HYLACH / Glycocore Pharma - LARVOL DELTA

Lactose-Modified Hyaluronic Acid Molecule Attenuates In Vitro Chondrocyte Inflammation. (PubMed, Cells) - "Hylach® exerts an early and more potent anti-inflammatory effect in inflamed 2D and 3D chondrocyte cultures when compared to HA. These findings suggest that targeting Gal-3 through selective HA derivatives may represent a promising strategy for modulating both inflammation and matrix remodelling in OA."

Journal • Preclinical • Immunology • Inflammation • Osteoarthritis • Pain • Rheumatology • IL1B • IL6 • LGALS3 • TNFA

Modeling the Detailed Conformational Effects of the Lactosylation of Hyaluronic Acid. (PubMed, Biomacromolecules) - "The derivatization of HA is achieved to varying extents by reacting 1-amino-1-deoxy-lactitol via the carboxyl group to form amide linkages, giving rise to the grafted polymer, HYLACH...Here, the conformation, size, secondary structure, hydrogen bond network, and hydration features of lactosylated HA derivatives were evaluated by using multiple independent molecular dynamics simulations. This revealed subtle but nevertheless significant changes in the HA scaffold, establishing the density of grafting as the key parameter determining its properties."

Journal • Fibrosis • Immunology • Inflammation