VC005 / Jiangsu Vcare Pharma - LARVOL DELTA

Jiangsu Weikaier VC005 topical treatment of mild to moderate atopic dermatitis Phase II clinical trial officially launched [Google translation] (zhihu.com) - "At the end of March 2025, Jiangsu Weikai Pharmaceutical Technology Co., Ltd. (referred to as 'Jiangsu Weikai') officially launched Phase II clinical trials for the topical treatment of mild to moderate atopic dermatitis with VC005 gel , a new generation of highly selective JAK1 inhibitors independently developed by the company. The enrollment of relevant subjects is in progress."

Trial status • Atopic Dermatitis

Phase II Clinical Study to Evaluate the Efficacy and Safety of VC005 in Adult Subjects With Mild to Moderate Atopic Dermatitis (clinicaltrials.gov) - P2 | N=114 | Not yet recruiting | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD

New P2 trial • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Phase III Clinical Study of VC005 Tablets in Adult Patients with Moderate to Severe Atopic Dermatitis (clinicaltrials.gov) - P3 | N=480 | Recruiting | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD | Not yet recruiting ➔ Recruiting

Enrollment open • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Phase III Clinical Study of VC005 Tablets in Adult Patients With Moderate to Severe Atopic Dermatitis (clinicaltrials.gov) - P3 | N=480 | Not yet recruiting | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD

New P3 trial • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Efficacy and Safety Clinical Study of VC005 Tablets in Subjects With Active Ankylosing Spondylitis. (clinicaltrials.gov) - P2 | N=180 | Completed | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD | Recruiting ➔ Completed | Trial completion date: Apr 2026 ➔ May 2024 | Trial primary completion date: Apr 2026 ➔ May 2024

Trial completion • Trial completion date • Trial primary completion date • Ankylosing Spondylitis • Immunology • Inflammatory Arthritis • Rheumatology • Seronegative Spondyloarthropathies

Safety, Tolerance and Pharmacokinetics Clinical Study of VC005 in Healthy Subjects and Patients With Mild to Moderate Atopic Dermatitis (clinicaltrials.gov) - P1 | N=80 | Completed | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD | Recruiting ➔ Completed | Trial completion date: Dec 2024 ➔ May 2024 | Trial primary completion date: Dec 2024 ➔ May 2024

Trial completion • Trial completion date • Trial primary completion date • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Efficacy and Safety Clinical Study of VC005 Tablets in Adult Patients With Moderate to Severe Atopic Dermatitis (clinicaltrials.gov) - P2 | N=149 | Completed | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD | Recruiting ➔ Completed | Trial completion date: Aug 2026 ➔ Jul 2024 | Trial primary completion date: Aug 2026 ➔ Jul 2024

Trial completion • Trial completion date • Trial primary completion date • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

A Phase I Clinical Study of VC005 Tablets in Subjects With Rheumatoid Arthritis. (clinicaltrials.gov) - P1 | N=30 | Completed | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD | Recruiting ➔ Completed | Trial completion date: Jun 2026 ➔ Oct 2023 | Trial primary completion date: Jun 2026 ➔ Oct 2023

Trial completion • Trial completion date • Trial primary completion date • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Safety, Tolerance and Pharmacokinetics Clinical Study of VC005 in Healthy Subjects and Patients With Mild to Moderate Atopic Dermatitis (clinicaltrials.gov) - P1 | N=80 | Recruiting | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD | Not yet recruiting ➔ Recruiting

Enrollment open • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Safety, Tolerance and Pharmacokinetics Clinical Study of VC005 in Healthy Subjects and Patients With Mild to Moderate Atopic Dermatitis (clinicaltrials.gov) - P1 | N=80 | Not yet recruiting | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD

New P1 trial • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Efficacy and Safety Clinical Study of VC005 Tablets in Adult Patients With Moderate to Severe Atopic Dermatitis (clinicaltrials.gov) - P2 | N=152 | Recruiting | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD | Not yet recruiting ➔ Recruiting

Enrollment open • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Efficacy and Safety Clinical Study of VC005 Tablets in Adult Patients With Moderate to Severe Atopic Dermatitis (clinicaltrials.gov) - P2 | N=152 | Not yet recruiting | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD

New P2 trial • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Efficacy and Safety Clinical Study of VC005 Tablets in Subjects With Active Ankylosing Spondylitis. (clinicaltrials.gov) - P2 | N=180 | Recruiting | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD | Not yet recruiting ➔ Recruiting

Enrollment open • Ankylosing Spondylitis • Immunology • Inflammatory Arthritis • Rheumatology • Seronegative Spondyloarthropathies

A Phase I Clinical Study of VC005 Tablets in Subjects With Rheumatoid Arthritis. (clinicaltrials.gov) - P1 | N=40 | Recruiting | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD | Not yet recruiting ➔ Recruiting

Enrollment open • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

A Phase I Clinical Study of VC005 Tablets in Subjects With Rheumatoid Arthritis. (clinicaltrials.gov) - P1 | N=40 | Not yet recruiting | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD

New P1 trial • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Efficacy and Safety Clinical Study of VC005 Tablets in Subjects With Active Ankylosing Spondylitis. (clinicaltrials.gov) - P2 | N=180 | Not yet recruiting | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD

New P2 trial • Ankylosing Spondylitis • Immunology • Inflammatory Arthritis • Rheumatology • Seronegative Spondyloarthropathies

Multiple-dose Escalation Clinical Study of VC005 Tablets in Healthy Subjects (clinicaltrials.gov) - P1 | N=60 | Completed | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD | Recruiting ➔ Completed

Trial completion • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease

Pharmacokinetics and Pharmacodynamics Clinical Study of VC005 Tablets in Healthy Subjects (clinicaltrials.gov) - P1 | N=78 | Completed | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD | Recruiting ➔ Completed

Trial completion • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease

Multiple-dose Escalation Clinical Study of VC005 Tablets in Healthy Subjects (clinicaltrials.gov) - P1 | N=48 | Recruiting | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD | Not yet recruiting ➔ Recruiting

Enrollment open • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease

Multiple-dose Escalation Clinical Study of VC005 Tablets in Healthy Subjects (clinicaltrials.gov) - P1 | N=48 | Not yet recruiting | Sponsor: Jiangsu vcare pharmaceutical technology co., LTD

New P1 trial • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease