PAC-MAN / Stanford University, DNARx - LARVOL DELTA

Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay. (PubMed, Sci Transl Med) - "The PAC-MANN assay combined with the clinical biomarker CA 19-9 was 85% sensitive for detection of stage I PDAC with 96% specificity. Therefore, the PAC-MANN assay is a rapid, high-throughput method that uses small blood volumes with the potential to enhance early PDAC detection, specifically among individuals at high risk of developing PDAC."

Biomarker • Journal • Gastrointestinal Disorder • Hepatology • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Pancreatitis • Solid Tumor

A comprehensive analysis and resource to use CRISPR-Cas13 for broad-spectrum targeting of RNA viruses. (PubMed, Cell Rep Med) - "We also build an online resource (crispr-pacman.stanford.edu) to support community use of CRISPR-Cas13 for broad-spectrum RNA virus targeting. Our work provides a new bioinformatic resource for using CRISPR-Cas13 to target diverse RNA viruses in order to facilitate development of CRISPR-based antivirals."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases