voriconazole / Generic mfg. - LARVOL DELTA

A decade of ocular fungal infections due to Penicillium-like fungi in France (2012 to 2021). (PubMed, Med Mycol) - "Most patients were treated with a combination of topical voriconazole and amphotericin B (n = 15, 62.5%), which was administered alongside oral voriconazole in nine cases (37.5%). Surgical intervention was required in six cases (25%) and included keratoplasty (n = 4) and enucleation (n = 2). This study provides a valuable overview of Penicillium-like fungal ocular infections and highlights the importance of systematically surveilling filamentous fungal keratitis."

Journal • Dermatology • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

Case Report: Rare Multidrug-Resistant Enterobacter Cloacae Complicated by Invasive Pulmonary Aspergillosis in an Elderly Patient with Advanced Lung Adenocarcinoma Treated with Osimertinib. (PubMed, Infect Drug Resist) - "We report a rare case of multidrug-resistant (MDR) Enterobacter cloacae pneumonia complicated by invasive pulmonary aspergillosis (IPA) in a 75-year-old male with lung adenocarcinoma who had been receiving osimertinib for 8 months. Prompt susceptibility-guided therapy with polymyxin B plus tigecycline (for MDR bacteria) and voriconazole (for aspergillosis) achieved complete resolution, highlighting the importance of rapid microbiological diagnosis and targeted antimicrobials in this vulnerable population."

Journal • Infectious Disease • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Pneumonia • Pulmonary Disease • Respiratory Diseases • Solid Tumor

Incidence of Voriconazole-induced periostitis in a tertiary medical center: a single-center retrospective analysis. (PubMed, BMC Infect Dis) - No abstract available

Journal • Retrospective data

Filamentous fungi, and their antifungal susceptibilities, isolated from patients at an oncology hospital in Turkey. (PubMed, Rev Iberoam Micol) - "The filamentous fungi recovered from the patients showed high antifungal MIC/MEC values, and some isolates had high amphotericin B MICs. Voriconazole was effective in vitro against A. fumigatus."

Journal • Review • Infectious Disease • Oncology

Safety and efficacy of echinocandin antifungal agents in Candida albicans endophthalmitis. (PubMed, Antimicrob Agents Chemother) - "To evaluate the safety and efficacy of echinocandins (rezafungin, RZF; anidulafungin, AFG) in Candida albicans (C...At 48 h post-infection, rabbits received intravitreal injections of liposomal amphotericin B (L-AmB, 10 μg), voriconazole (VCZ, 50 μg), RZF (35 μg), AFG (35 μg), or saline (control)...In vivo, RZF/AFG reduced clinical and histopathological scores, fungal burden, and TNF-α levels, performing similarly to traditional drugs. RZF and AFG demonstrate potent antifungal activity against C. albicans comparable to conventional drugs, along with significant anti-inflammatory effects and acceptable safety profiles."

Journal • Infectious Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • IL1B • TNFA

A deep dive into the diversity of the Aspergillus community in the lakes of northern Iran. (PubMed, Front Public Health) - "Elevated minimum inhibitory concentrations (MICs) against itraconazole and voriconazole were observed in 3.22 and 1% of isolates, respectively. Therefore, prioritizing microbial contamination control and improving hygienic awareness among visitors remain vital. However, seasonal sampling and section-level identification represent limitations that should be addressed in future studies."

Journal

Candida pelliculosa cluster endophthalmitis: clinical profile and surgical outcomes in twelve eyes. (PubMed, Int Ophthalmol) - "This first reported series of postoperative Candida pelliculosa cluster endophthalmitis underscores its subtle presentation and delayed onset. Early vitrectomy with IOL-bag explantation ensures infection control and favorable visual recovery."

Journal • Retrospective data • Cataract • Infectious Disease • Macular Edema • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Retinal Disorders

Voriconazole-induced fluorosis: not always associated with radiographic periostitis (ESCMID Global 2026) - No abstract available

EVALUATING the effects of weight-based initial dosing of oral voriconazole for treatment and prophylaxis of invasive fungal disease in adults (ESCMID Global 2026) - No abstract available

Clinical • Infectious Disease

In vitro evaluation of the combination of olorofim with voriconazole or fluconazole against clinical Scedosporium spp. (ESCMID Global 2026) - No abstract available

Preclinical

Assessing voriconazole Etest as a surrogate marker for isavuconazole and posaconazole susceptibility in Aspergillus species (ESCMID Global 2026) - No abstract available

