human menstrual blood derived stem cells / Zhejiang University - LARVOL DELTA

Human menstrual blood-derived stem cells secreted ECM1 directly interacts with LRP1α to ameliorate hepatic fibrosis through FoxO1 and mTOR signaling pathway. (PubMed, Stem Cell Res Ther) - "These findings highlight an extensive network of ECM1-LRP1 interaction, which serve as a link for providing promising insights into the mechanism of MenSC-based drug development for liver fibrosis. Our study also potentially presents novel avenues for clinical antifibrotic therapy."

Journal • Dyslipidemia • Fibrosis • Hepatology • Immunology • Liver Cirrhosis • LRP1

Human Menstrual Blood-Derived Stem Cells Protect against Tacrolimus-Induced Islet Dysfunction via Cystathionine β-Synthase Mediated IL-6/STAT3 Inactivation. (PubMed, Biomolecules) - "Diabetes imposes a huge burden worldwide. We further revealed that MenSCs exerted their therapeutic effects by inhibiting CBS expression to activate the IL6/JAK2/STAT3 pathway. In conclusion, we showed that MenSCs may be a potential strategy to improve tacrolimus-induced islet dysfunction."

Journal • Diabetes • Metabolic Disorders • Transplantation • IL6 • STAT3

Human menstrual blood-derived stem cells reverse sorafenib resistance in hepatocellular carcinoma cells through the hyperactivation of mitophagy. (PubMed, Stem Cell Res Ther) - "Our research suggests that combining sorafenib and MenSCs may be a potentially new strategy to reverse sorafenib resistance in HCC-SR cells."

IO biomarker • Journal • Gastrointestinal Cancer • Hepatocellular Cancer • Metabolic Disorders • Oncology • Solid Tumor • ANXA5 • BCL2 • BNIP3 • BNIP3L • TET2

Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway in vivo and in vitro. (PubMed, Front Med) - "Autoimmune hepatitis (AIH) is a severe globally distributed liver disease that could occur at any age. An AML12 co-culture system and JNK inhibitor (SP600125) were used to verify the JNK/MAPK and apoptosis signaling pathways. These findings suggested that MenSCs could be a promising strategy for AIH."

Journal • Preclinical • Acute Lung Injury • Hepatology • Immunology • Inflammation • Liver Failure • Respiratory Diseases • Transplantation • CASP3 • MAPK8

Comprehensive immune cell analysis of human menstrual-blood-derived stem cells therapy to concanavalin A hepatitis. (PubMed, Front Immunol) - "Autoimmune hepatitis is an autoimmune disease with increasing occurrence worldwide. The analysis of proinflammatory factors carried out by cytometric bead array demonstrated that tumor necrosis factor alpha (TNF-α), interleukin (IL)-17A, IL-12p70, IL-6, IL-2, IL-1b, and interferon gamma (IFN-γ) were upregulated after ConA injection and then rapidly decreased at 12 h. MenSCs also played an important role in downregulating these cytokines. Here, we described the comprehensive changes in leukocytes in the liver tissue of ConA-induced hepatitis at 12 h after ConA injection and found that MenSCs rescued ConA-induced hepatitis mostly by inhibiting macrophages and M1 polarization in mouse liver."

Journal • Hepatology • Immunology • Inflammation • Oncology • CD69 • IFNG • IL1B • IL2 • IL6 • PD-L1 • TNFA

Human menstrual blood-derived stem cell transplantation suppresses liver injury in DDC-induced chronic cholestasis. (PubMed, Stem Cell Res Ther) - "MenSC transplantation could be an effective treatment method for cholestatic liver injury in mice. MenSCs may exhibit therapeutic effects by regulating β-catenin expression."

Journal • Bone Marrow Transplantation • Cholestasis • Fibrosis • Hepatology • Immunology • Liver Failure • Transplantation • COL1A1 • TGFB1