recombinant human Complement Receptor Type 1 (CDX-1135) / Celldex - LARVOL DELTA

The calcineurin inhibitor, Sarah/Nebula, exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease. (PubMed) - Dis Model Mech - "Furthermore, sra-overexpressing flies displayed significantly decreased mitochondrial DNA and ATP levels, as well as increased susceptibility to oxidative stress compared to that of control flies. Taken together, our results demonstrating that sra overexpression augments Aβ42 cytotoxicity in Drosophila suggest that DSCR1 up-regulation or calcineurin down-regulation in the brain may exacerbate Aβ42-associated neuropathogenesis in AD or DS."

Journal • Alzheimer's Disease • Biosimilar

Oxidation of elemental mercury by modified spent TiO2-based SCR-DeNOx catalysts in simulated coal-fired flue gas. (PubMed) - "The XPS results illustrated that the surface oxygen was responsible for Hg(0) oxidation and NO conversion. Besides, the Hg(0) oxidation and NO conversion were thought to be aided by synergistic effect between the manganese and cerium oxides."

Journal • Biosimilar

Catching up with Celldex Therapeutics (SeekingAlpha) - Celldex about to begin a trial in renal disease for CDX-1135

Anticipated new trial • Renal Disease

Inhibition of complement C3 might rescue vascular hyporeactivity in a conscious hemorrhagic shock rat model. (PubMed) - Microvasc Res - "Inhibition of C3 might improve the reactivity of SMA to norepinephrine during hemorrhagic shock possibly through the downregulation of NO, ET1, TNF-α and reactive oxygen radicals."

Journal • Biosimilar • Inflammation