timbetasin intravenous (RGN-352) / RegeneRx, Lee's Pharm - LARVOL DELTA

Association Between Thymosin β4 and Coronary Arterial Lesions in Children with Kawasaki Disease. (PubMed, J Inflamm Res) - "Tβ4 levels were significantly lower in children with KD, particularly in those with CALs. These findings suggest that Tβ4 may be involved in the inflammatory pathogenesis of KD and the progression of CALs, thus could represent a potential target for future diagnostic or therapeutic interventions."

Journal • Cardiovascular • Heart Failure • Inflammation • Vasculitis • IL10 • IL1B • IL4 • TMSB4X • TNFA

Injectable Thymosin β4-Modified Hyaluronic Acid Hydrogel with Exosomes for Stem Cell Homing and Neuronic-Angiogenic-Osteogenic Coupled Cranial Repair. (PubMed, ACS Nano) - "Our results suggest that this hydrogel platform exerts a robust multisystemic regulatory effect, fostering rat bone repair through the synergistic promotion of in situ stem cell recruitment, angiogenesis, neurogenesis, and osteogenesis. As a simple-to-prepare and multifunctional integrated bone graft, this hydrogel platform holds a significant promise in establishing a conducive microenvironment for optimal bone healing."

Journal • RUNX2 • TMSB4X

Thymosin beta 4 prevents systemic lipopolysaccharide-induced plaque load in middle-age APP/PS1 mice. (PubMed, Int Immunopharmacol) - "It prevented LPS-induced amyloid burden in APP/PS1 mice but increased astrocytic and microglial proliferation in the hippocampus of LPS-treated WT mice. These data show that Tβ4 can alleviate the adverse effects of systemic LPS in the brain by preventing exacerbation of amyloid deposition in AD mice and by inducing reactive microgliosis in aging WT mice."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Infectious Disease • Inflammation • Septic Shock • TMSB4X

Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies. (PubMed, Int Immunopharmacol) - "Moreover, we discovered TB4 is capable of epicardial progenitor activation, and revealed the effect is independent of hypoxic injury. By observing the above results, we believe, further discoveries and consequential postnatal administration of developmentally relevant candidate molecules such as TB4 may likely result in reversing aging processes and accelerate organ regeneration in the human body."

Journal • Myocardial Infarction • TMSB4X

Enhancing cardiac regenerative therapies by reminding the adult heart on its embryonic state (HEART FAILURE 2022) - "Observing the broad capacity of TB4 we believe it is not the only molecule which nature conceals to our benefits. Hence, the discovery and postnatal administration of developmentally relevant agents along with other approaches may even result in reversing aging processes."

Clinical • Cardiovascular • Myocardial Infarction • TMSB4X

New Research Demonstrates Thymosin Beta 4's Potential Positive Effects on Alzheimer's Disease (PRNewswire) - "RegeneRx Biopharmaceuticals, Inc...today announced that a new research paper was published demonstrating Thymosin Beta 4's (Tβ4) positive effects on animal models related to Alzheimer's Disease....Tβ4 over-expression in the mouse models alone showed less amyloid beta peptide, or amyloid deposits, which correlates with the clinical status of the patient....In the study, Tβ4 down regulated certain known inflammatory pathways, while other drug combinations did not, in particular NF-κB signaling....The study, Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice, was published by Wang et. al, in the Journal of Neuroinflammation..."

Preclinical • Alzheimer's Disease • CNS Disorders

A Study of the Safety and Efficacy of Injectable Thymosin Beta 4 for Treating Acute Myocardial Infarction (clinicaltrials.gov) - P2; N=0; Withdrawn; Sponsor: RegeneRx Biopharmaceuticals, Inc.; N=75 ➔ 0; Suspended ➔ Withdrawn

Enrollment change • Trial withdrawal • Cardiovascular • Myocardial Infarction • MRI

A Phase 1b Study of the Intravenous Administration of Thymosin Beta 4 in Healthy Volunteers (clinicaltrials.gov) - P1b; N=30; Completed; Sponsor: Beijing Northland Biotech. Co., Ltd.

