adapalene / Generic mfg. - LARVOL DELTA

Clinical Improvement of Pediatric Epidermodysplasia Verruciformis Following Topical Adapalene and Adjunctive Homeopathic Therapy (EADV 2026) - No abstract available

Clinical • Pediatrics

Radiofrequency Treatment Versus Topical Therapy for Facial Acne Vulgaris (clinicaltrials.gov) - P=N/A | N=60 | Recruiting | Sponsor: Jeisys Medical Inc

New trial • Acne Vulgaris • Dermatology

Synthesis of Pyridin-2(1H)-ones and Isoquinolin-1(2H)-ones Using Calcium Carbide as an Acetylene Source under Redox-Neutral Conditions. (PubMed, Org Lett) - "On the basis of this method, a number of pyridin-2(1H)-one and isoquinolin-1(2H)-one derivatives, including some hybrid products containing the essential skeleton of probenecid, ataluren, or adapalene, were obtained. In general, this protocol features simple and economical substrates, a safe and convenient acetylene source, the absence of an external oxidant, good compatibility with labile functional groups, excellent step and atom economy, and ready scalability. Moreover, some products possess strong anticancer activities."

Journal • Hepatitis C • Infectious Disease • Oncology

Effectiveness, safety and tolerability of Ozenoxacin 2% lotion vs Clindamycin 1% lotion in mild to moderate truncal acne: An open label randomized controlled clinical trial. (PubMed, Clin Exp Dermatol) - "Ozenoxacin demonstrated comparable efficacy and tolerability to clindamycin when used in combination with adapalene, in truncal acne."

Clinical • Journal • Acne Vulgaris • Dermatology

Old molecule, new scrutiny: Benzoyl peroxide in dermatology. (PubMed, Clin Exp Dermatol) - "BPO has a favourable safety profile with predominantly mild, localised AEs. Further randomised controlled trials using validated outcome measures are required to establish efficacy in other dermatological conditions."

Journal • Acne Vulgaris • Dermatitis • Dermatology • Immunology • Oncology • Rosacea

Patient Expectations, Safety Concerns, and Adherence to Topical Acne Medications: Findings from a Web-Based Survey. (PubMed, Patient Prefer Adherence) - "Topical medications were commonly used, most frequently adapalene (40.92%), tretinoin (32.93%), benzoyl peroxide (24.75%), and clindamycin (20.96%). Young patients demonstrated limited comprehension of AV and lacked knowledge of topical medications and their appropriate application, as well as unrealistic expectations regarding onset time. Enhanced education on the nature of AV, along with detailed instructions on topical medication use, is crucial for improving patients' disease awareness and treatment adherence."

Journal • Acne Vulgaris • Cognitive Disorders • Dermatology

Adapalene inhibits the activity of CD44, a cancer stem cell biomarker in Triple negative breast cancer. (PubMed, Mol Biol Rep) - "Overall, this study highlights how CD44 overexpression accelerates the growth of breast cancer and transforms drug-resistant cells into stem cells, and that targeting CD44 with Adapalene may significantly enhance therapy results and defer the onset of drug resistance in breast cancer patients."

Biomarker • Journal • Acne Vulgaris • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • CD44

Partition-controlled drug release from polymeric nanocapsules: A physically consistent framework with formulation-specific corrections. (PubMed, Eur J Pharm Biopharm) - "The model is further evaluated using four release datasets (adapalene in two oily cores, capsaicin, and dihydrocapsaicin), yielding R2 values between 0.925 and 0.969 with Cmax fixed at the final experimental value. These results support partition-controlled release as a physically plausible and dimensionally consistent framework for describing drug release from polymeric nanocapsules."

Journal

Clinician Awareness of Dermatology Drug Costs (BAD 2026) - "Between April and June 2025, an audit identified the most frequently prescribed dermatological medications in one UK region: lymecycline, mometasone furoate 0.1% w/w cream, adapalene 1 mg (0.1% w/w) and benzoyl peroxide (2.5% w/w) gel, prednisolone, isotretinoin, acitretin, methotrexate and trimethoprim. Enhancing prescriber cost literacy and embedding cost information into electronic prescribing may support valuebased decision making and NHS financial sustainability. Integrating cost-awareness training into dermatology curricula represents a feasible strategy to address this need."

