TRIV-509
/ Triveni Bio
- LARVOL DELTA
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November 28, 2025
KLK5 and KLK7 is overexpressed in atopic dermatitis and correlates with epidermal thickness
(ISDS 2025)
- "This finding may correlate with severity of disease. Clinical trials of TRIV-509, an antibody inhibitor of KLK5/7, are underway in AD."
Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • KLK5 • KLK7
June 13, 2025
TRIV-509, a dual inhibitor of KLK5 and KLK7, normalizes epidermal hyper-proliferation, improves barrier integrity and reduces secretion of inflammatory cytokines in atopic dermatitis skin explants
(EADV 2025)
- "Approved biologics such as dupilumab, lebrikizumab, and tralokinumab directly target the IL- 4/IL-13 inflammatory pathway. Inhibition of KLK5 and KLK7 ameliorates the AD epidermal phenotype in ex vivo explant cultures by normalizing epidermal keratinocyte proliferation, improving barrier integrity, and reducing secretion of AD- associated cytokines. These data support therapeutic rationale for KLK5 and KLK7 inhibition and ongoing clinical development of TRIV-509 in AD."
Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Pruritus • FLG • IL13 • KLK5 • KLK7
September 16, 2025
A Study Evaluating TRIV-509 in Atopic Dermatitis
(clinicaltrials.gov)
- P2 | N=90 | Recruiting | Sponsor: Triveni Bio | Not yet recruiting ➔ Recruiting
Enrollment open • Atopic Dermatitis • Dermatitis • Dermatology • Immunology
September 12, 2025
A Study Evaluating TRIV-509 in Atopic Dermatitis
(clinicaltrials.gov)
- P2 | N=90 | Not yet recruiting | Sponsor: Triveni Bio
New P2 trial • Atopic Dermatitis • Dermatitis • Dermatology • Immunology
May 26, 2025
TRIV-509, a dual inhibitor of KLK5 and KLK7, rapidly improves barrier integrity and markers of epidermal differentiation in atopic dermatitis skin explants
(SID 2025)
- "Finally, TRIV-509 significantly increased the number of DSG1+ cells in the appropriate layers of the epidermis. Together this data demonstrates that KLK5 and KLK7 inhibition rapidly improves the barrier integrity and markers of epidermal differentiation ex vivo, thereby highlighting the therapeutic potential of TRIV-509 in AD."
Late-breaking abstract • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • Pruritus • DSC1 • KLK5 • KLK7
May 21, 2025
Triveni Bio Doses First Healthy Volunteers in Clinical Trial for TRIV-509, Coinciding with Preclinical Data Presentations Further Validating Novel Kallikrein 5/7 Biology in Atopic Dermatitis
(PRNewswire)
- "Triveni Bio, Inc...announced the initiation of dosing in healthy volunteers for its first-in-human Phase 1 clinical trial of TRIV-509. This study will assess the safety and tolerability of TRIV-509 and is the first of three clinical trials the company expects to begin in 2025 as Triveni advances its anti-kallikrein mechanism into patients with moderate-to-severe atopic dermatitis (AD)."
New trial • Trial status • Atopic Dermatitis
April 28, 2024
KLK5/7 targeting antibody, TRIV-509, ameliorates barrier dysfunction, inflammation and itch in atopic dermatitis models.
(SID 2024)
- No abstract available
Late-breaking abstract • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • KLK5
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