methadone / Generic mfg. - LARVOL DELTA

A Cost Analysis of Acute Pain Management After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy. (PubMed, Ann Surg Oncol) - "This study demonstrates that CWIS + methadone is a more cost-effective strategy in most cases, exhibiting dominance over epidural analgesia in 91.4% of simulations."

HEOR • Journal • Pain

Getting de Pointes Across: Isoproterenol for Refractory Methadone-Associated Torsades de Pointes in Alcohol Withdrawal. (PubMed, Cureus) - "We present a case of a young female on high-dose methadone, who developed TdP in the context of acute alcohol withdrawal and clonidine-associated bradycardia. Her arrhythmia persisted despite treatment with magnesium and lidocaine but resolved following initiation of an isoproterenol infusion. This case emphasizes the importance of systematic risk assessment in patients receiving methadone and supports the use of isoproterenol as a viable therapeutic option when TdP is refractory to first-line interventions."

Journal • Cardiovascular

Providers' Experiences in Implementation of Friendship Bench: A Problem-Solving Therapy-Based Mental Health Intervention Adapted for People on Methadone Maintenance Treatment Who Live with HIV in Vietnam. (PubMed, AIDS Behav) - P=N/A | "Application of aFB as a mental health intervention for care and treatment for MMT and ART patients could be a promising approach for Vietnam to address mental health care needs for this vulnerable population. Clinical Trial Number: NCT04790201 registered 3/10/2021."

Journal • CNS Disorders • Human Immunodeficiency Virus • Infectious Disease • Mental Retardation • Psychiatry

Methadone in THA for Post-op Pain and Opioid Reduction (clinicaltrials.gov) - P3 | N=162 | Recruiting | Sponsor: Medical University of South Carolina | Not yet recruiting ➔ Recruiting

Enrollment open • Orthopedics • Pain

PRECISE: Evaluation of Analgesia for Cardiac Elective Surgery in Children (clinicaltrials.gov) - P3 | N=500 | Recruiting | Sponsor: Senthil Sadhasivam | Not yet recruiting ➔ Recruiting

Enrollment open • Cardiovascular • Pediatrics

Differences in take-home methadone receipt by state policy and individual social factors in a multistate survey of people who use drugs: A cross-sectional study. (PubMed, J Subst Use Addict Treat) - "State take-home policy was most strongly associated with take-home methadone receipt. Receiving longer days of take-home supplies remains rare. Take-home eligibility guidelines should be established and consider potential social vulnerability factors to daily on-site dosing."

Journal • Observational data • Infectious Disease • Novel Coronavirus Disease • Substance Abuse

PRECISE: Evaluation of Analgesia for Spine Fusion Elective Surgery in Children (clinicaltrials.gov) - P3 | N=500 | Recruiting | Sponsor: Senthil Sadhasivam | Not yet recruiting ➔ Recruiting

Enrollment open

Methadone in TKA for Post-op Pain and Opioid Reduction (clinicaltrials.gov) - P3 | N=162 | Recruiting | Sponsor: Medical University of South Carolina | Not yet recruiting ➔ Recruiting

Enrollment open • Orthopedics • Pain

Association between intraoperative methadone administration and QTc interval prolongation: a propensity score-matched analysis. (PubMed, Reg Anesth Pain Med) - "The implementation of methadone for perioperative pain management was not associated with an increased incidence of intraoperative QTc interval prolongation."

Journal • Pain

Explaining Variation in VA Opioid Treatment Program Clinical Practice Following Regulatory Reform: A Qualitative Study. (PubMed, Subst Use Addctn J) - "This study reveals variation in OTP clinical practice across VA in the wake of regulatory reform. To inform decision-making in the new regulatory environment, research examining the effects of OTP clinical practices on patient engagement, retention, and quality of care should be prioritized."

Journal • Infectious Disease • Novel Coronavirus Disease

Task-related differences in network connectivity and dynamics in people with severe opioid use disorder compared with healthy controls. (PubMed, Transl Psychiatry) - "We collected fMRI data while people with sOUD receiving methadone (MD; n = 25) and HC (n = 22) completed the MID and cue reactivity tasks...The study design and planned analytical approach for the primary analyses was pre-registered [1]. This paper consists of secondary analyses which were not primary considerations when designing the research study that collected the data."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Cognitive Disorders • Psychiatry • Substance Abuse • DRD2

Travel Time to Methadone Treatment Via Personal Vehicle vs Public Transit. (PubMed, JAMA Netw Open) - "Current federal statutes and regulations governing methadone provision are the greatest barrier, as they directly require often daily transit to opioid treatment clinics. Reducing this barrier requires policy changes."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders

Population-Level Health Benefits and Harms Associated With Buprenorphine/Naloxone vs Methadone. (PubMed, JAMA Netw Open) - "Results from this study suggest that any advantages from a reduced risk of mortality with treatment with buprenorphine/naloxone were outweighed by deficits in treatment retention. Evaluated in a jurisdiction where both medications were available in office-based settings, these findings do not support recommendations of buprenorphine/naloxone as first-line treatment over methadone."