Genomic plasticity driven copy number variations underlie azole cross-resistance in Trichosporon asahii during voriconazole treatment (ESCMID Global 2026) - No abstract available

Refractory Neoscytalidium dimidiatum subcutaneous infection with dual CARD9/GATA2 variants: Synergistic clearance by voriconazole and targeted hyperthermia. (PubMed, JAAD Int) - No abstract available

Journal • Infectious Disease • CARD9 • GATA2

A Case of Disseminated Trichophytosis With Vascular Invasion and Multiple Ulcers: Case Report and Literature Review. (PubMed, J Dermatol) - "Invasive aspergillosis was initially suspected, and the patient was treated with voriconazole; however, the treatment proved ineffective. Ultimately, the patient succumbed to gastrointestinal hemorrhage due to malignant lymphoma. Here, we present a case report and literature review of disseminated trichophytosis."

Journal • Dermatology • Hematological Disorders • Hematological Malignancies • Immunology • Inflammatory Arthritis • Lupus • Lymphoma • Oncology • Pulmonary Disease • Respiratory Diseases • Systemic Lupus Erythematosus

Dual CARD9/GATA2 Mutations Promote Refractory Neoscytalidium dimidiatum Subcutaneous Infection: Synergistic Clearance by Voriconazole and Targeted Hyperthermia (AAD 2026) - "Initial oral itraconazole treatment (200-400 mg/d) showed transient improvement over 3 months but resulted in relapse with drug resistance after discontinuation...Successful management involved voriconazole (400 mg/d) combined with luliconazole cream and localized hyperthermia (42°C/d) based on antifungal susceptibility testing (MIC 0.06 μg/ml) and thermotolerance data showing no growth at 42°C, achieving significant lesion regression within 8 weeks without recurrence during follow-up. Notably, dermoscopic examination identified a "black-red dot sign" on erythematous bases with yellowish scales that resolved alongside clinical improvement, suggesting potential as a fungal subcutaneous infection biomarker. This case highlights CARD9/GATA2 mutations as possible contributors to chronic fungal infections and drug resistance mechanisms in immunocompetent individuals while demonstrating the therapeutic value of combined antifungal and thermotherapy..."

Cardiovascular • Hypertension • Infectious Disease • Inflammation • CARD9 • GATA2

A Comparison of the Protective effects of Systemic vs Oral Retinoids on Non Melanoma Skin Cancers in Acne Patients: A Retrospective Cohort Study (AAD 2026) - "Two matched cohorts were created: systemic retinoids (alitretinoin, isotretinoin, etretinate, acitretin; n=34,851) and topical retinoids (adapalene, tazarotene, bexarotene, tretinoin; n=34,851). Patients with known NMSC risk factors (chemical exposures, HPV, or use of BRAF inhibitors, cyclosporine, voriconazole, hydrochlorothiazide) were excluded... The enhanced protective effect of systemic retinoids may reflect their deeper influence on keratinocyte turnover and skin cell regeneration compared to topical formulations. Further studies are warranted to clarify the relative efficacy of individual agents and optimize retinoid prophylaxis in high-risk patients."

Retrospective data • Acne Vulgaris • Basal Cell Carcinoma • Genetic Disorders • Kaposi Sarcoma • Non-melanoma Skin Cancer • Sarcoma • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma

Successful Long-Term Use of Isavuconazole in a Tacrolimus-Treated Japanese Kidney Transplant Recipient With Disseminated Cryptococcosis and Probable Invasive Aspergillosis. (PubMed, Cureus) - "He was receiving immunosuppressive therapy with TAC, mycophenolate mofetil, and methylprednisolone...He received induction therapy with liposomal amphotericin B and flucytosine for approximately 10 weeks, but persistent intracranial hypertension required placement of a ventriculoperitoneal shunt...To our knowledge, reports describing more than 12 months of ISCZ therapy for cryptococcal infection are limited. This case highlights its potential as a maintenance option in transplant recipients, particularly when fluconazole or voriconazole are not suitable due to drug-drug interactions with TAC."

