methadone / Generic mfg. - LARVOL DELTA

The use of methadone in cardiac surgery: resurgence of an old drug? (PubMed, Curr Opin Anaesthesiol) - "Further studies are needed to explore the mechanisms and ideal protocols for incorporating methadone into routine use as part of existing enhanced recover protocols. Long-term treatment effects extending beyond the immediate postoperative period, outcomes when included with adjuncts, and broader dose-response analysis are needed to guide future implementation."

Journal • Cardiovascular • Pain

Trans-auricular vagal nerve stimulation as an innovative approach to pain treatment in sickle cell disease patients hospitalized with acute pain. (ASH 2025) - "At time of writing, one 18 yo female with HbSS was enrolled and treated for 7 days of an inpatient hospitalization for acute on chronic pain., with pain scores consistently 8-9/10 despite high doses of methadone and IV hydromorphone...Inflammatory biomarkers will be assessed at the end of the study to prevent batch effects and may be useful in identifying subgroups of patients likely to respond to taVNS. These findings will be crucial in informing subsequent randomized controlled trials of taVNS as a novel approach to pain management in SCD."

Clinical • Anesthesia • Cardiovascular • CNS Disorders • Depression • Epilepsy • Genetic Disorders • Hematological Disorders • Immunology • Inflammatory Arthritis • Lupus • Migraine • Pain • Rheumatoid Arthritis • Rheumatology • Sickle Cell Disease • Systemic Lupus Erythematosus • IL6 • TNFA

Healthcare utilization in patients with sickle cell disease on buprenorphine for chronic pain (ASH 2025) - "The studywas performed at the University of Chicago Medical Center and included patients aged 18 years andolder with a confirmed diagnosis of SCD (HbSS, HbSC, or HbSbeta0).Patients with acute-on-chronic pain were offered BUP if they were admitted for at least 7 days on IVopioids and unable to wean despite offering Ketamine or Lidocaine, or if they had at least 2 admissions inthe last 30 days. Patients on chronic opioid therapy with methadone or a prior diagnosis of opioid usedisorder were excluded from the study...Concurrent opioidutilization was assessed through prescription records, documenting daily morphine milligram equivalents(MME) for breakthrough opioid therapy.Primary outcomes included admission (Adm) rates and average length of stay (LOS) per admission,captured from inpatient encounter records...Otherfactors, such as access to outpatient care, psychosocial support, or disease-modifying therapies likehydroxyurea, may also have influenced outcomes.This study..."

Clinical • HEOR • Genetic Disorders • Hematological Disorders • Pain • Sickle Cell Disease • Substance Abuse

Acute Pain Service Utilization as a Lens on Inequities in Trauma and Inpatient Management. (PubMed, Healthcare (Basel)) - "Methadone use was a strong predictor of non-home discharge, including discharges to a medical facility, hospice, or against medical advice (AMA)...As APS teams regularly serve these populations, they are well-positioned to bridge broader gaps through the integration of addiction and social support services, individualized pain management, and seamless coordination of care across specialties. These findings underscore the need for standardized consultation criteria and integration of social and addiction medicine resources into APS care models."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Musculoskeletal Diseases • Orthopedics • Pain • Psychiatry

Dosing and Safety of Methadone Initiation in the Setting of Fentanyl: A Systematic Review. (PubMed, J Addict Med) - "The current observational literature is limited, with some support for accelerated methadone initiation in inpatient and outpatient settings for appropriately selected patients exposed to fentanyl."

Journal • Addiction (Opioid and Alcohol) • Anesthesia • Substance Abuse

Methadone Pharmacokinetics in Cardiac Surgery (clinicaltrials.gov) - P4 | N=69 | Not yet recruiting | Sponsor: Wake Forest University Health Sciences | Phase classification: P1 ➔ P4

Phase classification • Cardiovascular • Pain

Intraoperative pain management for patients undergoing medication-assisted rehabilitation: a scoping review. (PubMed, BMC Anesthesiol) - No abstract available

Journal • Anesthesia • Pain • Substance Abuse

Implementation challenges and opportunities in decentralized methadone service delivery. (PubMed, BMC Health Serv Res) - "Addressing community stigma, ensuring consistent service quality, supporting and enhancing clients' social connections, and fostering transparent and participatory planning processes will be critical to effectively implement decentralized methadone service delivery."

