sodium tungstate (OXO-001) / Oxolife - LARVOL DELTA

Intestinal oxygen and microbiota crosstalk: implications for pathogenesis of gastrointestinal diseases and emerging therapeutic strategies. (PubMed, Gut Pathog) - "Compounds like sodium tungstate inhibit microbial respiratory pathways, while PPAR-γ agonists enhance mitochondrial efficiency in colonic epithelial cells, thereby restoring proper hypoxia...We evaluate the potential for IO modulation to improve gut microbiota structure and explore its impact on microbial metabolism and disease pathogenesis. Additionally, we discuss the promise of dietary, probiotic, and pharmacological interventions in restoring the host's control over the IO microenvironment and microbiota, aiming to prevent and treat related diseases."

Journal • Review • Colorectal Cancer • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Oncology • Solid Tumor • Ulcerative Colitis

Tungsten residues in prefilled syringes promote monoclonal antibody aggregation and charge heterogeneity. (PubMed, Eur J Pharm Biopharm) - "This study systematically evaluates the effect of tungsten-derived from syringe needle pin extracts and commercial tungsten salts (sodium tungstate, sodium metatungstate)-on the stability of three therapeutic mAbs under accelerated conditions (40 °C, light)...Computational modeling suggests that mAb-2's heightened sensitivity might correlate with solvent-exposed asparagine residues. Collectively, our data highlight the imperative for tight tungsten control during PFS manufacture and antibody-specific stability assessments to mitigate risks to product quality."

Heterogeneity • Journal

Study on Loading of Na2WO4 and Silanization Treatment on Surface of Plasma Electrolytic Oxidation Coatings with Different Structures. (PubMed, Materials (Basel)) - "Secondly, sodium tungstate (Na2WO4) was loaded into the micropores and onto the surface of the PEO coatings via vacuum impregnation, and which were subsequently subjected to silanization treatment...After immersion in a 3.5 wt.% NaCl solution for 240 h, the composite coating formed at 350 V remains intact, and its low-frequency impedance modulus;Z|0.01Hz is as high as 1.06 × 106 cm2. This value is approximately two orders of magnitude higher than that of the composite coating fabricated at 400 V and about three orders of magnitude higher than that of the pure PEO coating prepared at 350 V."

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Enrichment of Calditenuis and Gearchaeales from Great Boiling Springs, Nevada (ASM Microbe 2025) - "Additionally, it was found that a synthetic medium supplemented with 200 nM sodium tungstate in a synthetic medium allowed for growth of these microbes without added spring water, which will better allow for growth under defined conditions. Further experiments using shotgun metagenome sequencing and fluorescence in situ hybridization with probes specific for Calditenuis will be used to confirm this level of enrichment."

Ti-Supported Oxide Coatings Based on MWO4 (M = Fe, Co, Ni): Plasma Electrolytic Synthesis, Characterization and Catalytic Properties in S, N-Heterocycles Peroxide Oxidation. (PubMed, Molecules) - "In this study, catalytically active coatings on titanium were synthesized by plasma electrolytic oxidation (PEO) in aqueous electrolytes based on sodium tungstate with the addition of sodium phosphate or sodium borate and chelate complexes of iron, cobalt or nickel...Replacing phosphate with borate in the electrolyte resulted in the preparation of catalysts with enhanced stability and activity. In contrast to PWM catalysts, the BWNi catalyst had selectivity toward the oxidation of pyridine in its mixture with thiophene."

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Regulation of lignan biosynthesis through signaling pathways mediated by H2O2 in Linum album cell culture in response to exogenous putrescine. (PubMed, Sci Rep) - "Besides, pre-treatment of cells with AG, imidazole, ethylene glycol-bis (β-aminoethyl ether)-N, N,N',N'-tetraacetic acid (EGTA) (Ca2+ chelator), Nɷ-nitro-L-arginine methyl ester (L-NAME), and Sodium tungstate (TUN) (NO generation inhibitors) diminished PAL and PLR transcript levels and PTOX and 6MPTOX accumulation, indicating the involvement of H2O2, NO, and Ca2+ in regulating lignan biosynthesis in L. album cells. Put also stimulated salicylic acid (SA) accumulation, being sensitive to all inhibitors used. Overall, this study suggests that Put-induced H2O2 generation in combination with NO and Ca2+ signals can regulate PAL and PLR genes expression and lignan production, likely in a SA-dependent manner."

