sodium tungstate (OXO-001) / Oxolife - LARVOL DELTA

Giant Polyoxometalate {W72Fe30} into Pure Inorganic Gel and Xerogel: Rheology and Proton Conduction. (PubMed, Chempluschem) - "Polyoxometalate (POM) gel is well-known but mostly with organic molecules.  Pure inorganic POM gel, i.e., a combination of a 'POM anion and a metal cation', is hardly known and unexplored area of materials research.  When an aqueous solution of sodium tungstate is mixed with an aqueous solution of ferric chloride, the resulting suspension forms a straw-color hydrogel...Interestingly, the title xerogel {W72Fe30}XG, which is nothing but an inorganic acid and an inexpensive metal-oxide-based material, exhibits proton conduction in its solid state. The xerogel material shows super proton conductivity of 1.71×10-2 S cm-1 at 80 ⁰C and 98% relative humidity with an activation energy (Ea) of 0.18 eV."

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Improved Corrosive Resistance of Micro-Arc-Oxidation Coating on 6063 Aluminum Alloy by Co-Doping with Graphite and Sodium Tungstate. (PubMed, Materials (Basel)) - "The film containing 6 g of Na2WO4 and 10 mL of graphene oxide dispersion (G10-6) exhibited optimal densification and thickness, with an Icorr value of 3.01 × 10-6 A·cm-2 and a low-frequency impedance film value of 108 Ω·cm2, thereby demonstrating the most advanced corrosion resistance among the films. The densification and corrosion resistance of the films were enhanced by the incorporation of Na2WO4 and graphene oxide dispersion into the alkaline electrolyte."

Journal • CNS Disorders • Psychiatry

Dietary manipulation of intestinal microbes prolongs survival in a mouse model of Hirschsprung disease. (PubMed, bioRxiv) - "Detrimental diet fed sl/sl also had aberrant-appearing mitochondria in distal colon epithelium, with elevated epithelial oxygen that drives lethal Enterobacteriaceae overgrowth via aerobic respiration. Elimination of Enterobacteriaceae with antibiotics or sodium tungstate improves survival of Piebald lethal fed the "Detrimental diet"."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Rare Diseases • Septic Shock

Operando Scanning Electron Microscopy Study of Support Interactions and Mechanisms of Salt-Assisted WS2 Growth. (PubMed, Chem Mater) - "We employ operando scanning electron microscopy to resolve the entire process of salt-assisted CVD of WS2, focusing on a model system of individual, small (20 μm) monolayer WS2 formation does not involve the salt droplet directly attached to the growth facets, rather the salt droplet drives WS2 layer growth in the contiguous halo interface region with a continuous supply of W. We compare this to SiO2 and NaOH treated sapphire where corrosive surface roughening dictates the salt wetting, and critically discuss our findings in the context of the connected wider literature."

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Study on the Photoelectrocatalytic Performance of Ti/Ti-W-O Coating Photoelectrodes Prepared by the Microarc Oxidation Method. (PubMed, Langmuir) - "In this study, the corrosion-resistant Ti/Ti-W-O ceramic coatings are prepared by changing the concentration of additives, microarc oxidation voltage, pulse frequency, and time using titanium alloy (TC4) as the substrate and sodium tungstate (Na2WO4) as the main additive via the microarc oxidation (MAO) method...In addition, the optimized Ti/Ti-W-O composite photoelectrode coupled with 304 stainless steel showed the largest negative shift in corrosion potential (447 mV vs) and improved degradation efficiency of the dyeing wastewater (improved by ∼20%). The above results demonstrate that the composite electrodes in this study exhibit good performance in photocathodic protection and photovoltaic synergy."

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Study on Synergistically Improving Corrosion Resistance of Microarc Oxidation Coating on Magnesium Alloy by Loading of Sodium Tungstate and Silane Treatment. (PubMed, Materials (Basel)) - "When the impregnation concentration of sodium tungstate is 0.1 mol/L or above, the MAO coating with sodium tungstate can be completely sealed. When the impregnation concentration of sodium tungstate is 0.125 mol/L, M-0.125W-SG composite coating has the best corrosion resistance, and its impedance modulus value can be maintained at 8.06 × 106 Ω·cm2 after soaking in 3.5 wt.% NaCl solution for 144 h, which is about three orders of magnitude higher than those of MAO coating and M-0.125W and M-SG composite coatings."

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Involvement of nitrate reductase in nitric oxide generation and in the induction of acclimation responses to phosphorus restriction in soybean plants. (PubMed, Plant Sci) - "The treatment of plants with L-NAME (a known inhibitor of NOS) did not markedly affect NO levels, while the inhibition of NR activity with sodium tungstate (W) reduced NO-related DAF-FM fluorescence...Treatment of P starved plants with W reduced NR activity as well as the magnitude of the acclimation responses studied. Overall, the data here presented suggest a role for NR as NO source, influencing the signaling pathways leading to early acclimation responses following P-deprivation in soybean plants."

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Red emitting fluorescence sensor based on Eu-tungstate complex for the detection of bilirubin in biological fluid. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "The Eu-tungstate complex was synthesized by a straightforward one-pot procedure at ambient temperature, utilizing Europium chloride and Sodium tungstate as the precursors. The Eu-tungstate complex exhibited a very strong red emission and demonstrated excellent stability. The fluorescence of the Eu-tungstate complex in aqueous mediacan be turned off regularly by the gradual addition of bilirubin with a limit of detection (LoD) of 0.27 μM and alimit of quantitative (LoQ) of 0.91 μM.Moreover, this sensing technology can be utilized to sense bilirubin in actual samples."

Journal • Hepatology

Sodium Tungstate Promotes Neurite Outgrowth and Confers Neuroprotection in Neuro2a and SH-SY5Y Cells. (PubMed, Int J Mol Sci) - "In Neuro2a cells, Na2WO4 increases protein synthesis by activating the mechanistic target of rapamycin (mTOR) and S6K kinases and GLUT3-mediated glucose uptake, providing the energy and protein synthesis needed for neurite outgrowth. These negative effects were corrected in both cell lines after incubation with Na2WO4. These findings support the role of Na2WO4 in neuronal plasticity, albeit further experiments using 3D cultures, and animal models will be needed to validate the therapeutic potential of the compound."

Journal • CNS Tumor • Neuroblastoma • Oncology • Solid Tumor • MEF2D • mTOR • SLC2A3

Silicon improves salt resistance by enhancing ABA biosynthesis and aquaporin expression in Nicotiana tabacum L. (PubMed, Plant Physiol Biochem) - "Moreover, sodium tungstate, an ABA biosynthesis inhibitor, was used to test the role of ABA on Si-regulating Lpr...Together, this study suggested that Si increased ABA content, leading to enhanced efficiency of water uptake by the roots, ultimately facilitating an adequate water supply to maintain leaf water balance. As a result, there was an improvement in salt resistance in tobacco seedling."

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Sodium Tungstate (NaW) Decreases Inflammation and Renal Fibrosis in Diabetic Nephropathy. (PubMed, Am J Med Sci) - "NaW could be an effective drug therapy for treating human diabetic nephropathy."

Journal • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Fibrosis • Immunology • Inflammation • Metabolic Disorders • Nephrology • Renal Disease • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus • ICAM1 • SMAD2 • TGFB1

The GA and ABA signaling is required for hydrogen-mediated seed germination in wax gourd. (PubMed, BMC Plant Biol) - "This study portrays insights into the mechanism of HRW-mediated seed germination, suggesting that HRW can regulate the balance between GA and ABA to mediate seed germination through ethylene signals in wax gourd."

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OXOART2: Phase II Clinical Trial to Evaluate the Ongoing Pregnancy Rate With OXO-001 in IVF/ICSI With Donor Oocytes. (clinicaltrials.gov) - P2 | N=408 | Completed | Sponsor: OXOLIFE | Active, not recruiting ➔ Completed | Trial primary completion date: Nov 2023 ➔ Aug 2023

Trial completion • Trial primary completion date • Gynecology • Infertility • Sexual Disorders

Exploring the redox properties and encapsulation of rare earth and actinide metals within the Preyssler anion: A multifaceted study using synthetic methodologies and spectroscopic analysis | Poster Board #822 (ACS-Sp 2024) - "The Preyssler anion, {Na[P5W30O110]}13-, is a unique POM structure formed from sodium tungstate and phosphoric acid, with a sodium cation at its core...We are developing synthetic methodologies with non-radioactive elements; europium, neodymium, and samarium, before working with actinide species (U and Pu). We have used P31 NMR, cyclic voltammetry (CV), infrared, and fluorescence spectroscopy to analyze and characterize the Preyssler and Lanthandie complexes and our results and observations are discussed."

Adsorption behavior of Mo(VI) from aqueous solutions using tungstate-modified magnetic nanoparticle. (PubMed, Environ Sci Pollut Res Int) - "A new magnetic nanoparticle modified with sodium tungstate (Mnp-Si-W) was synthesized and employed for the sorption of molybdenum from aqueous solutions...Moreover, the effect of some interfering anions on Mo(VI) ion sorption is found in the following order: phosphate < sulfate < chromate. Finally, the nanoparticle (Mnp-Si-W) can be successfully reused five times."

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Synthesis and characterization of Anderson-Evans type polyoxometalates, antibacterial properties. (PubMed, Turk J Chem) - "In the present work, the new aluminium-substituted polyoxometalates of the Anderson-Evans type have been prepared and structurally defined by the reaction of aluminium (III) chloride hexahydrate and sodium tungstate dihydrate/sodium molybdate dihydrate in an aqueous basic medium. Elemental analysis, FT-IR, TGA, H NMR, and P NMR analysis revealed that these polyoxometalates had the following formula: [PhP][Al(OH)MoO]·4HO 1, [PhP][Al(OH)WO]·4HO 2, [CHN][Al(OH)MoO]·4HO 3, [CHN][Al(OH)WO]·4HO 4. The compounds 1 and 2 show promising antibacterial activity against gram-positive Staphylcoccus aureus ATCC 25923 and gram-negative Escherichia coli ATCC 25922 bacteria."

Journal • Infectious Disease

High-Performance Single-Crystal Lithium-Rich Layered Oxides Cathode Materials via Na WO -Assisted Sintering. (PubMed, Small) - "In this study, a sodium tungstate (Na WO )-assisted sintering method is proposed to fabricate high-performance single-crystal LLOs cathode materials without large amounts of additives and additional washing steps...The prepared single-crystal LLOs exhibit outstanding capacity retention of 82.7% (compared to 65.0%, after 200 cycles at 1 C) and a low voltage decay rate of 0.76 mV per cycle (compared to 1.80 mV per cycle). This strategy provides a novel pathway for designing the next-generation high-performance cathode materials for Lithium-ion batteries (LIBs)."

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OXOART2: Phase II Clinical Trial to Evaluate the Ongoing Pregnancy Rate With OXO-001 in IVF/ICSI With Donor Oocytes. (clinicaltrials.gov) - P2 | N=351 | Active, not recruiting | Sponsor: OXOLIFE | Trial primary completion date: Oct 2022 ➔ Nov 2023

Trial primary completion date • Gynecology • Infertility • Sexual Disorders

Visible light-induced catalytic performance of composite photocatalyst synthesized with nanomaterials WO and two-dimensional ultrathin g-CN. (PubMed, Water Sci Technol) - "We have calibrated the optimal preparation conditions to be: WO/UCN ratio as 1:1, the stirring time of the UCN and sodium tungstate mixture as 9 h and the volume of concentrated hydrochloric acid as 6 mL which was poured into the mixture solution with an extra stirring time of 1.5 h. The optimal photocatalyst WU had porous and wrinkled configurations...WU retained a high RhB removal rate, it was 5.5% lower than the initial one after being reused for five cycles. The photodegradation mechanism was facilitated through the strong oxidation behaviors from the active free radicals ·O, ·OH and h generated by WUopt under the visible light irradiation."

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Fluorine removal from sodium tungstate ion exchange effluent by precipitation with addition of lanthanum chloride. (PubMed, Front Chem) - "More than 92% of the fluorine can be removed when the concentration of fluorine in the solution ranged from 60 to 400 mg/L, the dosage of lanthanum chloride was 1.3 times of the theoretical amount, the pH value was 8.0 at 60°C for 30 min. After removing fluorine from the solution, the resiual fluorine concentrtion was lower than 10 mg/L, which could meet the requirement of national wastewater discharge."

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A mulberry 9-cis-epoxycarotenoid dioxygenase gene MaNCED1 is involved in plant growth regulation and confers salt and drought tolerance in transgenic tobacco. (PubMed, Front Plant Sci) - "Inhibition of ABA synthesis by fluridone and sodium tungstate resulted in the decrease of root/stem ratio...This study demonstrated the roles of mulberry MaNCED1 in regulating plant development and abiotic stress responses. It gave further insights into the coordinated regulation of ABA, auxin, and ethylene in seed growth and germination."

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Efficient antibacterial activity of NiWO4 nanoparticles (ACS-Fall 2023) - "The NiWO4 NPs were synthesized via a facile hydrothermal method using nickel (II) nitrate hexahydrate and sodium tungstate dihydrate as precursors for nickel and tungstate, respectively...A minimum inhibitory concentration (MIC) of 10.06 mg/ml of NiWO4 NPs with an inhibition zone of 18±1.0 mm, and 12.43 mg/ml with a zone of 19±0.9 mm has been reported, respectively. Such results indicate that transition metal tungstate-based nanomaterial is a potential antibacterial agent."

Infectious Disease

Nitric oxide modulates folate-mediated one-carbon metabolism and mitochondrial energy levels of peaches during cold storage. (PubMed, Front Nutr) - "In this experiment, peaches were soaked with 1.5 mmol LS-nitrosoglutathione (GSNO) as NO donor, and the negative treatment (NT) solution containing 5 μmol L carboxy-PTIO (c-PTIO, NO scavenger), 200 μmol L N-Nitro--arginine methyl ester (-NAME, NO synthase-like enzyme inhibitor), and 200 μmol L sodium tungstate dihydrate (nitrate reductase inhibitor) and stored at 0°C...NT treatment exhibited the opposite results. In conclusion, these results suggested that NO could induce the accumulation of folate and FOCM flux and maintain mitochondrial energy levels, which might be responsible for maintaining the quality of peaches during cold storage."

Journal • MSRA

Characterization and metabolic pathway of Pseudomonas fluorescens 2P24 for highly efficient ammonium and nitrate removal. (PubMed, Bioresour Technol) - "The inhibitor allylthiourea had no impact on ammonium transformation, and diethyl dithiocarbamate and sodium tungstate did not inhibit nitrate removal...Moreover, the nitrogen metabolism functional genes (glnK, nasA, narG, nirBD, nxrAB, nirS, nirK, and norB) were identified in the strain. All results highlighted that P. fluorescens 2P24 is capable of assimilatory and dissimilatory nitrate reduction, ammonium assimilation and oxidation, and denitrification."

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Sialic acid exacerbates gut dysbiosis-associated mastitis through the microbiota-gut-mammary axis by fueling gut microbiota disruption. (PubMed, Microbiome) - "This study, for the first time, indicates that SA aggravates gut dysbiosis-induced mastitis by promoting gut microbiota disturbance and is regulated by commensal bacteria, indicating the important role of the microbiota-gut-mammary axis in mastitis pathogenesis and suggesting a potential strategy for mastitis intervention based on gut metabolism regulation. Video Abstract."

Journal • Gastrointestinal Disorder • Immunology • Inflammation • Liver Failure • Metabolic Disorders • Systemic Inflammatory Response Syndrome • Transplantation • NF-κβ • NLRP3 • TLR4