atosiban / Generic mfg. - LARVOL DELTA

Nifedipine-associated maternal oxygen desaturation in an IVF twin pregnancy complicated by preterm premature rupture of membranes: a case report. (PubMed, AJOG Glob Rep) - "This case, strengthened by two positive rechallenges occurring without concurrent magnesium sulfate, provides compelling temporal evidence for nifedipine-associated respiratory compromise in an IVF twin pregnancy with PPROM. The pattern of desaturation without radiographic alveolar pulmonary edema, elevated BNP, and resolution without diuresis suggests subclinical hemodynamic perturbation as the underlying mechanism. Clinicians should maintain heightened vigilance for unexplained oxygen desaturation during nifedipine tocolysis in this patient population."

Journal • Critical care • Respiratory Diseases

Elucidation of the Biosynthesis of Pantocin A. (PubMed, ACS Chem Biol) - "Moreover, we show that this species is accepted as a substrate by PaaB, an Fe(II)- and 2-oxoglutarate-dependent enzyme that catalyzes a unique 1,4-dehydrogenation to furnish the mature post-translational modification. These studies complete the biosynthetic pathway of pantocin A and the steps involved in its maturation."

Journal

Atosiban-Associated Non-cardiogenic Pulmonary Edema in a Dichorionic Diamniotic Twin Pregnancy: A Case Report. (PubMed, Cureus) - "Rapid clinical improvement following discontinuation of atosiban strongly supported a drug-related etiology. This case highlights a rare but clinically relevant adverse effect of atosiban and emphasizes the importance of early recognition, particularly in high-risk patients."

Journal • Acute Respiratory Distress Syndrome • Cardiovascular • Obstetrics • Respiratory Diseases

Ultrasound promoted disulfide bond formation for efficient peptide macrocyclization at infinite dilution | Poster Board #1170 (ACS-Fall 2026) - "Cyclic peptides containing disulfide bonds constitute an important class of bioactive molecules, and several approved therapeutics—including desmopressin, terlipressin, atosiban, selepressin, and oxytocin—feature this motif. Mass spectrometry and analytical HPLC confirmed efficient disulfide bond formation with reduced byproducts. We further demonstrate the applicability of this sonication induced on resin cyclization approach to more complex disulfide containing peptides, including Pegcetacoplan and Compstatin This method offers a streamlined and robust alternative to traditional cyclization strategies for preparing cyclic disulfide peptides."

Role of the tail of the ventral tegmental area in the regulation of maternal behaviour: a pharmacological study in postpartum rats. (PubMed, Neuropharmacology) - "During the first week after delivery, female rats received intra-tVTA/RMTg microinjections of vehicle and/or several pharmacological agents (glutamate, DAMGO, muscimol, oxytocin or atosiban) in a cross-design...Otherwise, modulation of the oxytocinergic transmission at the tVTA/RMTg reveals mild effects on maternal behaviour and the observed effect depend on the oxytocin dose. Overall, our results reveal an involvement of the tVTA/RMTg in maternal reward processing, since its activation or inhibition can critically modulate maternal behaviour."

Journal • Preclinical

Delicate Balance of Intra- and Inter-Molecular Entropic Effects in S-S Peptide Cyclization. (PubMed, J Phys Chem A) - "Based on this mechanistic insight, we develop a two-parameter kinetic model predicting the optimal iodine stoichiometry for S-S bond closure in peptides of varying ring size and structure. The model shows excellent agreement with experimental data for three desamino analogues of neurohypophyseal hormones: atosiban, desmopressin, and desaminooxytocin."

Journal • Immunology • Oncology

Strategies for the Identification of Cyclic Peptide Drugs and Their Impurities. (PubMed, J Am Soc Mass Spectrom) - "Applying optimized EThcD conditions and established fragmentation rules, impurities in atosiban and carbetocin were characterized, leading to the identification of three impurities in atosiban and two in carbetocin. This approach demonstrates the effectiveness of EThcD for structural elucidation and impurity profiling of cyclic peptide therapeutics."

Journal

Structural elucidation of succinimide-derived hydrolytic isomers of atosiban using a conventional CID-based Asp/IsoAsp discrimination strategy. (PubMed, RSC Adv) - "As a result, complete structural elucidation of four hydrolytic impurities with identical mass and modification sites was achieved. This work provides a practical and mechanistically grounded analytical strategy for the structural characterization of succinimide-derived impurities in peptide drugs, with potential applicability to other peptide systems sharing similar structural features."

Journal

Neutrophil-to-lymphocyte ratio is associated with early cervical shortening after cerclage: a single-center cohort study integrating C-reactive protein. (PubMed, Front Med (Lausanne)) - "This study aimed to explore whether pre-operative systemic inflammatory markers-neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP)-are associated with early post-cerclage cervical shortening and to examine whether atosiban use varied according to inflammatory status in this retrospective cohort...No causal inference, therapeutic claim, or clinical recommendation is justified. Prospective validation in randomized trials is essential."

Journal • CRP

Inhibitory Effects of Oxytocin on Jejunal Migrating Myoelectric Complex Activity in Fasted Rats: Role of Oxytocin and GLP-1 Receptors. (PubMed, Life (Basel)) - "To assess mechanisms, rats were pretreated with the OTR antagonist atosiban (2 mg/kg), the GLP-1R antagonist exendin (9-39) (200 µg/kg), or the nitric oxide synthase inhibitor NG-nitro-L-arginine (L-NNA; 5 mg/kg) before OT (16 µg/kg). L-NNA showed no significant effect. These findings indicate that OT inhibits jejunal MMC activity via OTR-dependent mechanisms with partial involvement of GLP-1R signaling but not NO pathways."

Journal • Preclinical • CNS Disorders

Randomised, triple-blind, placebo-controlled trial of atosiban in women with previous embryo implantation failure and abnormal uterine contractions undergoing single blastocyst-stage embryo transfer: a study protocol. (PubMed, BMJ Open) - P=N/A | "The study results will be disseminated at scientific conferences and published in peer-reviewed journals. NCT07185230."

Journal • Infertility

Dual Pathways Coupled to Oxytocin Molecular Signals in Cultured Astrocytes. (PubMed, Cells) - "We found that oxytocin receptors are expressed in both the soma and processes of astrocytes; oxytocin at nanomolar concentrations could induce dual responses in astrocytes, namely facilitation and inhibition of Ca2+ signals and glutamate release; the oxytocin facilitatory and inhibitory effects were duplicated by the biased agonists carbetocin and atosiban, respectively; and the facilitatory and the inhibitory effect were dependent on activation of a Gq and a Gi pathway, respectively. It is concluded that oxytocin effects in astrocytes could duplicate the effects in processes prepared from astrocytes matured in neuron-astrocyte networks, substantiating the use of astrocytes to study astrocytic oxytocin molecular signaling."

Journal

Oxytocin Alleviates the Cognitive and Memory Dysfunction Caused by Neuroinflammation through Blocking the TLR4/NLRP3/NF-κB Signaling Pathway. (PubMed, Brain Res Bull) - "Adult male C57BL/6 mice were intraperitoneally injected with LPS, with or without oxytocin and the oxytocin receptor antagonist atosiban, and subjected to behavioral assessments, including the Morris water maze, three-chamber social interaction test, open field test, and elevated plus maze...Pharmacological inhibition of the nucleotide-binding oligomerization domain-like receptor thermal protein domain-associated protein 3 (NLRP3) inflammasome using MCC950 mimicked the protective effects of oxytocin, whereas its activation using nigericin abolished them. These findings suggest that oxytocin alleviates LPS-induced cognitive and synaptic impairments by suppressing NLRP3 inflammasome-mediated neuroinflammation, highlighting its therapeutic potential in inflammation-associated cognitive dysfunction."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Inflammation • Mood Disorders • Oncology • Psychiatry • IL1B • IL6 • NLRC5 • NLRP3 • SYP • TLR4 • TNFA

Different dosage protocols of atosiban in repeated implantation failure before embryo transfer: A double-blind randomized controlled trial. (PubMed, Taiwan J Obstet Gynecol) - "The atosiban infusion protocol demonstrated a positive trend in pregnancy outcomes among patients with RIF. Further large-scale studies are needed to confirm its effectiveness and establish optimal strategies."

Clinical • Journal • Infertility • Sexual Disorders

Comparative effectiveness of intravenous remifentanil, epidural anesthesia and a two-step analgesic approach for external cephalic version: a large prospective single-center cohort study. (PubMed, Am J Obstet Gynecol) - "In this study, a single attempt with epidural anesthesia was the most effective strategy for external cephalic version, achieving the highest success and vaginal delivery rates while providing superior maternal pain control, but with higher complications. These findings may help support more informed counseling and shared decision-making when discussing analgesic options for external cephalic version."

HEOR • Journal • Anesthesia • Hypotension • Obstetrics • Pain

Successful Conservative Management After Expulsion Following Fetal Demise in a Triplet Pregnancy: A Case Report. (PubMed, Cureus) - "Conservative management with progesterone support, antibiotics, anticoagulation, tocolysis with atosiban (OXTR/V1A oxytocin and vasopressin V1A receptor antagonist), and antihypertensive therapy allowed prolongation of the pregnancy. At 33 weeks and two days, she underwent urgent cesarean delivery of two viable preterm infants for non-reassuring fetal heart rates (FHRs). This case highlights that with individualized management and intensive monitoring, continuation of pregnancy after selective fetal loss in a triplet gestation is possible, improving neonatal outcomes."

