P 979 / Piramal Phytocare - LARVOL DELTA

PPARd restricts intratumoral Treg function through negatively regulating the CIITA-MHCII axis (P979) (IMMUNOLOGY 2023) - "Our study demonstrated that PPARd restrains tumor Treg function by downregulating the CIITA-MHCII pathway, and identified a previously unrecognized MHCII+ tumor Treg subset as a potent suppressor of anti-tumor immunity. Targeting this Treg subset could open a new avenue for boosting anti-tumor immunity while mitigating autoimmunity risk."

Diabetes • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Metabolic Disorders • Oncology • Type 1 Diabetes Mellitus • CIITA

CRISPRi-mediated characterization of novel anti-tuberculosis targets: Mycobacterial peptidoglycan modifications promote beta-lactam resistance and intracellular survival. (PubMed, Front Cell Infect Microbiol) - "smegmatis ΔblaS1) and PM979 (M...While the amidation of D-iso-glutamate impacted cefotaxime and isoniazid resistance, the N-glycolylation of muramic acid substantially promoted resistance to the tested beta-lactams...Whole-genome sequencing revealed that these PG modifications are highly conserved in a set of 172 clinical strains of Mtb, demonstrating their potential as therapeutic targets against TB. Our results support the development of new therapeutic agents targeting these distinctive mycobacterial PG modifications."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis