adapalene / Generic mfg. - LARVOL DELTA

Differential Impact of Retinoid Agents on Risk of Melanoma and Non-Melanoma Skin Cancers: A Real-World Cohort Analysis (AAD 2026) - "Analyses were performed for overall retinoid exposure and for isotretinoin, tretinoin, vitamin A, and adapalene. Retinoid exposure is associated with lower melanoma and NMSC risk overall, but effects vary by agent. These findings underscore the need for agent-specific evaluation when considering retinoids in skin cancer prevention strategies."

Clinical • Real-world • Real-world evidence • Addiction (Opioid and Alcohol) • Basal Cell Carcinoma • Genetic Disorders • Human Immunodeficiency Virus • Infectious Disease • Non-melanoma Skin Cancer • Obesity • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma

Comparison of Systemic and Topical Retinoids and the Association of Inflammatory Bowel Disease in Ichthyosis Patients: A Population-Based Cohort Study (AAD 2026) - "Patients with acquired ichthyosis, congenital ichthyosis , or ichthyosis vulgaris treated with systemic retinoids such as alitretinoin, isotretinoin, etretinate, and acitretin (n=449) were identified using validated ICD-10 codes. A comparator cohort treated with topical retinoids such as adapalene, tazarotene, bexarotene, alitretinoin, and tretinoin (n=449) was established... These findings indicate that the protective association is specific to systemic retinoid therapy and highlights the importance of treatment selection in patients with ichthyosis who have comorbid or potential IBD. Future studies should further explore the role of systemic retinoids as potential disease-modifying agents for IBD and other inflammatory conditions in ichthyosis patients."

Clinical • Atopic Dermatitis • Crohn's disease • Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • Vitiligo

A Comparison of the Protective effects of Systemic vs Oral Retinoids on Non Melanoma Skin Cancers in Acne Patients: A Retrospective Cohort Study (AAD 2026) - "Two matched cohorts were created: systemic retinoids (alitretinoin, isotretinoin, etretinate, acitretin; n=34,851) and topical retinoids (adapalene, tazarotene, bexarotene, tretinoin; n=34,851). Patients with known NMSC risk factors (chemical exposures, HPV, or use of BRAF inhibitors, cyclosporine, voriconazole, hydrochlorothiazide) were excluded... The enhanced protective effect of systemic retinoids may reflect their deeper influence on keratinocyte turnover and skin cell regeneration compared to topical formulations. Further studies are warranted to clarify the relative efficacy of individual agents and optimize retinoid prophylaxis in high-risk patients."

Retrospective data • Acne Vulgaris • Basal Cell Carcinoma • Genetic Disorders • Kaposi Sarcoma • Non-melanoma Skin Cancer • Sarcoma • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma

Comparative Outcomes of Immunomodulatory Versus Conventional Therapies in Congenital Ichthyosis: A TriNetX Cohort Study (AAD 2026) - "Patients were divided into two cohorts: an immunomodulatory group (n=1,364) including dupilumab, azathioprine, ustekinumab, ixekizumab, infliximab, adalimumab, secukinumab, cyclosporine, and JAK inhibitors and a conventional therapy group (n=1,364) including keratolytics, isotretinoin, acretin, adapalene, etretinate, adapalene, and tretinoin. Immunomodulatory therapies, particularly biologics, were associated with a reduced burden of inflammatory comorbidities, suggesting potential improvements in disease control and quality of life. Larger studies are warranted to delineate the long-term effectiveness of specific biologics in this population."

Immunomodulating • Acne Vulgaris • Atopic Dermatitis • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Vitiligo

Efficacy and safety of combination treatment with clascoterone cream 1% and adapalene gel 0.3% for 16 weeks in patients with acne (AAD 2026) - "Sixteen-week topical combination treatment with clascoterone cream 1% and adapalene gel 0.3% decreased acne severity, improved QoL, and was well tolerated in patients with moderate-to-severe acne."