Journal • Addiction (Opioid and Alcohol) • Substance Abuse

Travel Time to Opioid Treatment Programs in Connecticut-Still Waiting for Methadone. (PubMed, JAMA Netw Open) - No abstract available

Journal

Successful Catheter-Directed Thrombolysis for a Patient With Intermediate-High-Risk Pulmonary Embolism: A Case Report. (PubMed, Clin Case Rep) - "The patient had a history of smoking, methadone addiction, and a recent motor vehicle accident, with a prior intracranial hemorrhage...This case highlights the potential of CDT as an effective and safe treatment for PE patients with intermediate-to-high risk who are not candidates for ST, a scenario with limited therapeutic options. CDT's routine use requires validation through additional studies and randomized trials."

Journal • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Psychiatry • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases

Self-Reported History of Precipitated Withdrawal: A Cross-Sectional Study of People Who Use Unregulated Opioids. (PubMed, J Addict Med) - "Buprenorphine-associated precipitated withdrawal was commonly reported. Improved guidance and treatment approaches should be prioritized to minimize these complications, particularly in outpatient settings."

Journal • Observational data • Substance Abuse

Public Support for Harm Reduction Strategies to Address the Opioid Pandemic in the United States: A Latent Class Analysis. (PubMed, Subst Use Misuse) - "We examine public support for five different types of common harm reduction strategies, including the legalization of safe consumption sites, FDA approval of over-the-counter/nonprescription naloxone, increased number of methadone clinic locations, decriminalizing Fentanyl testing strips, and implementation of syringe service programs, in a national representative sample. Demographics and past experiences with opioids and criminal legal involvement are differentially associated with these profiles. Information and educational programs should be designed to target different groups of individuals to increase understanding and support for harm reduction policies and programs."

Journal • Addiction (Opioid and Alcohol)

Adherence and efficacy of the 0 - 7 - 21-day versus the 0 - 1 - 6-month hepatitis B vaccination schedules among people who use drugs: a two-year randomized controlled trial. (PubMed, Expert Rev Vaccines) - P=N/A | "A randomized controlled trial was conducted in 1261 HBV-susceptible PWUD from compulsory isolated detoxification centers (CIDCs) and methadone maintenance treatment (MMT) clinics in Xi'an...Schedules should be selected based on the management models for PWUD and their individual characteristics. Chinese Clinical Trial Registry (ChiCTR1900022403)."

Journal • Hepatitis B • Infectious Disease • Inflammation

Exploring multi-level barriers and human-centered solutions to expand methadone for HIV prevention among people who inject drugs in Kyrgyzstan. (PubMed, J Subst Use Addict Treat) - "Applying human-centered design within implementation science frameworks identified context-specific barriers and actionable strategies. Addressing these client-prioritized challenges may be essential to improving methadone retention and could contribute to reducing HIV risk among PWID in Kyrgyzstan."

Journal • Human Immunodeficiency Virus • Infectious Disease • Substance Abuse

Older Adults, Methadone, and Cognitive Function (clinicaltrials.gov) - P=N/A | N=20 | Enrolling by invitation | Sponsor: University of Maryland, Baltimore | Not yet recruiting ➔ Enrolling by invitation

Enrollment open • Cognitive Disorders • Substance Abuse

Safety and Efficacy of Low-Dose Methadone as an Adjunctive Therapy with Other Opioids for Cancer-Related Pain (ChiCTR) - P4 | N=70 | Recruiting | Sponsor: Jiangsu Cancer Hospital; Jiangsu Cancer Hospital

New P4 trial • Oncology • Pain

Erector spinae plane block reduces intraoperative nociception in bitches undergoing ovariohysterectomy: A randomised clinical trial. (PubMed, Vet Rec) - "Ultrasound-guided ESP block reduces intraoperative opioid use in dogs undergoing ovariohysterectomy but has limited impact on postoperative pain control."

Journal • Anesthesia • Gynecology • Pain

Beyond the obvious: paediatric methadone toxicity with benzodiazepine co-exposure. (PubMed, BMJ Case Rep) - "Subsequent urine toxicology revealed co-ingestion of methadone and benzodiazepines, prompting the sequential addition of flumazenil, which led to full neurological recovery. This case highlights the critical importance of investigating co-ingestions when response to initial antidote therapy is inadequate, underscores the diagnostic role of neuroimaging in toxic encephalopathy, and emphasises the necessity of safe drug storage practices."

Journal • CNS Disorders • Pediatrics • Psychiatry

Evaluation of portable atmospheric-pressure solids analysis probe-quadrupole mass spectrometry and UPLC-MS for the rapid screening of illicit substances in human urine. (PubMed, J Chromatogr A) - "In this study, portable ASAP-quadrupole mass spectrometry (ASAP-QMS) method in positive ion mode was demonstrated for the rapid analysis of 9 drugs of abuse (amphetamine, methamphetamine, oxycodone, methadone, morphine, 3,4-methylenedioxymethamphetamine, ketamine, 6-monoacetylmorphine, and cocaine), fortified in water and urine samples, with analysis time of ∼30 s. Initially, a direct analysis approach without sample preparation was applied to fortified water and urine samples. The lower accuracy of ASAP-QMS was attributed to the poor spectral library matching (similarity scores < 850) in complex urine matrices, particularly for low-concentration drug compounds. Nevertheless, portable ASAP-QMS (with SPE) achieved a higher greenness assessment score (0.54) compared to UPLC-MS (0.37), highlighting its potential as a rapid and environmentally friendly drug screening approach."

Journal

Brief report: Ketamine-assisted "bridge therapy" for opioid tapering in complex cases. (PubMed, Am J Addict) - "This is a novel report to document a multifaceted improvement in this specific comorbidity cluster."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Pain • Psychiatry • Substance Abuse