Journal • Substance Abuse

Real-world longitudinal treatment trajectories following opioid use disorder diagnosis among commercially-insured beneficiaries in the United States. (PubMed, J Subst Use Addict Treat) - "Findings highlight a significant discordance between real-world treatment patterns and evidence-based guidelines for OUD treatment."

Journal • Real-world evidence • Addiction (Opioid and Alcohol) • Substance Abuse

Multilevel determinants of medication preferences for opioid use disorder among criminal-legal-involved populations: Insights from a scoping review. (PubMed, Drug Alcohol Depend Rep) - "Methadone was the most referenced (n = 30), with more articles noting negative attitudes than positive...Preferences/attitudes toward MOUD among criminal-legal-involved populations are shaped by intersecting multilevel determinants and differ by MOUD type. Identified factors might serve as intervention targets to better meet individuals' needs."

Journal • Review • Addiction (Opioid and Alcohol) • Substance Abuse

Public transit and methadone - Spatial analyses of opioid treatment program access in Greater Boston, 2020-2022. (PubMed, Prev Med Rep) - "Many areas in Greater Boston have unmet OTP access needs on public transit. Our results can inform decision-making to improve OTP access in Boston, such as increased early-morning transit service, expanding access to methadone beyond existing OTPs, or broadening non-emergent medical transit."

Journal • Addiction (Opioid and Alcohol) • Substance Abuse

Opioid use disorder and concurrent benzodiazepine use: clinical risks and management strategies. (PubMed, J Addict Dis) - "This article synthesizes current evidence on the prevalence, risks, and management of BZD co-use in OUD, focusing on patients receiving medications for OUD (MOUD) such as buprenorphine and methadone...We propose an evidence-informed framework for managing co-use, prioritizing OUD stabilization, close monitoring and harm reduction, gradual BZD tapering, and integrated psychosocial interventions. This approach balances safety and efficacy, ensuring patient-centered care while mitigating risks."

Journal • Review • Addiction (Opioid and Alcohol) • Substance Abuse

Integrating Methadone Services Into Primary Care in Ukraine: Two-Year Outcomes From a Randomized Trial. (PubMed, Ann Intern Med) - P=N/A | "Integrating methadone treatment into primary care settings improves adherence to guideline-concordant health care without compromising methadone retention and treatment quality. National Institute on Drug Abuse."

Journal • Substance Abuse

Integrating Methadone Into Primary Care: Lessons From Ukraine. (PubMed, Ann Intern Med) - No abstract available

Journal

Effective airway management strategy for tracheal resection in a dog with cervical tracheal stenosis. (PubMed, Vet Anaesth Analg) - "Premedication consisted of intravenous dexmedetomidine (2 μg kg-1) and methadone (0.2 mg kg-1). The dog recovered uneventfully. This case illustrates a staged and flexible airway management strategy using progressively smaller sterile tubes, bougie guidance and intraoperative endoscopy to maintain effective ventilation during complex tracheal surgery in dogs."

Journal • Anesthesia • Gynecology

Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit (clinicaltrials.gov) - P4 | N=9 | Terminated | Sponsor: Henry Ford Health System | N=46 ➔ 9 | Unknown status ➔ Terminated; PI no longer practicing at study institution.

Enrollment change • Trial termination • CNS Disorders • Cognitive Disorders • Critical care

Factors Associated With Preferences for Opioid Agonist Therapies Among People Dependent on Opioids. (PubMed, Drug Alcohol Rev) - "Nearly all participants preferred OAT, mostly reflecting prior experiences, underscoring the need for expanded access to OAT in Australia. Given the multiple stated preferences, OAT options should include a variety of treatment options aligned with patient preferences, including expanded take-home options."

