ONG41008 / OsteoNeuroGen - LARVOL DELTA

Eupatilin-derived compounds enhance antitumor activity and doxorubicin efficacy in triple-negative breast cancer. (PubMed, Front Oncol) - "Drug interactions with doxorubicin and paclitaxel were assessed using dose-response curves and the Loewe model. ONG41008 and ONG41003 exerted anticancer effects and enhanced the response to doxorubicin through distinct interactions. Increased doxorubicin accumulation may be associated with attenuation of ABCB1 expression, supporting further investigation of these compounds as partners for anthracycline-based chemotherapy."

Journal • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • ABCB1 • ABCG2

A Small Molecule That Promotes Cellular Senescence Prevents Fibrogenesis and Tumorigenesis. (PubMed, Int J Mol Sci) - "ONG41008 exhibited a comparable senogenic potential to that of dasatinib. Taken together, this is the first study to demonstrate that a small molecule can arrest uncontrolled proliferation during fibrogenesis or tumorigenesis via both senogenic and senolytic potential. ONG41008 could be a potential drug for a broad range of fibrotic or tumorigenic diseases."

Journal • Fibrosis • Immunology • Lung Cancer • Oncology • Pancreatic Cancer • Solid Tumor • CASP3 • CASP7 • TP53