Journal • Cardiovascular • CNS Disorders • Focal Segmental Glomerulosclerosis • Glomerulonephritis • Hypertension • Infectious Disease • Otorhinolaryngology • Pneumonia • Pulmonary Disease • Respiratory Diseases • Transplantation

Genomic Characterization of Candida spp. Highlights a Persistent, Azole-Resistant C. parapsilosis Clone Circulating in a Tertiary Care Hospital During the First COVID-19 Wave. (PubMed, Mycopathologia) - "All isolates of the main persistent group were resistant to fluconazoleresulting from the Y132F substitution in ERG11 and the N455D substitution in UPC2, while presenting variable levels of resistance to voriconazole and itraconazole. Interestingly, with the exception of the single isolate susceptible to both voriconazole and itraconazole, all the 61 isolates presented one unreported missense mutation in MRR1 (S1907C)."

Journal • Candidiasis • Gastrointestinal Disorder • Infectious Disease • Novel Coronavirus Disease

Therapeutic Penetrating Keratoplasty for Aspergillus Fungal Keratitis: A Case Report. (PubMed, Cureus) - "Prior to referral, he had been hospitalized at a tertiary center and treated with topical moxifloxacin and fluconazole without clinical improvement...Cultures demonstrated Aspergillus lentulus sensitive to voriconazole...TPK with meticulous anterior chamber lavage provided a definitive cure for fungal keratitis refractory to topical and systemic therapy. Postoperative administration of cyclosporine A instead of corticosteroids appears to be a safe and effective alternative for graft preservation after TPK for fungal keratitis."

Journal • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

Use of Topical Amphotericin for Adjunctive Management of Fungal Infections in Acute Burn Injuries (SCCM 2026) - "Systemic agents used to treat fungal infections, such as voriconazole and amphotericin B (AmB), are associated with treatment-limiting adverse effects including infusion-reactions, nephrotoxicity, hepatotoxicity, and electrolyte abnormalities...All three patients experienced successful treatment with combination therapy without adverse effects. Topical AmB, both liposomal and conventional formulations, was used successfully as adjunctive treatment in the management of burn-related invasive fungal infections. Given the challenges encountered in treating these infections, adjunctive topical therapy may optimize drug delivery and treatment."

Infectious Disease

Incidence of Therapeutic Azole Dosing in ECMO Patients (SCCM 2026) - "Azole antifungals during ECMO are therapeutic only 41.6% of the time, with voriconazole having a higher proportion of subtherapeutic concentrations (39% vs 50%). Voriconazole had a large variation in dosing required to be therapeutic and subsequent studies should investigate which patients may be more likely to need higher doses."

Clinical • Infectious Disease • Respiratory Diseases

Effects of Voriconazole on the Safety, Pharmacokinetics and Pharmacodynamics of Ciprofol (HSK3486), a Novel Intravenous Anaesthetic, in Healthy Participants: A Prospective, Randomized, Crossover Clinical Trial. (PubMed, Drug Des Devel Ther) - P1 | "The dose of ciprofol is suggested not be adjusted in patients receiving the CYP inhibitor voriconazole based on the PK, PD and safety characteristics. Clinicaltrials.gov, NCT04145583, registered on 25 October 2019."

Clinical • Journal • PK/PD data • Anesthesia • CYP2C9 • CYP3A4

Acute Eruption in a Child With Acute Lymphoblastic Leukemia. (PubMed, Pediatr Dermatol) - No abstract available

Journal • Acute Lymphocytic Leukemia • Dermatitis • Dermatology • Hematological Malignancies • Immunology • Leukemia • Oncology

Evidence that increased azole persistence and stress resistance precede the in vivo evolution of azole resistance in Aspergillus fumigatus. (PubMed, Microbiol Spectr) - "Here, we characterized voriconazole persistence by screening a global collection of 495 clinical and environmental A. fumigatus isolates...We propose that persistence is not a passive survival state, but an active evolutionary stepping stone that fosters a permissive landscape for the development of resistance. Understanding this "persistence-first" pathway is crucial for developing more effective diagnostics and therapeutic strategies to combat antifungal treatment failure."

Journal • Preclinical • Pulmonary Disease • Respiratory Diseases

ASPERGILLUS PERICARDITIS WITH TAMPONADE IN AN IMMUNOCOMPETENT PATIENT: CARDIAC INVASION AFTER LOBECTOMY (ACC 2026) - "Empiric voriconazole was started... Aspergillus pericarditis with tamponade can occur after lobectomy in immunocompetent patients via cardiac invasion. Combined surgery and prolonged antifungal therapy are curative and prevent recurrence."

Clinical • Cardiovascular • Diabetes • Fibrosis • Hematological Malignancies • Human Immunodeficiency Virus • Infectious Disease • Metabolic Disorders • Neutropenia • Pulmonary Disease • Respiratory Diseases • Tuberculosis