Clinical • Acne Vulgaris

Dowling-Degos Disease Presenting as an Isolated Perianal Reticulated Patch (AAD 2026) - "Therapies to be considered for this case include adapalene or hydrocortisone. This case illustrates an unusual presentation of DDD localized to the perianal region. The lesion's location and reticulated morphology closely resembled other potentially serious pigmentary disorders, and this overlap underscores the importance of clinicopathologic correlation to establish the correct diagnosis."

Genito-urinary Cancer • Non-melanoma Skin Cancer • Prostate Cancer • Pruritus • Rare Diseases • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Skin Cancer

Adapalene, an RAR agonist, exerts anti-inflammatory effects by regulating macrophage polarization through RAR[Formula: see text]-mediated signaling pathways. (PubMed, Sci Rep) - "Furthermore, chronic oral administration of adapalene in high-fat diet (HFD)-induced obese mice reduced pro-inflammatory markers while increasing anti-inflammatory markers in the liver. These findings suggest that adapalene exerts potent anti-inflammatory effects in macrophages through RARβ activation, thus highlighting its potential as a therapeutic agent for treating inflammatory and metabolic disorders."

Journal • Inflammation • Metabolic Disorders • Obesity • Septic Shock

Topical 5% Spironolactone Gel Versus 0.1% Adapalene Gel for Acne Vulgaris: A Randomized Split-Face Study (clinicaltrials.gov) - P2 | N=40 | Not yet recruiting | Sponsor: Assiut University

New P2 trial • Acne Vulgaris • Dermatology

Clinical Comparison of an OTC 1% Salicylic Acid & Witch Hazel Treatment and Prescription Adapalene 0.3% for Acne Management (AAD 2026) - "More importantly, the OTC product met a non-inferiority margin (10%) and demonstrated fewer and milder adverse events than adapalene, which saw several discontinuations due to moderate to severe irritation. These results suggest that the salicylic acid and witch hazel OTC formulation can be an effective and well-tolerated alternative to prescription adapalene 0.3% for mild to moderate acne management."

Clinical • Acne Vulgaris

Evaluation of Topical Dutasteride as a Potential New Therapy for Facial Acne Vulgaris Versus the Triple Combination Therapy (Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel) (clinicaltrials.gov) - P=N/A | N=50 | Not yet recruiting | Sponsor: Assiut University

New trial • Acne Vulgaris • Dermatology

Vitamins and the Skin: Vitamin A and Retinoids in Dermatology. (PubMed, Clin Dermatol) - "Retinoids used as therapeutic agents include oral retinoids, e.g. isotretinoin, acitretin, alitretinoin, and bexarotene, and topical retinoids, e.g. isotretinoin, tretinoin, adapalene, tazarotene, and trifarotene. In addition, other retinoids, with distinct routes of administration (oral or topical), and distinct dosing or safety profiles, are recommended for different skin disorders. We discuss the mode of action and indications of retinoids used as pharmacologic agents in dermatology and provide an update on their use, effectiveness and tolerability."

Journal • Acne Vulgaris • Atopic Dermatitis • Cutaneous T-cell Lymphoma • Dermatology • Dermatopathology • Hematological Malignancies • Immunology • Lymphoma • Oncology • Psoriasis • Skin Cancer • Squamous Cell Carcinoma • T Cell Non-Hodgkin Lymphoma • Vitiligo

Persistent methaemoglobinaemia due to unsupervised use of topical dapsone-adapalene. (PubMed, BMJ Case Rep) - "Discontinuation of the cream resulted in complete and sustained clinical resolution. This case highlights persistent methaemoglobinaemia due to ongoing topical oxidant exposure and underscores the importance of considering inadequate decontamination in refractory cases."

Journal • Alzheimer's Disease • Cognitive Disorders • Dermatology

Multifunctional Biomaterial Strategies to Regulate Inflammation and Promote Kidney Repair. (PubMed, Biomater Res) - "We developed a biofunctional hybrid scaffold (PMEAR/MM/uEV) combining a porous poly(lactic-co-glycolic acid)-porcine extracellular matrix, ricinoleic acid-modified magnesium hydroxide, metanephric mesenchyme-like cells, and ureteric bud-derived extracellular vesicles, with resveratrol and adapalene to confer antioxidant and pro-regenerative properties...mRNA sequencing revealed activation of angiogenesis, extracellular matrix remodeling, oxidative defense, and immune modulation, with Kyoto Encyclopedia of Genes and Genomes enrichment in tumor necrosis factor and interleukin-17 signaling and nuclear factor kappa B-associated pathways. These findings establish PMEAR/MM/uEV as an effective, multimodal platform for kidney regeneration."