Clinical • Drug cost • HEOR • Dermatology

A case of Trichodysplasia Spinulosa: a rare cutaneous eruption in immunosuppressed patients (BAD 2026) - "The lesions began 1 year after transplantation and were asymptomatic, but worsened following a change in immunosuppression from mycophenolate mofetil (discontinued after 11 months due to leucopenia and gastrointestinal intolerance) to azathioprine, which had been continued for the last year...Treatment with oral valganciclovir 450 mg twice daily, keratolytic emollients and adapalene was initiated...No standardized Abstracts i187 treatment exists; reported therapies include topical cidofovir 3%, oral valganciclovir and reduced immunosuppression. Awareness of TS is essential for early diagnosis and management in immunosuppressed patients."

Clinical • Alopecia • Dermatitis • Immunology • Leukopenia • Nephrology • Rare Diseases • Solid Organ Transplantation • TCHH

Comparison of Topical Clascoterone and Adapalene for Mild Acne Vulgaris (clinicaltrials.gov) - P1 | N=60 | Not yet recruiting | Sponsor: Khyber Teaching Hospital

New P1 trial • Acne Vulgaris • Dermatology

Trichodysplasia Spinulosa in a Japanese Pediatric Patient. (PubMed, J Dermatol) - No abstract available

Journal • Pediatrics • Transplantation

Efficacy and Safety of Clascoterone Cream 1% and Adapalene Gel 0.3% in Patients With Acne. (PubMed, J Drugs Dermatol) - P4 | "This open-label pilot study shows promising results for combination treatment with clascoterone cream 1% and adapalene gel 0.3% for the treatment of patients with acne. &nbsp."

Journal • Acne Vulgaris • Dermatology

Allergic Contact Dermatitis to Adapalene: A Rare Adverse Effect. (PubMed, Contact Dermatitis) - No abstract available

Adverse events • Journal • Acne Vulgaris • Contact Dermatitis • Dermatitis • Dermatology • Immunology

Pediatric Genital Endemic Kaposi Sarcoma with Partial Response to Adapalene. (PubMed, Am J Trop Med Hyg) - "Treatment with topical adapalene resulted in rapid resolution of smaller cutaneous lesions. This case highlights diagnostic challenges in resource-limited settings and supports the potential role of topical retinoids as a low-cost palliative therapy for cutaneous KS."

Journal • Epstein-Barr Virus Infections • Hepatology • Kaposi Sarcoma • Oncology • Palliative care • Pediatrics • Sarcoma • Solid Tumor

Efficacy and Tolerability of a Triple Acid-Containing Serum Combined With 0.1% Adapalene in Mild-to-Moderate Acne Vulgaris: A Randomized, Open-Label Controlled Trial. (PubMed, J Cosmet Dermatol) - "TAS in combination with AG was shown to improve mild-to-moderate acne with good tolerability and may effectively reduce the recurrence rate when applied as a maintenance treatment post-AG."

Clinical • Journal • Acne Vulgaris • Dermatology

Vitamin D Supplementation in Acne (clinicaltrials.gov) - P=N/A | N=58 | Completed | Sponsor: HITEC-Institute of Medical Sciences | Recruiting ➔ Completed | Trial completion date: Oct 2024 ➔ Aug 2025

Trial completion • Trial completion date • Acne Vulgaris • Dermatology

Post-inflammatory hyperpigmentation in third- vs. fourth-generation retinoids: A faers pharmacovigilance study (SID 2026) - "This mixed-methods study integrates published clinical evidence with post-market surveillance data to assess the relative safety and efficacy of third-generation (adapalene, tazarotene) and fourth-generation (trifarotene) retinoids for PIH in skin of color. These findings demonstrate that FAERS reporting patterns diverge substantially from randomized trial efficacy evidence, suggesting market-age bias obscures comparative safety assessment. This mixed-methods approach identifies an evidence gap and underscores the necessity for prospective, adequately powered randomized controlled trials evaluating fourth-generation retinoids for the management of PIH in darker phototypes, to guide evidence-based dermatologic practice in skin of color populations."

