) - "2 months ago, she had switched from duloxetine to sertraline 100mg for uncontrolled mood symptoms without psychiatric consultation...Per guidelines, sertraline was held, and budesonide, loperamide, cholestyramine, and dicyclomine were started. Symptoms resolved at 4 weeks.Since sertraline is a commonly used and well-tolerated first-line agent for mood disorders, clinicians should suspect MC in patients with chronic diarrhea after starting it. Discontinuation and close follow-up to monitor for relapses are key to management.Figure: Colonoscopy"

Chronic Obstructive Pulmonary Disease • CNS Disorders • Colonic Polyps • Depression • Fatigue • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Mood Disorders • Peptic Ulcer • Psychiatry • Respiratory Diseases

May-Thurner Meets the Gut-Brain Axis: Multilevel Dysfunction in Hypermobile Ehler-Danlos Sydnrome (ACG 2025) - "A medication review revealed chronic use of tramadol and dicyclomine. Pelvic venous outflow obstruction (e.g. MTS) and neurological impairments (e.g. TCS) may coexist and potentiate gut dysfunction, particularly in connective tissue disorders. A high index of suspicion and a multidisciplinary approach are essential for identifying and managing overlapping anatomic and functional contributors to intractable constipation in hEDS.Figure: The right common iliac artery compresses the left common iliac vein against the vertebra with venous collaterals into the spinal veins."

Cardiovascular • Constipation • Gastroenterology • Gastrointestinal Disorder • Hypertension • Inflammation • Inflammatory Bowel Disease • Rheumatology

Rectosigmoid Endometriosis Masquerading as Colon Cancer (ACG 2025) - "She has one bowel movement per week and uses dicyclomine...Radiological imaging is supportive, but endoscopic procedures like colonoscopy or endoscopic ultrasound with biopsies have diagnostic value. Surgical treatment is considered in symptomatic patients with invasive intestinal compromise, or for patients with progressive lesions, and impaired sexual function.Figure: Endoscopic view of rectosigmoid massFigure: Polypoid, frond like villous partially obstructing mass"

Anemia • Colon Cancer • Colorectal Cancer • Constipation • Endometriosis • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Gynecology • Oncology • Solid Tumor • Uterine Leiomyoma • Women's Health • ER

The Efficacy of Dicyclomine for the Unspecified Abdominal Pain (UAP) in the Emergency Department: A Retrospective Study (ACG 2025) - "The study included 280 patients with a median age of 40.7 ± 16.8 years; 55.7% were female. First-time ED presentation for UAP occurred in 57.1% (160), and 55.7% (156) had no known comorbidities. Dicyclomine was administered within 30 minutes of physician evaluation in 74.3% (208) of cases, and within 1 hour in 25.7% (72)."

Retrospective data • Gastrointestinal Disorder • Inflammatory Bowel Disease • Pain

Unintended consequences of medical interventions - A rare case of iatrogenic dicyclomine and paracetamol dependence. (PubMed, Indian J Psychiatry) - No abstract available

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