Journal • Preclinical

Safety, Tolerability and Pharmacokinetics of Sodium Tungstate (OXO-001) in Healthy Female Volunteers of Childbearing Age: A Randomized, Double-Blind, Dose-Finding, and Placebo-Controlled Phase I Study. (PubMed, Int J Fertil Steril) - "The administration of OXO-001 in volunteers of childbearing age was safe and well tolerated, with consistent PK linear profile within doses studied and without detrimental effect on endometrium or ovary-related variables, with similar effects in healthy weight and overweight participants. The maximum studied dose (300 mg/ day) was safe and well tolerated. These data are sufficient to support further clinical trials (registration number: 2016-001276-30)."

Clinical • Journal • P1 data • PK/PD data • Obesity

Giant Polyoxometalate {W72Fe30} into Pure Inorganic Gel and Xerogel: Rheology and Proton Conduction. (PubMed, Chempluschem) - "Polyoxometalate (POM) gel is well-known but mostly with organic molecules.  Pure inorganic POM gel, i.e., a combination of a 'POM anion and a metal cation', is hardly known and unexplored area of materials research.  When an aqueous solution of sodium tungstate is mixed with an aqueous solution of ferric chloride, the resulting suspension forms a straw-color hydrogel...Interestingly, the title xerogel {W72Fe30}XG, which is nothing but an inorganic acid and an inexpensive metal-oxide-based material, exhibits proton conduction in its solid state. The xerogel material shows super proton conductivity of 1.71×10-2 S cm-1 at 80 ⁰C and 98% relative humidity with an activation energy (Ea) of 0.18 eV."

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Improved Corrosive Resistance of Micro-Arc-Oxidation Coating on 6063 Aluminum Alloy by Co-Doping with Graphite and Sodium Tungstate. (PubMed, Materials (Basel)) - "The film containing 6 g of Na2WO4 and 10 mL of graphene oxide dispersion (G10-6) exhibited optimal densification and thickness, with an Icorr value of 3.01 × 10-6 A·cm-2 and a low-frequency impedance film value of 108 Ω·cm2, thereby demonstrating the most advanced corrosion resistance among the films. The densification and corrosion resistance of the films were enhanced by the incorporation of Na2WO4 and graphene oxide dispersion into the alkaline electrolyte."

Journal • CNS Disorders • Psychiatry

Dietary manipulation of intestinal microbes prolongs survival in a mouse model of Hirschsprung disease. (PubMed, bioRxiv) - "Detrimental diet fed sl/sl also had aberrant-appearing mitochondria in distal colon epithelium, with elevated epithelial oxygen that drives lethal Enterobacteriaceae overgrowth via aerobic respiration. Elimination of Enterobacteriaceae with antibiotics or sodium tungstate improves survival of Piebald lethal fed the "Detrimental diet"."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Rare Diseases • Septic Shock

Operando Scanning Electron Microscopy Study of Support Interactions and Mechanisms of Salt-Assisted WS2 Growth. (PubMed, Chem Mater) - "We employ operando scanning electron microscopy to resolve the entire process of salt-assisted CVD of WS2, focusing on a model system of individual, small (20 μm) monolayer WS2 formation does not involve the salt droplet directly attached to the growth facets, rather the salt droplet drives WS2 layer growth in the contiguous halo interface region with a continuous supply of W. We compare this to SiO2 and NaOH treated sapphire where corrosive surface roughening dictates the salt wetting, and critically discuss our findings in the context of the connected wider literature."

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Study on the Photoelectrocatalytic Performance of Ti/Ti-W-O Coating Photoelectrodes Prepared by the Microarc Oxidation Method. (PubMed, Langmuir) - "In this study, the corrosion-resistant Ti/Ti-W-O ceramic coatings are prepared by changing the concentration of additives, microarc oxidation voltage, pulse frequency, and time using titanium alloy (TC4) as the substrate and sodium tungstate (Na2WO4) as the main additive via the microarc oxidation (MAO) method...In addition, the optimized Ti/Ti-W-O composite photoelectrode coupled with 304 stainless steel showed the largest negative shift in corrosion potential (447 mV vs) and improved degradation efficiency of the dyeing wastewater (improved by ∼20%). The above results demonstrate that the composite electrodes in this study exhibit good performance in photocathodic protection and photovoltaic synergy."

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Study on Synergistically Improving Corrosion Resistance of Microarc Oxidation Coating on Magnesium Alloy by Loading of Sodium Tungstate and Silane Treatment. (PubMed, Materials (Basel)) - "When the impregnation concentration of sodium tungstate is 0.1 mol/L or above, the MAO coating with sodium tungstate can be completely sealed. When the impregnation concentration of sodium tungstate is 0.125 mol/L, M-0.125W-SG composite coating has the best corrosion resistance, and its impedance modulus value can be maintained at 8.06 × 106 Ω·cm2 after soaking in 3.5 wt.% NaCl solution for 144 h, which is about three orders of magnitude higher than those of MAO coating and M-0.125W and M-SG composite coatings."

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Involvement of nitrate reductase in nitric oxide generation and in the induction of acclimation responses to phosphorus restriction in soybean plants. (PubMed, Plant Sci) - "The treatment of plants with L-NAME (a known inhibitor of NOS) did not markedly affect NO levels, while the inhibition of NR activity with sodium tungstate (W) reduced NO-related DAF-FM fluorescence...Treatment of P starved plants with W reduced NR activity as well as the magnitude of the acclimation responses studied. Overall, the data here presented suggest a role for NR as NO source, influencing the signaling pathways leading to early acclimation responses following P-deprivation in soybean plants."

Journal

Red emitting fluorescence sensor based on Eu-tungstate complex for the detection of bilirubin in biological fluid. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "The Eu-tungstate complex was synthesized by a straightforward one-pot procedure at ambient temperature, utilizing Europium chloride and Sodium tungstate as the precursors. The Eu-tungstate complex exhibited a very strong red emission and demonstrated excellent stability. The fluorescence of the Eu-tungstate complex in aqueous mediacan be turned off regularly by the gradual addition of bilirubin with a limit of detection (LoD) of 0.27 μM and alimit of quantitative (LoQ) of 0.91 μM.Moreover, this sensing technology can be utilized to sense bilirubin in actual samples."

Journal • Hepatology

Sodium Tungstate Promotes Neurite Outgrowth and Confers Neuroprotection in Neuro2a and SH-SY5Y Cells. (PubMed, Int J Mol Sci) - "In Neuro2a cells, Na2WO4 increases protein synthesis by activating the mechanistic target of rapamycin (mTOR) and S6K kinases and GLUT3-mediated glucose uptake, providing the energy and protein synthesis needed for neurite outgrowth. These negative effects were corrected in both cell lines after incubation with Na2WO4. These findings support the role of Na2WO4 in neuronal plasticity, albeit further experiments using 3D cultures, and animal models will be needed to validate the therapeutic potential of the compound."

Journal • CNS Tumor • Neuroblastoma • Oncology • Solid Tumor • MEF2D • mTOR • SLC2A3

Silicon improves salt resistance by enhancing ABA biosynthesis and aquaporin expression in Nicotiana tabacum L. (PubMed, Plant Physiol Biochem) - "Moreover, sodium tungstate, an ABA biosynthesis inhibitor, was used to test the role of ABA on Si-regulating Lpr...Together, this study suggested that Si increased ABA content, leading to enhanced efficiency of water uptake by the roots, ultimately facilitating an adequate water supply to maintain leaf water balance. As a result, there was an improvement in salt resistance in tobacco seedling."

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Sodium Tungstate (NaW) Decreases Inflammation and Renal Fibrosis in Diabetic Nephropathy. (PubMed, Am J Med Sci) - "NaW could be an effective drug therapy for treating human diabetic nephropathy."