Journal • Addiction (Opioid and Alcohol) • Substance Abuse

Buprenorphine-based treatments outcomes in pregnant opioid-dependent women: A systematic review and meta-analysis. (PubMed, Addiction) - "Compared with methadone in treating opioid use disorder during pregnancy, buprenorphine-based therapies, buprenorphine-naloxone in particular, have demonstrated greater efficacy in enhancing neonatal outcomes."

Journal • Retrospective data • Review • Addiction (Opioid and Alcohol) • CNS Disorders • Psychiatry • Substance Abuse

Comparative study of three anaesthetic protocols (dexmedetomidine/ketamine, dexmedetomidine/midazolam, midazolam/ketamine) in dwarf rabbits undergoing elective orchiectomy. (PubMed, Vet J) - "Twenty-one pet rabbits were randomly allocated in study groups - MKM (7 rabbits): midazolam (0.2mg/kg), ketamine (20mg/kg), and methadone (0.3mg/kg) were administered subcutaneously (SC); DKM (7 rabbits): received dexmedetomidine (25µg/kg), ketamine (20mg/kg), and methadone (0.3mg/kg) SC; MDM (7 rabbits): received midazolam (0.2mg/kg), dexmedetomidine (25µg/kg), and methadone (0.3mg/kg) SC. The combination of dexmedetomidine/ketamine provides better sedation; however, it frequently induces ataxia/incoordination. The further addition of midazolam could promote muscle relaxation and tranquillisation, reducing handling stress in pet rabbits."

Journal • Preclinical • Anesthesia • Ataxia • Cardiovascular • Movement Disorders

Analysis of serum biomarkers associated with pain in Spanish greyhounds undergoing ovariohysterectomy. (PubMed, Vet Rec) - "Although glutamate, CGRP and cortisol levels fluctuated over time-with glutamate and CGRP peaking at T0-baseline-none proved useful for assessing postoperative pain compared with conventional clinical parameters."

Biomarker • Journal • Gynecology • Pain

Opioid Hypermetabolism in a Multiextremity Spine Trauma Patient: A Case Report. (PubMed, JBJS Case Connect) - "Genetic mutations in CYP2D6 can result in impaired opioid metabolism and impaired pain control. Impaired pain control in musculoskeletal trauma patients should raise concern for a potential CYP2D6 mutation. A proper understanding of this condition and adjustments in pain management can guide optimal care for these patients."

Journal • Musculoskeletal Diseases • Orthopedics • Pain • CYP2D6

Methadone Use in the Postanesthesia Care Unit Setting. (PubMed, J Perianesth Nurs) - No abstract available

Journal

Increasing ketamine administration in children's hospitals for youth with sickle cell disease. (PubMed, Blood Adv) - "Admissions with ketamine administration were also more likely to have administration of methadone and hydroxyurea. Early versus late ketamine administration was associated with shorter LOS and fewer parental opioid days, indicating randomized controlled studies are needed to determine not only which patients benefit from ketamine but also the impact of early administration."

Clinical • Journal • Critical care • Genetic Disorders • Hematological Disorders • Pain • Sickle Cell Disease

Expedited referrals from community health center to opioid treatment program: innovative approaches to improving access to methadone treatment for patients who use opioids and experience homelessness. (PubMed, Addict Sci Clin Pract) - No abstract available

Journal

Analysis of the Costs and Reach of Transportation Services to Reduce Barriers to Opioid Use Disorder (OUD) Treatment: Evidence from the Kentucky HEALing Communities Study. (PubMed, Res Sq) - P=N/A | "Individuals who are retained on methadone and buprenorphine treatment have a decreased risk of mortality when compared to others with OUD...Trial registration ClinicalTrials.gov, NCT04111939. Registered 30 September 2019, https//clinicaltrials.gov/ct2/show/NCT04111939."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Psychiatry • Substance Abuse