Journal • Chronic Kidney Disease • Fibrosis • Immune Modulation • Immunology • Inflammation • Nephrology • Oncology • Renal Disease • IL17A • IL4 • IL6 • PAX2 • TNFA

Divergent System Organ Class Safety Profiles of Isotretinoin Versus Topical Retinoids: An EudraVigilance Disproportionality Analysis. (PubMed, Pharmaceuticals (Basel)) - " Aggregated ADR data for isotretinoin and four topical retinoids (tretinoin, adapalene, tazarotene, trifarotene) were retrieved from the EMA ADRreports portal (April 2025). Isotretinoin presents a distinct safety profile characterized by consistently elevated reporting of psychiatric, gastrointestinal, and musculoskeletal adverse events, independent of age and sex. These results refine the comparative safety landscape of systemic versus topical retinoids and support focused pharmacovigilance monitoring."

Journal • Acne Vulgaris • Cardiovascular • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Mental Retardation • Musculoskeletal Diseases • Oncology • Otorhinolaryngology • Psychiatry • Rheumatology

Auricular Acupressure Combined With Adapalene for the Treatment of Acne Vulgaris (clinicaltrials.gov) - P=N/A | N=64 | Completed | Sponsor: University of Medicine and Pharmacy at Ho Chi Minh City

New trial • Acne Vulgaris • Dermatology

Integrated in vitro - in vivo evaluation of Angelica sinensis essential oil as an anti-acne agent: Mechanistic insights into bioactive compounds and multi-target therapeutic actions. (PubMed, J Ethnopharmacol) - "These findings demonstrate that 5%-10% AEO is a promising topical treatment for acne, offering efficacy with improved safety."

Journal • Preclinical • Acne Vulgaris • Dermatology • Inflammation • IL10 • IL1B • NR3C1 • TLR4

Skin-Derived Precursors-Derived Exosomes Alleviated Acne Inflammation via TLR2/MyD88/NF-κB Signaling Pathway: In Vitro and In Vivo Studies. (PubMed, FASEB J) - "The effect was comparable with topical adapalene gel application. The current study initiated mSKPs-exo research and provided theoretical support and experimental data for their potential application in inflammation regulation, acne treatment, and novel therapeutic targets identification."

Journal • Preclinical • Acne Vulgaris • Dermatitis • Dermatology • Inflammation • CD86 • IL6 • MMP3 • MYD88 • TLR2 • TNFA

Discovery of Essential Genes as Possible Targets for Prostate Cancer Drug Development. (PubMed, Int J Genomics) - "Following that, we considered these possible genes as targets for drugs, performed docking analysis with 255 meta-drug agents, and identified the top 10 candidate drugs (adapalene, ergotamine, imatinib, dutasteride, vistusertib, risperidone, zafirlukast, irinotecan hydrochloride, drospirenone, and telmisartan). This study uniquely combines multidataset transcriptomic integration, HubG prioritization, and MD validation to propose novel biomarker-drug pairings for PCa. The findings offer promising leads for future experimental and clinical validation."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • BIRC5 • CDCA5 • NUSAP1

Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% to Treat Acne Induced by Janus Kinase Inhibitor Treatment: A Case Report. (PubMed, J Clin Aesthet Dermatol) - "A 15-year-old female patient was administered the oral JAKi upadacitinib (15mg daily) for 16 weeks to treat atopic dermatitis that inadequately responded to dupilumab. Treatment guidelines for AV often recommend oral drugs, such as isotretinoin, for moderate-to-severe acne. This case presented here, however, demonstrates that topical CAB gel can treat moderate to severe JAKi-induced inflammatory acne."