Journal • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Fibrosis • Immunology • Inflammation • Metabolic Disorders • Nephrology • Renal Disease • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus • ICAM1 • SMAD2 • TGFB1

The GA and ABA signaling is required for hydrogen-mediated seed germination in wax gourd. (PubMed, BMC Plant Biol) - "This study portrays insights into the mechanism of HRW-mediated seed germination, suggesting that HRW can regulate the balance between GA and ABA to mediate seed germination through ethylene signals in wax gourd."

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OXOART2: Phase II Clinical Trial to Evaluate the Ongoing Pregnancy Rate With OXO-001 in IVF/ICSI With Donor Oocytes. (clinicaltrials.gov) - P2 | N=408 | Completed | Sponsor: OXOLIFE | Active, not recruiting ➔ Completed | Trial primary completion date: Nov 2023 ➔ Aug 2023

Trial completion • Trial primary completion date • Gynecology • Infertility • Sexual Disorders

Exploring the redox properties and encapsulation of rare earth and actinide metals within the Preyssler anion: A multifaceted study using synthetic methodologies and spectroscopic analysis | Poster Board #822 (ACS-Sp 2024) - "The Preyssler anion, {Na[P5W30O110]}13-, is a unique POM structure formed from sodium tungstate and phosphoric acid, with a sodium cation at its core...We are developing synthetic methodologies with non-radioactive elements; europium, neodymium, and samarium, before working with actinide species (U and Pu). We have used P31 NMR, cyclic voltammetry (CV), infrared, and fluorescence spectroscopy to analyze and characterize the Preyssler and Lanthandie complexes and our results and observations are discussed."

Adsorption behavior of Mo(VI) from aqueous solutions using tungstate-modified magnetic nanoparticle. (PubMed, Environ Sci Pollut Res Int) - "A new magnetic nanoparticle modified with sodium tungstate (Mnp-Si-W) was synthesized and employed for the sorption of molybdenum from aqueous solutions...Moreover, the effect of some interfering anions on Mo(VI) ion sorption is found in the following order: phosphate < sulfate < chromate. Finally, the nanoparticle (Mnp-Si-W) can be successfully reused five times."

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Synthesis and characterization of Anderson-Evans type polyoxometalates, antibacterial properties. (PubMed, Turk J Chem) - "In the present work, the new aluminium-substituted polyoxometalates of the Anderson-Evans type have been prepared and structurally defined by the reaction of aluminium (III) chloride hexahydrate and sodium tungstate dihydrate/sodium molybdate dihydrate in an aqueous basic medium. Elemental analysis, FT-IR, TGA, H NMR, and P NMR analysis revealed that these polyoxometalates had the following formula: [PhP][Al(OH)MoO]·4HO 1, [PhP][Al(OH)WO]·4HO 2, [CHN][Al(OH)MoO]·4HO 3, [CHN][Al(OH)WO]·4HO 4. The compounds 1 and 2 show promising antibacterial activity against gram-positive Staphylcoccus aureus ATCC 25923 and gram-negative Escherichia coli ATCC 25922 bacteria."

Journal • Infectious Disease

High-Performance Single-Crystal Lithium-Rich Layered Oxides Cathode Materials via Na WO -Assisted Sintering. (PubMed, Small) - "In this study, a sodium tungstate (Na WO )-assisted sintering method is proposed to fabricate high-performance single-crystal LLOs cathode materials without large amounts of additives and additional washing steps...The prepared single-crystal LLOs exhibit outstanding capacity retention of 82.7% (compared to 65.0%, after 200 cycles at 1 C) and a low voltage decay rate of 0.76 mV per cycle (compared to 1.80 mV per cycle). This strategy provides a novel pathway for designing the next-generation high-performance cathode materials for Lithium-ion batteries (LIBs)."

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OXOART2: Phase II Clinical Trial to Evaluate the Ongoing Pregnancy Rate With OXO-001 in IVF/ICSI With Donor Oocytes. (clinicaltrials.gov) - P2 | N=351 | Active, not recruiting | Sponsor: OXOLIFE | Trial primary completion date: Oct 2022 ➔ Nov 2023

Trial primary completion date • Gynecology • Infertility • Sexual Disorders