Clinical • New P1 trial • Immunology

New Research Paper Suggests RegeneRx’s Thymosin Beta 4 May be Useful in Treating COVID-19 (PRNewswire) - P=NA, N=49; "...COVID-19 elevates bradykinin levels in multiple tissues and systems that cause significant increases in vascular dilation, vascular permeability, and hypotension....Age was comparable between men and women in all data sets. In the case data series, men's cases tended to be more serious than women's (P = 0.035)....'Tβ4's ability to not only down-regulate inflammatory chemokines and cytokines and proinflammatory processes such as the bradykinin storm, but also increase fibrinolysis and accelerate wound repair in the heart, lungs, kidneys and other organs that are often affected by COVID-19 infection.'"

Biomarker • Clinical data • Infectious Disease • Novel Coronavirus Disease

[VIRTUAL] Oxytocin Mediates Neuroendocrine Reprogramming of the Epicardium in Heart Regeneration (BCVS 2020) - "Future studies will aim to further reveal the physiological contribution of OT to heart regeneration in vivo and determine its molecular mechanism of action. Our findings have the potential to uncover a novel mechanism of neuroendocrine reprogramming of the injured heart and yield significant translational advances in the treatment of CVD."

Cardiovascular • TMSB4X

Primary Mechanisms of Thymosin β4 Repair Activity in Dry Eye Disorders and Other Tissue Injuries. (PubMed) - "Such studies provide the rationale for use of Tβ4 in other types of eye disorders beyond dry eye. Finally, we will identify the gaps in our knowledge and propose future research avenues."

Journal • Biosimilar • Immunology • Inflammation

Serum Thymosin β4 Concentrations in Obstructive Sleep Apnea Syndrome Patients. (PubMed) - J Clin Lab Anal - "Serum thymosin β4 concentrations were correlated with the occurrence and severity of OSAS."

Journal • Biosimilar • Diabetes • Immunology • Osteoarthritis • Pain

Thymosin β4 impeded murine stem cell proliferation with an intact cardiovascular differentiation. (PubMed) - J Huazhong Univ Sci Technolog Med Sci - "In conclusion, Tβ4 suppressed mESCs proliferation by affecting the activity of STAT3, Akt, ERK and Wnt pathways. However, Tβ4 did not influence the in vitro cardiovascular differentiation."

Journal • Biosimilar

Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells. (PubMed) - "Thus, Tβ4 up-regulated MBP synthesis, and inhibited OGD-induced apoptosis in a novel miR-200a dependent EGFR signaling pathway. Our findings of miR-200a-mediated protection of progenitor cells may provide a new therapeutic importance for the treatment of neurological injury."

Journal • Biosimilar

Characterization of the protein components of matrix stones sheds light on the S100-A8 and A9 relevance in the inflammatory pathogenesis of these rare renal calculi. (PubMed) - J Urol - "The abundance of inflammatory molecules identified points to an inflammatory process being the event that initializes soft calculi formation, rather than a consequence. The post-translational oxidative changes in S100-A8 and A9, and the presence of Thymosin beta-4, Granulins and Ubiquitin also suggest the intervention of host defenses through a superimposed vigorous counter-inflammatory process. The post-translational changes seen in the proteins and peptides, and the known self-assembling capability of S100-A8 and A9 probably explain the gelatinous consistency of these stones."

Journal • Biosimilar

Protective Effect of Thymosin β4 against Abdominal Aortic Ischemia-Reperfusion-Induced Acute Lung Injury in Rats. (PubMed, Medicina (Kaunas)) - "Tβ4 reverted these parameters in both Tβ4-treated groups compared to the untreated IR group. Since there is no statistical difference between the prescribed results of both Tβ4-treated groups, our study demonstrates that Tβ4 reduced lung oxidative stress and inflammation following IR and prevented lung tissue injury regardless of timing of administration."

Journal • Preclinical