IN 1130 / SK Bio - LARVOL DELTA

Effect of transforming growth factor beta receptor I inhibitors on myotube formation in vitro. (PubMed, Sci Rep) - "The aim of this study was to investigate the effect of five transforming growth factor-beta receptor I (TGFßRI) inhibitors on myotube formation in vitro; galunisertib, SM16, AZ12799734, SB431542 and IN1130. Only galunisertib had no effect on the fusion index. These results show that galunisertib does not impair the formation of myotubes from C2C12 myoblasts and might be suitable as an anti-fibrotic therapy for muscle regeneration."

Journal • Preclinical • Fibrosis • Immunology

Antifibrotic activities of Scutellariae Radix extracts and flavonoids: Comparative proteomics reveals distinct and shared mechanisms. (PubMed, Phytomedicine) - "Baicalein, SRM and IN1130 repress TGF-β1-induced fibrogenesis in renal fibroblasts by regulating overlapping protein targets and biological pathways. Our findings offer a comprehensive view of shared, drug- and dose-specific pharmacological and toxicological mechanisms and provide a valuable resource for further research and development of more efficacious and safer antifibrotics."

Journal • Fibrosis • Immunology • ALDH3A1 • CCL2 • CCN1 • CTGF • MMP3 • PAI1 • PLOD2 • SERPINE1 • SQSTM1 • TGFB1

The correlation between blood pressure and kidney function decline in older people: a registry-based cohort study. (PubMed) - "The present study identified a decline in BP over time as a strong risk factor for kidney function decline in all age strata, adjusted for mCCI and baseline kidney function and BP."

Journal • Biosimilar