Journal • Cardiovascular • Endocrine Disorders • Gynecology • Hematological Disorders • Hypertension • Infertility • Sexual Disorders

Oxytocin receptor antagonism in migraine: a randomized, double-blind, placebo-controlled provocation study. (PubMed, J Headache Pain) - "Short-acting oxytocin receptor antagonism did not trigger migraine attacks, suggesting that acute suppression of oxytocin signaling alone is unlikely to trigger migraine under stable hormonal conditions. Instead, oxytocin may act as a modulatory factor within neurovascular networks. Future studies using longer-lasting or brain-penetrant antagonists are needed to further clarify oxytocin's role in migraine susceptibility."

Clinical • Journal • CNS Disorders • Migraine • Pain

An individual participant data network meta-analysis of the APOSTEL trials on the effect of tocolysis in threatened preterm birth between 30-33+6 weeks of gestation in twin pregnancies. (PubMed, Eur J Obstet Gynecol Reprod Biol) - "No clear benefit of nifedipine or atosiban over placebo on neonatal outcomes in twin pregnancies with threatened preterm birth between 30+0 and 33+6 weeks was found."

Journal • Retrospective data

Molecular basis of antagonism of the dimeric human arginine vasopressin receptor 1A. (PubMed, Nat Commun) - "Here, we present structures of human V1aR in its apo state and in complexes with antagonists: atosiban, balovaptan, and SRX246. Antagonist-bound structures, combined with mutagenesis and radioligand binding assays, uncover distinct binding modes and key determinants for antagonism and selectivity. These findings provide a comprehensive understanding of V1aR assembly and dynamic regulation, offering valuable insights for structure-guided development of new antagonists targeting dimeric V1aR for CNS disorders."

Journal • CNS Disorders

Effects of oxytocin receptor antagonization in migraine: A randomized, double-blind, placebocontrolled human provocation study (EHF-EHC 2025) - "Short-lasting oxytocin inhibition through the OT-receptor antagonist atosiban did not significantly increase the incidence of migraine attacks in women with episodic migraine, although a numerical trend was observed."

Clinical • CNS Disorders • Migraine • Pain

Atosiban-conjugated 3WJ-pRNA nanoparticles delivering GAS1-enhanced extracellular vesicles: targeting the decidua to combat recurrent miscarriage. (PubMed, J Nanobiotechnology) - "This study unveils that the GAS1-RAB39B axis may play a significant role in EV-mediated decidual communication and provide a potential non-invasive, RNA nanotechnology-driven strategy for RM treatment."

Journal • Immunology • GAS1

Atosiban as a potential treatment for endometriosis-related pain: results from the ENDOBAN pilot study. (PubMed, Fertil Steril) - No abstract available

Journal • Endometriosis • Gynecology • Pain • Women's Health

Atosiban in Women With Previous Implantation Failure and Abnormal Uterine Contractions (clinicaltrials.gov) - P=N/A | N=792 | Recruiting | Sponsor: Northwest Women's and Children's Hospital, Xi'an, Shaanxi | Not yet recruiting ➔ Recruiting

Enrollment open • Infertility • Sexual Disorders

Abnormal Endometrial Peristalsis in Frozen-Thawed Embryo Transfer: Risk Factors and Improvements of Atosiban Treatment. (PubMed, Reprod Fertil) - "The benefit was even greater when embryos were transferred at an early stage (Day 3 embryos). This suggests that detecting and treating abnormal uterine movements could improve the chances of pregnancy for some women undergoing IVF, especially those receiving early-stage embryos."

Journal • Infertility

Effects of oxytocin receptor ligands on anxiogenic-like effect, social avoidance and changes on medial prefrontal cortex oxytocin receptor expression evoked by chronic social defeat stress in rats. (PubMed, Prog Neurobiol) - "We investigated the effect of systemic administration of the synthetic oxytocin (OXT) analog carbetocin and/or OXT receptor antagonists (atosiban and L-368,899) on social avoidance and anxiogenic-like effect in male rats subjected to chronic social defeat stress (cSDS). Taken together, our study provides evidence for the critical role of the OXT system and its pharmacological manipulation in modulating anxiogenic-like effects evoked by social stress. Furthermore, the region-specific modulation of OXT receptor expression within the mPFC by stress and OXT system pharmacological manipulation emphasize the complex and dynamic nature of OXT receptor regulation in brain regions crucial for emotional processing."

Journal • Preclinical • Mood Disorders • Psychiatry