Adverse events

Case Report: Successful treatment of SAPHO syndrome refractory to adalimumab with upadacitinib. (PubMed, Front Immunol) - "Initial treatment of acne with adapalene gel combined with oral minocycline failed to improve skin symptoms, leading to the decision to ultimately pursue biologic therapy. This report of upadacitinib in SAPHO syndrome demonstrates its rapid and substantial efficacy in a patient refractory to adalimumab. Upadacitinib may represent a promising treatment option for difficult-to-treat SAPHO syndrome, particularly in cases with inadequate response to TNF-α inhibition."

Journal • Acne Vulgaris • Dermatitis • Dermatology • Immunology • Oncology • Pain • Pruritus

Topical Retinoids in Acne Vulgaris and Acne Scars-From Monotherapy to Combining Regimens. (PubMed, Pharmaceuticals (Basel)) - "A review of published clinical and experimental studies evaluating tretinoin, adapalene, tazarotene, and trifarotene was performed, including their use as monotherapy and in combination with other topical agents or procedural interventions. In conclusion, topical retinoids represent a relevant therapeutic option in acne vulgaris and acne scarring, from monotherapy in mild cases to components of multimodal treatment protocols in more severe disease. Further large-scale, comparative studies are needed to better define the optimal clinical use of advanced drug delivery systems for topical retinoids."

Journal • Monotherapy • Review • Acne Vulgaris • Dermatology • Inflammation

Risks of epistaxis and chronic rhinosinusitis in oral isotretinoin vs topical retinoid users (COSM 2026) - "Two groups were identified: new users of oral isotretinoin and new users of topical retinoids (tretinoin, adapalene, tazarotene) without oral exposure. This highlights the importance of preventive nasal care during treatment. Improved patient counseling and early ENT evaluation may reduce morbidity associated with these sinonasal adverse effects."

Hematological Disorders • Otorhinolaryngology • Respiratory Diseases • Sinusitis

Comparison of Efficacy of Topical Adaplene Gel Versus Crythotherapy in Recurrent Plantar Warts (clinicaltrials.gov) - P4 | N=98 | Recruiting | Sponsor: Khyber Teaching Hospital | Trial completion date: Dec 2025 ➔ Sep 2026 | Initiation date: Jun 2025 ➔ Sep 2025

Trial completion date • Trial initiation date • Dermatology

B(C6F5)3-Catalyzed Exhaustive Reduction of Carboxylic Acids to Alkanes with Pinacolborane. (PubMed, J Org Chem) - "Furthermore, its synthetic utility is highlighted by the successful gram-scale, late-stage functionalization of the dermatological drug adapalene. Mechanistic studies support a proposed pathway involving sequential hydroboration and deboration steps."

Journal

Screening chemical libraries for the development of oral treatments for bleeding disorders. (PubMed, Blood Vessel Thromb Hemost) - "We screened 3 chemical collections totaling > 2300 chemical compounds; we identified adapalene, a commercialized antiacneic compound (Differin), which is strongly hydrophobic...The mechanism of action was thoroughly investigated by a series of thrombin generation and enzymatic assays. These studies conclude that the procoagulant activity of the chemical compounds in FVIII-deficient plasma is due to the activation of FXII."

Journal • Hematological Disorders • Hemophilia • Hemophilia A • Rare Diseases

Adapalene in Acne Treatment: Innovations in Nanocarriers and Role of AI in Drug Delivery- A Comprehensive Review. (PubMed, Curr Drug Deliv) - "Adapalene-loaded nanocarriers represent a promising approach for improving therapeutic outcomes in acne treatment. Integration of AI-based optimization with clinical validation highlights its translational potential, paving the way toward safer, more efficient, and patient-specific dermatological therapies."

Journal • Acne Vulgaris • Dermatology