ENX-104
/ Engrail Therap
- LARVOL DELTA
Home
Next
Prev
1 to 4
Of
4
Go to page
1
December 08, 2025
ENX-104: a selective and potent D2/D3 receptor antagonist enhances dopamine neurotransmission and reward responsiveness in translational rodent models.
(PubMed, Neuropsychopharmacology)
- "Predictably, higher doses (65-80% receptor occupancy) were associated with antipsychotic-like effects in the rat conditioned avoidance response assay, while extrapyramidal side effects, such as catalepsy, emerged only at much higher occupancies ( > 80% receptor occupancy). Our integrated pharmacokinetic-pharmacodynamic modeling suggests that a once-daily oral dosing regimen of ENX-104 could enable low D2/D3 receptor occupancies, potentially offering a novel therapeutic approach for the treatment of psychiatric conditions characterized by deficits in reward responsiveness."
Journal • Preclinical • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry
November 29, 2025
A PET Study of ENX-104 in Healthy Volunteers
(clinicaltrials.gov)
- P1 | N=10 | Completed | Sponsor: Engrail Therapeutics INC
New P1 trial
November 29, 2025
ENX-104 MAD Study for Participants With Major Depressive Disorder With Anhedonia (aMDD)
(clinicaltrials.gov)
- P1 | N=42 | Recruiting | Sponsor: Engrail Therapeutics INC
New P1 trial • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry
September 18, 2024
Engrail Therapeutics Initiates ENX-104 Clinical Program for the Treatment of Major Depressive Disorder Characterized by Anhedonia
(GlobeNewswire)
- "Engrail Therapeutics...announced initiation of a Phase 1 single ascending dose clinical study for ENX-104 in healthy volunteers....The lead indication for ENX-104 is the treatment of major depressive disorder (MDD) characterized by anhedonia (aMDD)....The ENX-104 Phase 1 study is a randomized, double-blind, placebo-controlled single ascending dose clinical study that is expected to enroll up to 48 healthy adult volunteers."
Trial status • CNS Disorders • Major Depressive Disorder
1 to 4
Of
4
Go to page
1