Journal • Acne Vulgaris • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

The CML and the ALL inducing isoforms of BCR::ABL1 differ for the induction of genomic instablity (ASH 2025) - "These two isoforms differin the presence of the oncogenic pleckstrin- and DBL-homology domains (DH and PH) in p210BCR::ABL1...It is not yet clear whether GI may be independent of ABL1 kinase activity, a target ofTKI. It has to be confirmed by clinical studies."

Acute Lymphocytic Leukemia • Chronic Myeloid Leukemia • Hematological Malignancies • Leukemia • ABL1 • ETV6 • PBX1 • PLEK

BC01 Isotretinoin plus 420-nm intense pulsed light vs. isotretinoin alone for the treatment of acne vulgaris: a randomized, controlled study of efficacy, safety and patient satisfaction. (PubMed, Br J Dermatol) - "Topical agents for both groups included adapalene 0.1% gel and fusidic acid 2% cream. Other major advantages included lightening basic skin tone and relieving erythema. It achieved clinical improvement within a limited treatment duration, and may have a particularly beneficial effect in patients who expect a rapid remission."

Clinical • Journal • Acne Vulgaris • Dermatology

Identification and validation of microglia-associated genes in ischemic stroke using single-cell and bulk RNA-seq. (PubMed, Mol Brain) - "Interestingly, Tlr2 and Adapalene exhibited a strong binding affinity (- 9.73 kcal/mol). qRT-PCR analysis revealed significantly elevated mRNA expression levels of Cd14, Csf1, and Tlr2 in tMCAO mice compared to sham-operated controls (p < 0.01). This study identified and validated 3 key genes (Cd14, Csf1, and Tlr2) associated with IS, which may serve as novel targets for IS diagnosis and treatment strategies."

Journal • Cardiovascular • CNS Disorders • Infectious Disease • Ischemic stroke • Vascular Neurology • CD14 • CSF1 • TLR2

Impaired retinoic acid signaling mediated Rbm20 downregulation induces aberrant splicing of CaV1.2 calcium channel: Implications in myocardial hypertrophy. (PubMed, J Mol Cell Cardiol) - "Our findings reveal impaired RARβ drives CaV1.2 aberrant splicing by downregulating Rbm20, establishing a feedforward loop of intracellular calcium imbalances and hypertrophic remodeling. Significantly, ADP restores CaV1.2 AS and intracellular calcium homeostasis by activating RARβ in cardiomyocytes, highlighting a novel therapeutic approach for myocardial hypertrophy."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertrophic Cardiomyopathy

Assessment of the Efficacy of Topical Ketoconazole 2% Cream in Comparison With Topical Retinoids in the Treatment of Mild Comedonal and Papulopustular Acne (clinicaltrials.gov) - P=N/A | N=52 | Active, not recruiting | Sponsor: Cairo University

New trial • Acne Vulgaris

Dual drug co-encapsulation into liposomes and liposome-derived nanosystems for improved synergistic treatment of skin diseases. (PubMed, Drug Deliv Transl Res) - "Conventional and modified liposomes, niosomes, transfersomes, ethosomes, invasomes, cerosomes, liposomal gels, and niosomal gels were developed, co-encapsulating synthetic and nature-derived substances such as adapalene, amphotericin B, benzoyl peroxide, bicalutamide, bupivacaine, buprenorphine, curcumin, ginger, glycyrrhetinic acid, metformin, methotrexate, microRNA-21, minoxidil, nicotinamide, Nigella sativa seed oil, pentamidine, psoralen, resveratrol, simvastatin, tocopherol acetate, tretinoin, and virgin coconut oil. By co-encapsulating active substances with distinct mechanisms of action, the developed nanosystems provide synergistic therapeutic effects, leading to reduced toxicity and enhanced bioavailability, potentially resulting in improved clinical outcomes, and presenting a promising alternative to conventional treatments. Through addressing clinical and regulatory framework aspects, these innovative therapies might one day transition from bench to market to..."

Journal • Review • Acne Vulgaris • Alopecia • Dermatology • Immunology • Infectious Disease • Psoriasis • Vitiligo • MIR21