vorsetuzumab (SGN70) / Pfizer - LARVOL DELTA

[89Zr]Zr-RDT-008: A Site-Specifically Radiolabeled Anti-CD70 Antibody for Immuno-PET Imaging of Clear Cell Renal Cell Carcinoma (SNMMI 2026) - "In CD70 overexpressing 786-O cells, [89Zr]Zr-RDT-008 showed 74.0 +/- 7.45% internalization rate, outperforming clinical stage antibodies (cusatuzumab: 20.6 +/- 1.73%, vorsetuzumab: 33.9 +/- 2.41%). [89Zr]Zr-RDT-008 is the first 89Zr-labeled full-length anti-CD70 antibody demonstrating high-contrast, target-specific immuno-PET imaging of ccRCC. The site-specific conjugation strategy provides a homogeneous product suitable for clinical translation. This tracer may serve as a companion diagnostic for CD70-targeted therapies and warrants further investigation in clinical studies."

IO biomarker • IO Companion diagnostic • Clear Cell Renal Cell Carcinoma • Genito-urinary Cancer • Oncology • Solid Tumor • CD27 • CD70

[VIRTUAL] A Phase 1 Study of Sea-CD70 in Myeloid Malignancies (ASH 2020) - P1 | "Methods SGNS70-101 is a phase 1, open-label, multicenter, dose-escalation, and cohort expansion study designed to establish the safety, tolerability, and preliminary activity of SEA-CD70 in pts with myeloid malignancies (NCT04227847). Once dose escalation is complete and the recommended monotherapy dose is identified, combination cohorts will be considered in AML and MDS. The study is currently enrolling with sites opening in the US and EU."

IO Biomarker • P1 data • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Myelodysplastic Syndrome • Oncology • CD27 • CD70

Determination of drug-to-antibody ratio of antibody-drug conjugate in biological samples using microflow-liquid chromatography/high-resolution mass spectrometry. (PubMed, Bioanalysis) - " Vorsetuzumab maleimidocaproyl valine-citrulline p-aminobenzyloxycarbonyl monomethyl auristatin E was used to develop pretreatment and analytical workflows suitable for ADCs...Microflow-liquid chromatography/high-resolution mass spectrometry (LC-HRMS) resulted in a 4-7-fold improvement in detection sensitivity compared with conventional flow LC-HRMS. Microflow-LC-HRMS can be a useful tool in understanding the complex properties of ADCs in the body from a drug metabolism and pharmacokinetics point of view."

Journal • Oncology

[VIRTUAL] A CD70 antibody-drug conjugate is highly active and induces long term remission in patient-derived xenograft mouse models of cutaneous T cell lymphoma (AACR 2021) - "One week after tumor inoculation, mice were treated intraperitoneally with single-dosing of PBS, 100 μg/kg (SGN70A100) or 300 μg/kg (SGN70A300) of SGN-CD70A. Using CTCL PDX models, SGN-CD70A has marked anti-tumor activity, leading to long-term survival of treated mice. Our results provide a rationale for clinical investigation of SGN-CD70A in patients with TCL."

Preclinical • Cutaneous T-cell Lymphoma • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology • T Cell Non-Hodgkin Lymphoma • CD70